The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Dynamics of Cell Generation and Turnover in the Human Heart
Open accessAbstract
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analysis of the integration of nuclear bomb test-derived (14)C revealed a high turnover rate of endothelial cells throughout life (>15% per year) and more limited renewal of mesenchymal cells (<4% per year in adulthood). Cardiomyocyte exchange is highest in early childhood and decreases gradually throughout life to <1% per year in adulthood, with similar turnover rates in the major subdivisions of the myocardium. We provide an integrated model of cell generation and turnover in the human heart.
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Cites
Evidence for Cardiomyocyte Renewal in Humans
Bergmann, O., Bhardwaj, R. D., Bernard, S., Zdunek, S., Barnabé-Heider, F., Walsh, S., Zupicich, J., Alkass, K., Buchholz, B. A., Druid, H., et al. (2009) · Science · doi:10.1126/science.1164680 · Cited by 3,130
Self-citationMammalian heart renewal by pre-existing cardiomyocytes
Senyo, S. E., Steinhauser, M. L., Pizzimenti, C. L., Yang, V. K., Cai, L., Wang, M., Wu, T.-D., Guerquin-Kern, J.-L., Lechene, C. P., & Lee, R. T. (2013) · Nature · doi:10.1038/nature11682 · Cited by 1,343
Cited by
Revisiting Cardiac Cellular Composition
Pinto, A. R., Ilinykh, A., Ivey, M. J., Kuwabara, J. T., D’Antoni, M. L., Debuque, R., Chandran, A., Wang, L., Arora, K., Rosenthal, N. A., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.307778 · Cited by 1,400
“This is because of the variability and dynamism of the number of nuclei per cardiomyocyte in addition to the differences between rodents and humans—most murine cardiomyocytes are binucleated,(32,33) whereas most human cardiomyocytes are mononucleated.(2,34) Therefore, estimations of myocyte to nonmyocyte ratios will d…”
BackgroundResultSpatial multi-omic map of human myocardial infarction
Kuppe, C., Ramirez Flores, R. O., Li, Z., Hayat, S., Levinson, R. T., Liao, X., Hannani, M. T., Tanevski, J., Wünnemann, F., Nagai, J. S., et al. (2022) · Nature · doi:10.1038/s41586-022-05060-x · Cited by 772
Cardiomyocyte Maturation: New Phase in Development
Guo, Y., & Pu, W. T. (2020) · Circulation Research · doi:10.1161/circresaha.119.315862 · Cited by 653
Redefining the identity of cardiac fibroblasts
Tallquist, M. D., & Molkentin, J. D. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.57 · Cited by 581
Length-independent telomere damage drives post-mitotic cardiomyocyte senescence
Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., et al. (2019) · The EMBO Journal · doi:10.15252/embj.2018100492 · Cited by 532
“Although the majority of the adult CMs are considered post-mitotic, the adult heart retains limited potential for CM proliferation (Senyo et al , 2013; Bergmann et al , 2015; Richardson et al , 2015).”
Metadata
- Authors
- Bergmann, O., Zdunek, S., Felker, A., Salehpour, M., Alkass, K., Bernard, S., Sjostrom, S. L., Szewczykowska, M., Jackowska, T., dos Remedios, C., Malm, T., Andrä, M., Jashari, R., Nyengaard, J. R., Possnert, G., Jovinge, S., Druid, H., & Frisén, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 161
- Issue
- 7
- Pages
- 1566-1575
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1669479280
- Cited by
- 1,133
- References
- 2
- FWCI
- 32.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bergmann, O., Zdunek, S., Felker, A., Salehpour, M., Alkass, K., Bernard, S., Sjostrom, S. L., Szewczykowska, M., Jackowska, T., dos Remedios, C., Malm, T., Andrä, M., Jashari, R., Nyengaard, J. R., Possnert, G., Jovinge, S., Druid, H., & Frisén, J. (2015). Dynamics of Cell Generation and Turnover in the Human Heart. Cell. https://doi.org/10.1016/j.cell.2015.05.026
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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