How Ligands Illuminate GPCR Molecular Pharmacology
Cited by (568)
Items 501–568 of 568
- Biological Sensors for Microbiome DiagnosticsAmy M. Ehrenworth Breedon, Kathryn Beabout, Heidi G. Coia, Christina M. Davis, Svetlana V. Harbaugh, Camilla A. Mauzy, Mark Nelson, Roland Saldanha, Blake W. Stamps, Michael S. Goodson · 2022 · Wiley eBooks
- Faculty Opinions recommendation of Morphine-induced respiratory depression is independent of β-arrestin2 signalling.Maree Therese Smith · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics.Xuewu Zhang · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.Stephen H Safe · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of GPCRs show widespread differential mRNA expression and frequent mutation and copy number variation in solid tumors.Arun K. Shukla · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology.Arun K. Shukla · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of A selective ligand for estrogen receptor proteins discriminates rapid and genomic signaling.M Madan Babu, Maria Marti · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Biased signaling of the mu opioid receptor revealed in native neurons.Joël Bockaert · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of Mechanism of β2AR regulation by an intracellular positive allosteric modulator.Robert A. Copeland · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Two SKAP2 modular organizations differently recognize SRC kinases depending on their activation status and localizationLaurine Levillayer, Patricia Cassonnet, Marion Declercq, Mélanie Dos Santos, Louis Lebreton, Katerina Danezi, Caroline Demeret, Anavaj Sakuntabhai, Yves Jacob, Jean‐François Bureau · 2022 · Research Square
- Importance of Structure and Dynamics in the Rational Drug Design of G Protein‐Coupled Receptor ( GPCR ) ModulatorsRaudah Lazim, Yoonji Lee, Pratanphorn Nakliang, Sun Choi · 2022 · Wiley eBooks
- Comparative Study of State-Dependent Cholesterol Binding Sites in Adenosine A 2A and A 1 Receptors Using Coarse-Grained Molecular Dynamics Simulations in Biologically Relevant MembranesEva Tzortzini, Robin Adam Corey, Antonios Kolocouris · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Evaluación del impacto de la coexpresión del receptor de ghrelina (GHSR) y los receptores de dopamina tipo 1 y 2 (D1R y D2R) sobre la modulación de los canales de calcio operados por voltaje presinápticos (CaV2)Santiago Cordisco González · 2020
- Pharmacological actions of commonly used drugsJustin R. Yates · 2023 · Elsevier eBooks
- Bioluminescence-based biosensors to study histamine receptor activityXiaoyuan Ma · 2023
- Physiology of GPCRs in the nervous system and the contribution of orphan GPCRsNecla Birgül İyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Dogan Soner, Zafiroula Georgoussi, Jesús Giraldo, Anemarie Horvat et al. · 2023
- Insights into the molecular pharmacology of novel aminotetralins and known drug candidates at serotonin 5-HT1-type receptorsRyan P. McGlynn · 2023
- In Vitro Biology: Measuring Pharmacological Activity that Will Translate to Clinical EfficacyIain G. Dougall, Rachel L. Grimley, Per-Erik Strömstedt · 2023 · Royal Society of Chemistry eBooks
- Endogenous Promotor-Driven Split Nanoluciferase Biosensor for Assessing G Protein RecruitmentLaura J. Humphrys, Carina Höring, Albert Owusu Gattor · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Caracterização dos mecanismos moleculares envolvidos na ligação e sinalização da angiotensina II no receptor AT1Diego Ângelo Duarte · 2018 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
- Chapter 2. Neurotransmitters, Receptors, and TransportersKelly A. Berg, William P. Clarke, Lynette C. Daws, Alan Frazer, Milena Girotti, Daniel J. Lodge · 2024 · American Psychiatric Association Publishing eBooks
- Comparing haloperidol with clozapine as treatments for schizophreniaBingzhi Liao · 2024 · Theoretical and Natural Science
