The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise
Open accessAbstract
SUMMARY Zika virus (ZIKV) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we describe two mouse models of placental and fetal disease associated with in utero transmission of ZIKV. Female mice lacking type I interferon signaling (Ifnar1−/−) crossed to wild-type (WT) males produced heterozygous fetuses resembling the immune status of human fetuses. Maternal inoculation at embryonic day 6.5 (E6.5) or E7.5 resulted in fetal demise that was associated with ZIKV infection of the placenta and fetal brain. We identified ZIKV within trophoblasts of the maternal and fetal placenta, consistent with a trans-placental infection route. Antibody blockade of Ifnar1 signaling in WT pregnant mice enhanced ZIKV trans-placental infection although it did not result in fetal death. These models will facilitate the study of ZIKV pathogenesis, in utero transmission, and testing of therapies and vaccines to prevent congenital malformations.
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Cites
Zika Virus Associated with Microcephaly
Mlakar, J., Korva, M., Tul, N., Popović, M., Poljšak-Prijatelj, M., Mraz, J., Kolenc, M., Resman Rus, K., Vesnaver Vipotnik, T., Fabjan Vodušek, V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1600651 · Cited by 2,884
Characterization of a Novel Murine Model to Study Zika Virus
Rossi, S. L., Tesh, R. B., Azar, S. R., Muruato, A. E., Hanley, K. A., Auguste, A. J., Langsjoen, R. M., Paessler, S., Vasilakis, N., & Weaver, S. C. (2016) · The American Society of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.16-0111 · Cited by 458
Characterization of Lethal Zika Virus Infection in AG129 Mice
Aliota, M. T., Caine, E. A., Walker, E. C., Larkin, K. E., Camacho, E., & Osorio, J. E. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004682 · Cited by 322
Cited by
Shared and Distinct Functions of Type I and Type III Interferons
Lazear, H. M., Schoggins, J. W., & Diamond, M. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.025 · Cited by 1,138
Self-citationXu, M., Lee, E. M., Wen, Z., Cheng, Y., Huang, W.-K., Qian, X., TCW, J., Kouznetsova, J., Ogden, S. C., Hammack, C., et al. (2016) · Nature Medicine · doi:10.1038/nm.4184 · Cited by 641
Tabata, T., Petitt, M., Puerta-Guardo, H., Michlmayr, D., Wang, C., Fang-Hoover, J., Harris, E., & Pereira, L. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.002 · Cited by 486
Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses
Meertens, L., Labeau, A., Dejarnac, O., Cipriani, S., Sinigaglia, L., Bonnet-Madin, L., Le Charpentier, T., Hafirassou, M. L., Zamborlini, A., Cao-Lormeau, V.-M., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.045 · Cited by 450
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics
Savidis, G., McDougall, W. M., Meraner, P., Perreira, J. M., Portmann, J. M., Trincucci, G., John, S. P., Aker, A. M., Renzette, N., Robbins, D. R., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.028 · Cited by 363
Metadata
- Authors
- Miner, J. J., Cao, B., Govero, J., Smith, A. M., Fernandez, E., Cabrera, O. H., Garber, C., Noll, M., Klein, R. S., Noguchi, K. K., Mysorekar, I. U., & Diamond, M. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 165
- Issue
- 5
- Pages
- 1081-1091
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2384699986
- Cited by
- 812
- References
- 3
- FWCI
- 150.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miner, J. J., Cao, B., Govero, J., Smith, A. M., Fernandez, E., Cabrera, O. H., Garber, C., Noll, M., Klein, R. S., Noguchi, K. K., Mysorekar, I. U., & Diamond, M. S. (2016). Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell. https://doi.org/10.1016/j.cell.2016.05.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
