The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Root Regeneration Triggers an Embryo-like Sequence Guided by Hormonal Interactions
Open accessAbstract
Summary Plant roots can regenerate after excision of their tip, including the stem cell niche. To determine which developmental program mediates such repair, we applied a combination of lineage tracing, single cell RNA-Seq, and marker analysis to test different models of tissue reassembly. We show that multiple cell types can reconstitute stem cells, demonstrating the latent potential of untreated plant cells. The transcriptome of regenerating cells prior to stem cell activation resembles that of an embryonic root progenitor. Regeneration defects are more severe in embryonic than in adult root mutants. Furthermore, the signaling domains of the hormones auxin and cytokinin mirror their embryonic dynamics, and manipulation of both hormones alters the position of new tissues and stem cell niche markers. Our findings suggest that plant root regeneration follows, on a larger scale, the developmental stages of embryonic patterning and is guided by spatial information provided by complementary hormone domains.
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Cites
Spatial reconstruction of single-cell gene expression data
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055
Self-citationBridging the regeneration gap: Genetic insights from diverse animal models
Alvarado, A. S., & Tsonis, P. A. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1923 · Cited by 467
Allometric scaling and proportion regulation in the freshwater planarian Schmidtea mediterranea
Oviedo, N. J., Newmark, P. A., & Sánchez Alvarado, A. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10228 · Cited by 169 · cited 2×
“Indeed, in many regeneration systems, the newly replaced organs exhibit flexibility in scale in order to match the size of the remnant body parts (Oviedo et al., 2003).”
Cited by
Molecular Mechanisms of Plant Regeneration
Ikeuchi, M., Favero, D. S., Sakamoto, Y., Iwase, A., Coleman, D., Rymen, B., & Sugimoto, K. (2019) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050718-100434 · Cited by 521
High-Throughput Single-Cell Transcriptome Profiling of Plant Cell Types
Shulse, C. N., Cole, B. J., Ciobanu, D., Lin, J., Yoshinaga, Y., Gouran, M., Turco, G. M., Zhu, Y., O’Malley, R. C., Brady, S. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.054 · Cited by 432
A Jasmonate Signaling Network Activates Root Stem Cells and Promotes Regeneration
Zhou, W., Lozano-Torres, J. L., Blilou, I., Zhang, X., Zhai, Q., Smant, G., Li, C., & Scheres, B. (2019) · Cell · doi:10.1016/j.cell.2019.03.006 · Cited by 361
A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration
Zhang, T.-Q., Lian, H., Zhou, C.-M., Xu, L., Jiao, Y., & Wang, J.-W. (2017) · The Plant Cell · doi:10.1105/tpc.16.00863 · Cited by 357
Metadata
- Authors
- Efroni, I., Mello, A., Nawy, T., Ip, P.-L., Rahni, R., DelRose, N., Powers, A., Satija, R., & Birnbaum, K. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 165
- Issue
- 7
- Pages
- 1721-1733
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2395764428
- Cited by
- 314
- References
- 3
- FWCI
- 29.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Efroni, I., Mello, A., Nawy, T., Ip, P.-L., Rahni, R., DelRose, N., Powers, A., Satija, R., & Birnbaum, K. D. (2016). Root Regeneration Triggers an Embryo-like Sequence Guided by Hormonal Interactions. Cell. https://doi.org/10.1016/j.cell.2016.04.046
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