The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert A., Gygi, Melanie P., Shen, Kuang, Wyant, Gregory A., Wang, Tim, Harper, J. Wade, Gygi, Steven P., Sabatini, David M.·2016·Cell
Cited by (856)
Items 801–856 of 856
- Identification des mécanismes moléculaires impliqués dans la résistance des cellules à une carence en acides aminés.Florent Mesclon · 2016 · theses.fr (ABES)
- Mécanisme d’activation neuronale de mTORC1 et de son altération par le peptide amyloïde βDany Khamsing · 2017 · theses.fr (ABES)
- Exploring the Role of Intercellular and Intracellular Signaling in the Sustenance of Glioblastoma Stem-like CellsKathryn Jacobs · 2020 · theses.fr (ABES)
- Implication de la GTPase RagA dans l’activation et la polarisation de la réponse lymphocytaire TMehdi Attia · 2017 · theses.fr (ABES)
- Identification of neuronal populations controlling Dilps secretion and body growth according to nutrition in Drosophila melanogasterEleonora Meschi · 2018
- Role of p27/Kip1 in auphagy under metabolic stress conditionsAda Nowosad · 2018 · theses.fr (ABES)
- Translatome-based classification of pancreatic cancerSauyeun Shin · 2020 · theses.fr (ABES)
- Biochemical characterization of mTORC1 regulation by glutamine metabolismClément Bodineau · 2020 · theses.fr (ABES)
- Induction de la mort ferroptotique dans les cellules de cancer pancréatique : rôle essentiel de la cystéine et du transporteur xCTBoutaina Daher · 2020 · theses.fr (ABES)
- Overcoming drug resistance in diffuse large b-cell lymphoma by targeting cell metabolism and the alternative NF-kB pathwayStéphanie Nuan-Aliman · 2021 · theses.fr (ABES)
- Regulation of the Akt/mTORC1 Pathway by HIV Transcriptional Activator Tat in B CellsBurkitkan Akbay · 2021 · theses.fr (ABES)
- EVT-701 : targeting electron transport chain complex I as therapeutic approach in cancerRaquel Luna Yolba · 2021 · theses.fr (ABES)
- Cortical organoid model of DEPDC5-related focal cortical dysplasia and epilepsyM. Maletić · 2022 · theses.fr (ABES)
- Investigations génétiques et physiopathologiques des dysplasies corticales focales de type 2Théo Ribierre · 2020 · theses.fr (ABES)
- The role of GATOR1 complex, upstream regulator of mTORC1 pathway, in mitochondrial functionYahir A. Loissell-Baltazar · 2022 · theses.fr (ABES)
- Control of the invadopodia/MT1-MMP axis by mTORC1/TFEB signaling pathway in breast cancer cellsDavid Remy · 2022 · theses.fr (ABES)
- Role of brain somatic mutations in epileptogenic malformationsLina Sami · 2024 · theses.fr (ABES)
- Elucidating the Vulnerability of Glioblastoma Stem-like Cells to Lysosomal DysfunctionsClément Maghe · 2023 · theses.fr (ABES)
- Remote regulation of hepatic lipid secretion in the intestine by metabolic interaction of dietary arginine with ornithineHiroki Nishi, Sena Nakanishi, Lin Xie, Masayuki Fujinaga, Yiding Zhang, Daisuke Yamanaka, Suguru Fujita, Junji Saruwatari, Kentaro Oniki, Ming-Rong Zhang et al. · 2026 · Scientific Reports
- The role of the GATOR1 complex in mitochondrial function and quality controlHanxiao Zhang · 2025 · theses.fr (ABES)
- Signal sensing and transmission of amino acids in mTORC1 regulationHuan Zeng, Ruotong Li, Juan Li, Xiaoxiao Song, Ming-Yuan Su · 2026 · Oral Science and Homeostatic Medicine
- Activation of mitochondrial CPS1 promotes dormant ovarian follicle activation via arginine elevation and the mTORC1 pathwayStine Bundgaard Birkebæk, Mahboobeh Amoushahi, Karin Lykke‐Hartmann · 2026 · Frontiers in Cell and Developmental Biology
- The unexpected role of RagC in ketogenic diet-derived BHB sensingJian Fu, Xiaoqian Fu, Wenkai Ren · 2026 · Protein & Cell
- Dietary effects of early nutrition on muscle mass and accretion in mammalsMorteza Hosseini Ghaffari, Anuj Malik, Nisha Nisha, H Sauerwein, Harald Michael Hammon · 2026 · Best Practice & Research Clinical Endocrinology & Metabolism
