The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Chantranupong, Lynne, Scaria, Sonia M., Saxton, Robert A., Gygi, Melanie P., Shen, Kuang, Wyant, Gregory A., Wang, Tim, Harper, J. Wade +2 more·2016·Cell
Cited by (856)
Items 201–300 of 856
- l-Arginine promotes protein synthesis and cell growth in brown adipocyte precursor cells via the mTOR signal pathwayXi Ma, Meng Han, Defa Li, Shengdi Hu, Kyler R. Gilbreath, Fuller W. Bazer, Guoyao Wu · 2017 · Amino Acids
- Age-Related Dysfunction in Proteostasis and Cellular Quality Control in the Development of SarcopeniaHector G. Paez, Christopher R. Pitzer, Stephen E. Alway · 2023 · Cells
- Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting.R. Semba, Indi Trehan, M. Gonzalez-Freire, K. Kraemer, R. Moaddel, M. I. Ordiz, L. Ferrucci, M. Manary · 2016 · Advances in Nutrition
- Regulation of Muscle Growth in Early Postnatal Life in a Swine ModelM. Rudar, M. Fiorotto, T. Davis · 2018 · Annual Review of Animal Biosciences
- Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation.Sulhee Kim, Ina Yoon, Jonghyeon Son, Junga Park, Kibum Kim, Ji-ho Lee, Sam-Yong Park, B. Kang, Jung-Min Han, K. Hwang et al. · 2021 · Cell Reports
- Infection-Associated Thymic AtrophyMingli Luo, Lingxin Xu, Zheng-Yu Qian, Xi Sun · 2021 · Frontiers in Immunology
- The mTOR–lysosome axis at the centre of ageingJulian M. Carosi, Célia Fourrier, Julien Bensalem, Timothy J. Sargeant · 2021 · FEBS Open Bio
- The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and BeyondPeter L. Lee, Su Myung Jung, David A. Guertin · 2017 · Trends in Endocrinology and Metabolism
- Lysosomal Regulation of mTORC1 by Amino Acids in Mammalian CellsYao Yao, E. Jones, K. Inoki · 2017 · Biomolecules
- Nutritional Strategies to Offset Disuse-Induced Skeletal Muscle Atrophy and Anabolic Resistance in Older Adults: From Whole-Foods to Isolated IngredientsRyan N. Marshall, Benoit Smeuninx, Paul T. Morgan, Leigh Breen · 2020 · Nutrients
- Dietary Intervention Impacts Immune Cell Functions and Dynamics by Inducing Metabolic RewiringTakuma Okawa, Motoyoshi Nagai, Koji Hase · 2021 · Frontiers in Immunology
- Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation.Sung-Hoon Kim, Jung-Hyun Choi, Peng Wang, Christopher D. Go, G. Hesketh, A. Gingras, S. M. Jafarnejad, N. Sonenberg · 2020 · Molecules and Cells
- Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advancesShizhe Zhang, Xueyan Lin, Qiuling Hou, Zhiyong Hu, Yun Wang, Zhonghua Wang · 2021 · Animal nutrition
- Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemiaJoydeep Ghosh, R. Kapur · 2017 · Experimental Hematology
- Gtr/Ego-independent TORC1 activation is achieved through a glutamine-sensitive interaction with Pib2 on the vacuolar membraneHirofumi Ukai, Yasuhiro Araki, Shintaro Kira, Yu Oikawa, Alexander I. May, Takeshi Noda · 2018 · PLoS Genetics
- The complex network of mTOR signalling in the heartSebastiano Sciarretta, Maurizio Forte, Giacomo Frati, Junichi Sadoshima · 2021 · Cardiovascular Research
- The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome FunctionCai, Weili, Wei, Youheng, Jarnik, Michal, Reich, John, Lilly, Mary A. · 2016 · PLOS Genetics
- Chromatin accessibility governs the differential response of cancer and T cells to arginine starvationNicholas T. Crump, Andreas V. Hadjinicolaou, Xia Meng, John Walsby-Tickle, Uzi Gileadi, Ji‐Li Chen, Mashiko Setshedi, Lars Rønn Olsen, I‐Jun Lau, Laura Godfrey et al. · 2021 · Cell Reports
