The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships
Open accessAbstract
The current understanding of Inflammatory Bowel Disease (IBD) pathogenesis implicates a complex interaction between host genetics, host immunity, microbiome and environmental exposures. Mechanisms gleaned from genetics and molecular pathogenesis offer clues to the critical triggers of mucosal inflammation and guide the development of therapeutic interventions. A complex network of interactions between host genetic factors, microbes, and microbial metabolites governs intestinal homeostasis, making classification and mechanistic dissection of involved pathways challenging. In this review we discuss these challenges, areas of active translation, and opportunities for development of next-generation therapies.
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Cites
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
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Self-citationTreg induction by a rationally selected mixture of Clostridia strains from the human microbiota
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Cited by
Large-scale association analyses identify host factors influencing human gut microbiome composition
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Pathway paradigms revealed from the genetics of inflammatory bowel disease
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Self-citationGut microbiota-derived short chain fatty acids are potential mediators in gut inflammation
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Dopamine, Immunity, and Disease
Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J., & Gaskill, P. J. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000618 · Cited by 308
Ulcerative colitis: Recent advances in the understanding of disease pathogenesis
Porter, R. J., Kalla, R., & Ho, G.-T. (2020) · F1000Research · doi:10.12688/f1000research.20805.1 · Cited by 300
Metadata
- Authors
- Plichta, D. R., Graham, D. B., Subramanian, S., & Xavier, R. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 178
- Issue
- 5
- Pages
- 1041-1056
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2969869494
- Cited by
- 310
- References
- 31
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Plichta, D. R., Graham, D. B., Subramanian, S., & Xavier, R. J. (2019). Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships. Cell. https://doi.org/10.1016/j.cell.2019.07.045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