- Impact of Prematurity on Nutrient Signaling and Protein Synthesis in Skeletal MuscleAntonio C. Ramos dos Santos, Ki Beom Jang, Marta L. Fiorotto, Teresa A. Davis · 2026 · Annual Review of Nutrition
- Fetal growth is driven by a bimodal fetal beta cell response and reshaped by a ketogenic diet in a mouse model of maternal diabetesOmer Cohenshtam, Amnon Zung, Amy Yu, Hadar King, Polina Kotova, Ofer Gover, Itia Magenheim Samuel, Sarit Helman, MICHAEL D. WALKER, Danny Ben‐Zvi et al. · 2026 · Diabetologia
- Arginine metabolism supports de novo pyrimidine biosynthesis to block DNA damage and maintain Epstein-Barr virus latencyShaowen White, Yifei Liao, Yin Wang, Shunji Li, Eric M. Burton, John M. Asara, Benjamin E. Gewurz · 2026 · mBio
- Bovine rotavirus exploits host arginine metabolism to facilitate replication: A novel antiviral strategy targeting the arginase-iNOS axisFengshi Xie, Ziwei Liu, Jiankun Huang, Xuhua Ran, Xiaobo Wen · 2026 · Microbial Pathogenesis
- Solute carrier family 6 member 14 (SLC6A14): Expression, function, regulation, and impact on tumor progression.Wenchong Zang, Zhen-Tao Zhang, Ye Zhi, Wen Zhang, Feifeng Song, Ping Huang · 2026 · Biochemical Pharmacology
- Amino-acids-mTORC1-driven DDA1 phosphorylation promotes DNA repair and glioblastoma progressionXing Chen, Zhi-Xing Wang, An Yan, Yun-Peng Liu, Rui-Min Zhu, Li Li, Dou-Dou Xu, Rui-Xue Liu, Xiang-Wen Zhan, Bin Yin et al. · 2026 · Cell Communication and Signaling
- GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cyclingImane Hadj-Aissa, Maéline Muller, Jorge Soliz, Chantelle F. Sephton, Paul A. Dutchak · 2026 · EMBO Reports
- Immunometabolic Stress and Immune Suppression in Clear-Cell Renal Cell Carcinoma: Perspectives in Therapeutic StrategyTuong Vi Nguyen, Tien Hsu · 2026 · International Journal of Molecular Sciences
- mTORC1 suppression by Trp53 mutation drives resistance to immune checkpoint blockadeAlireza Labani‐Motlagh, Yang Li, David Shihong Gao, Eunseuk Lee, V. J. Chen, Lixian Yi, Fei Gao, Runzi Sun, Junchi Xu, Jason Shoush et al. · 2026 · Cell Death and Disease
- DDIT3, OTUB2, and ASS1 regulate arginine biosynthesis in colorectal cancer cells under arginine deficiencyMengying Li, Jie Zhang, Haitao Zhang, Xiaolin Chen, Xiuqun Zou, Jiamin Wang, Wenyan Huang, Haixia Peng, Hao Jia, Zhaoyuan Hou · 2026 · Cell Reports
- Regulation of the 26S Proteasome: From Homeostasis to Stress and DiseaseVictoria Cohen‐Kaplan, Aaron J. Ciechanover, Yelena Kravtsova‐Ivantsiv · 2026 · Cells
- The Emerging Role of mTOR in Shaping the Cancer Cell Secretome and PlasticityTyler T. Cooper, Ivan Topisirović, Lynne-Marie M Postovit · 2026 · Molecular and Cellular Biology
- Decoding the PI3K/Akt/mTOR-AMPK signalling nexus: molecular crosstalk, metabolic reprogramming and therapeutic targeting in human diseaseJosef Yakin, Faruk Alam, Jose Fernando G. Elpa · 2026 · Journal of Immunoassay and Immunochemistry
- Microbiome modulation in regeneration in jellyfishAki H. Ohdera, Matthew Wang, Maille Mansbridge, Changhua Yu, Ryan Ginn, Hannah Demerit, Isabella Guillen, Christy Lam, Andrew Hyunsoo Kim, Gianni Notaro et al. · 2026 · PLoS ONE
- Amino Acid Regulation of Cellular Aging Pathways and Therapeutic Perspectives for Healthspan and Lifespan EnhancementInga Sarenkova, Ugіs Kletnieks · 2026 · Advances in Gerontology
- Dietary Arginine Supplementation Mitigates Heat Stress-Induced Testicular Dysfunction Through Arginine-Related Metabolic Remodeling and Autophagy-Associated Stress Adaptation in a Rongchang Boar ModelXiao Lin, Kun Wu, Jingchang Ren, Yan Lin, Bin Feng, Lianqiang Che, Zhengfeng Fang, Shengyu Xu, Lun Hua, Guangmang Liu et al. · 2026 · Animals
