Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

Chomczyński, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 47,092 · see citing works

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

Feinberg, A. P., & Vogelstein, B. (1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90418-9 · Cited by 24,512 · see citing works

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works

Antibodies, a laboratory manual

(1989) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(89)90130-3 · Cited by 12,318 · see citing works

Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451 · see citing works

Effects of the <i>obese</i> Gene Product on Body Weight Regulation in <i>ob</i> / <i>ob</i> Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017 · see citing works

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

Campfield, L. A., Smith, F. J., Guisez, Y., Devos, R., & Burn, P. (1995) · Science · doi:10.1126/science.7624778 · Cited by 3,243 · see citing works

Body composition from fluid spaces and density: analysis of methods. 1961.

Siri, W. E. (1994) · PubMed · Cited by 2,556 · see citing works

Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women.

Pouliot, M.-C., Despres, J., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Nadeau, A., & Lupien, P. (1994) · American Journal of Cardiology · doi:10.1016/0002-9149(94)90676-9 · Cited by 2,238 · see citing works

Changes in Energy Expenditure Resulting from Altered Body Weight

Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012 · see citing works

Basic and Clinical Biostatistics,

(2002) · Survey of Ophthalmology · doi:10.1016/s0039-6257(02)00360-0 · Cited by 1,809 · see citing works

Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of pima indians

Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508 · see citing works

The role of depot fat in the hypothalamic control of food intake in the rat

Gc, K. (1953) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1953.0009 · Cited by 1,432 · see citing works

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

Coleman, D. L. (1978) · Diabetologia · doi:10.1007/bf00429772 · Cited by 1,307 · see citing works

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase

Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R., & Simsolo, R. B. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117899 · Cited by 1,305 · see citing works

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075 · see citing works

Diabetes Mellitus: Report of a WHO Study Group.

(1986) · Annals of Internal Medicine · doi:10.7326/0003-4819-104-4-597_2 · Cited by 1,030 · see citing works

Molecular characterization of the mouse agouti locus

Bultman, S. J., Michaud, E. J., & Woychik, R. P. (1992) · Cell · doi:10.1016/s0092-8674(05)80067-4 · Cited by 805 · see citing works

Evidence for an Endogenous Ultradian Rhythm Governing Growth Hormone Secretion in the Rat

Tannenbaum, G. S., & Martin, J. B. (1976) · Endocrinology · doi:10.1210/endo-98-3-562 · Cited by 749 · see citing works

Overexpression of the obese (ob) gene in adipose tissue of human obese subjects

Lönnqvist, F., Arner, P., Nordfors, L., & Schalling, M. (1995) · Nature Medicine · doi:10.1038/nm0995-950 · Cited by 708 · see citing works

Basic and clinical biostatistics

Price, W. A. (1991) · The Journal of Pediatrics · doi:10.1016/s0022-3476(05)83379-7 · Cited by 680 · see citing works

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

Naggert, J. Κ., Fricker, L. D., Varlamov, O., Nishina, P. M., Rouillé, Y., Steiner, D. F., Carroll, R. J., Paigen, B. J., & Leiter, E. H. (1995) · Nature Genetics · doi:10.1038/ng0695-135 · Cited by 664 · see citing works

Increased obese mRNA expression in omental fat cells from massively obese humans

Hamilton, B. S., Paglia, D., Kwan, A. Y. M., & Deitel, M. (1995) · Nature Medicine · doi:10.1038/nm0995-953 · Cited by 526 · see citing works

Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes.

MacDougald, O. A., Hwang, C.-S., Fan, H., & Lane, M. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9034 · Cited by 515 · see citing works

The effects of lesions in the hypothalamus in parabiotic rats

Hervey, G. R. (1959) · The Journal of Physiology · doi:10.1113/jphysiol.1959.sp006145 · Cited by 505 · see citing works

Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.

