Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders
Sullivan, Patrick F., Geschwind, Daniel H.·2019·Cell
Cited by (476)
Items 101–200 of 476
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- Genome‐wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk lociErik D Wiström, Kevin Sean O’Connell, Naz Karadag, Shahram Bahrami, Guy Hindley, Aihua Lin, Weiqiu Cheng, Nils Eiel Steen, Alexey A. Shadrin, Oleksandr Frei et al. · 2021 · Addiction
- Multivariate genomic analysis of 1.5 million people identifies genes related to addiction, antisocial behavior, and healthRichard Karlsson Linnér, T. Mallard, Peter B. Barr, S. Sanchez-Roige, J. Madole, Morgan N. Driver, H. Poore, A. Grotzinger, J. Tielbeek, E. Johnson et al. · 2020 · bioRxiv
- Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson’s DiseaseJulien Bryois, Nathan Skene, Thomas Folkmann Hansen et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysisVipavee Niemsiri, Sara Brin Rosenthal, Caroline M. Nievergelt, Adam X. Maihofer, Maria Carolina Marchetto, Renata Santos, Tatyana Shekhtman, Ney Alliey‐Rodriguez, Amit Anand, Yokesh Balaraman et al. · 2023 · Molecular Psychiatry
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- Genetic contributions to transdiagnostic symptom dimensions in patients with major depressive disorder, bipolar disorder, and schizophrenia spectrum disordersFriederike Sophie David, Frederike Stein, Till F. M. Andlauer, Fabian Streit, Stephanie H. Witt, Stefan Herms, Per Hoffmann, Stefanie Heilmann‐Heimbach, Nils Opel, Jonathan Repple et al. · 2023 · Schizophrenia Research
- Polygenic risk for schizophrenia and schizotypal traits in non-clinical subjectsIgor Nenadić, Tina Meller, Simon Schmitt, Frederike Stein, Katharina Brosch, Johannes Mosebach, Ulrich Ettinger, Phillip S. Grant, Susanne Meinert, Nils Opel et al. · 2020 · Psychological Medicine
- How genetic analysis may contribute to the understanding of avoidant/restrictive food intake disorder (ARFID)Kennedy, Hannah L., Dinkler, Lisa, Kennedy, Martin A., Bulik, Cynthia M., Jordan, Jennifer · 2022 · Journal of Eating Disorders
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- Big Data Begin in PsychiatryMyrna M. Weissman · 2020 · JAMA Psychiatry
- Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screeningSung-Hyun Kim, Sumin Yang, Key‐Hwan Lim, Euiseng Ko, Hyun‐Jun Jang, Mingon Kang, Pann‐Ghill Suh, Jae‐Yeol Joo · 2021 · Proceedings of the National Academy of Sciences
- Phenotypic complexities of rare heterozygous neurexin-1 deletionsMichael B. Fernando, Yu Fan, Yanchun Zhang, Alex Tokolyi, Aleta Murphy, Sarah Kammourh, P. J. Michael Deans, Sadaf Ghorbani, Ryan Onatzevitch, Adriana Pero et al. · 2025 · Nature
- Refining Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Genetic Loci by Integrating Summary Data From Genome-wide Association, Gene Expression, and DNA Methylation StudiesAnke R. Hammerschlag, Enda M. Byrne, Mawussé D. T. Agbessi, Habibul Ahsan, Isabel Alves, Anand Kumar Andiappan, Wibowo Arindrarto, Philip Awadalla, Alexis J. Battle, Frank Beutner et al. · 2020 · Biological Psychiatry
- The benefit of diagnostic whole genome sequencing in schizophrenia and other psychotic disordersAnna Alkelai, Lior Greenbaum, Anna R. Docherty, Andrey A. Shabalin, Gundula Povysil, Ayan Malakar, Daniel Hughes, Shannon L. Delaney, Emma P. Peabody, James McNamara et al. · 2021 · Molecular Psychiatry
- Current challenges and possible future developments in personalized psychiatry with an emphasis on psychotic disordersАnastasia Levchenko, Timur Nurgaliev, Alexander A Kanapin, Anastasia A. Samsonova, Raul R. Gainetdinov · 2020 · Heliyon
- Identifying pleiotropic genes for complex phenotypes with summary statistics from a perspective of composite null hypothesis testingTing Wang, Haojie Lu, Ping Zeng · 2021 · Briefings in Bioinformatics
