Cited by 1,475Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchPain Management and Treatment

Neuronal circuitry for pain processing in the dorsal horn

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Todd, Andrew J.·2010·Nature Reviews Neuroscience

Abstract

Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region.

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Crossref · 10.1038/nrn2947

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  • Activated microglia release inflammatory mediators (IL-1β, TNF-α, NO, ROS) that promote glutamate release and affect neuronal action potentials, leading to abnormal neural circuits.

    “Activated microglia released numerous inflammatory mediators (IL-1β, TNF-α, NO, and ROS) that led to changes in protein expression, as well as reached synapse endings, promoted glutamate release, and affected neuronal action potentials, thereby resulting in abnormal neural circuits (Todd, 2010, Ma et al., 2021, Costigan et al., 2009, Inoue and Tsuda, 2018, Chen et al., 2018).”

    From Picroside Ⅱ attenuates neuropathic pain by regulating inflammation and spinal excitatory synaptic transmission (2024) · cites this paper as Todd, 2010

    The Intrinsic plasticity section (page unavailable) describes changes in dorsal horn neuronal excitability, and the Mechanisms of hyperalgesia/allodynia section discusses altered spinal pain processing. Neither passage links those changes to activated microglia releasing IL-1β, TNF-α, NO, or ROS, or to microglia promoting glutamate release; searches for those mediators and that mechanism found no supporting passage. (LLM, conf=0.80)

    Experimental — accuracy not yet measured
  • Nerve injury induces hyperexcitability, causing functional alterations such as loss of function of inhibitory neurons in the dorsal horn, and results in neuropathic pain.

    “Nerve injury induces hyperexcitability, thereby causing functional alterations in the neuronal network such as loss of function of inhibitory neurons in the dorsal horn, and results in neuropathic pain (Prescott et al, 2014;Todd, 2010).”

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2 of the 162 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. [158]Todd AJ Cervero F Jensen TS Handbook of Clinical Neurology 3rd Series, Pain 2006 61 76 Elsevier Edinburgh

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Authors
Todd, A. J.
Affiliations
University of Glasgow (GB)
Corresponding author
Todd, Andrew J.
Venue
Nature Reviews Neuroscience
Published
2010-11-11
Volume
11
Issue
12
Pages
823-836
ISSN
  • 1471-003X (ISSN-L)
  • 1471-0048
OpenAlex
W2059635921
Cited by
1,475
References
162
Citations by year
2026: 100 · 2025: 114 · 2024: 95 · 2023: 108 · 2022: 122 · 2021: 137 · 2020: 106 · 2019: 125 · 2018: 85 · 2017: 85 · 2016: 90 · 2015: 86 · 2014: 75 · 2013: 76 · 2012: 39
FWCI
4.69
Type
journal article
Language
en
Open access
Locations
  • Nature reviews. Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
Funders
Wellcome Trust (076976)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
dorsal horn, spinal cord, pain processing, neural circuits, hyperalgesia, allodynia, sensory neurons, analgesic targets, nerve injury, inflammation, pain perception
MeSH terms
Afferent Pathways, Animals, Brain, Disease Models, Animal, Humans, Nerve Net, Nociceptors, Pain, Posterior Horn Cells

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