IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen

Krogh, A., Larsson, B., von Heijne, G., & Sonnhammer, E. L. L. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.4315 · Cited by 12,654

WebLogo: A Sequence Logo Generator: Figure 1Preprint

Crooks, G. E., Hon, G. C., Chandonia, J., & Brenner, S. E. (2004) · Genome Research · doi:10.1101/gr.849004 · Cited by 12,418

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

Dereeper, A., Guignon, V., Blanc, G., Audic, S., Buffet, S., Chevenet, F., Dufayard, J.-F., Guindon, S., Lefort, V., Lescot, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn180 · Cited by 4,700

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495

Activation and regulation of the inflammasomes

Latz, E., Xiao, T. S., & Stutz, A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3452 · Cited by 2,884

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627

Mechanisms and Functions of Inflammasomes

Lamkanfi, M., & Dixit, V. M. (2014) · Cell · doi:10.1016/j.cell.2014.04.007 · Cited by 2,579

Non-canonical inflammasome activation targets caspase-11

Kayagaki, N., Warming, S., Lamkanfi, M., Walle, L. V., Louie, S., Dong, J., Newton, K., Qu, Y., Liu, J., Heldens, S., et al. (2011) · Nature · doi:10.1038/nature10558 · Cited by 2,530

The cytoplasmic sensor, the AIM2 inflammasome: A precise therapeutic target in vascular and metabolic diseases

Lin, J., Wang, J., Fang, J., Li, M., Xu, S., Little, P. J., Zhang, D., & Liu, Z. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16355 · Cited by 20

Impaired interferon-γ signaling promotes the development of silicosis

Peng, Z., Duan, M., Tang, Y., Wu, J., Zhao, K., Zhong, Y., He, Z., Meng, J., Chen, F., Xiao, X., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104647 · Cited by 17

Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy

Nardo, D. D. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5987-2_1 · Cited by 16

Symptomatology and microbiology of the gastrointestinal tract in post‐COVID conditions

Masir, M. N., & Shirvaliloo, M. (2022) · JGH Open · doi:10.1002/jgh3.12811 · Cited by 19

A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation

Kim, W., Kim, S., Woo, H., Jojare, R. A., Mall, R., Nicotra, A., Py, B. F., Ngo, C., Man, S. M., Patel, C., et al. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.08.006 · Cited by 19

The induction of inflammation by the cGAS–STING pathway in human dental pulp cells: A laboratory investigation

Tian, X., Liu, C., & Wang, Z. (2021) · International Endodontic Journal · doi:10.1111/iej.13636 · Cited by 16

Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration

Sekar, R., Wooff, Y., Cioanca, A. V., Kurera, M., Ngo, C., Man, S. M., & Natoli, R. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02927-2 · Cited by 16

Organelle stress in NLRP3 inflammasome: a central mediator of neurodegenerative diseases

Jia, H., Ma, L., Liu, J., Gao, M., Liang, X., Zhang, F., Gao, Y., Liu, M., Jiang, W., Wei, M., et al. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00922-0 · Cited by 18

Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases

Parashar, K., Kopping, E. J., Frank, D. M., Sampath, V., Thanassi, D. G., & Carpino, N. (2017) · Infection and Immunity · doi:10.1128/iai.00406-17 · Cited by 14

Common Differences: The Ability of Inflammasomes to Distinguish Between Self and Pathogen Nucleic Acids During Infection

Lupfer, C. R., Rippee‐Brooks, M. D., & Anand, P. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.10.001 · Cited by 17

Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer

Currey, N., Jahan, Z., Caldon, C. E., Tran, P. N., Benthani, F. A., Lacavalerie, P. D., Roden, D. L., Gloss, B., Campos, C., Bean, E. G., et al. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.01.009 · Cited by 13

Preventing NLRP3 inflammasome activation: Therapeutic atrategy and challenges in atopic dermatitis

Sun, Y., Zhou, Y., Peng, T., Huang, Y., Lü, H., Ying, X., Kang, M., Jiang, H., Wang, J., Zheng, J., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113696 · Cited by 14

Galectin‐3 regulates proinflammatory cytokine function and favours Brucella abortus chronic replication in macrophages and mice

Tana, F. L., Guimarães, E. S., Cerqueira, D. M., Campos, P. C., Gomes, M. T. R., Marinho, F. V., & Oliveira, S. C. (2021) · Cellular Microbiology · doi:10.1111/cmi.13375 · Cited by 13

