Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J.; Podolsky, D. K.

doi:10.1038/nature06005

Cited by 4,364Inflammatory Bowel DiseaseGut microbiota and healthOcular Diseases and Behçet’s Syndrome

Unravelling the pathogenesis of inflammatory bowel disease

Xavier, R. J., Podolsky, D. K.·2007·Nature

DOI 10.1038/nature06005

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Abstract

Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation. First, IBD has been found to be the most tractable of complex disorders for discovering susceptibility genes, and these have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis. Second, efforts directed towards the identification of environmental factors implicate commensal bacteria (or their products), rather than conventional pathogens, as drivers of dysregulated immunity and IBD. Third, murine models, which exhibit many of the features of ulcerative colitis and seem to be bacteria-driven, have helped unravel the pathogenesis/mucosal immunopathology of IBD.

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Decreased Muc2 expression has been implicated in the etiopathogenesis of sporadic and IBD-associated colon cancers.
“Additionally, decreased Muc2 expression has been implicated in the etiopathogenesis of sporadic and IBD-associated colon cancers.14,15”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [15]

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Autophagy and Viruses: Adversaries or Allies?
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Inflammatory bowel disease: Pathogenesis
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Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor
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Mucins in cancer: function, prognosis and therapy
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Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
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Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
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Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
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Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
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Ecology drives a global network of gene exchange connecting the human microbiome
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Microbial genes and pathways in inflammatory bowel disease
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Epithelial antimicrobial defence of the skin and intestine
Gallo, R. L., & Hooper, L. V. (2012) · Nature reviews. Immunology · doi:10.1038/nri3228 · Cited by 959 · see citing works
The genetics and immunopathogenesis of inflammatory bowel disease
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The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation
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Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis
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Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks
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Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila
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Probiotic bacteria and intestinal epithelial barrier function
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Host–microbiota interactions in inflammatory bowel disease
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Pathway paradigms revealed from the genetics of inflammatory bowel disease
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Mesenchymal Stem Cells Derived from Human Gingiva Are Capable of Immunomodulatory Functions and Ameliorate Inflammation-Related Tissue Destruction in Experimental Colitis
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Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis
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High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease
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Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
Shen, Y., Torchia, M. L. G., Lawson, G. W., Karp, C. L., Ashwell, J. D., & Mazmanian, S. K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.004 · Cited by 714 · see citing works
Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies
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Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions
Varol, C., Vallon-Eberhard, A., Elinav, E., Aychek, T., Shapira, Y., Luche, H., Fehling, H. J., Hardt, W., Shakhar, G., & Jung, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.025 · Cited by 710 · see citing works
Role of cytokines in inflammatory bowel disease
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Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis
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The light and dark sides of intestinal intraepithelial lymphocytes
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The role of neutrophils during intestinal inflammation
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The Gut–Lung Axis in Respiratory Disease
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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
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Importance of disrupted intestinal barrier in inflammatory bowel diseases
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Self-citation

Authors: Xavier, R. J., & Podolsky, D. K.
Affiliations: Harvard University (US)
Corresponding author: Podolsky, D. K.
ORCID: Xavier, R. J.
Podolsky, D. K.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2007-07
Volume: 448
Issue: 7152
Pages: 427-434
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature06005
OpenAlex: W2078621117
Cited by: 4,364
References: 100
Citations by year: 2026: 134 · 2025: 183 · 2024: 224 · 2023: 247 · 2022: 258 · 2021: 230 · 2020: 249 · 2019: 211 · 2018: 217 · 2017: 221 · 2016: 255 · 2015: 279 · 2014: 286 · 2013: 236 · 2012: 258
FWCI: 21.38
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: inflammatory bowel disease, Crohn's disease, ulcerative colitis, pathogenesis, susceptibility genes, epithelial barrier function, innate immunity, adaptive immunity, commensal bacteria, immune dysregulation, macrophages, mouse model
MeSH terms: Animals, Autophagy, Colitis, Humans, Immunity, Innate, Intestinal Mucosa, Inflammatory Bowel Diseases, Genetic Predisposition to Disease

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