The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
Open accessPublished version of a preprint
Abstract
Most loci identified by GWASs have been found in populations of European ancestry (EUR). In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including 184,535 non-EUR individuals, we identified 5,552 trait-variant associations at p < 5 × 10-9, including 71 novel associations not found in EUR populations. We also identified 28 additional novel variants in ancestry-specific, non-EUR meta-analyses, including an IL7 missense variant in South Asians associated with lymphocyte count in vivo and IL-7 secretion levels in vitro. Fine-mapping prioritized variants annotated as functional and generated 95% credible sets that were 30% smaller when using the trans-ethnic as opposed to the EUR-only results. We explored the clinical significance and predictive value of trans-ethnic variants in multiple populations and compared genetic architecture and the effect of natural selection on these blood phenotypes between populations. Altogether, our results for hematological traits highlight the value of a more global representation of populations in genetic studies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“This locus on chromosome 13 is well-known for its association with blood cell traits and autoimmune diseases [40][41][42]”
From Plasma proteomic associations with genetics and health in the UK Biobank (2023) · cites this paper as [40]
Experimental — accuracy not yet measuredIn the citing paper
“Population-based genetic variation has largely been studied for blood cell traits, and over ten thousand loci have been defined across the allelic spectrum that explain inter-individual variation in such traits (Astle et al., 2016; Chen et al., 2020; Vuckovic et al., 2020).”
From Unraveling Hematopoiesis through the Lens of Genomics (2020) · cites this paper as Chen et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
ESTIMATING F -STATISTICS FOR THE ANALYSIS OF POPULATION STRUCTURE
Weir, B. S., & Cockerham, C. C. (1984) · Evolution · doi:10.1111/j.1558-5646.1984.tb05657.x · Cited by 18,909
Estimating F-Statistics for the Analysis of Population Structure
Weir, B. S., & Cockerham, C. C. (1984) · Evolution · doi:10.2307/2408641 · Cited by 11,023
The UK Biobank resource with deep phenotyping and genomic data
Bycroft, C., Freeman, C., Petkova, D., Band, G., Elliott, L. T., Sharp, K., Motyer, A., Vukcevic, D., Delaneau, O., O’Connell, J., et al. (2018) · Nature · doi:10.1038/s41586-018-0579-z · Cited by 8,876
An integrated map of genetic variation from 1,092 human genomes
The 1000 Genomes Project Consortium (2012) · Nature · doi:10.1038/nature11632 · Cited by 7,711
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Bulik-Sullivan, B. K., Loh, P.-R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., & Neale, B. M. (2015) · Nature Genetics · doi:10.1038/ng.3211 · Cited by 5,559
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205
An atlas of genetic correlations across human diseases and traits
ReproGen Consortium, Bulik-Sullivan, B., Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium 3, Finucane, H. K., Anttila, V., Gusev, A., Day, F. R., Loh, P.-R., Duncan, L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3406 · Cited by 4,255
Next-generation genotype imputation service and methods
Das, S., Forer, L., Schönherr, S., Sidore, C., Locke, A. E., Kwong, A., Vrieze, S. I., Chew, E. Y., Levy, S., McGue, M., et al. (2016) · Nature Genetics · doi:10.1038/ng.3656 · Cited by 3,808
A reference panel of 64,976 haplotypes for genotype imputation
the Haplotype Reference Consortium (2016) · Nature Genetics · doi:10.1038/ng.3643 · Cited by 2,836
Clinical use of current polygenic risk scores may exacerbate health disparities
Martin, A. R., Kanai, M., Kamatani, Y., Okada, Y., Neale, B. M., & Daly, M. J. (2019) · Nature Genetics · doi:10.1038/s41588-019-0379-x · Cited by 2,821
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 692
Park, J. S., Kim, Y., & Kang, J. (2021) · Journal of Human Genetics · doi:10.1038/s10038-021-00991-1 · Cited by 12
