Genome Organization Drives Chromosome Fragility

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Items 301–383 of 383

1. The Roles of Topoisomerases in Transcriptional Regulation
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2. Confined migration induces non-lethal DNA damage in developing neurons
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3. How Topoisomerases Relax and Disentangle the Genome During DNA Replication
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5. Targeting the 3D genome by anthracyclines for chemotherapeutic effects
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6. Some Aspects of Carcinogenesis Associated with Genetic and Epigenetic Factors
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8. Identification of proteins involved in Trypanosoma brucei DNA replication fork dynamics using nascent DNA proteomics
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9. Topoisomerase IIβ targets DNA crossovers formed between distant homologous sites to modulate chromatin structure and gene expression
   Mary Miyaji, Ryohei Furuta, Osamu Hosoya, Kuniaki Sano, Norikazu Hara, Ryozo Kuwano, Jiyoung Kang, Masaru Tateno, Kimiko Tsutsui, Ken Tsutsui · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
10. Control of RNA polymerase II promoter-proximal pausing by DNA supercoiling
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11. Transcriptional networks are dynamically regulated during cell cycle progression in human Pluripotent Stem Cells
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12. Characterization of the role of spatial proximity of DNA double-strand breaks in the formation of CRISPR-Cas9-induced large structural variations
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13. Boosting Macroevolution: Genomic Changes Triggering Qualitative Expansions of Regulatory Potential
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14. Contribution of Radiation Sensitive Protein 51 Genotypes to Pterygium Risk in a Taiwanese Population
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15. Modulation of AAV transduction and integration targeting by topoisomerase poisons
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16. Coordinated control of genome–nuclear lamina interactions by topoisomerase 2B and lamin B receptor
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17. Breaking the script: transcriptional addiction as a driver of genome instability in cancer
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18. Fibrillarin and fibrillarin-like their role in cancer progression: new approaches and perspectives
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19. Endless forms – how genome organization underlies evolution and development
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20. Discovery of an Endonuclease G-inhibitory Ku80-peptide protecting against leukemogenic rearrangements at the MLL breakpoint cluster
    Julia Eberle, Ahmed Abdelraouf Salem, Mara Hofmann, Anja Reisser, Yasser B. Ruiz‐Blanco, Yasser Almeida‐Hernández, Boris Gole, Melanie Rall-Scharpf, Jessica Angulo-Capel, Thomas Monecke et al. · 2026 · Nature Communications
21. The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of wild-type adeno-associated virus type 2 (wtAAV2) to cellular sites of DNA damage
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22. Folding a broken genome: the versatile roles of cohesin in genome maintenance
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23. Cohesin Entangling During Loop Extrusion as a Driving Event for Chromosomal Aberrations: Approach to Modeling BCR-ABL Translocation
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24. Homologous recombination in mammalian cells: From molecular mechanisms to pathology
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25. Key roles of CCCTC-binding factor in cancer evolution and development
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26. ChromInSight: Revealing DNA Double‐Strand Breaks Through Chromatin Structural Insights With an Interpretable Graph Neural Network Framework
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27. The function of lncRNAs in aging-related diseases and 3D genome
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28. Dysregulation of Cis-Regulatory Elements in Cancer
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29. Chromosome instability induced by mutations in TAD anchors leads to tumors
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30. Analysis of differentially expressed genes on human X chromosome harboring large deletion induced by X-rays
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31. Chromosome structure due to phospho-mimetic H2A modulates DDR through increased chromatin mobility
