The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin
Open accessAbstract
Summary Nucleosome positioning varies between cell types. By deep sequencing cell-free DNA (cfDNA) isolated from circulating blood plasma, we generated maps of genome-wide in vivo nucleosome occupancy, and found that short cfDNA fragments harbor footprints of transcription factors. The cfDNA nucleosome occupancies correlate well with the nuclear architecture, gene structure and expression observed in cells, suggesting that they could indicate the cell-type of origin. Nucleosome spacing inferred from cfDNA in healthy individuals correlates most strongly with epigenetic features of lymphoid and myeloid cells, consistent with hematopoietic cell death as the normal source of cfDNA. We build on this observation to show how nucleosome footprints can be used to infer cell types contributing to cfDNA in pathological states such as cancer. Since this strategy does not rely on differing cfDNA and cellular DNA genotypes, it may enable the noninvasive monitoring of a much broader set of clinical conditions than currently possible.
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Cites
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Systematic Localization of Common Disease-Associated Variation in Regulatory DNA
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A view on drug resistance in cancer
Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770
Liquid biopsies come of age: Towards implementation of circulating tumour DNA
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Tumor microenvironment complexity and therapeutic implications at a glance
Baghban, R., Roshangar, L., Jahanban-Esfahlan, R., Seidi, K., Ebrahimi-Kalan, A., Jaymand, M., Kolahian, S., Javaheri, T., & Zare, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0530-4 · Cited by 1,784
Current and future perspectives of liquid biopsies in genomics-driven oncology
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Genome-wide cell-free DNA fragmentation in patients with cancer
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Metadata
- Authors
- Snyder, M. W., Kircher, M., Hill, A. J., Daza, R. M., & Shendure, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 164
- Issue
- 1-2
- Pages
- 57-68
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2239118478
- Cited by
- 1,464
- References
- 5
- FWCI
- 42.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Snyder, M. W., Kircher, M., Hill, A. J., Daza, R. M., & Shendure, J. (2016). Cell-free DNA Comprises an In Vivo Nucleosome Footprint that Informs Its Tissues-Of-Origin. Cell. https://doi.org/10.1016/j.cell.2015.11.050
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