Cited by 133RNA Research and SplicingRNA and protein synthesis mechanismsRNA regulation and disease

Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay

Mugridge, Jeffrey S., Coller, Jeff, Gross, John D.·2018·Nature Structural & Molecular Biology

Abstract

5'-3' RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5'-3' decay, but detailed understanding of how these activities are coordinated is only beginning to emerge. Here we review recent mechanistic insights into the control of 5'-3' RNA decay, including coupling between translation and decay, coordination between the complexes and activities that process 5' and 3' RNA termini, conformational control of enzymatic activity, liquid phase separation, and RNA modifications.

Integrity signals

Registry

Crossref · 10.1038/s41594-018-0164-z

Cites

119 of 119 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A sufficiently long poly(A) tail (100-150 bp) is necessary to interact with poly(A) binding proteins that form complexes necessary for initiating translation and protecting the cap from degradation by decapping enzymes.

    “A sufficiently long tail (100–150 bp) is necessary to interact with poly(A) binding proteins that form complexes necessary for initiating translation11,12 and protecting the cap from degradation by decapping enzymes13.”

Cites

Flagged first, then by citations

1 of the 120 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Mugridge, J. S., Coller, J., & Gross, J. D.
Affiliations
  • University of California, San Francisco (US)
  • Case Western Reserve University (US)
Corresponding author
Gross, John D.
Venue
Nature Structural & Molecular Biology
Published
2018-12
Volume
25
Issue
12
Pages
1077-1085
ISSN
  • 1545-9985 (ISSN-L)
  • 1545-9993
OpenAlex
W2901347859
Cited by
133
References
120
Citations by year
2026: 9 · 2025: 12 · 2024: 27 · 2023: 9 · 2022: 23 · 2021: 22 · 2020: 25 · 2019: 6
FWCI
1.30
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Structural & Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of General Medical Sciences (R01GM080465)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords
deadenylation, decapping, liquid phase separation, RNA modification, gene expression regulation, mRNA quality control
MeSH terms
Gene Expression Regulation, Models, Molecular, RNA, Messenger, RNA Stability

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review