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32. From DNA Topology to Pubertal Onset: Using Integrative Genomic Approaches to Study Transcriptional Regulation
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33. A Phosphorylated Histone H2A Variant Displays Properties of Chromatin Insulator Proteins in Drosophila
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34. A dual-activity Topoisomerase Complex Regulates both Transcription and Translation
    Shuaikun Su, Yutong Xue, Alexei A. Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L. Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De et al. · 2021 · Research Square
35. The human RNA polymerase I structure reveals an HMG-like transcription factor docking domain specific to metazoans
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36. A dual-activity topoisomerase complex regulates translation and abundance of mRNAs important for psychiatric disorders
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37. Genomic landscape of TP53 -mutated myeloid malignancies
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38. The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of Adeno-Associated Virus Type 2 (wtAAV2) to cellular sites of DNA damage
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39. Chromatin, Nuclear Organization, and Genome Stability in Mammals
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40. Analysis of Relevance and Redundance on Topoisomerase 2b (TOP2B) Binding Sites: A Feature Selection Approach
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41. НЕКОТОРЫЕ АСПЕКТЫ КАНЦЕРОГЕНЕЗА, СВЯЗАННЫЕ С ГЕНЕТИЧЕСКИМИ И ЭПИГЕНЕТИЧЕСКИМИ ФАКТОРАМИ, "Успехи современной биологии"
    Mikhaĭlov Vf, Л. В. Шуленина, И. М. Васильева, Д. В. Салеева, Г. Д. Засухина · 2018 · Успехи современной биологии
42. Fork Stalling and Recombination of the Nascent DNA: Addressing the Limitations
    Saeed Taheri · 2020 · Genomics & Gene Therapy International Journal
43. The genetic sequences prone to copy number variation and single nucleotide polymorphism are linked to the repair of the poisoned DNA topoisomerase II
    Chuo Jiang, Cong Ma, Detao Wang, Li Liu, Chunxiu Zhang, Fuxue Chen, Jiaxi Wu · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
44. Chromatin structuring factor HMGA2 controls subtelomere stability and cancer chemosensitivity
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45. Beyond the Fanconi anemia pathway: new mechanisms of DNA interstrand crosslink repair
    Alice Bolner · 2021
46. [Delusion and Rose's disease].
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47. Faculty Opinions recommendation of Spatial inter-centromeric interactions facilitated the emergence of evolutionary new centromeres.
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48. Chromatin, nuclear organization and genome stability in mammals
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49. Faculty Opinions recommendation of ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
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50. Chromothripsis Rearrangements Are Informed by 3D-Genome Organization
    Natalia V. Petukhova, Alexey Zabelkin, Vitaly Dravgelis, Sergey S. Aganezov, Nikita Alexeev · 2022 · Lecture notes in computer science
51. Interactions of parvoviruses with the cellular DNA damage response and CTCF
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52. The Role of Telomerase Activators in Antiaging Strategies and their Clinical Potential
    Yasemi̇n Aydin, Banu Orta Yılmaz · 2023 · Springer eBooks
53. Data from Cancer Mutational Processes Vary in Their Association with Replication Timing and Chromatin Accessibility
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54. Sensitivity of DNA double-strand break loci is coupled with spatial interaction density of chromatin
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55. Gene Co-Expression Networks Describe the Catalytic Inhibition of DNA Topoisomerase Iigene
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56. Additional file 2 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
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57. TFII-I/GTF2I regulates globin gene expression and stress response in erythroid cells
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58. Genome Organization, Evolution of
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59. The multiscale distribution of radiation-induced DNA damage and its impact on local genome structure
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60. Conserved 3D genome reorganization during DNA repair