Bocher, O., Ludwig, T. E., Ogloblinsky, M. C., Marenne, G., Deleuze, J., Suryakant, S., Odeberg, J., Morange, P., Trégouët, D., Perdry, H., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1009923 · Cited by 13
Gao, Y., & Cui, Y. (2024) · Genome Medicine · doi:10.1186/s13073-024-01345-0 · Cited by 13
Wang, J., Zhang, Z., Lu, Z., Mancuso, N., & Gazal, S. (2024) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.07.021 · Cited by 16
Yu, X., Hu, X., Wan, X., Zhang, Z., Wan, X., Cai, M., Yu, T., & Xiao, J. (2025) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2024.12.018 · Cited by 12
rs9459874 and rs1012656 in CCR6/FGFR1OP confer susceptibility to primary biliary cholangitis
Hitomi, Y., Aiba, Y., Ueno, K., Nishida, N., Kawai, Y., Kawashima, M., Yasunami, M., Gervais, O., Ito, M., Cordell, H. J., et al. (2021) · Journal of Autoimmunity · doi:10.1016/j.jaut.2021.102775 · Cited by 11
Non-coding RNA network associated with obesity and rheumatoid arthritis
Auer, E. D., Santos, D. D. C., de Lima, I. J. V., & Boldt, A. B. W. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152281 · Cited by 11
Lecluze, E., & Lettre, G. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.07.011 · Cited by 11
Muiño, E., Cárcel‐Márquez, J., Carrera, C., Llucià‐Carol, L., Gallego-Fábrega, C., Cullell, N., Lledós, M., Castillo, J., Sobrino, T., Campos, F., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10143137 · Cited by 11
Bayesian model comparison for rare-variant association studies
Venkataraman, G. R., DeBoever, C., Tanigawa, Y., Aguirre, M., Ioannidis, A. G., Mostafavi, H., Spencer, C. C. A., Poterba, T., Bustamante, C. D., Daly, M. J., et al. (2021) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2021.11.005 · Cited by 11
Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy
Ebel, E. R., Uricchio, L. H., Petrov, D. A., & Egan, E. S. (2022) · Trends in Parasitology · doi:10.1016/j.pt.2021.12.007 · Cited by 11
Glucocorticoids unmask silent non-coding genetic risk variants for common diseases
Nguyen, T. T. L., Gao, H., Liu, D., Philips, T. J., Ye, Z., Lee, J., Shi, G., Copenhaver, K. M., Zhang, L., Wei, L., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac1045 · Cited by 10
A second update on mapping the human genetic architecture of COVID-19Preprint
Initiative, T. C.-1. H. G., & Ganna, A. (2022) · medRxiv · doi:10.1101/2022.12.24.22283874 · Cited by 11
Rajabli, F., Benchek, P. H., Tosto, G., Kushch, N. A., Sha, J., Bazemore, K., Zhu, C., Lee, W., Haut, J., Hamilton‐Nelson, K. L., et al. (2023) · medRxiv · doi:10.1101/2023.07.06.23292311 · Cited by 11
Uncovering the architecture of selection in two Bos taurus cattle breeds
Rowan, T. N., Schnabel, R. D., & Decker, J. E. (2024) · Evolutionary Applications · doi:10.1111/eva.13666 · Cited by 10
Leblanc, F., Jin, X., Kang, K., Lee, C. J. M., Xu, J., Xuan, L., Ma, W., Belhaj, H., Benzaki, M., Mehta, N., et al. (2024) · iScience · doi:10.1016/j.isci.2024.110660 · Cited by 12
Konieczny, M. J., Omarov, M., Zhang, L., Malik, R., Richardson, T. G., Baumeister, S., Bernhagen, J., Dichgans, M., & Georgakis, M. K. (2025) · Communications Biology · doi:10.1038/s42003-025-07453-w · Cited by 14
Body mass index and adipose distribution have opposing genetic impacts on human blood traits
Thom, C. S., Wilken, M. B., Chou, S. T., & Voight, B. F. (2022) · eLife · doi:10.7554/elife.75317 · Cited by 9
Ramirez, N.-G. P., Lee, J., Zheng, Y., Li, L., Dennis, B., Chen, D., Challa, A., Planelles, V., Westover, K. D., Alto, N. M., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28772-0 · Cited by 10
Genetics of osteonecrosis in children and adults with systemic lupus erythematosus
Webber, D., Cao, J., Domínguez, D., Gladman, D. D., Knight, A., Levy, D. M., Liao, F., Ng, L., Paterson, A. D., Touma, Z., et al. (2023) · Lara D. Veeken · doi:10.1093/rheumatology/kead016 · Cited by 10
Approach to Clinical Trials for the Prevention of Pulmonary Fibrosis
Kim, J. S., Montesi, S. B., Adegunsoye, A., Humphries, S. M., Salisbury, M. L., Hariri, L. P., Kropski, J. A., Richeldi, L., Wells, A. U., Walsh, S. L. F., et al. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202303-188ps · Cited by 11