- Amino acid deprivation induces AKT activation by inducing GCN2/ATF4/REDD1 axisHyeon‐Ok Jin, Sung‐Eun Hong, Ji-Young Kim, Se‐Kyeong Jang, In‐Chul Park · 2021 · Cell Death and Disease
- FOXO1 cooperates with C/EBPδ and ATF4 to regulate skeletal muscle atrophy transcriptional program during fastingMamoru Oyabu, Kaho Takigawa, Sako Mizutani, Yukino Hatazawa, Mariko Fujita, Yuto Ohira, Takumi Sugimoto, Osamu Suzuki, Kyoichiro Tsuchiya, Takayoshi Suganami et al. · 2022 · The FASEB Journal
- Autophagosome biogenesis machinery.Simon A. Walker, N. Ktistakis · 2019 · Journal of Molecular Biology
- Role of autophagy in muscle diseaseAnaïs Franco‐Romero, Marco Sandri · 2021 · Molecular Aspects of Medicine
- Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitinationYansong Zhang, Siyuan Lin, Jingyu Peng, Xiaojuan Liang, Qi Yang, Xue Bai, Yajuan Li, Jinhua Li, Wei Dong, Yue Wang et al. · 2022 · Molecular Cell
- Stress Granules in CancerMinseok Song, Elda Grabocka · 2020 · Reviews of physiology, biochemistry and pharmacology
- Serine is required for the maintenance of redox balance and proliferation in the intestine under oxidative stressLiuqin He, Jing Long, Xihong Zhou, Yonghui Liu, Tiejun Li, Xin Wu · 2020 · The FASEB Journal
- Intracellular galectin-3 is a lipopolysaccharide sensor that promotes glycolysis through mTORC1 activationXing Chen, Chunyu Yu, Xin-Hua Liu, Bei-bei Liu, Xiao-Di Wu, Jia-Jing Wu, Dong Yan, Lu-Lu Han, Zifan Tang, Xinyi Yuan et al. · 2022 · Nature Communications
- Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathwayZhong-Chao Gai, Qian Wang, Cangjing Yang, Lei Wang, Wei Deng, Geng Wu · 2016 · Cell Discovery
- ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine DeprivationDandan Xu, Weiwei Dai, Lydia Kutzler, Holly A. Lacko, Leonard S. Jefferson, Michael Don Dennis, Scot R. Kimball · 2019 · Journal of Nutrition
- Enzyme-based autophagy in anti-neoplastic management: From molecular mechanisms to clinical therapeuticsAmir Ajoolabady, Ayuob Aghanejad, Yaguang Bi, Yingmei Zhang, Hamid Aslkhodapasandhukmabad, Alireza Abhari, Jun Tao Ren · 2020 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseasesGuan Yang, Yaoyao Xia, Wenkai Ren · 2020 · Science China Life Sciences
- Arginine metabolism: a potential target in pancreatic cancer therapyJinshou Yang, Chengcheng Wang, Jiangdong Qiu, Bo Ren, Lei You · 2020 · Chinese Medical Journal
- Nutrient Sensing in CancerMargaret E. Torrence, Brendan D. Manning · 2017 · Annual Review of Cancer Biology
- Regulation of mTORC1 by Small GTPases in Response to Nutrients.Min Zhu, Xiu-Qi Wang · 2020 · Journal of NutriLife
- Mechanisms Underlying Muscle Protein Imbalance Induced by AlcoholScot R. Kimball, Charles H. Lang · 2018 · Annual Review of Nutrition
- Next Generation Strategies for Geroprotection via mTORC1 InhibitionSabrina N. Dumas, Dudley W. Lamming · 2019 · The Journals of Gerontology Series A
- Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROSJiao Wu, Sai‐Ching J. Yeung, Sicheng Liu, Aiham Z. Qdaisat, Dewei Jiang, Wenli Liu, Zhuo Cheng, Wenjing Liu, Haixia Wang, Lu Li et al. · 2021 · Signal Transduction and Targeted Therapy