Maffei, M., Fei, H., Lee, G., Dani, C., Leroy, P., Zhang, Y., Proenca, R., Négrel, R., Ailhaud, G. P., & Friedman, J. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6957 · Cited by 465 · see citing works

Human Obese Gene Expression: Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

Masuzaki, H., Ogawa, Y., Isse, N., Satoh, N., Okazaki, T., Shigemoto, M., Mori, K., Tamura, N., Hosoda, K., Yoshimasa, Y., et al. (1995) · Diabetes · doi:10.2337/diab.44.7.855 · Cited by 454 · see citing works

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.Preprint

Miller, M. W., Duhl, D. M. J., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M., & Barsh, G. S. (1993) · Genes & Development · doi:10.1101/gad.7.3.454 · Cited by 430 · see citing works

Strategies of Anti‐Cytokine Monoclonal Antibody Development: Immunoassay of IL‐10 and IL‐5 in Clinical Samples

Abrams, J. S., Roncarolo, M., Yssel, H., Andersson, U., Gleich, G. J., & Silver, J. E. (1992) · Immunological Reviews · doi:10.1111/j.1600-065x.1992.tb01406.x · Cited by 347 · see citing works

Obesity in the Pima Indians: its magnitude and relationship with diabetes

Knowler, W. C., Pettitt, D. J., Saad, M., Charles, M.-A. A., Nelson, R., Howard, B., Bogardus, C., & Bennett, P. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.6.1543s · Cited by 284 · see citing works

Fat (fat) and Tubby (tub): Two Autosomal Recessive Mutations Causing Obesity Syndromes in the Mouse

Coleman, D., & Eicher, E. M. (1990) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a111019 · Cited by 279 · see citing works

Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice

Trayhurn, P., Thomas, M. E., Duncan, J. S., & Rayner, D. V. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00719-p · Cited by 268 · see citing works

The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7.Preprint

Green, E. D., Maffei, M., Braden, V. V., Proenca, R., DeSilva, U., Zhang, Y., Chua, S. C., Leibel, R. L., Weissenbach, J., & Friedman, J. M. (1995) · Genome Research · doi:10.1101/gr.5.1.5 · Cited by 252 · see citing works

Molecular mapping of the mouse ob mutation

Friedman, J. M., Leibel, R. L., Siegel, D. S., Walsh, J., & Bahary, N. (1991) · Genomics · doi:10.1016/0888-7543(91)90032-a · Cited by 182 · see citing works

Appetite and the regulation of body composition

Weigle, D. S. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.3.8143936 · Cited by 155 · see citing works

Rat obesity gene fatty (fa) maps to chromosome 5: evidence for homology with the mouse gene diabetes (db).

Truett, G. E., Bahary, N., Friedman, J. M., & Leibel, R. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.17.7806 · Cited by 137 · see citing works

The Effects of Weight Loss on the Activity and Expression of Adipose-Tissue Lipoprotein Lipase in Very Obese Humans

Kern, P. A., Ong, J. M., Saffari, B., & Carty, J. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004123221506 · Cited by 130 · see citing works

Cloning of Rat Obese cDNA and Its Expression in Obese Rats

Murakami, T., & Shima, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1589 · Cited by 129 · see citing works

Enhanced Expression of Rat Obese (ob) Gene in Adipose Tissues of Ventromedial Hypothalamus-Lesioned Rats

Funahashi, T., Shimomura, I., Hiraoka, H., Arai, T., Takahashi, M., Nakamura, T., Nozaki, S., Yamashita, S., Takemura, K., Tokunaga, K., et al. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1837 · Cited by 126 · see citing works

Development of a simple valid method for the complete removal of insulin-like growth factor (IGF)-binding proteins from IGFs in human serum and other biological fluids: comparison with acid-ethanol treatment and C18 Sep-Pak separation.

Mohan, S., & Baylink, D. J. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.2.7531716 · Cited by 119 · see citing works

The regulation of adipose tissue and muscle lipoprotein lipase in runners by detraining.

Simsolo, R. B., Ong, J. M., & Kern, P. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116813 · Cited by 109 · see citing works

Adipocyte-Specific Expression and Regional Differences in the Adipose Tissue

Masuzaki, H., Ogawa, Y., Isse, N., et al. (1995) · Cited by 77 · see citing works

Gold thioglucose obesity syndrome.