Identifying independent causal cell types for human diseases and risk variantsPreprint
Kim, A., Zhang, Z., Legros, C., Lu, Z., de Smith, A. J., Moore, J. E., Durvasula, A., Mancuso, N., & Gazal, S. (2024) · medRxiv · doi:10.1101/2024.05.17.24307556 · Cited by 10
Structural variation across 138,134 samples in the TOPMed consortium
Jun, G., English, A., Metcalf, G., Yang, J., Chaisson, M., Pankratz, N., Menon, V., Salerno, W., Krasheninina, O., Smith, A., et al. (2023) · doi:10.21203/rs.3.rs-2515453/v1 · Cited by 24
Genetic evidence for causal effects of leukocyte counts on risk for rheumatoid arthritis
You, J.-M., Zhang, Y., Fan, K., Bai, S.-K., Zhang, Z., Zhang, H., Cheng, T., Huo, Y.-H., Wang, C., Li, X., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-46888-1 · Cited by 10
Wilken, M. B., Fonar, G., Qiu, R., Bennett, L. F., Tober, J. M., Nations, C. C., Pavani, G., Tsao, V., Garifallou, J. P., Petit, C., et al. (2024) · Stem Cell Reports · doi:10.1016/j.stemcr.2024.08.001 · Cited by 9
Sequence variants influencing the regulation of serum IgG subclass levels
Olafsdottir, T. A., Þorleifsson, G., Portilla, A. L. D. L., Jonsson, S., Stefánsdóttir, L., Niroula, A., Jónasdóttir, Á., Eggertsson, H. P., Halldorsson, G. H., Thorlacius, G. E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52470-8 · Cited by 12
Ancestral origins and post-admixture adaptive evolution of highland Tajiks
Wen, J., Liu, J., Feng, Q., Lü, Y., Yuan, K., Zhang, X., Zhang, C., Gao, Y., Wang, X., Mamatyusupu, D., et al. (2024) · National Science Review · doi:10.1093/nsr/nwae284 · Cited by 9
Shine, B.-K., Choi, J., Park, Y., & Hong, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312690 · Cited by 10
Circulating platelet count and glycans
Rivadeneyra, L., Falet, H., & Hoffmeister, K. M. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000682 · Cited by 9
Misuse of the term ‘trans-ethnic’ in genomics research
Kamariza, M., Crawford, L. A., Jones, D. S., & Finucane, H. K. (2021) · Nature Genetics · doi:10.1038/s41588-021-00952-6 · Cited by 10
Magavern, E. F., Smedley, D. P., & Caulfield, M. J. (2023) · iScience · doi:10.1016/j.isci.2023.107795 · Cited by 9
Casares‐Marfil, D., Guillén‐Guío, B., Lorenzo-Salazar, J. M., Rodríguez‐Pérez, H., Kerick, M., Campos, M. A. J., Díaz, M. L., Estupiñán‐Moreno, E., Echeverría, L. E., González, C. I., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab213 · Cited by 8
A Co-Association Network Analysis Reveals Putative Regulators for Health-Related Traits in Pigs
Crespo‐Piazuelo, D., Ramayo‐Caldas, Y., González-Rodríguez, O., Pascual, M., Quintanilla, R., & Ballester, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.784978 · Cited by 11
Soremekun, O. S., Soremekun, C., Machipisa, T., Soliman, M. E. S., Nashiru, O., Chikowore, T., & Fatumo, S. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.749415 · Cited by 9
Lam, D. D., Nikolic, A. A., Zhao, C., Mirza‐Schreiber, N., Krężel, W., Oexle, K., & Winkelmann, J. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab355 · Cited by 10
Feltes, B. C., Vieira, I. A., Álava, J. A. P., Meza, J., Portmann, E., Terán, L., & Dorn, M. (2022) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2022.105228 · Cited by 9
Hong, K. U., Walls, K. M., & Hein, D. W. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1091976 · Cited by 9
Human genetics implicates a BACH2-NRF2 axis in fetal heamoglobin activationPreprint
Guo, C., Arora, U. P., Cheng, X., Xu, W., Cato, L. D., Li, R., Lu, H. Y., Lee, A., Yu, F., Agarwal, G., et al. (2023) · medRxiv · doi:10.1101/2023.03.24.23287659 · Cited by 9
Germline predisposition for clonal hematopoiesis
Kubota, Y., & Viny, A. D. (2024) · Seminars in Hematology · doi:10.1053/j.seminhematol.2024.01.007 · Cited by 9
Ma, Y., Jiang, D., Li, J., Zheng, G., Deng, Y. J., Gou, X., Gao, S., Cheng Ann, C. H. E. N., Zhou, Y., Zhang, Y., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03243-4 · Cited by 9
Ma, X., Lü, Y., Stoneking, M., & Xu, S. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404393122 · Cited by 8
DNA methylation and aeroallergen sensitization: The chicken or the egg?