Cell-autonomousToxoplasmakilling program requires Irgm2 but not its microbe vacuolar localization

Pradipta, A., Sasai, M., Motani, K., Su, J., Lee, Y., Kosako, H., & Yamamoto, M. (2021) · Life Science Alliance · doi:10.26508/lsa.202000960 · Cited by 13

Mechanism of Microbiota-Gut-Brain in Perimenopausal Depression: An Inflammatory Perspective

Yu, X., Zuo, Y., Yang, Y., Cheng, W., Shi, M., Cheng, L., Shao, Q., Xu, Y., & Chen, L. (2025) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2025.10011 · Cited by 12

The noncanonical inflammasome in health and disease

Cahoon, J. G., Yang, D., & Wang, P. (2022) · Infectious Medicine · doi:10.1016/j.imj.2022.09.001 · Cited by 12

Strategies of bacterial detection by inflammasomes

Jastrab, J. B., & Kagan, J. C. (2024) · Cell chemical biology · doi:10.1016/j.chembiol.2024.03.009 · Cited by 14

The role of NLRP3 inflammasome-mediated pyroptosis in astrocytes during hyperoxia-induced brain injury

Liu, Q., Tan, Y., Zhang, Z., Tang, W., Han, L., Peng, K., Liu, M., & Tian, G. (2025) · Inflammation Research · doi:10.1007/s00011-024-01984-4 · Cited by 12

Type I interferons induce guanylate-binding proteins and lysosomal defense in hepatocytes to control malaria

Marques-da-Silva, C., Schmidt-Silva, C., Bowers, C., Charles-Chess, N. A. E., Samuel, C., Shiau, J. C., Park, E., Yuan, Z., Kim, B.-H., Kyle, D. E., et al. (2025) · Cell Host & Microbe · doi:10.1016/j.chom.2025.03.008 · Cited by 12

Autophagy and Bacterial infections

Cadwell, K., Abraham, C., Bel, S., Chauhan, S., Coers, J., Colombo, M. I., Davis, J. R., Hofius, D., Nguyen, H. T. T., Ogawa, M., et al. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2542904 · Cited by 12

New concepts in Chlamydia induced inflammasome responses

Webster, S. J., & GOODALL, J. C. (2017) · Microbes and Infection · doi:10.1016/j.micinf.2017.11.011 · Cited by 11

Comparative analysis of absent in melanoma 2-inflammasome activation in Francisella tularensis and Francisella novicida

Alqahtani, M., Ma, Z., Miller, J., Yu, J., Malik, M., & Bakshi, C. S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1188112 · Cited by 10

Activation of inflammasomes and mechanisms for intracellular recognition of Listeria monocytogenes

Matsuda, Y., Yamauchi, H., & Hara, H. (2023) · Microbiology and Immunology · doi:10.1111/1348-0421.13091 · Cited by 11

Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase-4/11 by LPS through lncRNA57RIK

Gao, Y., Yue, J., Ha, F., Wang, Y., Wang, R., Yang, X., Zhang, J., Liu, X., Zhang, Y., Han, T., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.97059 · Cited by 10

Comparative study of GBP recruitment on two cytosol-dwelling pathogens, Francisella novicida and Shigella flexneri highlights differences in GBP repertoire and in GBP1 motif requirements

Valeva, S., Degabriel, M., Michal, F., Gay, G., Rohde, J. R., Randow, F., Lagrange, B., & Henry, T. (2023) · Pathogens and Disease · doi:10.1093/femspd/ftad005 · Cited by 10

Sepsis take-out: Inhibiting bacterial deliveries

Christgen, S. L., & Kanneganti, T. (2021) · Immunity · doi:10.1016/j.immuni.2021.02.010 · Cited by 9

Activation and manipulation of inflammasomes and pyroptosis during bacterial infections

Bernard, E. M., & Brož, P. (2022) · Biochemical Journal · doi:10.1042/bcj20220051 · Cited by 10

Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood–Milk Barrier

Zou, Y., Wang, X., Xu, J., Wang, S., Li, S., Zhu, Y., & Wang, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113279 · Cited by 9

Collab or Cancel? Bacterial Influencers of Inflammasome Signaling

Herrmann, B. I., Grayczyk, J. P., & Brodsky, I. E. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032521-024017 · Cited by 9

Guanylate‐binding protein 5‐mediated cell‐autonomous immunity suppresses inflammation in dental pulpitis: An in vitro study

