Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

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5. A de novo ARIH2 gene mutation was detected in a patient with autism spectrum disorders and intellectual disability
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6. Promotion of RNF168‐Mediated Nucleosomal H2A Ubiquitylation by Structurally Defined K63‐Polyubiquitylated Linker Histone H1
   Qiang Shi, Zhiheng Deng, Liying Zhang, Zebin Tong, Jiabin Li, Guo‐Chao Chu, Huasong Ai, Lei Liu · 2024 · Angewandte Chemie International Edition
7. Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
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8. Convallatoxin inhibits IL‐1β production by suppressing zinc finger protein 91 (ZFP91)‐mediated pro‐IL‐1β ubiquitination and caspase‐8 inflammasome activity
   Yue Xing, Jing Ying Wang, Ming Yue Li, Zhi Hong Zhang, Hong Lan Jin, Hong Xiang Zuo, Juan Ma, Xuejun Jin · 2021 · British Journal of Pharmacology
9. Termination of Eukaryotic Replication Forks
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10. Characterization of RING-Between-RING E3 Ubiquitin Transfer Mechanisms
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11. Molecular basis for specificity of the Met1-linked polyubiquitin signal
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12. Cullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and New Physiologic Players
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13. Enzymatic analysis of WWP2 E3 ubiquitin ligase using protein microarrays identifies autophagy-related substrates
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14. Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling
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15. Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
    Daniel Horn‐Ghetko, Linus V. M. Hopf, Ishita Tripathi‐Giesgen, Jiale Du, Sebastian Kostrhon, Duc Tung Vu, Viola Beier, Barbara A. Steigenberger, Jesuraj Rajan Prabu, Luca J. Stier et al. · 2024 · Nature Structural & Molecular Biology
16. Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C)
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17. Stabilization of p27 Kip1 /CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell‐cycle control
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18. Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H
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19. SCFFbxw5 targets kinesin‐13 proteins to facilitate ciliogenesis
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20. Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
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21. Combinatorial ubiquitin code degrades deubiquitylation-protected substrates
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22. Harnessing the ubiquitin code to respond to environmental cues
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23. Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex
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24. Downregulation of SELENBP1 enhances oral squamous cell carcinoma chemoresistance through KEAP1–NRF2 signaling
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25. PINK1 signalling in neurodegenerative disease
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26. Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain
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27. Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis
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28. Mechanisms of eukaryotic replisome disassembly
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29. The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation
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30. Tag Team Ubiquitin Ligases
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31. Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics
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32. Trade-off and flexibility in the dynamic regulation of the cullin-RING ubiquitin ligase repertoire
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33. Dynamic interactions between SPX proteins, the ubiquitination machinery, and signalling molecules for stress adaptation at a whole-plant level
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34. Cullin neddylation may allosterically tune polyubiquitin chain length and topology
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35. Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes
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36. Advances in the potential roles of Cullin-RING ligases in regulating autoimmune diseases
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37. The von Hippel–Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases
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38. Transcriptomic and Proteomic Profiling of Human Mesenchymal Stem Cell Derived from Umbilical Cord in the Study of Preterm Birth
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39. Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase
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40. Preserving genome integrity: The vital role of SUMO-targeted ubiquitin ligases
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41. Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases
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42. Dual-color pulse-chase ubiquitination assays to simultaneously monitor substrate priming and extension
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43. Review of NEDDylation inhibition activity detection methods
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44. Chemical Tools for Probing the Ub/Ubl Conjugation Cascades
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45. A Nanobody-based TRIM-away targets the intracellular protein degradation of African swine fever virus
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46. The E3 Ubiquitin Ligase ARIH1 Facilitates Colorectal Cancer Progression by Promoting Oxidative Phosphorylation via the Mitochondrial Translocation of K63‐Linked Ubiquitinated PHB1
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48. Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid–liquid phase separation–based method
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49. From seeds to trees: how E2 enzymes grow ubiquitin chains
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50. KLHL12 can form large COPII structures in the absence of CUL3 neddylation
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51. Parkin-mediated ubiquitination inhibits BAK apoptotic activity by blocking its canonical hydrophobic groove
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52. The Fate of Two Unstoppable Trains After Arriving Destination: Replisome Disassembly During DNA Replication Termination
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54. Molecular basis for PHF7-mediated ubiquitination of histone H3
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55. Degrons and degradation signals beyond short linear motifs
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56. Modulation of Cullin-RING E3 ubiquitin ligase-dependent ubiquitination by small molecule compounds
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57. Transfer of ubiquitin protein caught in the act
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58. Clinicopathological and Genomic Characterization of a Simmental Calf with Generalized Bovine Juvenile Angiomatosis
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59. Putative Factors Interfering Cell Cycle Re-Entry in Alzheimer’s Disease: An Omics Study with Differential Expression Meta-Analytics and Co-Expression Profiling
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60. Association between Cullin-3 Single-Nucleotide Polymorphism rs17479770 and Essential Hypertension in the Male Chinese Han Population
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61. APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies
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62. Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report
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63. Cystin is required for maintaining fibrocystin ( FPC ) levels and safeguarding proteome integrity in mouse renal epithelial cells
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65. Regulation of germ cell development by ARI1 family ubiquitin ligases in C. elegans
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66. HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation
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69. A Pro‐Fluorescent Ubiquitin‐Based Probe to Monitor Cysteine‐Based E3 Ligase Activity
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70. Monoubiquitination empowers ubiquitin chain elongation
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71. Illuminating ubiquitination mechanisms: How cryo-EM has shed light on Cullin RING E3 ligase function
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72. Biochemical analysis of PD-L1 ubiquitination by CRL3SPOP, ARIH1, and NEDD4 family ubiquitin ligases
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76. Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complex
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