Kilanowski, A., Merid, S. K., Abrishamcar, S., Feil, D., Thiering, E., Waldenberger, M., Melén, E., Peters, A., Standl, M., & Hüls, A. (2022) · Clinical Epigenetics · doi:10.1186/s13148-022-01332-5 · Cited by 8
White blood cells and chronic rhinosinusitis: a Mendelian randomization study
Pongdee, T., Bielinski, S. J., Decker, P. A., Kita, H., & Larson, N. B. (2022) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-022-00739-2 · Cited by 8
Genetic Predisposition to Clonal Hematopoiesis
Quirós, P. M., & Vassiliou, G. S. (2023) · HemaSphere · doi:10.1097/hs9.0000000000000947 · Cited by 8
Germline genetic regulation of the colorectal tumor immune microenvironment
Schmit, S. L., Tsai, Y.-Y., Bonner, J. D., Pamplona, R. S., Joshi, A. D., Ugai, T., Lindsey, S. S., Melas, M., McDonnell, K., Idos, G., et al. (2024) · BMC Genomics · doi:10.1186/s12864-024-10295-1 · Cited by 7
Li, G., Huang, T., Li, J.-X., Liu, J., Gao, X., Yang, N., & Zhou, H. (2024) · BMC Cancer · doi:10.1186/s12885-024-12495-0 · Cited by 8
eSCAN: scan regulatory regions for aggregate association testing using whole-genome sequencing data
Yang, Y., Sun, Q., Huang, L., Broome, J., Correa, A., Reiner, A. P., Raffield, L. M., Yang, Y., & Li, Y. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab497 · Cited by 8
Possible association of 16p11.2 copy number variation with altered lymphocyte and neutrophil counts
Giannuzzi, G., Chatron, N., Männik, K., Auwerx, C., Pradervand, S., Willemin, G., Hoekzema, K., Nuttle, X., Chrast, J., Sadler, M. C., et al. (2022) · npj Genomic Medicine · doi:10.1038/s41525-022-00308-x · Cited by 9
Polygenic risk scores and the need for pharmacotherapy in neonatal abstinence syndrome
Bibi, S., Gaddis, N., Johnson, E. O., Lester, B. M., Kraft, W. K., Singh, R., Terrin, N. C., Adeniyi-Jones, S. C., & Davis, J. M. (2022) · Pediatric Research · doi:10.1038/s41390-022-02243-0 · Cited by 9
Upadhyai, P., Shenoy, P. U., Banjan, B., Albeshr, M. F., Mahboob, S., Manzoor, I., & Das, R. (2022) · Life · doi:10.3390/life12091300 · Cited by 8
Renner, W., Kaiser, M., Khuen, S., Trummer, O., Mangge, H., & Langsenlehner, T. (2020) · Genes · doi:10.3390/genes11111305 · Cited by 8
Elliott, H. R., Burrows, K., Min, J. L., Tillin, T., Mason, D., Wright, J., Santorelli, G., Smith, G. D., Lawlor, D. A., Hughes, A. D., et al. (2022) · medRxiv · doi:10.1101/2022.04.06.22273496 · Cited by 8
Sun, Q., Rowland, B., Chen, J. C., Mikhaylova, A. V., Avery, C. L., Peters, U., Lundin, J. I., Matise, T. C., Buyske, S. G., Tao, R., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.06.511219 · Cited by 8
Single-cell analysis of human diversity in circulating immune cellsPreprint
Kock, K. H., Tan, L. M., Han, K. Y., Ando, Y., Jevapatarakul, D., Chatterjee, A., Lin, Q. X. X., Buyamin, E. V., Sonthalia, R., Rajagopalan, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.30.601119 · Cited by 8
Robust fine-mapping in the presence of linkage disequilibrium mismatchPreprint
Zhang, W., Lu, T., SLADEK, R. M., Dupuis, J., & Lettre, G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.29.620968 · Cited by 8
Toivonen, J., Allara, E., FinnGen, Castrén, J., Angelantonio, E. D., & Arvas, M. (2023) · Vox Sanguinis · doi:10.1111/vox.13564 · Cited by 11
Target genes regulated by CLEC16A intronic region associated with common variable immunodeficiency
Huang, X., Huang, J., Li, X., Fan, J., Zhou, D., Qu, H., Glessner, J., Ji, D., Jia, Q., Ding, Z., et al. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.12.023 · Cited by 7