- Indole-3-acetic acid is a physiological inhibitor of TORC1 in yeastRaffaele Nicastro, Serena Raucci, Agnès H. Michel, M. Stumpe, Guillermo Miguel Garcia Osuna, Malika Jaquenoud, B. Kornmann, C. De Virgilio · 2021 · PLoS Genetics
- RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradationTingting Li, Xian Wang, Enguo Ju, Suzane Ramos da Silva, Luping Chen, Xinquan Zhang, Shan Wei, Shou‐Jiang Gao · 2021 · Nature Communications
- Cryo-EM structure of the full-length Bacillus subtilis glyQS T-box riboswitch in complex with tRNA-GlyShuang Li, Zhaoming Su, J. Zhang, Wah Chiu · 2019 · Worldwide Protein Data Bank
- Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genesSheng-Chieh Hsu, Chia‐Lin Chen, Mei‐Ling Cheng, Cheng-Ying Chu, Chun A. Changou, Yen‐Ling Yu, Shauh-Der Yeh, Tse-Chun Kuo, Cheng-Chin Kuo, Chih‐Pin Chuu et al. · 2021 · Theranostics
- Taurine from tumour niche drives glycolysis to promote leukaemogenesisSonali Sharma, Benjamin J. Rodems, Cameron D. Baker, Christina M. Kaszuba, Edgardo I. Franco, Bradley R. Smith, Takashi Ito, Kyle Swovick, Kevin A. Welle, Yi Zhang et al. · 2025 · Nature
- Whi2 is a conserved negative regulator of TORC1 in response to low amino acidsXianghui Chen, Guiqin Wang, Yu Zhang, Margaret Dayhoff-Brannigan, N. Diny, Mingjun Zhao, G. He, Cierra N. Sing, Kyle A Metz, Zachary D. Stolp et al. · 2018 · PLoS Genetics
- Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson’s DiseaseMark Frederick McCarty, Aaron Lerner · 2020 · International Journal of Molecular Sciences
- The Regulatory Role of Key Metabolites in the Control of Cell SignalingRiccardo Milanesi, Paola Coccetti, Farida Tripodi · 2020 · Biomolecules
- How the amino acid leucine activates the key cell-growth regulator mTORTibor Vellai · 2021 · Nature
- Effect of dietary replacement of fish meal with low-gossypol cottonseed protein concentrate on growth performance and expressions of genes related to protein metabolism for swimming crab (Portunus trituberculatus)Shichao Xie, Qicun Zhou, Xiangsheng Zhang, Tingting Zhu, Chen Guo, Zheng Yang, Jiaxiang Luo, Ye Yuan, Xiaoyin Hu, Lefei Jiao et al. · 2021 · Aquaculture
- Regulation of mTORC1 by the Rag GTPasesTshering D. Lama-Sherpa, Mi‐Hyeon Jeong, Jenna L. Jewell · 2023 · Biochemical Society Transactions
- Citrulline regulates macrophage metabolism and inflammation to counter aging in miceZhangdan Xie, Moubin Lin, Beizi Xing, Hongmiao Wang, Haosong Zhang, Zimu Cai, Xinyu Mei, Zheng‐Jiang Zhu · 2025 · Science Advances
- Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell linesMariia Lunová, A. Prokhorov, Milan Jirsa, Martin Hof, Agnieszka Olżyńska, Piotr Jurkiewicz, Šárka Kubinová, Oleg Lunov, Alexandr Dejneka · 2017 · Scientific Reports
- Transposable element insertions in fission yeast drive adaptation to environmental stressCaroline Esnault, Michael Lee, Chloe Ham, Henry L. Levin · 2018 · Genome Research
- PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2Cong Jiang, Jing Liu, Shaohui He, Wei Xu, Run-Zhi Huang, W. Pan, Xiao-Long Li, Xiao-Ming Dai, Jianping Guo, Tao Zhang et al. · 2023 · Cell Metabolism
- The Lysosome and Intracellular Signalling.G. Hesketh, L. Wartosch, Luther J. Davis, Nicholas A. Bright, J. P. Luzio · 2018 · Progress in molecular and subcellular biology
- Molecular mechanisms relating to amino acid regulation of protein synthesisYangchun Cao, Shimin Liu, Kai Liu, Imtiaz Hussain Raja Abbasi, Chuanjiang Cai, Junhu Yao · 2019 · Nutrition Research Reviews
