Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

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Items 601–658 of 658

1. Role of common host genome variants in Childhood Acute Lymphoblastic Leukemia
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2. The genetic architecture of HIV-1 virulence
   François Blanquart, C. Wymant, Matthew D. Hall, R. Power, T. Golubchik, Astrid Gall, M. de Cesare, G. Macintyre-Cockett, Margreet Bakker, D. Bezemer et al. · 2025 · Virus Evolution
3. Using pre-training and interaction modeling for ancestry-specific disease prediction using multiomics data from the UK Biobank
   Thomas Le Menestrel, Erin Craig, Robert John Tibshirani, Trevor J. Hastie, Manuel A. Rivas · 2025 · PLoS ONE
4. Cross-cohort genetic risk prediction for Alzheimer’s disease: a transfer learning approach using GWAS and deep learning models
   I. Ihianle, Wathsala Samarasekara, K. Brookes, P. Machado · 2025 · BioData Mining
5. Critical appraisal of transporter gene polymorphisms on metformin efficacy in type 2 diabetes mellitus
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6. Analysis and Identification of Genetic Predisposition and Clinical Risk Factors for Lung Cancer: A Regional Genetic Study
   Jen-Kang Wong, I. Chen, Chia-Man Chou, Sheng-Yang Huang · 2025 · Oncology
7. Brain transcriptome-wide association studies in diverse ancestral populations reveal genes implicated in an anxiety-related phenotype
   Manu Sharma, Heather E. Wheeler · 2025 · G3 Genes Genomes Genetics
8. A machine learning framework for classifying dementia risk in mild cognitive impairment: evidence from a Korean genome-wide association study cohort
   Myeongji Cho, Hyo‐Jeong Ban, Hye Ryeong Nam, Chang Hee Chu, Jae Pil Jeon, Sang Cheol Kim · 2025 · Alzheimer s Research & Therapy
9. Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for gout
   Weiquan Liao, Huiying Chen, Yuying Li, Lijuan Xiao, Zai-xing Qiu, Shasha Hu, Si-hui He, Lan Luo, Jing-jing Xie, Jianyong Zhang · 2025 · Naunyn-Schmiedeberg s Archives of Pharmacology
10. An Integrated Multi-Omics Analysis Identifies Oxeiptosis-Related Biomarkers in Diabetic Retinopathy
    Jiao-Yu Deng, Peng-Fei Ge, Ying Gao, Hong-Ying Li, Yi-Fan Lin, Yang-Yang Lu, Hai-Yue Xie, Dian-shuang Xu, Ping Xie, Zi-Zhong Hu · 2025 · Biomedicines
11. A Reassessment of the Genomic Ancestry of the World's Largest Captive Baboon Colony
    Giacomo Mercuri, Fabrizio Dallaspezia, Francesco Montinaro, Cristian Capelli · 2025 · American Journal of Primatology
12. Menopausal hormone therapy and risk of neuropsychiatric disease: a drug target Mendelian randomisation study
    Louise S. Schindler, Dipender Gill, Hannah Oppenheimer, Cláudia Barth, Ole A. Andreassen, Bogdan Draganski, Lars Tjelta Westlye, Anya Topiwala, Ann‐Marie G. de Lange · 2026 · npj Women s Health
13. Functional Genomics Studies of Psychiatric Disorders in Individuals of Latin American Populations: A Scoping Review
    Luz M Porras, Isabelle Rodríguez‐Lausell, Gabriel Iglesias‐Maldonado, Emily Val F. Tuliao, Gabriela Martínez, Chelsey Leveque, Julian Tobon, Rachel Eloy, Sintia Iole Belangero, Cynthia Marie Bulik et al. · 2025 · American Journal of Medical Genetics Part B Neuropsychiatric Genetics
14. Genome-wide association study of adolescent-onset depression
    Poppy Zenzi Grimes, Brittany L. Mitchell, Katherine Nina Thompson, Qingkun Deng, Xueyi Shen, Jareth C. Wolfe, Jodi T. Thomas, Robyn E. Wootton, Daniel E. Adkins, Saranya Arirangan et al. · 2025 · medRxiv
