Roth, Bryan L.

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Gordon, D. E., Jang, G. M., Bouhaddou, M., Xu, J., Obernier, K., White, K. M., O’Meara, M. J., Rezelj, V. V., Guo, J. Z., Swaney, D. L., et al. (2020) · Nature

SARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methods

Cited by 4,405

Relating protein pharmacology by ligand chemistry

Keiser, M. J., Roth, B. L., Armbruster, B. N., Ernsberger, P., Irwin, J. J., & Shoichet, B. K. (2007) · Nature Biotechnology

Computational Drug Discovery MethodsReceptor Mechanisms and Signaling

Cited by 2,402

The expanded biology of serotonin

Berger, M., Gray, J. A., & Roth, B. L. (2009) · Annual Review of Medicine

Receptor Mechanisms and SignalingNeurotransmitter Receptor Influence on Behavior

Cited by 2,100

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 2,046

DREADDs for neuroscientists

Roth, B. L. (2016) · Neuron

Photoreceptor and optogenetics researchNeuroscience and Neuropharmacology Research

Cited by 1,742

Predicting new molecular targets for known drugs

Keiser, M. J., Setola, V., Irwin, J. J., Laggner, C., Abbas, A. I., Hufeisen, S. J., Jensen, N. H., Kuijer, M. B., Matos, R. C., Tran, T. B., et al. (2009) · Nature

Computational Drug Discovery MethodsReceptor Mechanisms and Signaling

Cited by 1,667

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation

Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on Behavior

Cited by 1,578

Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

Rajkowska, G., Miguel-Hidalgo, J. J., Wei, J., Dilley, G., Pittman, S. D., Meltzer, H. Y., Overholser, J. C., Roth, B. L., & Stockmeier, C. A. (1999) · Biological Psychiatry

Treatment of Major DepressionNeural and Behavioral Psychology Studies

Cited by 1,477

Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

Roth, B. L., Sheffler, D. J., & Kroeze, W. K. (2004) · Nature Reviews Drug Discovery

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 1,155

Ultra-large library docking for discovering new chemotypes

Lyu, J., Wang, S., Balius, T. E., Singh, I., Levit, A., Moroz, Y. S., O’Meara, M. J., Che, T., Algaa, E., Tolmachova, K., et al. (2019) · Nature

Computational Drug Discovery MethodsSynthesis and Characterization of Heterocyclic Compounds

Cited by 998

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

Goldberg, M. S., Fleming, S. M., Palacino, J. J., Cepeda, C., Lam, H. A., Bhatnagar, A., Meloni, E. G., Wu, N., Ackerson, L. C., Klapstein, G. J., et al. (2003) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 913

The promise and peril of chemical probes

Arrowsmith, C. H., Audia, J. E., Austin, C., Baell, J., Bennett, J., Blagg, J., Bountra, C., Brennan, P. E., Brown, P. J., Bunnage, M. E., et al. (2015) · Nature Chemical Biology

Click Chemistry and ApplicationsComputational Drug Discovery Methods

Cited by 839

Automated design of ligands to polypharmacological profiles

Besnard, J., Ruda, G. F., Setola, V., Abecassis, K., Rodriguiz, R. M., Huang, X.-P., Norval, S., Sassano, M. F., Shin, A. I., Webster, L. A., et al. (2012) · Nature

Computational Drug Discovery MethodsCholinesterase and Neurodegenerative Diseases

Cited by 832

Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

Roth, B. L., Baner, K., Westkaemper, R., Siebert, D., Rice, K. C., Steinberg, S., Ernsberger, P., & Rothman, R. B. (2002) · Proceedings of the National Academy of Sciences

Alkaloids: synthesis and pharmacologyPsychedelics and Drug Studies

Cited by 784

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

Kroeze, W. K., Sassano, M. F., Huang, X.-P., Lansu, K., McCorvy, J. D., Giguère, P. M., Sciaky, N., & Roth, B. L. (2015) · Nature Structural & Molecular Biology

Receptor Mechanisms and SignalingComputational Drug Discovery Methods

Cited by 755

Evidence for Possible Involvement of 5-HT 2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

Rothman, R. B., Baumann, M. H., Savage, J. E., Rauser, L., McBride, A., Hufeisen, S. J., & Roth, B. L. (2000) · Circulation

Neurotransmitter Receptor Influence on BehaviorCardiac Valve Diseases and Treatments

Cited by 722

Endocrine Regulation of Male Fertility by the Skeleton

Oury, F., Sumara, G., Sumara, O., Ferron, M., Chang, H., Smith, C. E., Hermo, L., Suarez, S., Roth, B. L., Ducy, P., et al. (2011) · Cell

Sperm and Testicular FunctionBone Metabolism and Diseases

Cited by 628

How Ligands Illuminate GPCR Molecular Pharmacology

Wacker, D., Stevens, R. C., & Roth, B. L. (2017) · Cell

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 560

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

Kim, K., Che, T., Panova, O., DiBerto, J. F., Lyu, J., Krumm, B. E., Wacker, D., Robertson, M. J., Seven, A. B., Nichols, D. E., et al. (2020) · Cell

Receptor Mechanisms and SignalingPsychedelics and Drug Studies

Cited by 481

Drugs and Valvular Heart Disease

Roth, B. L. (2007) · New England Journal of Medicine

Cardiac Valve Diseases and TreatmentsPharmacology and Obesity Treatment

Cited by 479

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization

Ferguson, S. M., Eskenazi, D., Ishikawa, M., Wanat, M. J., Phillips, P. E. M., Dong, Y., Roth, B. L., & Neumaier, J. F. (2011) · Nature Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 418

Synthon-based ligand discovery in virtual libraries of over 11 billion compounds

Sadybekov, A. A., Sadybekov, A. V., Liu, Y., Iliopoulos-Tsoutsouvas, C., Huang, X.-P., Pickett, J., Houser, B., Patel, N., Tran, N. K., Tong, F., et al. (2022) · Nature

Computational Drug Discovery MethodsChemical Synthesis and Analysis

Cited by 417

Generation of a synthetic memory trace

Garner, A. R., Rowland, D. C., Hwang, S. Y., Baumgaertel, K., Roth, B. L., Kentros, C., & Mayford, M. (2012) · Science

Memory and Neural MechanismsNeural dynamics and brain function

Cited by 387

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Huang, H.-S., Allen, J. A., Mabb, A. M., King, I. F., Miriyala, J., Taylor-Blake, B., Sciaky, N., Dutton, J. W., Lee, H.-M., Chen, X., et al. (2012) · Nature

Genetic Syndromes and ImprintingGenetics and Neurodevelopmental Disorders

Cited by 387