- Mitochondrial hyperfusion via metabolic sensing of regulatory amino acidsMahmud O. Abdullah, Run X. Zeng, Chelsea L. Margerum, David J. Papadopoli, Cian Monnin, Kaylee B. Punter, Charles Chu, Mohammad Al-Rofaidi, Naser F. Al‐Tannak, Domenica Berardi et al. · 2022 · Cell Reports
- Targeting cancer-specific metabolic pathways for developing novel cancer therapeuticsSoumik Pal, Amit Kumar Sharma, Sam Padalumavunkal Mathew, Bithiah Grace Jaganathan · 2022 · Frontiers in Immunology
- Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brainLynne Chantranupong, Jessica L. Saulnier, Wengang Wang, Drew R. Jones, Michael E. Pacold, Bernardo Luis Sabatini · 2020 · eLife
- Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry womenBabatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas U. Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine D. Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng et al. · 2021 · Nature Communications
- Neurotrophic effects of intermittent fasting, calorie restriction and exercise: a review and annotated bibliographyEric Mayor · 2023 · Frontiers in Aging
- Prognostic Ability of Enhancer RNAs in Metastasis of Non-Small Cell Lung CancerJun Liu, Jingyi Jia, Siqiao Wang, Junfang Zhang, Shuyuan Xian, Zixuan Zheng, Lin Deng, Lin Deng, Yuan Zhang, Yuan Zhang · 2022 · Molecules
- AMPK-dependent phosphorylation of the GATOR2 component WDR24 suppresses glucose-mediated mTORC1 activationXiaoming Dai, Cong Jiang, Qiwei Jiang, Lan Fang, Hai-Hong Yu, Jin-He Guo, Pei-Qiang Yan, Fang-Tao Chi, Tao Zhang, H. Inuzuka et al. · 2023 · Nature Metabolism
- Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTORCarlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro · 2019 · Cell Communication and Signaling
- Autophagy drives plasticity and functional polarization of tumor‐associated macrophagesWan-Ting Kuo, Jia-Ming Chang, Chien-Chin Chen, N. Tsao, Chih-Peng Chang · 2021 · IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology
- Mechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of Metabolism and HealthGuoyan Wang, Lei Chen, Senlin Qin, Tingting Zhang, Junhu Yao, Yanglei Yi, Lu Deng · 2022 · Advances in Nutrition
- The Central Role of mTORC1 in Amino Acid SensingShusheng Yue, Guanya Li, Shanping He, Tingting Li · 2022 · Cancer Research
- The Role of Tumor Metabolic Reprogramming in Tumor ImmunityXianhong Zhang, Weiguo Song, Yue Gao, Yu Zhang, Yuqi Zhao, Shuailin Hao, Ting Ni · 2023 · International Journal of Molecular Sciences
- Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogrammingXujia Wu, Huairui Yuan, Qiulian Wu, Yixin Gao, Tingting Duan, Kailin Yang, Tengfei Huang, Shuai Wang, Fanen Yuan, Derrick Lee et al. · 2024 · Nature Cancer
- Importance of Serum Amino Acid Profile for Induction of Hepatic Steatosis under Protein MalnutritionHiroki Nishi, Daisuke Yamanaka, Hiroyasu Kamei, Yuki Goda, Mikako Kumano, Yuka Toyoshima, Asako Takenaka, Masato Masuda, Yasushi NAKABAYASHI, Ryuji Shioya et al. · 2018 · Scientific Reports
- Kaposi sarcoma–associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesisTingting Li, Enguo Ju, Shou‐Jiang Gao · 2019 · Journal of Clinical Investigation