15. A simple approach for multiple observations improves power to detect genetic effects and genomic prediction accuracy
    Luke M. Evans, Christopher H. Arehart, Raine A Gibson, Grace I. Bowman, Christopher R. Gignoux · 2026 · Human Genetics and Genomics Advances
16. Evaluating the contribution of genome 3D folding to variation in human height using machine learning
    Wanjun Gu, Erin N. Gilbertson, Sergio E. Baranzini, Rany S. Salem, John A. Capra · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
17. Predictive modeling of biogeographical ancestry using a novel SNP panel and supervised learning approaches
    Cosimo Grazzini, Giorgia Spera, Stefania Morelli, Daniele Castellana, Giulia Cosenza, Michela Baccini, Giulia Cereda, Elena Pilli · 2025 · Expert Systems with Applications
18. How Everything Is Connected to Everything Else – Population‐Specific Connections between Adaptive Evolution, Disease Susceptibility, and Drug Responsiveness
    Ji Tang, Hao Zhu · 2025 · Advanced Genetics
19. Molecular epidemiology of traumatic brain injury outcome amongst individuals of Black racial identity or African ancestry: a scoping review protocol
    Tadeusz Hayduk Wroblewski, Erum Ajmal, Marie-Claire Roberts, Tim B. Bigdeli, Ernest Joseph Barthélemy · 2025 · BMJ Open
20. Genetic polymorphisms and their association with atopic dermatitis in skin of color – A comprehensive review
    Sahana P. Raju · 2025 · Indian Journal of Skin Allergy
21. Association analysis between polygenic risk scores and traits: practical guidelines and tutorial with an illustrative data set of schizophrenia
    I. Irigoien, P. Mas-Bermejo, S. Papiol, N. Barrantes-Vidal, A. Rosa, Concepción Arenas · 2025 · Frontiers in Psychiatry
22. Intergenerational Transmission of Cannabis Use: Testing Genetic Risk and the Mitigating Influences of Parent Positive Behavior Support in Early Childhood
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23. Reporting of RACE in Australian brain and mental health research: protocol for a scoping review and diversity audit
    John Noel M. Viaña, Ben Albert Steward, Darren Suryawijaya Ong · 2025 · medRxiv
24. Cohort profile update: the Korean Cancer Prevention Study-II (KCPS-II) biobank
    H. Kimm, K. Jung, W. Spiller, Y. Yang, So Young Kim, M. Park, Sun-Mi Lee, Ha-Jee Sun · 2025 · Epidemiology and Health
25. A pangenomics-enabled platform for the high-throughput discovery of antifungal resistance factors in crop pathogens
    Guido Puccetti, Daniel Flückiger, Dominique Edel, Camille Delude, Sabina Moser Tralamazza, Thomas Badet, G. Scalliet, D. Croll · 2025 · bioRxiv
26. Does the Association Between Eye Disease and Cognitive Function Vary by Genetic Risk of Cognitive Decline? An Analysis of Hospital Data With Replication in the Canadian Longitudinal Study on Aging
    Emily Tran, M. Rakesh, Gisele Li, E. E. Freeman, Marie-Hélène Roy-Gagnon · 2025 · Investigative Ophthalmology and Visual Science
27. Gene-environment interplay in internalising and externalising psychopathology in adolescence
    A. Musial, A. Allegrini, R. Cheesman, A. Ronald, E. Viding, T. Eley, K. Rimfeld, R. Plomin, M. Malanchini · 2025 · medRxiv
28. Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL
    Xin Wang, T. Sofer, O. Frei, R. Kaplan, K. Perreira, N. Franceschini, Humberto Parada, Laura Y. Zhou, Ole A. Andreassen, H. González et al. · 2025 · medRxiv
29. A genome-wide association study of methamphetamine use among people with HIV
    A. Venkataraman, T. Jia, S. Ruderman, C. Haas, R. Nance, L. Mixson, K. Mayer, M. Saag, G. Chander, R. Moore et al. · 2025 · BMC Medical Genomics