Huang, M., Zhan, C., Yang, B., Lu, Y., Yang, X., & Hou, J. L. (2023) · International Endodontic Journal · doi:10.1111/iej.14006 · Cited by 8

NLRP3 Inflammasome Activation Is Involved in Geniposide‐Induced Hepatotoxicity

Liu, Y., Liu, B., Shi, M., Ye, T., & Li, H. (2025) · Mediators of Inflammation · doi:10.1155/mi/4112856 · Cited by 8

Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption

Ha, H. J., Chun, H. L., Lee, S. Y., Jeong, J., Kim, Y., & Park, H. H. (2021) · Communications Biology · doi:10.1038/s42003-020-01640-7 · Cited by 8

The NLRP3-P2X7 Axis and Cytokine Crosstalk in Alzheimer's Disease: Mechanisms, Implications, and Therapeutic Opportunities

Kurmi, S., Doshi, G., & Parab, S. B. (2025) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273377780250505115039 · Cited by 7

Innate Immune Responses and Pulmonary Diseases

Liu, T., Liu, S., & Zhou, X. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-68748-9_4 · Cited by 8

Novel Insights into the Interaction between Enteropathogenic Bacteria, Pyroptosis and IBD

Bao, Z., Deng, Y., Qian, Z., & Zhuang, Y. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2907254 · Cited by 9

The IFN‐inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice

Christgen, S. L., Place, D. E., Zheng, M., Briard, B., Yamamoto, M., & Kanneganti, T. (2021) · European Journal of Immunology · doi:10.1002/eji.202149305 · Cited by 7

Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon‐Inducible GTPases

Brown, H. M., Biering, S. B., Zhu, A. C., Choi, J., & Hwang, S. (2018) · BioEssays · doi:10.1002/bies.201700231 · Cited by 7

Role of non-canonical pyroptosis in sepsis and other inflammatory diseases.

Liang, H., Huang, Y., & Gao, Q. F. (2021) · PubMed Central · doi:10.11817/j.issn.1672-7347.2021.210174 · Cited by 8

From mechanisms to therapies: the multifaceted roles of guanylate-binding protein 2 in immunity, cancer, and beyond

Cui, W., Wang, T., & Feng, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1708319 · Cited by 6

The intricate interactions between inflammasomes and bacterial pathogens: Roles, mechanisms, and therapeutic potentials

Kim, J. K., Sapkota, A., Roh, T., & Jo, E. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108756 · Cited by 7

Crystal structures reveal nucleotide-induced conformational changes in G motifs and distal regions in human guanylate-binding protein 2

Roy, S., Wang, B., Roy, K., Tian, Y., Bhattacharya, M., Williams, S., & Yin, Q. (2025) · Communications Biology · doi:10.1038/s42003-025-07727-3 · Cited by 6

Proton-activated chloride channel governs phagosome-mediated antibacterial immunity in peritoneal macrophages

Cheng, Y., Chu, J., Limjunyawong, N., Chen, J., Ye, Y., Chen, K. H., Koylass, N., Sun, S., Dong, X., & Qiu, Z. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20250312 · Cited by 6

A role for the Sts phosphatases in negatively regulating IFNγ‐mediated production of nitric oxide in monocytes

Parashar, K., & Carpino, N. (2020) · Immunity Inflammation and Disease · doi:10.1002/iid3.336 · Cited by 6

Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection

Guo, Y., Mao, R., Xie, Q., Cheng, X., Xu, T., Wang, X., Du, Y., & Qi, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.743335 · Cited by 6

Detection of Gasdermin Activation and Lytic Cell Death During Pyroptosis and Apoptosis

Demarco, B., Ramos, S., & Brož, P. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2449-4_14 · Cited by 6

Mouse guanylate‐binding protein 1 does not mediate antiviral activity against influenza virus in vitro or in vivo

Tessema, M. B., Tuipulotu, D. E., Oates, C. V. L., Brööks, A. G., Man, S. M., Londrigan, S. L., & Reading, P. C. (2023) · Immunology and Cell Biology · doi:10.1111/imcb.12627 · Cited by 6

Natural products targeting NLRP3 inflammasome for metabolic dysfunction-associated fatty liver disease: the known unknowns

Meng, J., Wang, Q., Wang, H., Shen, X., Qin, T., Zhao, W. H., Li, H., & Yuan, Z. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60970-8 · Cited by 5

Cellular signaling, molecular activation, and regulation of the AIM2 inflammasome