Debons, A. F., KRIMSKY, I., MAAYAN, M. L., Fani, K., & Jemenez, F. A. (1977) · PubMed · Cited by 65 · see citing works

Relationship between Nutrition and Aging

Barrows, C. H., & Kokkonen, G. C. (1977) · Springer eBooks · doi:10.1007/978-1-4613-9928-5_10 · Cited by 46 · see citing works

Finding an Obesity Gene — A Tale of Mice and Man

Lindpaintner, K. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321012 · Cited by 37 · see citing works

Beyond Overeating

Bennett, W. I. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321009 · Cited by 37 · see citing works

A biologic radar system for the assessment of body mass the model of a geometry sensitive endocrine system is presented

Leibel, R. L. (1977) · Journal of Theoretical Biology · doi:10.1016/0022-5193(77)90173-4 · Cited by 19 · see citing works

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works

Obesity as a medical problem

Kopelman, P. G. (2000) · Nature · doi:10.1038/35007508 · Cited by 4,795 · see citing works

Identification and expression cloning of a leptin receptor, OB-R.

Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works

Role of leptin in the neuroendocrine response to fasting

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E., & Flier, J. S. (1996) · Nature · doi:10.1038/382250a0 · Cited by 3,117 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

Congenital leptin deficiency is associated with severe early-onset obesity in humans

Montague, C. T., Farooqi, I. S., Whitehead, J. P., Soos, M. A., Rau, H., Wareham, N. J., Sewter, C. P., Digby, J. E., Mohammed, S. N., Hurst, J. A., et al. (1997) · Nature · doi:10.1038/43185 · Cited by 2,936 · see citing works

Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome

Wajchenberg, B. L. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0415 · Cited by 2,961 · see citing works

Short-chain fatty acids in control of body weight and insulin sensitivity

Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.128 · Cited by 2,298 · see citing works

Leptin Inhibits Bone Formation through a Hypothalamic Relay

Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077 · see citing works

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works

New Criteria for `Obesity Disease' in Japan

The Examination Committee of Criter (2002) · Circulation Journal · doi:10.1253/circj.66.987 · Cited by 1,650 · see citing works

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works

Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422 · see citing works

The Leptin Receptor

Tartaglia, L. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6093 · Cited by 1,289 · see citing works

The Need to Feed

Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120 · see citing works

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086 · see citing works

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8878 · Cited by 1,033 · see citing works

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014 · see citing works

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

Schwartz, M. W., Peskind, E., Raskind, M., Boyko, E. J., & Porte, D. (1996) · Nature Medicine · doi:10.1038/nm0596-589 · Cited by 1,014 · see citing works

Mitofusin-2 Determines Mitochondrial Network Architecture and Mitochondrial Metabolism

Bach, D., Pich, S., Soriano, F. X., Vega, N., Baumgartner, B., Oriola, J., Daugaard, J. R., Lloberas, J., Camps, M., Zierath, J. R., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212754200 · Cited by 832 · see citing works

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791 · see citing works

Leptin Regulation of Neuroendocrine Systems

Ahima, R. S., Saper, C. B., Flier, J. S., & Elmquist, J. K. (2000) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2000.0197 · Cited by 767 · see citing works

TNF-α Is a Predictor of Insulin Resistance in Human Pregnancy

Kirwan, J. P., Hauguel-De Mouzon, S., Lepercq, J., Challier, J.-C., Huston-Presley, L., Friedman, J. E., Kalhan, S. C., & Catalano, P. M. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2207 · Cited by 738 · see citing works

Cardiovascular Risk Reduction in High-Risk Pediatric Patients: A Scientific Statement From the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: <i>Endorsed by the American Academy of Pediatrics</i>

Kavey, R.-E. W., Allada, V., Daniels, S. R., Hayman, L. L., McCrindle, B. W., Newburger, J. W., Parekh, R. S., & Steinberger, J. (2006) · Circulation · doi:10.1161/circulationaha.106.179568 · Cited by 707 · see citing works

Leptin and the endocrine control of energy balance

Friedman, J. M. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0095-y · Cited by 661 · see citing works

The role of SOCS-3 in leptin signaling and leptin resistance

Bjørbæk, C., El-Haschimi, K., Frantz, J. D., & Flier, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.30059 · Cited by 639 · see citing works

Dietary fructose: implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism.