- CASTOR1 Regulates Humoral Immune Responses and Contributes to the Pathogenesis of Systemic Lupus ErythematosusTakeshi Kusuda, Toshihiko Komai, Takahiro Itamiya, Tatsuki Abe, Tomohisa Okamura, Keishi Fujio · 2026 · Arthritis & Rheumatology
- Comparative Evaluation of Plant and Whey Protein Hydrolysates: Bioavailability, Intestinal Cellular Response and Cholesterol-Regulating Gene Expression in A Caco-2 ModelBrijesh Lekhak, Minakshi Dutta, Nitin Kumar Singhal, Prashat G. Rama, Navita Bansal, Suneha Goswami, Ranjeet Ranjan Kumar, Aruna Tyagi, T. Vinutha · 2026 · Current Research in Nutrition and Food Science Journal
- mTOR-Mediated Neuron–Cancer InteractionsJoel Karikari Nyarkoh, Matthew J Wolan, David M. Feliciano · 2026 · Kinases and Phosphatases
- The Role of L-Arginine in Digestive System Cancers: From Metabolism to TherapyHongmei Wu, Yan Qin, Linfeng Mo, Lishan Tang, Yan Chen, Shuya Ye, Wenyan Hong · 2026 · Journal of Biosciences and Medicines
- D-amino acid prodrug DLMEH activates mTORC1 via Sestrin2 to restore muscle protein synthesis in sarcopeniaJae Ho Shim, Ji Yeon Lee, Byung Kook Ahn, Sang Woo Woo, Jihye Han, Hyeon Soo Kim · 2026 · Molecular Therapy
- Advances of research on amino acid sensingMiao Yin, Wen-Ying ZHU, Yuan SHEN, Lei Qun‐Ying · 2026 · Shengming kexue
- L- Arginine supplementation improves the survival of virus-specific CD8+ T cells during in vitro expansionTakahiro Tomoda, Ai Kawana‐Tachikawa, Shigeomi Shimizu, Satoshi Takahashi, Hirokazu Kanegane, Takahiro Kamiya, 井上久美, Masatoshi Takagi, Tomohiro Morio · 2025 · Immunotherapy Advances
- Regional signaling controls stem cell-mediated regeneration in an invertebrate chordateTal Gordon, Tom Levy, Chester Jiamu Yu, Benyamin Rosental, Lauren Lubeck, Lucia Manni, Irving L. Weissman, Ayelet Voskoboynik · 2026 · PLoS Biology
- Dose-dependent arginine availability is associated with metabolic remodeling and immune phenotypes during developmentYu-Tsun Su, Mao‐Meng Tiao, Yun-Ju Lai, You‐Lin Tain, Chien‐Ning Hsu, I-Chun Lin, Chih-Hao Chang, Chih‐Yung Chiu, Hong‐Ren Yu · 2026 · Biomedical Journal
- Aging of Skeletal Muscle: From Molecular Mechanisms to Therapeutic InterventionsTing Liu, Yaomin Hu · 2026 · MedComm
- Rapamycin across biology and medicine: From molecular mechanisms to clinical and translational frontiersLyvia Neves Rebello Alves, Eldamária de Vargas Wolfgramm dos Santos, Raquel Silva dos Reis Trabach, Débora Dummer Meira, Iúri Drumond Louro · 2026 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Defensins–thioredoxin crosstalk in innate immunity: A redox switch linking barrier defense, inflammation, and diseaseOmer M. A. Dagah, Zakir Ullah, Alaa Majeed Mutashar Alhameed, Hamdi Al-Azzani, Rakia Manzoor, Mussa Yussuf Khamis, Zhenbao Liu, Jun Lu · 2026 · Molecular Immunology
- CASTOR2 restricts PRRSV internalization through AKT–mTOR signaling and interacting with viral glycoprotein GP5Yuchao Yan, Changyan Li, Xin Ma, Yinhao Zhang, Junyang Zhang, Xinyi Zhang, Qinye Song, Jinhai Huang · 2026 · Veterinary Microbiology
- Nutrients and Their Role in Autophagy RegulationNiall Wilson, Gamze Koçak, Sovan Sarkar, Yoana Rabanal Ruiz, Viktor I. Korolchuk · 2026 · Biochemistry
- CASTOR1 functional inactivation drives KRAS -mutant NSCLC and therapy resistance by a noncanonical mechanism of tumor suppressionXian Wang, Ling Ding, Wen Meng, Elaine Byrnes, Suet Kee Loo, Shenyu Sun, Luping Chen, Tingting Li, Man-Tzu Wang, Arjun Pennathur et al. · 2026 · Science Advances
- Arginine rewires eIF4F translation initiation to overcome fever-induced CAR T cell dysfunction.Taisuke Kondo, Makoto Ando, Josquin Moraly, Justyn DuSold, Abdalla Abdelmaksoud, Hannah W. Song, L. Balagopalan, D. Jia, L. Racine, Andy D. Tran et al. · 2026 · Cell Metabolism