30. A Genetic Test to Identify People at High Risk of Heart Failure
    X. Ge, Bek Brittain, L. Dawson, G. Dwivedi, D. M. Kaye, Grant Morahan · 2025 · International Journal of Molecular Sciences
31. Identification of Hub Genes Involved in Early-onset Schizophrenia: From Genetic Susceptibility to Predicted Regulated Gene Expression
    Ya-Wen Jen, Sung-Liang Yu, Po-Chang Hsiao, Po-Hsiu Kuo, Chih-Min Liu, Chen-Chung Liu, T. Hwang, Ming H. Hsieh, Yi-Ling Chien, Yi-Ting Lin et al. · 2025 · Research Square
32. Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations
    Cuihua Xia, Ney Alliey‐Rodriguez, Carol A. Tamminga, Matcheri S. Keshavan, Godfrey D. Pearlson, Sarah Keedy, Brett A. Clementz, Jennifer E. McDowell, David Parker, Rebekka Lencer et al. · 2024 · Molecular Psychiatry
33. MIP4IBD: An Easy and Rapid Genotyping-by-Sequencing Assay for the Inflammatory Bowel Diseases Risk Loci
    Sare Verstockt, Laurens Hannes, Deborah Sarah Jans, Stephanie Deman, Erika L. Souche, Ilse van der Werf, Liv Vandermeulen, Triana Lobatón, Debby Laukens, Bram Verstockt et al. · 2024 · Inflammatory Bowel Diseases
34. Reporting of Race, Ethnicity, and Ancestry Remains Inadequate in Kidney Research
    Jian Roushani, Abigail J. Berube, Matthew Bruce Lanktree · 2024 · Kidney International Reports
35. Adaptation of Cinderella Gown into a Strapless Evening Gown Model with Brocade Tulle and Swarovski Embellishments
    Farisa Syahla Nur Alifah, Pipin Tresna Prihatin, Cucu Ruhidawati · 2024 · Riwayat: Educational Journal of History and Humanities
36. Understanding Genetic Testing in Healthy Individuals, and Related Regulations in Korea
    Kyung Park, Yoonjung Kim, Saeam Shin, In Ho Park, Kyung‐A Lee, Jong‐Won Kim · 2024 · Laboratory Medicine Online
37. Differential Results of Polygenic Risk Scoring for Multiple Sclerosis in European and African American Populations
    C. Rivier, S. Payabvash, H.-Y. Zhao, D. Hafler, G. Falcone, E. Longbrake · 2024 · medRxiv
38. Toll-Like Receptor Gene Polymorphisms in a Population-Based Study of HIV and Tuberculosis Patients from Eastern Europe and Central Asia
    S. Salamaikina, V. Korchagin, K. Mironov, E. Kulabukhova, V. Zimina, A. Kravtchenko · 2024 · Russian Journal of Genetics
39. Implications of self-identified race, ethnicity, and genetic ancestry on genetic association studies in biobanks within health systems
    Ruth Johnson, Bogdan Paşaniuc · 2024 · arXiv (Cornell University)
40. No clear evidence for relationships of Apolipoprotein E genotype with measures of common infections in three UK cohorts
    R. Green, A. Fernández-Sanlés, C. Felici, C. Warren-Gash, Julia Butt, T. Waterboer, M. Richards, Jonathan M. Schott, A. Hughes, N. Chaturvedi et al. · 2024 · medRxiv
41. Improving genetic risk modeling of dementia from real-world data in underrepresented populations
    Timothy Chang, Ming-Zhou Fu, Leopoldo Valiente-Banuet, Satpal S. Wadhwa, Bogdan Pasaniuc, Keith Vossel · 2024 · Research Square
42. Race and Research: Perspectives on Minority Participation in Health Studies, 2nd ed.
    2024 · American Public Health Association eBooks
43. The accuracy of polygenic score models for anthropometric traits and Type II Diabetes in the Native Hawaiian Population
    Ying-Chu Lo, T. Chan, Soyoung Jeon, G. Maskarinec, K. Taparra, Nathan Nakatsuka, Ming-Rui Yu, Chia-Yen Chen, Yen-Feng Lin, L. Wilkens et al. · 2023 · medRxiv
44. [Statistical association between genetic markers and food addiction: methodological considerations].