Havel, P. J. (2005) · Nutrition Reviews · doi:10.1111/j.1753-4887.2005.tb00132.x · Cited by 607 · see citing works

Leptin and reproduction: a review

Moschos, S., Chan, J. L., & Mantzoros, C. S. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)03010-2 · Cited by 557 · see citing works

Unraveling the central nervous system pathways underlying responses to leptin

Elmquist, J. K., Maratos-Flier, E., Saper, C. B., & Flier, J. S. (1998) · Nature Neuroscience · doi:10.1038/2164 · Cited by 520 · see citing works

Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine

Johnstone, A. M., Murison, S. D., Duncan, J. S., Rance, K. A., & Speakman, J. R. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.5.941 · Cited by 514 · see citing works

Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake

Merz, K. E., & Thurmond, D. C. (2020) · Comprehensive Physiology · doi:10.1002/cphy.c190029 · Cited by 494 · see citing works

Pathophysiological role of leptin in obesity-related hypertension

Aizawa-Abe, M., Ogawa, Y., Masuzaki, H., Ebihara, K., Satoh, N., Iwai, H., Matsuoka, N., Hayashi, T., Hosoda, K., Inoue, G., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8341 · Cited by 477 · see citing works

Obesity in mice with adipocyte-specific deletion of clock component Arntl

Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465 · see citing works

Obesity and related consequences to ageing

Jura, M., & Kozak, L. P. (2016) · AGE · doi:10.1007/s11357-016-9884-3 · Cited by 473 · see citing works

The effects of intense exercise on the female reproductive system

Warren, M., & Perlroth, N. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700003 · Cited by 446 · see citing works

Mechanisms of Sympathetic Activation in Obesity-Related Hypertension

Esler, M., Straznicky, N., Eikelis, N., Masuo, K., Lambert, G., & Lambert, E. (2006) · Hypertension · doi:10.1161/01.hyp.0000242642.42177.49 · Cited by 443 · see citing works

Regulation of fatty acid homeostasis in cells: Novel role of leptin

Unger, R. H., Zhou, Y.-T., & Orci, L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2327 · Cited by 435 · see citing works

The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations

Cnop, M., Landchild, M. J., Vidal, J., Havel, P. J., Knowles, N. G., Carr, D. R., Wang, F., Hull, R. L., Boyko, E. J., Retzlaff, B. M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1005 · Cited by 432 · see citing works

Relevance of Sympathetic Nervous System Activation in Obesity and Metabolic Syndrome

Thorp, A. A., & Schlaich, M. P. (2015) · Journal of Diabetes Research · doi:10.1155/2015/341583 · Cited by 425 · see citing works

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis.

Varela, L., & Horvath, T. L. (2012) · The EMBO Reports · doi:10.1038/embor.2012.174 · Cited by 426 · see citing works

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

Gao, Q., Mezei, G., Nie, Y., Rao, Y., Choi, C. S., Bechmann, I., Leranth, C., Toran-Allerand, D., Priest, C. A., Roberts, J. L., et al. (2007) · Nature Medicine · doi:10.1038/nm1525 · Cited by 416 · see citing works

Role of the gut microbiota in host appetite control: bacterial growth to animal feeding behaviour

Fetissov, S. O. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.150 · Cited by 403 · see citing works

Mitochondrial dysfunction in cardiovascular disease

Ballinger, S. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.014 · Cited by 405 · see citing works

Hormonal regulation of food intake

Stanley, S., Wynne, K., McGowan, B., & Bloom, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00015.2004 · Cited by 372 · see citing works

The evolving role of inflammation in obesity and the metabolic syndrome

Lee, Y.-H., & Pratley, R. E. (2005) · Current Diabetes Reports · doi:10.1007/s11892-005-0071-7 · Cited by 369 · see citing works

Sixteen years and counting: an update on leptin in energy balance

Gautron, L., & Elmquist, J. K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45888 · Cited by 367 · see citing works

Modern science versus the stigma of obesity

Friedman, J. M. (2004) · Nature Medicine · doi:10.1038/nm0604-563 · Cited by 368 · see citing works

Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake

Raben, A., Agerholm-Larsen, L., Flint, A., Holst, J. J., & Astrup, A. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/77.1.91 · Cited by 365 · see citing works

Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors

Bjørbæk, C., Buchholz, R. M., Davis, S. M., Bates, S. H., Pierroz, D. D., Gu, H., Neel, B. G., Myers, M. G., & Flier, J. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007439200 · Cited by 364 · see citing works

Timed high-fat diet resets circadian metabolism and prevents obesity

Sherman, H., Genzer, Y., Cohen, R., Chapnik, N., Madar, Z., & Froy, O. (2012) · The FASEB Journal · doi:10.1096/fj.12-208868 · Cited by 360 · see citing works