Lozano‐Ruiz, B., Tzoumpa, A., Picó, J., Huang, Y., & González-Navajas, J. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91802-2.00027-x · Cited by 5

Guanylate-binding protein 5: a promising biomarker and therapeutic target

Lu, J., & Wang, W. (2025) · Infection and Immunity · doi:10.1128/iai.00026-25 · Cited by 6

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis infection

Chan, F. H. M., Yeap, H. W., Liu, Z., Rosli, S. N., Low, K. E., Bonne, I., Wu, Y., Chong, S. Z., & Chen, K. W. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115216 · Cited by 3

The dual roles of human PYHIN family proteins in cancer: mechanisms and therapeutic implications

Zeng, S., Zhou, Z., Li, Y., Wu, D., Xiao, Q., & Peng, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1576674 · Cited by 3

Identification of specific molecular markers in severe heatstroke using transcriptomics techniques

Duan, Z., Wang, M., Zhou, Y.-C., Lu, J., Ma, Y., Xu, Y.-Z., Deng, J., Liu, H., & Chen, J. (2025) · International Journal of Legal Medicine · doi:10.1007/s00414-025-03634-8 · Cited by 3

Structural insights into GM4951 as a lipid droplet GTPase regulating hepatic lipid metabolism

Raj, R., Jiang, Y., Jha, R. K., Moresco, E. M. Y., Joshi, H., Zhang, Z., & Beutler, B. (2025) · Nature Communications · doi:10.1038/s41467-025-66253-2 · Cited by 3

Pharmacological targeting of the NLRP3 LRR domain with isothiazolinones overcomes CRID3-resistant inflammation

Woo, H., Jang, Y., Kim, S., Kim, W., Zhang, F., Mall, R., Patel, C., Kurera, M., Ngo, C., Jiang, S., et al. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00425-5 · Cited by 5

Inflammasome-Mediated Mechanisms Of Systemic Inflammation In COVID-19 And Asthma

Виткина, Т. И., Lobova, T. G., Bogomaz, T., & Korableva, E. V. (2024) · Russian Open Medical Journal · doi:10.15275/rusomj.2024.0201 · Cited by 3

A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments

Liu, S., & Zhang, J. (2025) · Journal of Cell Communication and Signaling · doi:10.1002/ccs3.70035 · Cited by 2

IRGB10 Exposes Bacteria’s Intimate Secrets

Hoß, F., Budden, C. F., & Latz, E. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.09.026 · Cited by 3

LncRNA29RIK in macrophages promotes LPS-mediated sensitivity to obesity

Wang, R., Gao, Y., Wang, Y., Zhang, Y., & Yang, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1574507 · Cited by 2

Cytosolic receptors and signaling in antifungal immunity

Khau, S., Désoubeaux, G., Si‐Tahar, M., Biquand, É., & Briard, B. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00627-6 · Cited by 3

Investigation of the immunomodulatory effects and molecular mechanisms of cichoric acid on cyclophosphamide-induced immunosuppression in mice

Bai, L., Feng, C., Xu, X. L., Ge, W., Yang, Y., Liu, X., Li, Z., Qin, Z., Li, S., & Li, J. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115865 · Cited by 2

Intracellular lipopolysaccharide binds RETREG1/FAM134B to regulate ER remodeling upon bacterial infection

Cheng, Y., Mello-Vieira, J., Covarrubias‐Pinto, A., González, A., Kuncha, S. K., Kew, C., Zhang, K., Afzal, M. A., Diab, N., Borchert, S., et al. (2026) · Autophagy · doi:10.1080/15548627.2026.2669978 · Cited by 2

Innate immune sensors of inflammasomes and PANoptosomes: structural–mechanistic insights and therapeutic implications

Upadhyay, S., Nagampalli, R., Resende, S., & Kanneganti, T. (2026) · Cell Research · doi:10.1038/s41422-026-01287-9 · Cited by 2

War on Viruses: LC3 Recruits GTPases

Kuriakose, T., & Kanneganti, T. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.06.019 · Cited by 2

Virulence of Pathogens and the Counteracting Responses of the Host

Land, W. G. (2023) · Springer eBooks · doi:10.1007/978-3-031-21776-0_3 · Cited by 4

Structural basis of IRGB10 oligomerization by GTP hydrolysis

Ha, H. J., Kim, J. H., Lee, G. H., Kim, S., & Park, H. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1254415 · Cited by 2

Insights into ubiquitinome dynamics in the host‒pathogen interplay during Francisella novicida infection

