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Leptin Mediates the Increase in Blood Pressure Associated with Obesity
Open accessAbstract
Obesity is associated with increased blood pressure (BP), which in turn increases the risk of cardiovascular diseases. We found that the increase in leptin levels seen in diet-induced obesity (DIO) drives an increase in BP in rodents, an effect that was not seen in animals deficient in leptin or leptin receptors (LepR). Furthermore, humans with loss-of-function mutations in leptin and the LepR have low BP despite severe obesity. Leptin's effects on BP are mediated by neuronal circuits in the dorsomedial hypothalamus (DMH), as blocking leptin with a specific antibody, antagonist, or inhibition of the activity of LepR-expressing neurons in the DMH caused a rapid reduction of BP in DIO mice, independent of changes in weight. Re-expression of LepRs in the DMH of DIO LepR-deficient mice caused an increase in BP. These studies demonstrate that leptin couples changes in weight to changes in BP in mammalian species.
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Self-citationLeptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
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Cited by
Obesity, Adipose Tissue and Vascular Dysfunction
Koenen, M., Hill, M. A., Cohen, P., & Sowers, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318093 · Cited by 904
Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity
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The cellular and molecular bases of leptin and ghrelin resistance in obesity
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The Hunger Genes: Pathways to Obesity
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Self-citationLeptin and the maintenance of elevated body weight
Pan, W. W., & Myers, M. G. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.168 · Cited by 344
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Metadata
- Authors
- Simonds, S. E., Pryor, J. T., Ravussin, E., Greenway, F. L., Dileone, R., Allen, A. M., Bassi, J., Elmquist, J. K., Keogh, J. M., Henning, E., Myers, M. G., Licinio, J., Brown, R. D., Enriori, P. J., O’Rahilly, S., Sternson, S. M., Grove, K. L., Spanswick, D. C., Farooqi, I. S., & Cowley, M. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 159
- Issue
- 6
- Pages
- 1404-1416
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2147984307
- Cited by
- 351
- References
- 66
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Simonds, S. E., Pryor, J. T., Ravussin, E., Greenway, F. L., Dileone, R., Allen, A. M., Bassi, J., Elmquist, J. K., Keogh, J. M., Henning, E., Myers, M. G., Licinio, J., Brown, R. D., Enriori, P. J., O’Rahilly, S., Sternson, S. M., Grove, K. L., Spanswick, D. C., Farooqi, I. S., & Cowley, M. A. (2014). Leptin Mediates the Increase in Blood Pressure Associated with Obesity. Cell. https://doi.org/10.1016/j.cell.2014.10.058
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