- Structure-function relationships in sensory G protein-coupled receptorsNeda Razzaghi · 2022 · UPCommons institutional repository (Universitat Politècnica de Catalunya)
- Post-translational modifications orchestrate the intrinsic signaling bias of orphan receptor GPR52Bingjie Zhang, Mengna Ma, Wei Ge, Shanshan Li, Guang Yang, Huilan Wang, Boxun Lu, Wenqing Shui · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Peptidergic G-Protein-Coupled Receptor Signaling Systems in Cancer: Examination of Receptor Structure and Signaling to Foster Innovative Pharmacological SolutionsFrancisco David Rodriguez, Rafael Coveñas · 2024 · Future Pharmacology
- Scaled and Weighted Laplacian Matrices as Functional Descriptors for GPCR LigandsGuillermo Goode‐Romero, Laura Domı́nguez · 2025 · Journal of Computational Chemistry
- Applications and prospects of synthetic receptors for therapeutic protein deliveryDanhong Zhou, Yunxuan Chen, He Jin, Qinmeng Zhang, Zhiwei Jiang, Guoli Yang · 2025 · European Journal of Pharmaceutics and Biopharmaceutics
- Binding pose depth modulates photoswitchable ligands’ efficacy at the 5-HT2A receptorVerena Weber, Giacomo Salvadori, Federico Natale, Hubert Gerwe, Michael W. Decker, Paolo Carloni, Giulia Rossetti · 2026 · Communications Chemistry
- New modalities: Drugging the undruggable GPCR targetsP. Zawadzki, Piotr P. Graczyk, Jakub Staroń · 2025 · Elsevier eBooks
- A chemogenetic strategy for inhibiting G protein-coupled receptor activity using metal coordinationTomohiro Doura, Takuto Sugawara, Hajime Inoue, Muneo Tsujikawa, Yukiko Michibata, Itaru Hamachi, Shigeki Kiyonaka · 2025 · Chemistry Letters
- Characterizing the role of extracellular domain in GLP-1R biased agonismLinshan Xie, Rong Xu, Huining Liu, Man Na, Qikai Qin, Fei Xu, Raymond C. Stevens, Yan Liu · 2025 · The International Journal of Biochemistry & Cell Biology
- To Be Biased or Not to Be: A Play for G-Protein Coupled ReceptorsNikitas G. Liolitsas, Evangelia Pantazaka, Εvangelia Papadimitriou · 2025 · International Journal of Translational Medicine
- Additional file 1 of Decrypting orphan GPCR drug discovery via multitask learningHuang, Wei-Cheng, Lin, Wei-Ting, Hung, Ming-Shiu, Lee, Jinq-Chyi, Tung, Chun-Wei · 2024 · Figshare
- Additional file 1 of Droplet-based microfluidic platform for detecting agonistic peptides that are self-secreted by yeast expressing a G-protein-coupled receptorRirika Asama, Cher J. S. Liu, Masahiro Tominaga, Cheng, Yu-Ru, Yasuyuki Nakamura, Akihiko Kondo, Wang, Hsiang-Yu, Jun Ishii · 2024 · Figshare
- Role of Berberine in the Modulation of the PI3K/AKT/mTOR PathwayHéctor Eduardo López-Valdés, Hilda Martínez‐Coria, Juan Angel Ortiz-Lara · 2026 · Springer eBooks
- Research Progress on the Biological Functions and Clinical Translational Applications of GPR182远嘉 任 · 2026 · Advances in Clinical Medicine
- An atypical venus fly trap domain receptor regulates motility and phagocytosis in the protozoan parasite Entamoeba histolyticaRivo Yudhinata Brian Nugraha, Ghulam Jeelani, Herbert J. Santos, Tomoyoshi Nozaki · 2026 · PLoS Pathogens
- Functional Evaluation of Tetrahydroisoquinoline-Derived Ligands Reveals Distinct Modulatory Profiles at the Muscarinic M1 ReceptorJuan Pablo González-Gutiérrez, Damián Castillo-Ríos, Ignacio Alejandro González-Gutiérrez, Dante R. Palma-Ruíz, Isabel Vidal-Beltrán, Ingrid Carvacho, Fernando Hinostroza · 2026 · ACS Medicinal Chemistry Letters
- Medicinal chemistry, adenosine receptors as a case study of developments in the GPCR fieldStephanie Federico, Giampiero Spalluto · 2026 · Elsevier eBooks
- GPR162 Drives Obesity-Associated Lung Adenocarcinoma Suppression via Fatty Acid Oxidation-Induced Cuproptosis and Metabolic-Immune ReprogrammingYongguang Tao, Yao Long, Wei Wang, Can Cao, Molly S. C. Li, Lei Li, Shuang Liu, Desheng Xiao · 2026 · Research Square
- Méthodes RMN pour la découverte de nouveaux ligands ciblant les récepteurs couplés aux protéines GClaire Raingeval · 2019 · theses.fr (ABES)