Yang, L., Li, Y., Xie, Q., Xu, T., & Qi, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01887-1 · Cited by 2

Immune mechanisms and signatures in lethal and non-lethal sepsis revealed by single-cell transcriptomics

Zhang, X., Cao, Y., Zhao, Z., Tang, L., Zhang, B., Liao, C., Li, G., & Cai, W. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf140 · Cited by 2

Human GBP1 promotes pathogen vacuole rupture and inflammasome activation during Legionella pneumophila infectionPreprint

Bass, A. R., & Shin, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.27.120477 · Cited by 2

Stress granule component TIA-1 is a negative regulator of the non-canonical NLRP3 inflammasomePreprint

Lamichhane, P. P., Aditi, A., Neil, B. H., Kilgore, P. B., Torres, A. G., Chopra, A. K., & Samir, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.12.634801 · Cited by 2

Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitisPreprint

Lv, Y., Fan, Y., Gao, Q., Chen, Q., Hu, Y., Wang, L., Shi, H., Chen, E., Xu, Q., Cai, Y., et al. (2025) · eLife · doi:10.7554/elife.107339 · Cited by 2

A review of PANoptosis mechanism: current knowledge on pyroptosis, apoptosis and necroptosis in fish

Jin, G., Lv, A., Hu, X., Liu, X., & Chen, Y. (2025) · Reviews in Fish Biology and Fisheries · doi:10.1007/s11160-025-09960-9 · Cited by 1

Beta-Glucan modulates monocyte plasticity and differentiation capacity to mitigate DSS-induced colitis

Lv, Y., Fan, Y., Gao, Q., Chen, Q., Hu, Y., Wang, L., Shi, H., Chen, E., Xu, Q., Cai, Y., et al. (2026) · eLife · doi:10.7554/elife.107339.3 · Cited by 1

Inflammasome Activation Differences Underpin Different Mycobacterium tuberculosis Infection Outcomes

Kumar, R., Kolloli, A., Bhargavi, G., Husain, S., Chang, T. L.-Y., Ghanny, S., Soteropoulos, P., & Subbian, S. (2025) · MedComm · doi:10.1002/mco2.70486 · Cited by 1

Stress granule component protein TIA1 is a negative regulator of the noncanonical NLRP3 inflammasome

Lamichhane, P. P., Aditi, Neil, B. H., Kilgore, P. B., Torres, A. G., Chopra, A. K., & Samir, P. (2025) · ImmunoHorizons · doi:10.1093/immhor/vlaf050 · Cited by 3

IFN-α and IFN-β inhibit NLRP1-driven PANoptosis

Sharma, B. R., Mummareddy, H., Chadchan, S. B., Sarkar, R., Farran, C. A. E., & Kanneganti, T. (2026) · EMBO Reports · doi:10.1038/s44319-026-00888-0 · Cited by 1

The NLRP3 inflammasome at the crossroads of innate immune signaling and cell death

Xiao, N., Lu, Z., Cooper, D. K., & Chen, J. (2026) · Cellular and Molecular Immunology · doi:10.1038/s41423-026-01463-2 · Cited by 2

Inflammasome effector functions: a Tale of Fire and Ice

Jha, S., & Ting, J. P. ‐. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91802-2.00031-1 · Cited by 1

A Continuous IC Glaciochemical Record of the last Glacial Period from the NGRIP Ice Core

Siggaard‐Andersen, M., Hansson, M., Fischer, H., Bigler, M., Roethlisberger, R., Goto‐Azuma, K., Steffensen, J. P., Ruth, U., Andersen, K. K., Clausen, H. B., et al. (2005) · AGUFM · Cited by 1

Faculty Opinions recommendation of The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.

Triantafilou, K. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.734357156.793560837 · Cited by 1

Dual role of Toxoplasma gondii ROP5 and ROP18 for NLRP3 inhibitionPreprint

Murillo-Léon, M., Bastidas-Quintero, A. M., Singh, S., Mueller, X., Gorka, O., Saller, B. S., Arenas, A. F., Campos, C., Gómez‐Marín, J. E., Groß, O., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.17.558105 · Cited by 1

Type-I IFNs induce GBPs and lysosomal defense in hepatocytes to control malariaPreprint

Marques-da-Silva, C., Schmidt-Silva, C., Bowers, C., Charles-Chess, N. A. E., Shiau, J. C., Park, E., Yuan, Z., Kim, B.-H., Kyle, D. E., Harty, J. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.22.619707 · Cited by 1