- Cationic Amino Acid Transporter-1-Mediated Arginine Uptake Is Essential for Chronic Lymphocytic Leukemia Cell Proliferation and ViabilityAnke Werner, Daniel Pieh, Hakim Echchannaoui, Johanna Rupp, Krishnaraj Rajalingam, Matthias Theobald, Ellen Ildicho Closs, Markus Munder · 2019 · Frontiers in Oncology
- Analyzing One Cell at a TIME: Analysis of Myeloid Cell Contributions in the Tumor Immune MicroenvironmentVitaliy Davidov, Garrett L. Jensen, Sunny Mai, Shu‐Hsia Chen, Ping‐Ying Pan · 2020 · Frontiers in Immunology
- Mycobacterium tuberculosis produces d-serine under hypoxia to limit CD8+ T cell-dependent immunity in miceHong-Yu Cheng, Zhe Ji, Yang Wang, Shen-Zhi Li, Tianqi Tang, Fei Wang, Cheng Peng, Xiang-Yang Wu, Yuan-Na Cheng, Zhong-Hua Liu et al. · 2024 · Nature Microbiology
- A Novel Amino Acid Composition Ameliorates Short-Term Muscle Disuse Atrophy in Healthy Young MenTanya M. Holloway, Chris McGlory, Sean R. McKellar, Adrienne K Morgan, Mike Hamill, Raffi Afeyan, William C. Comb, Scharmen Confer, Peng Zhao, M. Hinton et al. · 2019 · Frontiers in Nutrition
- Amino acid transportation, sensing and signal transduction in the mammary gland: key molecular signalling pathways in the regulation of milk synthesisZhihui Wu, Jinghui Heng, Min Tian, Hanqing Song, Fang Chen, Wutai Guan, Shihai Zhang · 2020 · Nutrition Research Reviews
- Regulation of Metabolic Homeostasis in Cell Culture BioprocessesConor M. O’Brien, Bhanu Chandra Mulukutla, Douglas G. Mashek, Wei‐Shou Hu · 2020 · Trends in biotechnology
- Age‐related differences in the translational landscape of mammalian oocytesEdgar Del Llano, Tomáš Mašek, Lenka Gahurová, Martin Pospíšek, Markéta Končická, Anna Jindrova, Denisa Jansová, Rajan Iyyappan, Kristina Roučová, Alexander W. Bruce et al. · 2020 · Aging Cell
- Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signalingXin Tang, Yifan Zhang, Guanchao Wang, Chunxiao Zhang, Fang Wang, Jiawen Shi, Tian-Long Zhang, Jian-Ping Ding · 2022 · Science Advances
- Protein intake and amino acid supplementation regulate exercise recovery and performance through the modulation of mTOR, AMPK, FGF21, and immunityIván Torre-Villalvazo, Gabriela Alemán, Ricardo Valle‐Rios, Lilia Guadalupe Noriega · 2019 · Nutrition Research
- Regulation of ex-translational activities is the primary function of the multi-tRNA synthetase complexHaissi Cui, Mridu Kapur, Jolene K. Diedrich, John R. Yates, Susan L. Ackerman, PAUL R. SCHIMMEL · 2020 · Nucleic Acids Research
- Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysisShagun Sharma, Navneet Agnihotri, Sandeep Kumar · 2022 · Biochemical Pharmacology
- Unlocking the Potential of Arginine Deprivation Therapy: Recent Breakthroughs and Promising Future for Cancer TreatmentYu‐De Chu, Ming‐Wei Lai, Chau‐Ting Yeh · 2023 · International Journal of Molecular Sciences
- mTOR Complexes as a Nutrient Sensor for Driving Cancer ProgressionMio Harachi, Kenta Masui, Yukinori Okamura, Ryota Tsukui, Paul S. Mischel, Noriyuki Shibata · 2018 · International Journal of Molecular Sciences
- Pathogens MenTORing Macrophages and Dendritic Cells: Manipulation of mTOR and Cellular Metabolism to Promote Immune EscapeLonneke V. Nouwen, Bart Everts · 2020 · Cells
- FGFR-inhibitor-mediated dismissal of SWI/SNF complexes from YAP-dependent enhancers induces adaptive therapeutic resistanceYihao Li, Xintao Qiu, Xiaoqing Wang, Hui Liu, Renee C. Geck, Alok K. Tewari, Tengfei Xiao, Alba Font‐Tello, Klothilda Lim, Kristen L. Jones et al. · 2021 · Nature Cell Biology