Foyzun, T., Whiting, M., Velasco, K. K., Jacobsen, J. C., Connor, M. A., & Grimsey, N. L. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16383 · Cited by 8
Admission neutrophil-to-lymphocyte ratio to predict mortality in burn patients: a meta-analysis
Awad, M., Elsahhar, A., Alwakeel, M. I., Awad, R., Gomaa, N., Salem, A. M. A., Ramadan, M., Elsahhar, G., Abdelbaky, R. E. R., & Fadell, F. (2024) · Intensive Care Medicine Experimental · doi:10.1186/s40635-024-00668-x · Cited by 8
Wu, Z., Gao, S., Feng, X., Li, H., Sompairac, N., Jamshidi, S., Choy, D., Reis, R. A. D., Gao, Q., Kajigaya, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60213-6 · Cited by 7
Advances in Understanding Adaptive Hemoglobin Concentration at High Altitude
Childebayeva, A., Zhu, K. T., & Bigham, A. W. (2025) · American Journal of Human Biology · doi:10.1002/ajhb.70087 · Cited by 8
Smith, M. D., Plaisier, S. B., Breen, J., Bogias, K. J., Jankovic‐Karasoulos, T., McCullough, D., McAninch, D., Arthurs, A. L., Wilson, M. A., Pillman, K. A., et al. (2025) · Biology of Sex Differences · doi:10.1186/s13293-025-00781-w · Cited by 8
A Multi-Marker Test for Analyzing Paired Genetic Data in Transplantation
Arthur, V. L., Li, Z., Cao, R., Oetting, W. S., Israni, A. K., Jacobson, P. A., Ritchie, M. D., Guan, W., & Chen, J. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.745773 · Cited by 7
Translating non-coding genetic associations into a better understanding of immune-mediated disease
Stankey, C. T., & Lee, J. C. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049790 · Cited by 9
Chen, Y., Lou, L., Zhang, X., Jin, L., Chen, Y., Chen, L., Li, Z., Zhang, F., Fu, T., Hu, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1041591 · Cited by 7
Liu, Y., Zhu, Q., Guo, G., Xie, Z., Li, S., Lai, C., Wu, Y., Wang, L., & Zhong, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1342653 · Cited by 7
Qi, L., Li, Y., Chen, Z., Wei, C., Wen, X., Hu, S., Wu, H., Lv, Z., Xu, Z., & Xia, L. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1408778 · Cited by 8
Fang, F., Hazegh, K. E., Mast, A. E., Triulzi, D. J., Spencer, B. R., Gladwin, M. T., Busch, M. P., Kanias, T., & Page, G. P. (2022) · BMC Genomics · doi:10.1186/s12864-022-08461-4 · Cited by 8
Raveane, A., Molinaro, L., Aneli, S., Capodiferro, M. R., de Gennaro, L., Ongaro, L., Migliore, N. R., Soffiati, S., Scarano, T., Torroni, A., et al. (2022) · Genomics · doi:10.1016/j.ygeno.2022.110405 · Cited by 8
Nan, J., Yang, S., Zhang, X., Leng, T., Zhuoma, J., Zhuoma, R., Yuan, J., Pi, J., Sheng, Z., & Li, S. (2022) · Animal Genetics · doi:10.1111/age.13268 · Cited by 8
Nowak, J. K., Dybska, E., Adams, A. T., & Walkowiak, J. (2022) · Central European Journal of Immunology · doi:10.5114/ceji.2022.120618 · Cited by 7
A review of the genomics of neonatal abstinence syndrome
Yen, E., Gaddis, N., Jantzie, L. L., & Davis, J. M. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1140400 · Cited by 8
Gagnon, M.-F., Provost, S., Sun, M., Ayachi, S., Buscarlet, M., Mollica, L. R., Szuber, N., Dubé, M., & Busque, L. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008793 · Cited by 8
Sun, P., Zhou, W., Fu, Y., Cheung, C. Y. Y., Dong, Y., Yang, M., Zhang, H., Jia, J., Huo, Y., Willer, C. J., et al. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab062 · Cited by 7
Identification of the genetic mechanism that associates L3MBTL3 to multiple sclerosis
