The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Widespread Co-translational RNA Decay Reveals Ribosome Dynamics
Open accessAbstract
Summary It is generally assumed that mRNAs undergoing translation are protected from decay. Here we show that mRNAs are in fact co-translationally degraded. This is a widespread and conserved process affecting most genes, where 5’-3’ transcript degradation follows the last translating ribosome, producing an in vivo ribosomal footprint. By sequencing the ends of 5’phosphorylated mRNA degradation intermediates, we obtain a genome-wide drug-free measurement of ribosome dynamics. We identify general translation termination pauses in both normal and stress conditions. In addition, we describe novel codon-specific ribosomal pausing sites in response to oxidative stress, which are dependent on the RNase Rny1. Our approach is simple and straightforward, and does not require the use of translational inhibitors or in vitro RNA footprinting that can alter ribosome protection patterns.
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Bailey, T. L., Boden, M., Buske, F. A., Frith, M., Grant, C. E., Clementi, L., Ren, J., Li, W. W., & Noble, W. S. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp335 · Cited by 10,648
Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes
Gasch, A. P., Spellman, P. T., Kao, C. M., Carmel-Harel, O., Eisen, M. B., Storz, G., Botstein, D., & Brown, P. O. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4241 · Cited by 4,815
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
Ingolia, N. T., Lareau, L. F., & Weissman, J. S. (2011) · Cell · doi:10.1016/j.cell.2011.10.002 · Cited by 2,187
Ingolia, N. T., Brar, G. A., Rouskin, S., McGeachy, A. M., & Weissman, J. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.086 · Cited by 1,259
Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin
Schneider-Poetsch, T., Ju, J., Eyler, D. E., Dang, Y., Bhat, S., Merrick, W. C., Green, R., Shen, B., & Liu, J. O. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.304 · Cited by 1,014
An evolutionarily conserved mechanism for controlling the efficiency of protein translation
Tuller, T., Carmi, A., Vestsigian, K., Navon, S., Dorfan, Y., Zaborske, J., Pan, T., Dahan, O., Furman, I., & Pilpel, Y. (2010) · Cell · doi:10.1016/j.cell.2010.03.031 · Cited by 874
Global identification of microRNA–target RNA pairs by parallel analysis of RNA ends
German, M. A., Pillay, M., Jeong, D.-H., Hetawal, A., Luo, S., Janardhanan, P., Kannan, V., Rymarquis, L. A., Nobuta, K., German, R., et al. (2008) · Nature Biotechnology · doi:10.1038/nbt1417 · Cited by 839
P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation
Decker, C. J., & Parker, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012286 · Cited by 804
Endogenous siRNA and miRNA Targets Identified by Sequencing of the Arabidopsis Degradome
Addo-Quaye, C., Eshoo, T. W., Bartel, D. P., & Axtell, M. J. (2008) · Current Biology · doi:10.1016/j.cub.2008.04.042 · Cited by 786
Cited by
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Ingolia, N. T. (2016) · Cell · doi:10.1016/j.cell.2016.02.066 · Cited by 409
Ishimura, R., Nagy, G., Dotu, I., Chuang, J. H., & Ackerman, S. L. (2016) · eLife · doi:10.7554/elife.14295 · Cited by 221
Lahtvee, P.-J., Sánchez, B. J., Smialowska, A., Kasvandik, S., Elsemman, I. E., Gatto, F., & Nielsen, J. (2017) · Cell Systems · doi:10.1016/j.cels.2017.03.003 · Cited by 193
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
Mugridge, J. S., Coller, J., & Gross, J. D. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0164-z · Cited by 133
Metadata
- Authors
- Pelechano, V., Wei, W., & Steinmetz, L. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 6
- Pages
- 1400-1412
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1585169926
- Cited by
- 324
- References
- 49
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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