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61. Additional file 3 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
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62. Additional file 2 of Secondary structure of the human mitochondrial genome affects formation of deletions
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63. Additional file 4 of Secondary structure of the human mitochondrial genome affects formation of deletions
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64. Additional file 3 of Secondary structure of the human mitochondrial genome affects formation of deletions
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65. Additional file 1 of Secondary structure of the human mitochondrial genome affects formation of deletions
    Victor Shamanskiy, Mikhailova, Alina A., Evgenii O. Tretiakov, Kristina Ushakova, Alina G. Mikhailova, Oreshkov, Sergei, Knorre, Dmitry A., Natalia Ree, Jonathan B. Overdevest, Samuel W. Lukowski et al. · 2023 · Figshare
66. Additional file 1 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
    Sun, Yu, Xu, Xiang, Lin Lin, Xu, Kang, Zheng, Yang, Ren, Chao, Huan Tao, Wang, Xu, Huan Zhao, Tu, Weiwei et al. · 2023 · Figshare
67. Additional file 4 of A graph neural network-based interpretable framework reveals a novel DNA fragility–associated chromatin structural unit
    Sun, Yu, Xu, Xiang, Lin, Lin, Xu, Kang, Zheng, Yang, Ren, Chao, Huan Tao, Wang, Xu, Huan Zhao, Tu, Weiwei et al. · 2023 · Figshare
68. Additional file 1 of Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia
    Xing, Zhihao, 麦惠容, Liu, Xiaorong, Fu, Xiaoying, Zhang, Xingliang, Xie, Lichun, Chen, Yunsheng, Adam Shlien, Wen, Feiqiu · 2022 · Figshare
69. Additional file 3 of Single-cell diploid Hi-C reveals the role of spatial aggregations in complex rearrangements and KMT2A fusions in leukemia
    Zhihao Xing, 麦惠容, Xiaorong Liu, Fu, Xiaoying, Zhang, Xingliang, Xie, Lichun, Chen, Yunsheng, Adam Shlien, Wen, Feiqiu · 2022 · Figshare
70. The functional organization of chromosome territories in single nuclei during zygotic genome activation
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71. Le syndrome Xeroderma Pigmentosum-C - étude des mécanismes moléculaires impliqués dans la prédisposition des patients XP-C aux cancers cutanés non mélanocytaire agressifs
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72. Maintien de l'hétérochromatine en réponse aux dommages à l'ADN dans des cellules de mammifères
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73. Impact of low replication stress on the replication program of cancer and non-tumor cells
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74. Accurate Detection of Multiple Chromosome Rearrangements and Copy Number Variations by PacBio Sequencing in Complex Chromosomal Abnormality
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75. Analyse de données et modèle pour l'étude de la chromatine, des G-quadruplexes et de la réparation de l'ADN
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76. PDS5A and TOP2B cooperate for chromatin recruitment via CTCF
    Edgar González-Buendía, Havva Ortabozkoyun, Danny Reinberg · 2026 · Science Advances
77. Drosophila intestinal stem cell response to DNA damage and replication stress
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78. Identification de nouveaux facteurs impliqués dans la réponse aux lésions de l'ADN chez Arabidopsis thaliana
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79. DNA methylation changes CTCF binding and reorganizes 3D genome structure in breast cancer cells
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80. L'implication des hybrides ADN : ARN et de la modification m6A des ARN dans la réparation des cassures double-brins de l'ADN
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81. The biogenesis of extrachromosomal circular DNA is associated with enhancer-promoter dynamics and chromatin architecture
    Yuxi Gu, Yidan Song, Shuhua Wang, Yue Wang, Zhihe Zhao, Jun Liu · 2026 · International Journal of Biological Macromolecules
82. The heat shock transcription factor, HSF1, stimulates the catalytic engagement of topoisomerase IIβ over topoisomerase IIα
    Lahiri Konada, Thomas E. Catley, Lance Heady, Morgan Crewe, Ilse Delint‐Ramírez, Laura Wiggins, Sandra Fajardo Briseno, Mohd Younus Bhat, Amir Segev, Alice L. B. Pyne et al. · 2026 · Molecular Cell
83. Chromosome-scale genome remodeling in tumor evolution: Copy number alterations and structural variants as two sides of the same coin
    Daisuke Sato, Satoru Miyawaki, Yu Sakai, Hiroki Hongo, Yudai Hirano, Yu Teranishi, Shotaro Ogawa, Takahiro Tsuchiya, So Hirata, Hideaki Ono et al. · 2026 · Critical Reviews in Oncology/Hematology