Alcina, A., Fedetz, M., Vidal-Cobo, I., Andrés‐León, E., García-Sanchéz, M.-I., Jesus, A. B.-D., Eichau, S., Gil‐Varea, E., Villar, L.-M., Saiz, A., et al. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac009 · Cited by 7
Fibroblast growth factor 5: a novel biomarker for familial hypercholesterolaemia
Baragetti, A., Alieva, A. S., Grigore, L., Pellegatta, F., Lupi, A., Scrimali, C., Cefalu, A. B., Hutten, B. A., Wiegman, A., Knaapen, P., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf045 · Cited by 6
Genetics of circulating proteins in newborn babies at high risk of type 1 diabetes
Tutino, M., Yu, N., Hatzikotoulas, K., Park, Y., Kreitmaier, P., Katsoula, G., Berner, R., Casteels, K., Larsson, H. E., Kordonouri, O., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58972-3 · Cited by 6
CROMER, S. J., Cobran, E. K., Iyer, H. S., Hysong, M. R., Vargas, L. B., Smith, J. L., Konigsberg, I. R., Bogumil, D. D., Glover, L. M., King, G. A., et al. (2026) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2026.02.007 · Cited by 7
Ingold, N., Seviiri, M., Ong, J., Gordon, S. D., Neale, R. Ε., Whiteman, D. C., Olsen, C. M., MacGregor, S., & Law, M. H. (2024) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2024.02.019 · Cited by 7
Clinical associations with a polygenic predisposition to benign lower white blood cell counts
Mosley, J. D., Shelley, J. P., Dickson, A. L., Zanussi, J., Daniel, L. L., Zheng, N. S., Bastarache, L. A., Wei, W., Shi, M., Jarvik, G. P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47804-5 · Cited by 6
Yao, Y., Zhou, Z., Wang, X., Liu, Z., Zhai, Y., Chi, X., Du, J., Luo, L., Zhao, Z., Wang, X., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2024.100583 · Cited by 6
Clinical and Metabolic Signatures of FAM47E–SHROOM3 Haplotypes in a General Population Sample
Ghasemi-Semeskandeh, D., König, E., Foco, L., Đorđević, N., Gögele, M., Rainer, J., Ralser, M., Acoba, D., Domingues, F. S., Peters, D. J. M., et al. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.02.018 · Cited by 6
CD46 Genetic Variability and HIV-1 Infection Susceptibility
Serrano-Rísquez, C., Omar, M., Gómez-Vidal, M. A., Real, L. M., Pineda, J. A., Rivero, A., Rivero‐Juárez, A., Forthal, D. N., Márquez, F. J., Caputo, S. L., et al. (2021) · Cells · doi:10.3390/cells10113094 · Cited by 6
Nguyen, A., Khafagy, R. T. M., Hashemy, H., Kuo, K. H. M., Roshandel, D., Paterson, A. D., & Dash, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1146099 · Cited by 9
Osman, W. M., Mousa, M., Albreiki, M. S., Baalfaqih, Z., Daggag, H., Hill, C., McKnight, A. J., Maxwell, A. P., & AlSafar, H. S. (2023) · Scientific Reports · doi:10.1038/s41598-023-31701-w · Cited by 6
Genetic susceptibility for autoimmune diseases and white blood cell count
Vaitinadin, N. S., Stein, C. M., Mosley, J. D., & Kawai, V. K. (2023) · Scientific Reports · doi:10.1038/s41598-023-32799-8 · Cited by 7
Lu, H., Zhang, S., Jiang, Z., & Zeng, P. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad232 · Cited by 6
Constantinescu, A., Hughes, D. A., Bull, C. J., Fleming, K., Mitchell, R. E., Zheng, J., Kar, S., Timpson, N. J., Amulic, B., & Vincent, E. E. (2024) · Human Genomics · doi:10.1186/s40246-024-00585-w · Cited by 6
Poisner, H. M., Faucon, A. B., Cox, N. J., & Bick, A. G. (2024) · Nature Communications · doi:10.1038/s41467-024-51095-1 · Cited by 7
Interpreting SNP heritability in admixed populations
Huang, J., Kleman, N., Basu, S., Shriver, M. D., & Zaidi, A. A. (2025) · Genetics · doi:10.1093/genetics/iyaf100 · Cited by 8