- DNA methylation in regulatory elements of the FKBP5 and NR3C1 gene in mother-child binomials with depressionMendonça, Mariana S., Mangiavacchi, Paula M., Mendes, Ana V., Loureiro, Sonia R., Martín-Santos, Rocio, Glória, Leonardo S., Marques, Wilson, De Marco, Silmara P.G., Kanashiro, Milton M., Hallak, Jaime E.C. et al. · 2023 · Journal of Affective Disorders
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- A matter of space and time: Emerging roles of disease-associated proteins in neural developmentGeorgia Panagiotakos, Sergiu P. Pașca · 2021 · Neuron
- Investigating genetic links between grapheme–colour synaesthesia and neuropsychiatric traitsAmanda K. Tilot, Arianna Vino, Katerina S. Kucera, Duncan A. Carmichael, Loes van den Heuvel, Joery den Hoed, Anton V. Sidoroff-Dorso, Archie Campbell, David John Porteous, Beaté St Pourcain et al. · 2019 · Philosophical Transactions of the Royal Society B Biological Sciences
- A study of genetic heterogeneity in autism spectrum disorders based on plasma proteomic and metabolomic analysis: multiomics study of autism heterogeneityXiaoxiao Tang, Chengyun Feng, Yuxi Zhao, Huajie Zhang, Yan Ling Gao, Xueshan Cao, Hong Qi, Lin Jing, Hongbin Zhuang, Yuying Feng et al. · 2023 · MedComm
- Polygenic risk scores in psychiatry – Large potential but still limited clinical utilityOlav Bjerkehagen Smeland, Ole A. Andreassen · 2021 · European Neuropsychopharmacology
- Structural variants identified using non-Mendelian inheritance patterns advance the mechanistic understanding of autism spectrum disorderDavid Kainer, Alan R. Templeton, Erica Teixeira Prates, Daniel Jacboson, Euan R.O. Allan, Sharlee Climer, Michael R. Garvin · 2022 · Human Genetics and Genomics Advances
- Lessons Learned From Parsing Genetic Risk for Schizophrenia Into Biological PathwaysGiulio Pergola, Nora Penzel, Leonardo Sportelli, Alessandro Bertolino · 2022 · Biological Psychiatry
- IPRS: Leveraging Gene-Environment Interaction to Reconstruct Polygenic Risk ScoreYingdan Tang, Dongfang You, Honggang Yi, Sheng Yang, Yang Zhao · 2022 · Frontiers in Genetics
- From Personalized Medicine to Precision Psychiatry?Češková E, Šilhán P · 2021 · DOAJ (DOAJ: Directory of Open Access Journals)
- Causal relationships between blood lipids and major psychiatric disorders: Univariable and multivariable mendelian randomization analysisBozhi Li, Yue Qu, Zhixin Fan, Xiayu Gong, Hanfang Xu, Lili Wu, Can Yan · 2023 · BMC Medical Genomics
- Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling SystemsKristina Rehbach, Michael B. Fernando, Kristen Brennand · 2020 · Journal of Neuroscience
- Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitorsNana Matoba, Brandon D. Le, Jordan M. Valone, Justin M. Wolter, Jessica T. Mory, Dan Liang, Nil Aygün, K. Alaine Broadaway, Marielle L. Bond, Karen L. Mohlke et al. · 2024 · Nature Neuroscience
- Targeted sequencing and integrative analysis of 3,195 Chinese patients with neurodevelopmental disorders prioritized 26 novel candidate genesTao Wang, Yi Zhang, Liqui Liu, Yan Wang, Huiqian Chen, Tianda Fan, Jinchen Li, Kun Xia, Zhong Sheng Sun · 2021 · Journal of genetics and genomics/Journal of Genetics and Genomics
- A single-nucleotide polymorphism influences brain morphology in drug-naïve patients with major depressive disorderAsuka Katsuki, Shingo Kakeda, Keita Watanabe, Ryohei Igata, Yuka Otsuka, Taro Kishi, LeHoa Nguyen, Issei Ueda, Nakao Iwata, Yukunori Korogi et al. · 2019 · Neuropsychiatric Disease and Treatment
- Broad transcriptomic dysregulation across the cerebral cortex in ASDJillian R. Haney, Brie Wamsley, George T Chen, Sepideh Parhami, Prashant S. Emani, Nathan Chang, Gil D. Hoftman, Diego de Alba, Gaurav Prashant Kale, Gokul Ramaswami et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
