MiR-128-3p – a gray eminence of the human central nervous system
Open accessAbstract
MicroRNA-128-3p (miR-128-3p) is a versatile molecule with multiple functions in the physiopathology of the human central nervous system. Perturbations of miR-128-3p, which is enriched in the brain, contribute to a plethora of neurodegenerative disorders, brain injuries, and malignancies, as this miRNA is a crucial regulator of gene expression in the brain, playing an essential role in the maintenance and function of cells stemming from neuronal lineage. However, the differential expression of miR-128-3p in pathologies underscores the importance of the balance between its high and low levels. Significantly, numerous reports pointed to miR-128-3p as one of the most depleted in glioblastoma, implying it is a critical player in the disease's pathogenesis and thus may serve as a therapeutic agent for this most aggressive form of brain tumor. In this review, we summarize the current knowledge of the diverse roles of miR-128-3p. We focus on its involvement in the neurogenesis and pathophysiology of malignant and neurodegenerative diseases. We also highlight the promising potential of miR-128-3p as an antitumor agent for the future therapy of human cancers, including glioblastoma, and as the linchpin of brain development and function, potentially leading to the development of new therapies for neurological conditions.
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Cites a retracted work: 10.1007/s13311-018-0649-9
MajorThe cited work was retracted on 2018-10-14 (notice 10.1007/s13311-018-0649-9), before this paper was published (2024-03). Its authors could have known.
Cited work 10.1007/s13311-018-0649-9 · retracted 2018-10-14 · notice 10.1007/s13311-018-0649-9 · this paper published 2024-03
“Fu, 2018, LncRNA PVT1 Facilitates Tumorigenesis and Progression of Glioma via Regulation of MiR-128-3p/GREM1 Axis and BMP Signaling Pathway, Neurotherapeutics, 15, 1139, 10.1007/s13311-018-0649-9”
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MajorThe cited work was retracted on 2019-01-15 (notice 10.1016/j.ejphar.2018.11.004), before this paper was published (2024-03). Its authors could have known.
Cited work 10.1016/j.ejphar.2018.11.004 · retracted 2019-01-15 · notice 10.1016/j.ejphar.2018.11.004 · this paper published 2024-03
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Self-citationNoncoding RNAs in Glioblastoma: Emerging Biological Concepts and Potential Therapeutic Implications
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LncRNA NEAT1/miR-128-3p/AQP4 axis regulating spinal cord injury-induced neuropathic pain progression
Xian, S., Ding, R., Li, M., & Chen, F. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577457 · Cited by 48 · see citing works
The nuclear DICER–circular RNA complex drives the deregulation of the glioblastoma cell microRNAome
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MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells
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Self-citationmiR-137: A Novel Therapeutic Target for Human Glioma
Wang, Y., Chen, R., Zhou, X., Guo, R., Yin, J., Li, Y., & Ma, G. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.06.028 · Cited by 43 · see citing works
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Nusinersen: A Review in 5q Spinal Muscular Atrophy
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Polycomb complexes redundantly maintain epidermal stem cell identity during developmentPreprint
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Bmi-1 induces radioresistance in MCF-7 mammary carcinoma cells
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The evolutionary pattern of mutations in glioblastoma reveals therapy-mediated selection
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Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools
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Synaptic plasticity and depression: the role of miRNAs dysregulation
Rahmani, S., Kadkhoda, S., & Ghafouri‐Fard, S. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07461-7 · Cited by 36 · see citing works
Pathogenesis of Börjeson-Forssman-Lehmann syndrome: Insights from PHF6 function
Jahani‐Asl, A., Cheng, C., Zhang, C., & Bonni, A. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.09.011 · Cited by 32 · see citing works
MicroRNA-128-3p Alleviates Neuropathic Pain Through Targeting ZEB1
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Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium
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Flagged first, then by citations
4 of the 243 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
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Compartmentalized Suspension Array for the Isothermal, Digital, and Multiplex Detection of microRNAs
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- Authors
- Kiel, K., Król, S. K., Bronisz, A., & Godlewski, J.
- Affiliations
- Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
- Corresponding author
- Godlewski, Jakub
- Venue
- Molecular Therapy Nucleic Acids
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 35
- Issue
- 1
- Pages
- 102141
- ISSN
- 2162-2531 (ISSN-L)
- PMC
- PMC10899074
- OpenAlex
- W4391560391
- Semantic Scholar
- a213686cc1f2818483d4843b67ade1f58e74bb93
- Cited by
- 15
- References
- 243
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 3
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Therapy — Nucleic Acids (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Agency for Academic Exchange (PPN / PPO/2019/1/00001)
- National Science Centre Poland (2021/41/N/NZ6/02682, 2022/45/B/NZ5/04226, 2021/41/B/NZ6/02436, 2018/29/B/NZ1/01016, 2020/39/B/NZ5/02893)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- miR-128-3p, microRNA, central nervous system, neurodegenerative diseases, neurogenesis, glioblastoma, brain tumors, brain development, neuronal lineage, cancer therapy, gene expression regulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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