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

Williams, K. W., Margatho, L. O., Lee, C. E., Choi, M., Lee, S., Scott, M. M., Elias, C. F., & Elmquist, J. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3118-09.2010 · Cited by 352 · see citing works

Energy balance and body composition in sports and exercise

Loucks, A. B. (2004) · Journal of Sports Sciences · doi:10.1080/0264041031000140518 · Cited by 344 · see citing works

The impact of aging on adipose function and adipokine synthesis

Mancuso, P., & Bouchard, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00137 · Cited by 314 · see citing works

How Palatable Food Disrupts Appetite Regulation

Erlanson‐Albertsson, C. (2005) · Basic &amp; Clinical Pharmacology &amp; Toxicology · doi:10.1111/j.1742-7843.2005.pto_179.x · Cited by 330 · see citing works

The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes

Frias, J. P., Bastyr, E. J., Vignati, L., Tschöp, M. H., Schmitt, C., Owen, K., Christensen, R. H., & DiMarchi, R. D. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.011 · Cited by 321 · see citing works

Metabolic disturbances connecting obesity and depression

Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322 · see citing works

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

Ghilardi, N., & Skoda, R. C. (1997) · Molecular Endocrinology · doi:10.1210/mend.11.4.9907 · Cited by 326 · see citing works

Role of Selective Leptin Resistance in Diet-Induced Obesity Hypertension

Rahmouni, K., Morgan, D. A., Morgan, G. M., Mark, A. L., & Haynes, W. G. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2012 · Cited by 319 · see citing works

Hyperleptinemia Is Required for the Development of Leptin Resistance

Knight, Z. A., Hannan, K. S., Greenberg, M. L., & Friedman, J. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011376 · Cited by 311 · see citing works

Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.

Kulkarni, R. N., Wang, Z. L., Wang, R. M., Hurley, J. D., Smith, D. M., Ghatei, M. A., Withers, D. J., Gardiner, J. V., Bailey, C. J., & Bloom, S. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119818 · Cited by 296 · see citing works

Effect of Fasting, Refeeding, and Dietary Fat Restriction on Plasma Leptin Levels

Weigle, D. S. (1997) · Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.82.2.561 · Cited by 287 · see citing works

The role of dopamine in motivation for food in humans: implications for obesity

Wang, G.-J., Volkow, N. D., & Fowler, J. S. (2002) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.6.5.601 · Cited by 285 · see citing works

Leptin at 14 y of age: an ongoing story

Friedman, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26788b · Cited by 272 · see citing works

Leptin Resistance and Obesity

Enriori, P. J., Evans, A. E., Sinnayah, P., & Cowley, M. A. (2006) · Obesity · doi:10.1038/oby.2006.319 · Cited by 281 · see citing works

Circadian dysfunction induces leptin resistance in mice

Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260 · see citing works

20 YEARS OF LEPTIN: Human disorders of leptin action

Farooqi, I. S., & O'Rahilly, S. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0480 · Cited by 280 · see citing works

Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects

Miyazawa-Hoshimoto, S., Takahashi, K., Bujo, H., Hashimoto, N., & Saito, Y. (2003) · Diabetologia · doi:10.1007/s00125-003-1221-6 · Cited by 254 · see citing works

Testosterone Substitution Normalizes Elevated Serum Leptin Levels in Hypogonadal Men

Jockenhövel, F., Blum, W. F., Vogel, E., Englaro, P., Müller-Wieland, D., Reinwein, D., Rascher, W., & Krone, W. (1997) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.82.8.4174 · Cited by 261 · see citing works

The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes

Rajapurohitam, V., Gan, X. T., Kirshenbaum, L. A., & Karmazyn, M. (2003) · Circulation Research · doi:10.1161/01.res.0000089255.37804.72 · Cited by 248 · see citing works

The effects of obesity on skeletal muscle regeneration

Akhmedov, D., & Berdeaux, R. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00371 · Cited by 241 · see citing works

Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding

Heinonen, M. V., Purhonen, A. K., Miettinen, P., Pääkkönen, M., Pirinen, E., Alhava, E., Åkerman, K., & Herzig, K. H. (2005) · Regulatory Peptides · doi:10.1016/j.regpep.2005.05.003 · Cited by 232 · see citing works