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- What a finding of gene copy number variation can add to the diagnosis of developmental neuropsychiatric disordersJacob A. S. Vorstman, Stephen W. Scherer · 2021 · Current Opinion in Genetics & Development
- Present and Future Modeling of Human Psychiatric Connectopathies With Brain OrganoidsJean‐Paul Urenda, Ashley Del Dosso, Marcella Birtele, Giorgia Quadrato · 2022 · Biological Psychiatry
- Identification of relevant hub genes for early intervention at gene coexpression modules with altered predicted expression in schizophreniaJulio A. Rodriguez‐Lopez, Manuel Arrojo, Eduardo Paz, Mario Páramo, Javier Costas · 2019 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric DisordersAnke Hoffmann, Michael J. Ziller, Dietmar Spengler · 2020 · Cells
- Effect of pharmacogenomic testing on the clinical treatment of patients with depressive disorder: A randomized clinical trialLei Xu, Liyin Li, Qiutang Wang, Bing Pan, Leilei Zheng, Lin Zheng · 2024 · Journal of Affective Disorders
- A genome-wide association study identifies a gene network associated with paranoid schizophrenia and antipsychotics-induced tardive dyskinesiaАnastasia Levchenko, Alexander A Kanapin, Anastasia A. Samsonova, Olga Y. Fedorenko, Elena G. Kornetova, Timur Nurgaliev, Galina Elevna Mazo, Arkadiy V. Semke, Alexander O. Kibitov, Nikolay A. Bokhan et al. · 2020 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donors’ Brains With Ventral Forebrain Organoids Derived From the Same Individuals With SchizophreniaTomoyo Sawada, André R. Barbosa, Bruno Henrique Silva Araújo, Alejandra E. McCord, Laura D’Ignazio, Kynon JM Benjamin, Bonna Sheehan, Michael Zabolocki, Arthur Sant’Anna Feltrin, Ria Arora et al. · 2023 · American Journal of Psychiatry
- What Do We Know About the Genetic Architecture of Psychopathology?Evan J. Giangrande, Ramona S. Weber, Eric Turkheimer · 2022 · Annual Review of Clinical Psychology
- The “missing heritability”—Problem in psychiatry: Is the interaction of genetics, epigenetics and transposable elements a potential solution?Dietrich van Calker, Tsvetan Serchov · 2021 · Neuroscience & Biobehavioral Reviews
- Nanoparticle Based Gene Therapy Approach: A Pioneering Rebellion in the Management of Psychiatric DisordersSaleha Rehman, Bushra Nabi, Faheem Hyder Pottoo, Sanjula Baboota, Javed Ali · 2020 · Current Gene Therapy
- Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex2023
- Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiationDan Liang, Angela L. Elwell, Nil Aygün et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Dissecting the biology of feeding and eating disordersLaura M. Huckins, Kristen Brennand, Cynthia Marie Bulik · 2024 · Trends in Molecular Medicine
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- Genetic Risk Assessment in PsychiatryHolly Landrum Peay · 2019 · Cold Spring Harbor Perspectives in Medicine
- Overlap of neuroanatomical involvement in frontotemporal dementia and primary psychiatric disorders: a Meta-analysisUlugut, Hulya, Trieu, Calvin, Groot, Colin, van ’t Hooft, Jochum J., Tijms, Betty M., Scheltens, Philip, Ossenkoppele, Rik, Barkhof, Frederik, van den Heuvel, Odile A., Pijnenburg, Yolande A.L. · 2023 · Biological Psychiatry
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- Using Stem Cell Models to Explore the Genetics Underlying Psychiatric Disorders: Linking Risk Variants, Genes, and Biology in Brain DiseaseKristen Brennand · 2022 · American Journal of Psychiatry
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- At the Crossroad Between Resiliency and Fragility: A Neurodevelopmental Perspective on Early-Life ExperiencesGabriele Chelini, Luca Pangrazzi, Yuri Bozzi · 2022 · Frontiers in Cellular Neuroscience
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