The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing
Open accessAbstract
SUMMARY Triple-negative breast cancer (TNBC) is an aggressive subtype that frequently develops resistance to chemotherapy. An unresolved question is whether resistance is caused by the selection of rare pre-existing clones or alternatively through the acquisition of new genomic aberrations. To investigate this question, we applied single cell DNA and RNA sequencing in addition to bulk exome sequencing to profile longitudinal samples from 20 TNBC patients during neoadjuvant chemotherapy (NAC). Deep-exome sequencing identified 10 patients where NAC led to clonal extinction and 10 patients where clones persisted after treatment. In 8 patients, we performed a more detailed study using single cell DNA sequencing to analyze 900 cells and single cell RNA sequencing to analyze 6,862 cells. Our data showed that resistant genotypes were pre-existing and adaptively selected by NAC, while transcriptional profiles were acquired by reprogramming in response to chemotherapy in TNBC patients.
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Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes
Gao, R., Bai, S., Henderson, Y. C., Lin, Y., Schalck, A., Yan, Y., Kumar, T., Hu, M., Sei, E., Davis, A., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-020-00795-2 · Cited by 917
Self-citationSingle-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer.
Kieffer, Y., Hocine, H. R., Gentric, G., Pelon, F., Bernard, C., Bourachot, B., Lameiras, S., Albergante, L., Bonneau, C., Guyard, A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1384 · Cited by 910
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Metadata
- Authors
- Kim, C., Gao, R., Sei, E., Brandt, R., Hartman, J., Hatschek, T., Crosetto, N., Foukakis, T., & Navin, N. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 173
- Issue
- 4
- Pages
- 879-893.e13
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2800852522
- Cited by
- 1,104
- References
- 29
- FWCI
- 29.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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