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Cited by 325

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

N-methyladenine DNA Modification in Glioblastoma

Open access
Xie, Qi, Wu, Tao P., Gimple, Ryan C., Li, Zheng, Prager, Briana C., Wu, Qiulian, Yu, Yang, Wang, Pengcheng, Wang, Yinsheng, Gorkin, David U., Zhang, Cheng, Dowiak, Alexis V., Lin, Kaixuan, Zeng, Chun, Sui, Yinghui, Kim, Leo J.Y., Miller, Tyler E., Jiang, Li, Lee-Poturalski, Christine, Huang, Zhi, Fang, Xiaoguang, Zhai, Kui, Mack, Stephen C., Sander, Maike, Bao, Shideng, Kerstetter-Fogle, Amber E., Sloan, Andrew E., Xiao, Andrew Z., Rich, Jeremy N.·2018·Cell
DOI 10.1016/j.cell.2018.10.006
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Abstract

SUMMARY Genetic drivers of cancer can be dysregulated through epigenetic modifications of DNA. While the critical role of DNA 5-methylcytosine (5mC) in the regulation of transcription is recognized, the functions of other non-canonical DNA modifications remain obsure. Here, we report the identification of novel N(6)-methyladenine (N6-mA) DNA modifications in human tissues and implicate this epigenetic mark in human disease, specifically the highly malignant brain cancer, glioblastoma. Glioblastoma markedly upregulated N6-mA levels, which co-localized with heterochromatic histone modifications, predominantly H3K9me3. N6-mA levels were dynamically regulated by the DNA demethylase, ALKBH1, depletion of which led to transcriptional silencing of oncogenic pathways through decreasing chromatin accessibility. Targeting the N6-mA regulator, ALKBH1, in patient-derived human glioblastoma models inhibited tumor cell proliferation and extended survival of tumor-bearing mice, supporting this novel DNA modification as a potential therapeutic target for glioblastoma. Collectively, our results uncover a novel epigenetic node in cancer through the DNA modification, N6-mA.

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Metadata

Authors
Xie, Q., Wu, T. P., Gimple, R. C., Li, Z., Prager, B. C., Wu, Q., Yu, Y., Wang, P., Wang, Y., Gorkin, D. U., Zhang, C., Dowiak, A. V., Lin, K., Zeng, C., Sui, Y., Kim, L. J. Y., Miller, T. E., Jiang, L., Lee-Poturalski, C., Huang, Z., Fang, X., Zhai, K., Mack, S. C., Sander, M., Bao, S., Kerstetter-Fogle, A. E., Sloan, A. E., Xiao, A. Z., & Rich, J. N.
Venue
Cell
Publisher
Elsevier BV
Published
2018-11
Volume
175
Issue
5
Pages
1228-1243.e20
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2018.10.006
OpenAlex
W2898871895
Cited by
325
References
63
FWCI
10.52
Type
journal article
Language
en
Open access
bronze
Licence
Funders
  • Ludwig Family Foundation (CA197718, CA154130, CA169117, CA171652, NS087913, NS089272, NS103434)
  • CPRIT
  • Alex's Lemonade Stand Foundation
  • Rally
  • BEAR Necessities Pediatric Cancer Foundation
  • Children's Cancer Research Fund
  • Baylor College of Medicine (A217956-01, CA187780, NS089272)
  • Coulter Foundation
  • Ferry Foundation
  • Kimble Foundation
  • Gerald Kaufman Jr. Foundation
  • Peter D. Cristal Chair

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CoChat. (2026). Citation check: N-methyladenine DNA Modification in Glioblastoma. https://app.cochat.ai/papers/10.1016/j.cell.2018.10.006
The paper
Xie, Q., Wu, T. P., Gimple, R. C., Li, Z., Prager, B. C., Wu, Q., Yu, Y., Wang, P., Wang, Y., Gorkin, D. U., Zhang, C., Dowiak, A. V., Lin, K., Zeng, C., Sui, Y., Kim, L. J. Y., Miller, T. E., Jiang, L., Lee-Poturalski, C., . . . Rich, J. N. (2018). N-methyladenine DNA Modification in Glioblastoma. Cell. https://doi.org/10.1016/j.cell.2018.10.006

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.