Leptin—Much More Than a Satiety Signal

Harris, R. B. S. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.45 · Cited by 222 · see citing works

Circadian rhythms in the development of obesity: potential role for the circadian clock within the adipocyte

Bray, M. S., & Young, M. E. (2007) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00277.x · Cited by 213 · see citing works

Higher production of IL-8 in visceral vs. subcutaneous adipose tissue. Implication of nonadipose cells in adipose tissue

Bruun, J. M., Lihn, A. S., Madan, A. K., Pedersen, S. B., Schiøtt, K. M., Fain, J. N., & Richelsen, B. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00269.2003 · Cited by 215 · see citing works

The arcuate nucleus as a primary site of satiety effect of leptin in rats

Satoh, N., Ogawa, Y., Katsuura, G., Hayase, M., Tsuji, T., Imagawa, K., Yoshimasa, Y., Nishi, S., Hosoda, K., & Nakao, K. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00163-8 · Cited by 213 · see citing works

Weekly Subcutaneous Pegylated Recombinant Native Human Leptin (PEG-OB) Administration in Obese Men

Hukshorn, C. J., Saris, W. H. M., Westerterp-Plantenga, M. S., Farid, A. R., Smith, F. J., & Campfield, L. A. (2000) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.85.11.6955 · Cited by 220 · see citing works

Leptin Inhibits Directly Glucocorticoid Secretion by Normal Human and Rat Adrenal Gland**This work was supported by a grant from the Swiss National Science Foundation (No. 3100–050748.97/1).

Pralong, F. P., Roduit, R., Waeber, G., Castillo, E., Mosimann, F., Thorens, B., & Gaillard, R. C. (1998) · Endocrinology · doi:10.1210/endo.139.10.6254 · Cited by 202 · see citing works

Leptin and its role in hippocampal synaptic plasticity

HARVEY, J., SOLOVYOVA, N., & IRVING, A. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.03.001 · Cited by 202 · see citing works

Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin

Havel, P. J., Uriu-Hare, J. Y., Liu, T., Stanhope, K. L., Stern, J. S., Keen, C. L., & Ahrén, B. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.5.r1482 · Cited by 198 · see citing works

Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194 · see citing works

Adipose tissue and metabolic syndrome: too much, too little or neither

Grundy, S. M. (2015) · European Journal of Clinical Investigation · doi:10.1111/eci.12519 · Cited by 187 · see citing works

Obesity, diabetes and the central nervous system

Porte Jr., D., Seeley, R. J., Woods, S. C., Baskin, D. G., Figlewicz, D. P., & Schwartz, M. W. (1998) · Diabetologia · doi:10.1007/s001250051002 · Cited by 186 · see citing works

Dexamethasone increases leptin expression in humans in vivo

Papaspyrou-Rao, S., Schneider, S. H., Petersen, R. N., & Fried, S. K. (1997) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.82.5.3928 · Cited by 185 · see citing works

Peripheral metabolic actions of leptin

Muoio, D. M., & Lynis Dohm, G. (2002) · Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism · doi:10.1053/beem.2002.0223 · Cited by 183 · see citing works

The alphabet of weight control.

Friedman, J. M. (1997) · Nature · doi:10.1038/385119a0 · Cited by 180 · see citing works

The challenge of keeping it off, a descriptive systematic review of high‐quality, follow‐up studies of obesity treatments

Nordmo, M., Danielsen, Y. S., & Nordmo, M. (2020) · Obesity Reviews · doi:10.1111/obr.12949 · Cited by 169 · see citing works

Leptin Treatment Rescues the Sterility of Genetically Obese ob/ob Males*

Mounzih, K., Lu, R., & Chehab, F. F. (1997) · Endocrinology · doi:10.1210/en.138.3.1190 · Cited by 482 · see citing works

Genetic rescue of nonclassical ERα signaling normalizes energy balance in obese Erα-null mutant mice

Park, C. J., Zhao, Z., Glidewell-Kenney, C., Lazic, M., Chambon, P., Krust, A., Weiss, J., Clegg, D. J., Dunaif, A., Jameson, J. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci41702 · Cited by 162 · see citing works

