The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19
Open accessPublished version of a preprint
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. A complication is the rare multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, presenting 4-6 weeks after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation. The pathogenesis is unclear but has overlapping features with Kawasaki disease suggestive of vasculitis and a likely autoimmune etiology. We apply systems-level analyses of blood immune cells, cytokines, and autoantibodies in healthy children, children with Kawasaki disease enrolled prior to COVID-19, children infected with SARS-CoV-2, and children presenting with MIS-C. We find that the inflammatory response in MIS-C differs from the cytokine storm of severe acute COVID-19, shares several features with Kawasaki disease, but also differs from this condition with respect to T cell subsets, interleukin (IL)-17A, and biomarkers associated with arterial damage. Finally, autoantibody profiling suggests multiple autoantibodies that could be involved in the pathogenesis of MIS-C.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“MIS-C has distinct immunological features different from the two with respect to circulating cytokine profiles and composition of the T cell compartment”
From COVID-19 and the human innate immune system (2021) · cites this paper as Consiglio et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30183-5 · Cited by 48,884
Self-citationlimma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286
Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
Feldstein, L. R., Rose, E. B., Horwitz, S. M., Collins, J. P., Newhams, M. M., Son, M. B. F., Newburger, J. W., Kleinman, L. C., Heidemann, S. M., Martin, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2021680 · Cited by 2,691
Hyperinflammatory shock in children during COVID-19 pandemic
Riphagen, S. D., Gomez, X., González-Martínez, C., Wilkinson, N. M., & Theocharis, P. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31094-1 · Cited by 2,492
Verdoni, L., Mazza, A., Gervasoni, A., Martelli, L., Ruggeri, M., Ciuffreda, M., Bonanomi, E., & D’Antiga, L. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31103-x · Cited by 2,426
SARS-CoV-2 Infection in Children
Lü, X., Zhang, L., Du, H. N., Zhang, J., Li, Y. Y., Qu, J., Zhang, W., Wang, Y., Bao, S., Li, Y., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2005073 · Cited by 2,423
Flagged first, then by citations
Research works printed but not linked: 2
- Anft, 2020, COVID-19 progression is potentially driven by T cell immunopathogenesis, medRxiv
- Moraleda, 2020, Multi-Inflammatory Syndrome in Children related to SARS-CoV-2 in Spain, Clin. Infect. Dis.
Cited by
Sorted by citations
Items 301–400 of 917
Co-Infection Associated with SARS-CoV-2 and Their Management
Chavda, V. P., Patel, A., Pandya, A., Vora, L. K., Patravale, V. B., Tambuwala, Z. M., Aljabali, A. A. A., Serrano‐Aroca, Á., Mishra, V. K., & Tambuwala, M. M. (2022) · Future Science OA · doi:10.2144/fsoa-2022-0011 · Cited by 18
Review and future directions for PIMS-TS (MIS-C)
Roarty, C., & Waterfield, T. (2022) · Archives of Disease in Childhood · doi:10.1136/archdischild-2021-323143 · Cited by 16
Dermatological Manifestations of COVID-19 in Children
Panda, M., Agarwal, A., & Hassanandani, T. (2022) · Indian Pediatrics · doi:10.1007/s13312-022-2521-6 · Cited by 16
Zambrano, L. D., Ly, K. N., Link‐Gelles, R., Newhams, M. M., Akande, M. Y., Wu, M., Feldstein, L. R., Tarquinio, K. M., Sahni, L. C., Riggs, B. J., et al. (2022) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003689 · Cited by 17
Severe pediatric COVID-19: a review from the clinical and immunopathophysiological perspectives
Sun, Y., Wang, C., Lin, P., Hu, L., Ye, J., Gao, Z., Lin, R., Li, H., Shu, Q., Huang, L., et al. (2024) · World Journal of Pediatrics · doi:10.1007/s12519-023-00790-y · Cited by 19
Coronavirus Desease 2019 (COVID-19) in Children: Lessons from Pediatric Rheumatology
Kaleda, M. I., Никишина, И. П., Fedorov, E. S., & Nasonov, E. L. (2020) · Rheumatology Science and Practice · doi:10.47360/1995-4484-2020-469-479 · Cited by 16
Severe Acute Respiratory Syndrome Coronavirus 2 Infections in Children
Chow, E. J., & Englund, J. A. (2022) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2022.01.005 · Cited by 21
Ura, B., Capaci, V., Aloisio, M., Lorenzo, G. D., Romano, F., Ricci, G., & Monasta, L. (2022) · Biomedicines · doi:10.3390/biomedicines10081857 · Cited by 16
Wang, J. Y., Zhang, W., Roehrl, V. B., Roehrl, M. W., & Roehrl, M. H. A. (2023) · Australian Journal of Chemistry · doi:10.1071/ch22267 · Cited by 16
Self-citationPorritt, R. A., Paschold, L., Rivas, M. N., Cheng, M. H., Yonker, L. M., Chandnani, H. K., Lopez, M., Simnica, D., Schultheiß, C., Santiskulvong, C., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.09.372169 · Cited by 16
COVID-19-associated neurological and psychological manifestations
Wilson, J. E., Gurdasani, D., Helbok, R., Ozturk, S., Fraser, D. D., Filipović, S. R., Peluso, M. J., Iwasaki, A., Yasuda, C. L., Bocci, T., et al. (2025) · Nature Reviews Disease Primers · doi:10.1038/s41572-025-00674-7 · Cited by 16
SARS-CoV-2 paediatric inflammatory syndrome
Evans, C., & Davies, P. (2020) · Paediatrics and Child Health · doi:10.1016/j.paed.2020.12.003 · Cited by 15
Immune Responses against SARS-CoV-2—Questions and Experiences
Mangge, H., Kneihsl, M., Schnedl, W. J., Sendlhofer, G., Curcio, F., & Domenis, R. (2021) · Biomedicines · doi:10.3390/biomedicines9101342 · Cited by 16
Progress in the Diagnosis and Treatment of COVID-19 in Children: A Review
Wang, L., Li, G., Yuan, C., Yang, Y., Ling, G., Zheng, J., Zhou, Y., Zhang, T., Lin, W., & Lin, Z. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s335888 · Cited by 15
Celiac Disease and Targeting the Molecular Mechanisms of Autoimmunity in COVID Pandemic
Ailioaie, L. M., Ailioaie, C., Litscher, G., & Chiran, D. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147719 · Cited by 16
Santilli, V., Manno, E. C., Giancotta, C., Rossetti, C., Cotugno, N., Amodio, D., Rotulo, G. A., Deodati, A., Bianchi, R., Lucignani, G., et al. (2022) · Vaccines · doi:10.3390/vaccines10071136 · Cited by 14
Self-citationSARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity
Amormino, C., Tedeschi, V., Paldino, G., Arcieri, S., Fiorillo, M. T., Paiardini, A., Tuosto, L., & Kunkl, M. (2022) · Cells · doi:10.3390/cells11162526 · Cited by 15
Molinero, M., Gómez-Anca, S., Benitez, I. D., Vengoechea, J. J., González, J., Polanco, D., Gort‐Paniello, C., