Liquid biopsies come of age: Towards implementation of circulating tumour DNA
Open accessAbstract
Improvements in genomic and molecular methods are expanding the range of potential applications for circulating tumour DNA (ctDNA), both in a research setting and as a 'liquid biopsy' for cancer management. Proof-of-principle studies have demonstrated the translational potential of ctDNA for prognostication, molecular profiling and monitoring. The field is now in an exciting transitional period in which ctDNA analysis is beginning to be applied clinically, although there is still much to learn about the biology of cell-free DNA. This is an opportune time to appraise potential approaches to ctDNA analysis, and to consider their applications in personalized oncology and in cancer research.
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Therapeutic pressure from KRAS inhibition can rapidly reshape tumor clonal architecture.
“Therapeutic pressure from KRAS inhibition can rapidly reshape tumor clonal architecture [35,36,47,81].”
From Precision Targeting of KRAS-Mutant Cancers: Beyond G12C Toward G12D and Pan-RAS Therapeutic Strategies (2026) · cites this paper as [81]
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- Authors
- Wan, J. C. M., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J. D., Caldas, C., Pacey, S., Baird, R., & Rosenfeld, N.
- Affiliations
- Cancer Research UK (GB)
- University of Cambridge (GB)
- Corresponding author
- Rosenfeld, Nitzan
- ORCID
- Venue
- Nature Reviews Cancer
- Published
- 2017-02-24
- Volume
- 17
- Issue
- 4
- Pages
- 223-238
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2590954301
- Cited by
- 2,809
- References
- 13
- Citations by year
- 2026: 373 · 2025: 358 · 2024: 268 · 2023: 308 · 2022: 286 · 2021: 309 · 2020: 311 · 2019: 276 · 2018: 221 · 2017: 92 · 2016: 2 · 2015: 1 · 2013: 1
- FWCI
- 25.07
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Research Explorer (The University of Manchester) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Apollo
- Funders
- AstraZeneca
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Cancer Research UK (22905, A15601, 20240, 15601, A20240, C14303 / A17197, 16942, A11906)
- National Institute for Health and Care Research (NF-SI-0515-10090, NF-SI-0611-10154)
- European Commission (2007–2013, FP/2007/2013)
- Healthway (22905)
- Chinese University of Hong Kong
- Sociedad Española de Oncología Médica
- Hutchison Whampoa Limited
- FP7 Ideas: European Research Council (337905)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Keywords
- circulating tumor DNA, liquid biopsy, cell-free DNA, molecular profiling, disease surveillance, precision oncology, clinical implementation, cancer research
- MeSH terms
- Biopsy, DNA, Neoplasm, Humans, Mutation, Neoplasm Staging, Neoplasms, Biomarkers, Tumor, Early Detection of Cancer, Precision Medicine, Clonal Evolution, ErbB Receptors
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