The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“High-throughput genomic, epigenomic, and transcriptomic profiling of glioblastoma cells revealed three main subtypes harboring distinct molecular and phenotypic landscapes that affect response to the therapy and clinical outcome: mesenchymal, proneural, and classical subtypes.96,97,98,99,100”
From MiR-128-3p – a gray eminence of the human central nervous system (2024) · cites this paper as [99]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Verhaak, R. G. W., Hoadley, K. A., Purdom, E., Wang, V., Qi, Y., Wilkerson, M. D., Miller, C. R., Ding, L., Golub, T., Mesirov, J. P., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.020 · Cited by 7,575
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
Patel, A. P., Tirosh, I., Trombetta, J. J., Shalek, A. K., Gillespie, S. M., Wakimoto, H., Cahill, D. P., Nahed, B. V., Curry, W. T., Martuza, R. L., et al. (2014) · Science · doi:10.1126/science.1254257 · Cited by 5,063
Self-citationThe Somatic Genomic Landscape of Glioblastoma
Brennan, C. W., Verhaak, R. G. W., McKenna, A., Campos, B., Noushmehr, H., Salama, S. R., Zheng, S., Chakravarty, D., Sanborn, J. Z., Berman, S. H., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.034 · Cited by 5,016
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science · doi:10.1126/science.aad0501 · Cited by 4,944
Self-citationA restricted cell population propagates glioblastoma growth after chemotherapy
Chen, J., Li, Y., Yu, T.-S., McKay, R. M., Burns, D. K., Kernie, S. G., & Parada, L. F. (2012) · Nature · doi:10.1038/nature11287 · Cited by 2,354
Zhu, Q., Zhao, X., Zheng, K., Li, H., Huang, H., Zhang, Z., Mastracci, T., Wegner, M., Chen, Y., Sussel, L., et al. (2014) · Development · doi:10.1242/dev.095323 · Cited by 150
Flagged first, then by citations
Research works printed but not linked: 25
- Bao, 2006, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, 444, 756, 10.1038/nature05236 · DOI
- Darmanis, 2017, Single-cell RNA-seq analysis of infiltrating neoplastic cells at the migrating front of human glioblastoma, Cell Rep., 21, 1399, 10.1016/j.celrep.2017.10.030 · DOI
- Filbin, 2018, Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq, Science, 360, 331, 10.1126/science.aao4750 · DOI
- Friedmann-Morvinski, 2012, Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice, Science, 338, 1080, 10.1126/science.1226929 · DOI
- Holland, 1998, A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice, Genes Dev., 12, 3675, 10.1101/gad.12.23.3675 · DOI
- Kerman, 2015, In vitro myelin formation using embryonic stem cells, Development, 142, 2213, 10.1242/dev.116517 · DOI
- Lathia, J.D., Mack, S.C., Mulkearns-Hubert, E.E., Valentim, C.L., and Rich, J.N. (2015). Cancer stem cells in glioblastoma. In Genes & development (United States), pp. 1203–1217. · DOI · Paper page
- Li, B., and Dewey, C.N. (2011). RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome. B.M.C. Bioinformatics, ed. (England), pp. 323. · DOI · Paper page
- Lim, 2012, Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells, Stem Cells, 30, 1509, 10.1002/stem.1114 · DOI
- Müller, 2016, Single-cell sequencing maps gene expression to mutational phylogenies in PDGF- and EGF-driven gliomas, Mol. Syst. Biol., 12, 889, 10.15252/msb.20166969 · DOI
- Nowakowski, 2017, Spatiotemporal gene expression trajectories reveal developmental hierarchies of the human cortex, Science, 358, 1318, 10.1126/science.aap8809 · DOI · Paper page
- Parada, 2017, Brain tumor stem cells remain in play, J. Clin. Oncol., 35, 2428, 10.1200/JCO.2017.73.9540 · DOI
- Picelli, S., Faridani, O.R., Bjorklund, A.K., Winberg, G., Sagasser, S., and Sandberg, R. (2014). Full-length RNA-seq from single cells using Smart-seq2. In Nat Protoc (England), pp. 171–181. · DOI · Paper page
- Pollen, 2015, Molecular identity of human outer radial glia during cortical development, Cell, 163, 55, 10.1016/j.cell.2015.09.004 · DOI · Paper page
- Puram, 2017, Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer, Cell, 171, 1611, 10.1016/j.cell.2017.10.044 · DOI · Paper page
- Sottoriva, 2013, Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics, Proc. Natl. Acad. Sci. USA, 110, 4009, 10.1073/pnas.1219747110 · DOI · Paper page
- Sun, 2005, Asymmetric distribution of EGFR receptor during mitosis generates diverse CNS progenitor cells, Neuron, 45, 873, 10.1016/j.neuron.2005.01.045 · DOI
- Suvà, 2014, Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells, Cell, 157, 580, 10.1016/j.cell.2014.02.030 · DOI
- Tanay, 2017, Scaling single-cell genomics from phenomenology to mechanism, Nature, 541, 331, 10.1038/nature21350 · DOI · Paper page
- Tirosh, 2019, Deciphering Human Tumor Biology by Single-Cell Expression Profiling, Annual Review of Cancer Biology, 3, 10.1146/annurev-cancerbio-030518-055609 · DOI
- Tirosh, I., Venteicher, A.S., Hebert, C., Escalante, L.E., Patel, A.P., Yizhak, K., Fisher, J.M., Rodman, C., Mount, C., Filbin, M.G., et al. (2016b). Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. In Nature (England), pp. 309–313. · DOI
- Venteicher, 2017, Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq, Science, 355, eaai8478, 10.1126/science.aai8478 · DOI
- Wakimoto, 2012, Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells, Neuro-oncol., 14, 132, 10.1093/neuonc/nor195 · DOI
- Wang, 2017, Tumor evolution of glioma-intrinsic gene expression subtypes associates with immunological changes in the microenvironment, Cancer cell, 32, 42, 10.1016/j.ccell.2017.06.003 · DOI
- Yuan, 2018, Single-cell transcriptome analysis of lineage diversity in high-grade glioma, Genome Med., 10, 57, 10.1186/s13073-018-0567-9 · DOI
Cited by
Sorted by citations
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
Ji, A. L., Rubin, A. J., Thrane, K., Jiang, S., Reynolds, D. L., Meyers, R. M., Guo, M. G., George, B. M., Mollbrink, A., Bergenstråhle, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.039 · Cited by 1,117
“This is an open access article und tions that drive drug resistance, predict metastatic risk, and mediate plasticity (Neftel et al., 2019; Puram et al., 2017; Tirosh et al., 2016a).”
