The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients
Open accessAbstract
Summary Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by breakdown of tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular heterogeneity, we longitudinally profiled the blood transcriptome of 158 pediatric patients. Using mixed models accounting for repeated measurements, demographics, treatment, disease activity (DA) and nephritis class, we confirmed a prevalent IFN signature and identified a plasmablast signature as the most robust biomarker of DA. We detected gradual enrichment of neutrophil transcripts during progression to active nephritis, and distinct signatures in response to treatment in different nephritis subclasses. Importantly, personalized immunomonitoring uncovered individual correlates of disease activity that enabled patient stratification into seven groups, which were supported by patient genotypes. Our study uncovers the molecular heterogeneity of SLE and provides an explanation for the failure of clinical trials. This approach may improve trial design and implementation of tailored therapies in genetically and clinically complex autoimmune diseases.
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Self-citationDensely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis
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A Modular Analysis Framework for Blood Genomics Studies: Application to Systemic Lupus Erythematosus
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Trial of Anifrolumab in Active Systemic Lupus Erythematosus
Morand, E. F., Furie, R., Tanaka, Y., Bruce, I. N., Askanase, A. D., Richez, C., Bae, S.-C., Brohawn, P. Z., Pineda, L., Berglind, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1912196 · Cited by 1,379
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Autoimmunity and organ damage in systemic lupus erythematosus
Tsokos, G. C. (2020) · Nature Immunology · doi:10.1038/s41590-020-0677-6 · Cited by 580
The IBD interactome: an integrated view of aetiology, pathogenesis and therapy
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A diet-sensitive commensal Lactobacillus strain Mediates TLR7-dependent systemic autoimmunity
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Metadata
- Authors
- Banchereau, R., Hong, S., Cantarel, B., Baldwin, N., Baisch, J., Edens, M., Cepika, A.-M., Acs, P., Turner, J., Anguiano, E., Vinod, P., Khan, S., Obermoser, G., Blankenship, D., Wakeland, E., Nassi, L., Gotte, A., Punaro, M., Liu, Y.-J., Banchereau, J., Rossello-Urgell, J., Wright, T., & Pascual, V.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 165
- Issue
- 3
- Pages
- 551-565
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2321809676
- Cited by
- 731
- References
- 7
- FWCI
- 67.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Banchereau, R., Hong, S., Cantarel, B., Baldwin, N., Baisch, J., Edens, M., Cepika, A.-M., Acs, P., Turner, J., Anguiano, E., Vinod, P., Khan, S., Obermoser, G., Blankenship, D., Wakeland, E., Nassi, L., Gotte, A., Punaro, M., Liu, Y.-J., . . . Pascual, V. (2016). Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients. Cell. https://doi.org/10.1016/j.cell.2016.03.008
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