The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Transcriptional Addiction in Cancer
Open accessAbstract
Summary Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.
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Cites
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Self-citationThe landscape of somatic copy-number alteration across human cancers
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Self-citationMachine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
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Self-citationEpigenetic plasticity and the hallmarks of cancer
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The dTAG system for immediate and target-specific protein degradation
Nabet, B., Roberts, J. M., Buckley, D. L., Paulk, J., Dastjerdi, S., Yang, A., Leggett, A. L., Erb, M. A., Lawlor, M. A., Souza, A., et al. (2018) · Nature Chemical Biology · doi:10.1038/s41589-018-0021-8 · Cited by 1,118
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Metadata
- Authors
- Bradner, J. E., Hnisz, D., & Young, R. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 168
- Issue
- 4
- Pages
- 629-643
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2586373162
- Cited by
- 1,194
- References
- 47
- FWCI
- 32.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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