Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin

Keyes, Brice E., Liu, Siqi, Asare, Amma, Naik, Shruti, Levorse, John, Polak, Lisa, Lu, Catherine P., Nikolova, Maria +2 more·2016·Cell
DOI 10.1016/j.cell.2016.10.052

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  11. [Research advances on the mechanism of dendritic epidermal T lymphocytes in wound healing].
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  17. From systemic disease to the eye: Why senescence deserves attention in ocular infections
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  19. Low temperatures promote the healing of skin micro-injuries by inhibiting IL1β
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  22. Cutaneous epithelial stem cells
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  24. Determinants of Murine Skin Microbiota Composition in Homeostasis and Wound Healing
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  25. Chronic overexpression of neuropeptide Y in the skin is sufficient to induce inflammation and epidermal and dermal pathology
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  32. Assessment of Frailty In Elderly Patients Attending A Multidisciplinary Wound Care Center: A Cohort Study.
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  33. Faculty Opinions recommendation of Biological Processes Modulating Longevity across Primates: A Phylogenetic Genome-Phenome Analysis.
    Björn Schumacher · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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  36. Peer Review #4 of "Inflammatory auxo-action in the stem cell division theory of cancer (v0.1)"
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  40. Peer Review #4 of "Inflammatory auxo-action in the stem cell division theory of cancer (v0.2)"
    2023 · PeerJ
  41. Peer Review #3 of "Inflammatory auxo-action in the stem cell division theory of cancer (v0.2)"
    2023 · PeerJ
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    Qi Li, Liu H, Jiahui Zhang, Mengqi Zhang, Aoli Wu, Hengchang Zang · 2026 · Colloids and Surfaces A Physicochemical and Engineering Aspects
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  57. Mesenchymal stem cells and extracellular vesicles in skin regeneration
    Reshma Murali, Anugya Bhatt · 2026 · Elsevier eBooks
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