The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration
Open accessAbstract
Plant cells are totipotent and competent to regenerate from differentiated organs. It has been known for six decades that cytokinin-rich medium induces shoot regeneration from callus cells. However, the underlying molecular mechanism remains elusive. The homeodomain transcription factor WUSCHEL (WUS) is essential for de novo establishment of the shoot stem cell niche in Arabidopsis thaliana. We found that WUS-positive (WUS+) cells mark the shoot progenitor region during regeneration. A cytokinin-rich environment initially promotes the removal of the repressive histone mark H3K27me3 at the WUS locus in a cell cycle-dependent manner. Subsequently, the B-type ARABIDOPSIS RESPONSE REGULATORs (ARRs) ARR1, ARR2, ARR10, and ARR12, which function as transcriptional activators in the cytokinin signaling pathway, spatially activate WUS expression through binding with microRNA165/6-targeted HD-ZIP III transcription factors. Thus, our results provide important insights into the molecular framework for cytokinin-directed shoot regeneration and reveal a two-step mechanism for de novo activation of WUS.
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A member of the KNOTTED class of homeodomain proteins encoded by the STM gene of Arabidopsis
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Self-citationZuo, J., Niu, Q., & Chua, N. (2000) · The Plant Journal · doi:10.1046/j.1365-313x.2000.00868.x · Cited by 1,177
Radial Patterning of Arabidopsis Shoots by Class III HD-ZIP and KANADI Genes
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New Insights Into Tissue Culture Plant-Regeneration Mechanisms
Long, Y., Yang, Y., Pan, G., & Shen, Y. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.926752 · Cited by 270
Epigenetics and Plant Hormone Dynamics: A Functional and Methodological Perspective
Rudolf, J., Tomovicova, L., Panzarova, K., Fajkus, J., Hejatko, J., & Skalak, J. (2024) · Journal of Experimental Botany · doi:10.1093/jxb/erae054 · Cited by 35
Metadata
- Authors
- Zhang, T.-Q., Lian, H., Zhou, C.-M., Xu, L., Jiao, Y., & Wang, J.-W.
- Venue
- The Plant Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-04-07
- Volume
- 29
- Issue
- 5
- Pages
- 1073-1087
- ISSN
- 1040-4651 (ISSN-L)
- 1532-298X
- OpenAlex
- W2605310505
- Cited by
- 357
- References
- 78
- FWCI
- 26.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, T.-Q., Lian, H., Zhou, C.-M., Xu, L., Jiao, Y., & Wang, J.-W. (2017). A Two-Step Model for de Novo Activation of WUSCHEL during Plant Shoot Regeneration. The Plant Cell. https://doi.org/10.1105/tpc.16.00863
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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