BackgroundJacob, F., Salinas, R. D., Zhang, D. Y., Nguyen, P. T. T., Schnoll, J. G., Wong, S. Z. H., Thokala, R., Sheikh, S., Saxena, D., Prokop, S., et al. (2020) · Cell · doi:10.1016/j.cell.2019.11.036 · Cited by 1,149
Wen, P. Y., Weller, M., Lee, E. Q., Alexander, B. M., Barnholtz-Sloan, J. S., Barthel, F. P., Batchelor, T. T., Bindra, R. S., Chang, S. M., Chiocca, E. A., et al. (2020) · Neuro-Oncology · doi:10.1093/neuonc/noaa106 · Cited by 1,168
Self-citationPombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00789-y · Cited by 704
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Raghavan, S., Winter, P. S., Navia, A. W., Williams, H. L., DenAdel, A., Lowder, K. E., Galvez-Reyes, J., Kalekar, R. L., Mulugeta, N., Kapner, K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.017 · Cited by 592
Metadata
- Authors
- Neftel, C., Laffy, J., Filbin, M. G., Hara, T., Shore, M. E., Rahme, G. J., Richman, A. R., Silverbush, D., Shaw, M. L., Hebert, C. M., Dewitt, J., Gritsch, S., Perez, E. M., Gonzalez Castro, L. N., Lan, X., Druck, N., Rodman, C., Dionne, D., Kaplan, A., Bertalan, M. S., Small, J., Pelton, K., Becker, S., Bonal, D., Nguyen, Q.-D., Servis, R. L., Fung, J. M., Mylvaganam, R., Mayr, L., Gojo, J., Haberler, C., Geyeregger, R., Czech, T., Slavc, I., Nahed, B. V., Curry, W. T., Carter, B. S., Wakimoto, H., Brastianos, P. K., Batchelor, T. T., Stemmer-Rachamimov, A., Martinez-Lage, M., Frosch, M. P., Stamenkovic, I., Riggi, N., Rheinbay, E., Monje, M., Rozenblatt-Rosen, O., Cahill, D. P., Patel, A. P., Hunter, T., Verma, I. M., Ligon, K. L., Louis, D. N., Regev, A., Bernstein, B. E., Tirosh, I., & Suvà, M. L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 178
- Issue
- 4
- Pages
- 835-849.e21
- ISSN
- 0092-8674
- PMC
- PMC6703186
- Cited by
- 2,873
- References
- 7
- Language
- en
- Licence
- Funders
- Sontag Foundation
- Wang Family Fund
- Smith Family Foundation
- Chan-Zuckerberg
- Alex’s Lemonade Stand Foundation
- V Foundation for Cancer Research
- The Swiss National Science Foundation Sinergia
- Zuckerman STEM Leadership Program
- Human Frontiers Science Program
- Mexican friends new generation
- Benoziyo Endowment Fund (Career Award for Medical Scientist)
- Burroughs Wellcome Fund
- K12 Paul Calabresi Career Award for Clinical Oncology (K12CA090354)
- Placide Nicod Foundation (Grant-in-Aid for JSPS Fellows)
- Japan Society for the Promotion of Science
- Howard Hughes Medical Institute
- Klarman Cell Observatory
- STARR cancer consortium
- NCI (1U24CA180922, R33CA202820)
- Koch Institute Support (P30CA14051)
- National Cancer Institute (DP1CA216873)
- Ludwig Center
- Broad Institute (Career Award for Medical Scientist)
- BWF Career Award in the Medical Sciences
- Tawingo Chair Fund
- NIH Common Fund
- American Cancer Society
- Ludwig Center at Harvard Medical School
- Bernard and Mildred Kayden MGH Research Institute Chair (1S10RR023440, -01A1, P30CA014195, S10-OD023689)
- NIH (R01CA195613)
- Helmsley Center for Genomic Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