Autophagy Regulates Inflammatory Responses in Antigen-Presenting Cells

Harris, J., Lang, T., & Sukkar, M. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812146-7.00015-9

Immune control of Legionella pneumophila lung infection

Yang, C. (2018) · Minerva Access (University of Melbourne)

Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection

Zu, Q. (2018) · doi:10.21007/etd.cghs.2018.0462

The impact of sex and species of cells in herpes simplex virus infection

Tseng, Y. (2019) · ANU Open Research (Australian National University) · doi:10.25911/5d77831416351

Novel therapeutic targets in uveitis

Tempest-Roe, S. (2017) · Spiral (Imperial College London) · doi:10.25560/75500

Bacterial Endotoxin Activates Coagulation Cascades Through GSDMD-Dependent Phosphatidylserine ExposurePreprint

Yang, X., Cheng, X., Tang, Y., Qiu, X., Liu, Y., Kang, H., Chen, F., Xiao, X., Mackman, N., Billiar, T. R., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3385688

Role of Inflammatory Cytokine Signaling in Control of Bacterial Infection

Saxena, P. (2020) · uO Research (University of Ottawa) · doi:10.20381/ruor-25300

Evaluación de mecanismos inmunológicos involucrados en el control de enfermedades infecciosas resurgentes (pertussis) y emergentes (COVID-19)

Elizagaray, M. L. (2022) · El Servicio de Difusión de la Creación Intelectual (National University of La Plata) · doi:10.35537/10915/134431

Cell-Autonomous Defenses Against Intracellular Bacteria and Protozoa

Brož, P. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00044-4

Faculty Opinions recommendation of Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11.

Weiss, J. P. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.732498116.793545009

Faculty Opinions recommendation of DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

McDermott, M., & Caseley, E. A. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736591724.793575100

Faculty Opinions recommendation of DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.

Fitzgerald, K., & Ketelut-Carneiro, N. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736591724.793566817

Faculty Opinions recommendation of Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems.

Mecsas, J. C. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727304248.793562320

Cellular signaling, molecular activation, and regulation of the noncanonical inflammasome

Dorfleutner, A., & Stehlik, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91802-2.00028-1

The Role of the AIM2 Gene in Obesity-Related Glucose and Lipid Metabolic Disorders: A Recent Update

Zhang, Y., Xuan, X., Ye, D., Liu, D., Song, Y., Gao, F., & Lu, S. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s488978

Prevalence Around Inflammatory Caspases in Urinary Tract Infections, Review

Nisha, N., Sharma, D. C., Sharma, R. D., & Tomar, J. (2024) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3308

AIM2 and IFI16 as nucleic acid sensors in Periodontitis-Driven systemic inflammation: emerging evidence and therapeutic implications

Wang, S., & Jie, B. (2025) · Clinical Oral Investigations · doi:10.1007/s00784-025-06369-3

Ben_0691 functions as an IRG-47 mycoplasma stimulator that mediates host cell resistance to Mycoplasma mycoides subsp. mycoides infection

Liu, T., Zhao, H., Wang, X., Xu, Q., Li, Y., Wu, Q., Wei, Y., Xin, J., & Pan, Q. (2025) · Communications Biology · doi:10.1038/s42003-025-08950-8

IRGB10 supplies bacterial ligands to activate AIM2 and NLRP3 inflammasomes

Shrivastava, G., Gutiérrez‐Castañeda, B., García‐Cordero, J., León‐Juárez, M., & Cedillo‐Barrón, L. (2017) · Journal of Public Health and Emergency · doi:10.21037/jphe.2017.02.07

IRGB10 Exposes Bacteria’s Intimate Secrets

Hoß, F., Budden, C. F., & Latz, E. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.09.026 · Cited by 3

Guanylate-binding proteins and other interferon-inducible proteins are essential for the activation of the inflammasomes

Man, S. M., Karki, R., & Kanneganti, T. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.196.supp.62.6

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

Man, S. M., Karki, R., Malireddi, R. K. S., Neale, G., Vogel, P., Yamamoto, M., Lamkanfi, M., & Kanneganti, T.-D. (2015) · Nature Immunology · doi:10.1038/ni.3118 · Cited by 380

Sensing bacterial infections by NAIP receptors in NLRC4 inflammasome activation

Gong, Y., & Shao, F. (2012) · Protein & Cell · doi:10.1007/s13238-012-2028-3 · Cited by 42