- Lysosomes at the Crossroads of Cell Metabolism, Cell Cycle, and StemnessA. Nowosad, A. Besson · 2022 · International Journal of Molecular Sciences
- Metabolic regulation of suppressive myeloid cells in cancerAntonio Sica, Laura Strauss, Francesca Maria Consonni, Cristina Travelli, Armando A. Genazzani, Chiara Porta · 2017 · Cytokine & Growth Factor Reviews
- Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer TherapyYing-Ying Li, Lynn G. Feun, Angkana Thongkum, Chiao-Hui Tu, Shu-Mei Chen, Medhi Wangpaichitr, Chunjing Wu, Macus Tien Kuo, Niramol Savaraj · 2017 · International Journal of Molecular Sciences
- Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interactionRituraj Pal, M. Palmieri, A. Chaudhury, Tiemo J. Klisch, Alberto di Ronza, J. Neilson, G. Rodney, Marco Sardiello · 2018 · Nature Communications
- Mammalian Target of RapamycinMatthew F. Wipperman, David C. Montrose, Antonio M. Gotto, David P. Hajjar · 2019 · American Journal Of Pathology
- Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by MethionineMunehiro Kitada, Jing Xu, Yoshio Ogura, Itaru Monno, Daisuke Koya · 2020 · Frontiers in Cell and Developmental Biology
- The regulation of healthspan and lifespan by dietary amino acidsReji Babygirija, Dudley W. Lamming · 2021 · Translational Medicine of Aging
- A glutamine sensor that directly activates TORC1Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N. Noda, Kouhei Tsumoto, Tatsuya Maeda · 2021 · Communications Biology
- Long non‐coding RNAs in cancer metabolismZhen‐Dong Xiao, Li Zhuang, Boyi Gan · 2016 · BioEssays
- piR-16404 drives ferroptotic liver injury via CASTOR1/mTORC1/GPX4 dysregulation in HepG2 cells and mice: a novel toxicity mechanism of N, N-dimethylformamideWanli Ma, Xiaoyu Huo, Ruoxi Li, Jingjing Xing, Lin Xu, Dianke Yu · 2025 · Archives of Toxicology
- Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalanceCharlotte E. Johnson, Andrew R. Tee · 2017 · Essays in Biochemistry
- Sensors for the mTORC1 pathway regulated by amino acidsXiu-zhi Li, Xianghua Yan · 2019 · Journal of Zhejiang University SCIENCE B
- Supply of methionine and arginine alters phosphorylation of mechanistic target of rapamycin (mTOR), circadian clock proteins, and α-s1-casein abundance in bovine mammary epithelial cellsLiangyu Hu, Yifei Chen, Ismael Martínez-Cortés, D.N. Coleman, Hongyu Dai, Yusheng Liang, C. Parys, C. Fernández, Mengzhi Wang, Juan J. Loor · 2020 · Food & Function
- Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibitionGianluca Figlia, Sandra Müller, Anna M. Hagenston, Susanne Kleber, Mykola Roiuk, Jan-Philipp Quast, Nora ten Bosch, Damian Carvajal Ibañez, Daniela Mauceri, Ana Martín-Villalba et al. · 2022 · Nature Cell Biology
- mTORC1 beyond anabolic metabolism: Regulation of cell deathJiajun Zhu, Hua Wang, Xuejun Jiang · 2022 · The Journal of Cell Biology
- Structural insight into the arginine-binding specificity of CASTOR1 in amino acid-dependent mTORC1 signalingXia, Jing, Wang, Rong, Zhang, Tianlong, Ding, Jianping · 2016 · Cell Discovery
- Lighting up arginine metabolism reveals its functional diversity in physiology and pathologyRui Li, Yan Li, Kun Jiang, Lijuan Zhang, Ting Li, Aihua Zhao, Zhuo Zhang, Yale Xia, Kun Ge, Yaqiong Chen et al. · 2024 · Cell Metabolism