    S. Flores, Ángel Roco-Videla, N. Maureira-Carsalade, Mariela Olguín-Barraza · 2023 · Nutrición Hospitalaria
45. Homocysteine and Vitamin D Levels: An Association with Depression and its Severity
    Asif Azeem Bajwa, Sikandar Ali Khan, Hassan Raza, Tashfeen Bin Nazir · 2023 · Life and Science
46. Importance of including individuals of Latin American ancestry in genetic studies of feeding and eating disorders
    José Murgueito, José Jaime Martínez‐Magaña, Eva Trujillo, Shantal Anid Cortés Morales, Emilio Juan Compte, Eric A. Storch, Beatríz Camarena, Carolina Muniz Carvalho, Roseann Elizabeth Peterson, Sintia Iole Belangero et al. · 2023 · Revista Puertorriqueña de Psicologí­a
47. Geographically Biased Composition of NetMHCpan Training Datasets and Evaluation of MHC-Peptide Binding Prediction Accuracy on Novel Alleles
    T. K. Atkins, Arnav Solanki, G. Vasmatzis, James L. Cornette, Mark S. Riedel · 2023 · bioRxiv
48. Assessment of multi-population polygenic risk scores for lipid traits in African Americans
    Domenica E. Drouet, Shiying Liu, Dana C. Crawford · 2023 · PeerJ
49. Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries
    Gerard G. Dumancas, Megan Rachal, Pia Regina Fatima C. Zamora, Romulo de Castro · 2022 · Current Epidemiology Reports
50. Searching for subgroup-specific associations while controlling the false discovery rate
    M. Sesia, Tian-Shu Sun · 2022
51. The Danger of Genetic Risk Scores for Worsening Race-Based Disparities in Healthcare
    Sohail Zahid · 2022 · Harvard Medical Student Review
52. Mixed ancestry analysis of whole-genome sequencing identifies TBX5 and PTK7 as susceptibility genes for posterior urethral valves
    M. Chan, O. Sadeghi-Alavijeh, F. M. Lopes, A. Hilger, H. Stanescu, C. Voinescu, G. Beaman, W. Newman, M. Zaniew, S. Weber et al. · 2021 · medRxiv
53. Consenso multisocietario mexicano sobre la integración del riesgo poligénico en la estratificación del riesgo cardiovascular: implicaciones para la medicina cardiovascular de precisión en México
    Juan José Parcero-Valdés, Antonio Magaña-Serrano, Alexandra Arias‐Mendoza, Carlos Alfredo Narváez-Oríani, Esmeralda Altamirano-Cardoso, Vivencio Barrios, Luis Alcocer Díaz-Barreiro, Abel Alberto Pavía López, Enrique Gómez-Álvarez · 2026 · Cardiovascular and Metabolic Science
54. Multi-Omics Target Discovery after Data Integration: An Umbrella Review of Causal Evidence, Reproducibility, and Translational Readiness
    Nathan Jones, Olivia Taylor, Samantha Reid, David Clarke · 2025 · Pharmacophore
55. Causal Precision Pharmacotherapy from Genotype to Dose through Phenoconversion, Treatment History, Time-Varying Clinical Context, and Competing Therapeutic Goals
    Peter Nilsson, Eva Johansson, Lars Andersson · 2025 · International Journal Of Pharmaceutical Research And Allied Sciences
56. Precision Pharmacotherapy without Exclusion: An Equity-by-Design Framework for Ancestry Diversity, Access, Interpretability, and Clinical Implementation across Health Systems
    Lukas Weber, Sophie Janssen, Jonas Richter, Elena Fischer · 2025 · International Journal Of Pharmaceutical Research And Allied Sciences
57. Africa’s genomic role: Q&A with Conrad Iyegbe & Niran Okewole
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58. Genetic Screening for Detecting Individuals at Elevated Risk of Heart Failure
    T. Nguyen, D. K. Moore, J. White · 2022 · Bulletin of Pioneering Researches of Medical and Clinical Science