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese

Wang, Z., Li, V., Chan, G. C. K., Phan, T., Nudelman, A. S., Xia, Z., & Storm, D. R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006979 · Cited by 159 · see citing works

Exposure to a High-Fat Diet Alters Leptin Sensitivity and Elevates Renal Sympathetic Nerve Activity and Arterial Pressure in Rabbits

Prior, L. J., Eikelis, N., Armitage, J. A., Davern, P. J., Burke, S. L., Montani, J.-P., Barzel, B., & Head, G. A. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.141119 · Cited by 157 · see citing works

Increased Maternal Plasma Leptin in Early Pregnancy and Risk of Gestational Diabetes Mellitus

Qiu, C., Williams, M. A., Vadachkoria, S., Frederick, I. O., & Luthy, D. A. (2004) · Obstetrics &amp; Gynecology · doi:10.1097/01.aog.0000113621.53602.7a · Cited by 146 · see citing works

Region-Specific Reduction in Leptin-Induced Phosphorylation of Signal Transducer and Activator of Transcription-3 (STAT3) in the Rat Hypothalamus Is Associated with Leptin Resistance during Pregnancy

Ladyman, S. R., & Grattan, D. R. (2004) · Endocrinology · doi:10.1210/en.2004-0338 · Cited by 144 · see citing works

Effect of three treatment schedules of recombinant methionyl human leptin on body weight in obese adults: a randomized, placebo‐controlled trial

Zelissen, P. M. J., Stenlof, K., Lean, M. E. J., Fogteloo, J., Keulen, E. T. P., Wilding, J., Finer, N., Rössner, S., Lawrence, E., Fletcher, C., et al. (2005) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2005.00468.x · Cited by 144 · see citing works

Steroid biosynthesis in adipose tissue

Li, J., Papadopoulos, V., & Vihma, V. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.016 · Cited by 130 · see citing works

Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononuclear cells in overweight and obese people with or without weight-loss diet

Zarrati, M., Salehi, E., Nourijelyani, K., Mofid, V., Zadeh, M. J. H., Najafi, F., Ghaflati, Z., Bidad, K., Chamari, M., Karimi, M., et al. (2014) · Journal of the American College of Nutrition · doi:10.1080/07315724.2013.874937 · Cited by 130 · see citing works

Adiponectin—Consideration for its Role in Skeletal Muscle Health

Krause, M. P., Milne, K. J., & Hawke, T. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071528 · Cited by 121 · see citing works

Abnormal regulation of the leptin gene in the pathogenesis of obesity.

Ioffe, E., Moon, B., Connolly, E., & Friedman, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11852 · Cited by 117 · see citing works

Assessment of body condition in African (Loxodonta africana) and Asian (Elephas maximus) elephants in North American zoos and management practices associated with high body condition scores

Morfeld, K. A., Meehan, C. L., Hogan, J. N., & Brown, J. L. (2016) · PLOS ONE · doi:10.1371/journal.pone.0155146 · Cited by 114 · see citing works

Relationship Between Muscle Sympathetic Nerve Activity and Plasma Leptin Concentration

Snitker, S., Pratley, R. E., Nicolson, M., Tataranni, P. A., & Ravussin, E. (1997) · Obesity Research · doi:10.1002/j.1550-8528.1997.tb00561.x · Cited by 110 · see citing works

Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism

Hanlon, E. C., & Van Cauter, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101338108 · Cited by 110 · see citing works

Faculty Opinions recommendation of Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis.

Jiménez, C. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732635806.793548425

Effect of TGFß–2 in an in vivo rodent model of posterior capsule opacification.

Lois, N., Taylor, J., McKinnon, A., et al. (2004) · Investigative Ophthalmology & Visual Science

Retinal neuronal mtDNA alterations in a rodent model of diabetic retinopathy

Masser, D. R., Wronowski, B., Stanford, D. R., et al. (2015) · Investigative Ophthalmology & Visual Science

Rodent respiratory findings with mGlu5 positive allosteric modulator RG7342, translation to non-rodent and man

Dinklo, T., Waiz, D., Roberts, S., et al. (2019) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2019.05.149

Rodent models for ovarian cancer research

Stakleff, K. S., & von Gruenigen, V. E. (2003) · International Journal of Gynecological Cancer · doi:10.1046/j.1525-1438.2003.13317.x · Cited by 48 · see citing works