Cited by 447Inflammatory Bowel DiseaseBioinformatics and Genomic NetworksGut microbiota and health

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy

de Souza, Heitor S. P., Fiocchi, Claudio, Iliopoulos, Dimitrios·2017·Nature Reviews Gastroenterology & Hepatology

Abstract

Crohn's disease and ulcerative colitis are prototypical complex diseases characterized by chronic and heterogeneous manifestations, induced by interacting environmental, genomic, microbial and immunological factors. These interactions result in an overwhelming complexity that cannot be tackled by studying the totality of each pathological component (an '-ome') in isolation without consideration of the interaction among all relevant -omes that yield an overall 'network effect'. The outcome of this effect is the 'IBD interactome', defined as a disease network in which dysregulation of individual -omes causes intestinal inflammation mediated by dysfunctional molecular modules. To define the IBD interactome, new concepts and tools are needed to implement a systems approach; an unbiased data-driven integration strategy that reveals key players of the system, pinpoints the central drivers of inflammation and enables development of targeted therapies. Powerful bioinformatics tools able to query and integrate multiple -omes are available, enabling the integration of genomic, epigenomic, transcriptomic, proteomic, metabolomic and microbiome information to build a comprehensive molecular map of IBD. This approach will enable identification of IBD molecular subtypes, correlations with clinical phenotypes and elucidation of the central hubs of the IBD interactome that will aid discovery of compounds that can specifically target the hubs that control the disease.

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Crossref · 10.1038/nrgastro.2017.110

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  • IBD is considered an immune-mediated intestinal disorder resulting from complex interactions among genetics, environmental factors, and gut microbiota.

    “IBD is considered to be an immune-mediated intestinal disorder, resulting from complex interactions among genetics, environmental factors, and gut microbiota (9).”

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Authors
de Souza, H. S. P., Fiocchi, C., & Iliopoulos, D.
Affiliations
  • Cleveland Clinic (US)
  • University of California, Los Angeles (US)
Corresponding author
Fiocchi, Claudio
Venue
Nature Reviews Gastroenterology & Hepatology
Published
2017-08-23
Volume
14
Issue
12
Pages
739-749
ISSN
  • 1759-5045 (ISSN-L)
  • 1759-5053
OpenAlex
W2749616891
Cited by
447
References
136
Citations by year
2026: 27 · 2025: 49 · 2024: 44 · 2023: 55 · 2022: 84 · 2021: 64 · 2020: 41 · 2019: 47 · 2018: 31 · 2017: 4 · 2015: 1
FWCI
4.31
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Gastroenterology & Hepatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
inflammatory bowel disease, Crohn's disease, ulcerative colitis, systems biology, multi-omics integration, molecular networks, intestinal inflammation, dysbiosis, molecular subtypes, targeted therapy, central hub, etiology, pathogenesis
MeSH terms
Gastrointestinal Microbiome, Gastrointestinal Agents, Humans, Inflammatory Bowel Diseases, Genetic Predisposition to Disease, Proteomics, Systems Biology, Drug Discovery, Epigenomics, Transcriptome, Gene-Environment Interaction

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