Tapia, A. L., Rowland, B., Rosen, J. D., Preuss, M. H., Young, K., Graff, M., Choquet, H., Couper, D. J., Buyske, S. G., Bien, S. A., et al. (2021) · Genetic Epidemiology · doi:10.1002/gepi.22436 · Cited by 5
Gene-Based Variant Analysis of Whole-Exome Sequencing in Relation to Eosinophil Count
Höglund, J., Hadizadeh, F., Ek, W. E., Karlsson, T., & Johansson, Å. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.862255 · Cited by 7
Hanscombe, K. B., Persyn, E., Traylor, M., Glanville, K. P., Hamer, M., Coleman, J. R. I., & Lewis, C. M. (2020) · medRxiv · doi:10.1101/2020.12.08.20243337 · Cited by 6
Kachuri, L., Mak, A. C. Y., Hu, D., Eng, C. S., Huntsman, S., Elhawary, J. R., Gupta, N., Gabriel, S., Xiao, S., Keys, K. L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.19.456901 · Cited by 6
Högel-Starck, C., Timonen, V. A., Atarsaikhan, G., Mogollón, I., Polso, M., Hassinen, A., Honkanen, J. K., Sarmento, C. D., Koski, J., Soini, J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.17.594648 · Cited by 5
TYK2 : p.Pro1104Ala Variant Protects Against Autoimmunity by Modulating Immune Cell Levels
Steri, M., Orrù, V., Sidore, C., Mulas, A., Pitzalis, M., Busonero, F., Maschio, A., Serra, V., Dei, M., Lai, S., et al. (2025) · Immunology · doi:10.1111/imm.13902 · Cited by 6
Kashatnikova, D. A., Gracheva, A. S., Redkin, I. V., Zakharchenko, V. E., Krylova, T. N., Kuzovlev, A. N., & Salnikova, L. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031239 · Cited by 5
Meng, Z., Zhang, C., Liu, S., Li, W., Wang, Y., Zhang, Q., Peng, B., Ye, W., Jiang, Y., Song, Y., et al. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1502839 · Cited by 6
Mandla, R., Shi, Z., Hou, K., Wang, Y., Mies, G., Aw, A. J., Cullina, S., BioBank, P. M., Aw, A., Kenny, E. E., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-75515-6 · Cited by 4
Zhou, F., Astle, W. J., Butterworth, A. S., & Asimit, J. L. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.100847 · Cited by 4
Metadata
- Authors
- Chen, M.-H., Raffield, L. M., Mousas, A., Sakaue, S., Huffman, J. E., Moscati, A., Trivedi, B., Jiang, T., Akbari, P., Vuckovic, D., Bao, E. L., Zhong, X., Manansala, R., Laplante, V., Chen, M., Lo, K. S., Qian, H., Lareau, C. A., Beaudoin, M., Hunt, K. A., Akiyama, M., Bartz, T. M., Ben-Shlomo, Y., Beswick, A., Bork-Jensen, J., Bottinger, E. P., Brody, J. A., van Rooij, F. J. A., Chitrala, K., Cho, K., Choquet, H., Correa, A., Danesh, J., Di Angelantonio, E., Dimou, N., Ding, J., Elliott, P., Esko, T., Evans, M. K., Floyd, J. S., Broer, L., Grarup, N., Guo, M. H., Greinacher, A., Haessler, J., Hansen, T., Howson, J. M. M., Huang, Q. Q., Huang, W., Jorgenson, E., Kacprowski, T., Kähönen, M., Kamatani, Y., Kanai, M., Karthikeyan, S., Koskeridis, F., Lange, L. A., Lehtimäki, T., Lerch, M. M., Linneberg, A., Liu, Y., Lyytikäinen, L.-P., Manichaikul, A., Martin, H. C., Matsuda, K., Mohlke, K. L., Mononen, N., Murakami, Y., Nadkarni, G. N., Nauck, M., Nikus, K., Ouwehand, W. H., Pankratz, N., Pedersen, O., Preuss, M., Psaty, B. M., Raitakari, O. T., Roberts, D. J., Rich, S. S., Rodriguez, B. A. T., Rosen, J. D., Rotter, J. I., Schubert, P., Spracklen, C. N., Surendran, P., Tang, H., Tardif, J.-C., Trembath, R. C., Ghanbari, M., Völker, U., Völzke, H., Watkins, N. A., Zonderman, A. B., Wilson, P. W. F., Li, Y., Butterworth, A. S., Gauchat, J.-F., Chiang, C. W. K., Li, B., Loos, R. J. F., Astle, W. J., Evangelou, E., van Heel, D. A., Sankaran, V. G., Okada, Y., Soranzo, N., Johnson, A. D., Reiner, A. P., Auer, P. L., & Lettre, G.