- Analysis of CXCR4 and ACKR3 oligomerisationJoyce Heuninck · 2019 · theses.fr (ABES)
- Développement et caractérisation d'outils immunologiques dirigés contre des récepteurs membranaires d'intérêt thérapeutiqueLucie Hartmann · 2019
- Exploiting G protein-coupled receptors : exploring new possibilities for protein-based biosensorsSimon Harris · 2019 · theses.fr (ABES)
- Numerical modeling of olfactionCaroline Bushdid · 2018
- Dynamique structurale de complexes RCPG - neuropeptidesGuillaume Ferré · 2019
- Structural and functional characterization of the protein PDZD7 as part of the Usher2 complexBaptiste Colcombet-Cazenave · 2022
- Démonstration de l’existence des récepteurs mGlu7 hétérodimériques par des approches innovantesKawthar Belkacemi · 2024 · theses.fr (ABES)
- Improving AlphaFold2 Performance in Virtual Screens Targeting GPCRs by Enhancing Binding-Site Conformational SamplingNúria Mitjavila-Domènech, Alejandro Díaz‐Holguín, Huabin Hu, Nour Aldin Kahlous, Israel Cabeza de Vaca, Björn Wallner, Jens Carlsson · 2026 · Journal of Chemical Information and Modeling
- A BBB-permeable β 3 -AR probe enables redox imaging, natural inhibitors discovery, and therapeutic monitoring in glioblastomaWei Cheng, Zhuoying Chen, Yani Liu, Xiangjie Luo, Zheng Li, Huiquan Yang, Yifan Zhong, Xinyi Cai, Zhigang Sun, Ling Zhou et al. · 2026 · Science Advances
- Translating GPCR Movements into Therapeutic InnovationsJunaid Tantray, Sajad Ahmad Bhat, Mohammed Azam Hyder, Syrsulu Myrzagulova, Prashant Tiwari, Steward Mudenda · 2026 · Springer eBooks
- GPCR Drug Development from Preclinical Insights to Clinical ApplicationsVaibhavkumar Patel, Maitree Chauhan, Arya Nair, Kinjal Prahaladbhai Patel, Prashant Tiwari, Sunil Kumar Kadiri, Babita Kaundal · 2026 · Springer eBooks
- GPCR Biased Signaling: Opportunities and ChallengesBryan L. Roth · 2026 · Biochemistry
- The Dopamine D3 Receptor as an Emerging Therapeutic Target in Parkinson’s Disease: Structural Advances, Signaling Bias and Neuroprotective PerspectivesFelipe Patricio, Eliud Morales Dávila, Aleidy Patricio-Martínez, Abel Villa-Mancera, Jose Manuel Perez‐Aguilar, Ilhuicamina Daniel Limón · 2026 · Receptors
- Dynamic interactions in GPCR–G protein coupling: Distinguishing specificity and pluripotencyAditya Manoj, Durba Sengupta · 2026 · Elsevier eBooks
- Regulation of Translation by PKA Signaling PathwayLele Yang, Kun Hou, Huayu Qi · 2026 · International Journal of Molecular Sciences
- Ligand-Dependent Affinity but State-Dominated Efficacy in Structure-Based GPCR Pharmacology PredictionJianxiang Huang, Xin Qiao, Chunhao Zhu, Xiaobing Lan, Shaoyong Lu · 2026 · Journal of Medicinal Chemistry
- Thermodynamic, Kinetic, and Structural Determinants of Ligand Selectivity in A2A and A2B Adenosine ReceptorsOmar Josue Alsina Gutierrez, Samuele Di Cristofano, Stefano Raniolo, Vittorio Limongelli · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Peptidomimetics in GPCRs: From structural insights to clinical blockbustersG. Li, Qingtong Zhou, Ming‐Wei Wang · 2026 · Acta Pharmaceutica Sinica B
- BindingDB Entry 50017445: The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50022489: Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50008987: DBindingDB · 2021 · UC San Diego
- BindingDB Entry 50008908: Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine DBindingDB · 2021 · UC San Diego
- BindingDB Entry 50016203: Discovery of β-Arrestin-Biased 25CN-NBOH-Derived 5-HTBindingDB · 2023 · UC San Diego
- BindingDB Entry 50006785: Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50006764: Small Molecule Allosteric Modulators of G-Protein-Coupled Receptors: Drug-Target Interactions.BindingDB · 2021 · UC San Diego
- BindingDB Entry 50002445: Discovery of β-Arrestin Biased Ligands of 5-HTBindingDB · 2020 · UC San Diego
- Structural and functional insights into rhodopsin‐like and secretin‐like GPCR –arrestin interactions and regulationVarsha Gupta, Annette G. Beck‐Sickinger · 2026 · FEBS Journal