Epigenetic plasticity and the hallmarks of cancer

Flavahan, William A.; Gaskell, Elizabeth; Bernstein, Bradley E.

doi:10.1126/science.aal2380

Cited by 1,340Epigenetics and DNA MethylationChromatin Remodeling and CancerGenomics and Chromatin Dynamics

Epigenetic plasticity and the hallmarks of cancer

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Flavahan, William A., Gaskell, Elizabeth, Bernstein, Bradley E.·2017·Science

DOI 10.1126/science.aal2380PMC PMC5940341

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Abstract

Cancer epigenetics in the driver's seat: Recent cancer genome projects unexpectedly highlighted the role of epigenetic alterations in cancer development. About half of human cancers were found to harbor mutations in chromatin proteins. In a Review, Flavahan et al. propose that chromatin and epigenetic aberrations have the potential to confer on cells the full range of oncogenic properties represented in the classic “hallmarks” depiction of cancer. They suggest that genetic, environmental, and metabolic factors can make chromatin aberrantly permissive or restrictive. Permissive chromatin creates a state of “epigenetic plasticity,” which can activate oncogene expression or cell fate changes that drive cancer development. Science , this issue p. eaal2380

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Alterations in chromatin state are associated with many diseases, including several cancers.
“Alterations in chromatin state have been associated with many diseases including several cancers1.”
From Profiling the genetic determinants of chromatin accessibility with scalable single-cell CRISPR screens (2021) · cites this paper as [1]
Ipilimumab induces expression of EZH2, an epigenetic enzyme important in cellular plasticity.
“It was demonstrated that ipilimumab induces the expression of EZH2, a key epigenetic enzyme that plays an important role in cellular plasticity (115-118).”
From The Next Decade of Immune Checkpoint Therapy (2021) · cites this paper as [115]

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Hallmarks of Cancer: New Dimensions
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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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Authors: Flavahan, W. A., Gaskell, E., & Bernstein, B. E.
Affiliations: Broad Institute (US)
Corresponding author: Bernstein, Bradley E.
ORCID: Flavahan, William A.
Gaskell, Elizabeth
Bernstein, Bradley E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2017-07-21
Volume: 357
Issue: 6348
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.aal2380
PMC: PMC5940341
OpenAlex: W2737272162
Cited by: 1,340
References: 117
Citations by year: 2026: 142 · 2025: 127 · 2024: 156 · 2023: 168 · 2022: 160 · 2021: 188 · 2020: 174 · 2019: 128 · 2018: 80 · 2017: 15
FWCI: 10.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (award310374, DP1CA216873)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: epigenetic plasticity, cancer hallmarks, chromatin, epigenetic landscape, tumor suppressor, oncogene activation, cell fate transitions, tumor evolution, tumor initiation, driver mutations, cell differentiation
MeSH terms: Chromatin, Humans, Neoplasms, Oncogenes, DNA Methylation, Epigenesis, Genetic, Carcinogenesis

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Epigenetic plasticity and the hallmarks of cancer

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