- Affiliations
- University of Southern California (US)
- University of North Carolina at Chapel Hill (US)
- Montreal Heart Institute (CA)
- RIKEN Center for Integrative Medical Sciences (JP)
- VA Boston Healthcare System (US)
- Icahn School of Medicine at Mount Sinai (US)
- Queen Mary University of London (GB)
- University of Cambridge (GB)
- Wellcome Sanger Institute (GB)
- Broad Institute (US)
- Vanderbilt University (US)
- University of Wisconsin–Milwaukee (US)
- Université de Montréal (CA)
- Kyushu University (JP)
- University of Washington (US)
- University of Bristol (GB)
- Brigham and Women's Hospital (US)
- Kaiser Permanente (US)
- University of Mississippi Medical Center (US)
- University of Ioannina (GR)
- Wake Forest University Health Sciences (US)
- Imperial College Healthcare NHS Trust (GB)
- National Institutes of Health (US)
- Erasmus MC (NL)
- University of Copenhagen (DK)
- Universitätsmedizin Greifswald (DE)
- Fred Hutch Cancer Center (US)
- Chinese National Human Genome Center (CN)
- Tampere University (FI)
- Massachusetts General Hospital (US)
- University of Colorado Anschutz (US)
- Duke University (US)
- University of Virginia (US)
- The University of Tokyo (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- National Health Service (GB)
- University of Minnesota (US)
- Kaiser Permanente Washington Health Research Institute (US)
- University of Turku (FI)
- NHS Blood and Transplant (GB)
- National Heart, Lung, and Blood Institute (US)
- The Lundquist Institute (US)
- Stanford Medicine (US)
- King's College London (GB)
- Mashhad University of Medical Sciences (IR)
- Atlanta VA Medical Center (US)
- The University of Osaka (JP)
- Corresponding author
- Auer, Paul L.
- Lettre, Guillaume
- ORCID
- Chen, Ming-Huei
- Raffield, Laura M.
- Mousas, Abdou
- Sakaue, Saori
- Huffman, Jennifer E.
- Moscati, Arden
- Akbari, Parsa
- Vuckovic, Dragana
- Bao, Erik L.
- Zhong, Xue
- Manansala, Regina
- Chen, Minhui
- Lo, Ken Sin
- Qian, Huijun
- Lareau, Caleb A.
- Beaudoin, Mélissa
- Hunt, Karen A.
- Akiyama, Masato
- Bartz, Traci M.
- Beswick, Andrew
- Brody, Jennifer A.
- Cho, Kelly
- Choquet, Hélène
- Correa, Adolfo
- Danesh, John
- Dimou, Niki
- Ding, Jingzhong
- Elliott, Paul
- Esko, Tõnu
- Evans, Michele K.
- Floyd, James S.
- Broer, Linda
- Grarup, Niels
- Guo, Michael H.
- Greinacher, Andreas
- Hansen, Torben
- Howson, Joanna M.M.
- Huang, Qin Qin
- Huang, Wei
- Jorgenson, Eric
- Kacprowski, Tim
- Kähönen, Mika
- Kanai, Masahiro
- Karthikeyan, Savita
- Lehtimäki, Terho
- Lerch, Markus M.
- Linneberg, Allan
- Liu, Yongmei
- Lyytikäinen, Leo-Pekka
- Manichaikul, Ani
- Martin, Hilary C.
- Matsuda, Koichi
- Mohlke, Karen L.
- Mononen, Nina
- Nadkarni, Girish N.
- Nauck, Matthias
- Nikus, Kjell
- Ouwehand, Willem H.
- Pankratz, Nathan
- Pedersen, Oluf
- Preuss, Michael
- Psaty, Bruce M.
- Raitakari, Olli T.
- Roberts, David J.
- Rich, Stephen S.
- Rodriguez, Benjamin A.T.
- Rosen, Jonathan D.
- Rotter, Jerome I.
- Schubert, Petra
- Spracklen, Cassandra N.
- Surendran, Praveen
- Tang, Hua
- Tardif, Jean-Claude
- Trembath, Richard C.
- Ghanbari, Mohsen
- Völker, Uwe
- Völzke, Henry
- Zonderman, Alan B.
- Wilson, Peter W.F.
- Li, Yun
- Butterworth, Adam S.
- Chiang, Charleston W.K.
- Li, Bingshan
- Loos, Ruth J.F.
- Astle, William J.
- Sankaran, Vijay G.
- Okada, Yukinori
- Soranzo, Nicole
- Johnson, Andrew D.
- Auer, Paul L.
- Lettre, Guillaume
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 182
- Issue
- 5
- Pages
- 1198-1213.e14
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7480402
- OpenAlex
- W3082575318
- Cited by
- 661
- References
- 85
- Citations by year
- 2026: 75 · 2025: 142 · 2024: 146 · 2023: 108 · 2022: 98 · 2021: 82 · 2020: 9
- FWCI
- 10.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- Bristol Research (University of Bristol) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- publish.UP (University of Potsdam) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by-nc-nd)
- Funders
- Canadian Institutes of Health Research
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- hematological traits, lymphocyte count, IL-7, fine mapping, natural selection, genetic architecture, South Asians, non-European populations
- MeSH terms
- Genetics, Humans, Phenotype, Interleukin-7, Mutation, Missense, Polymorphism, Single Nucleotide, White People, Asian People, Genome-Wide Association Study, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
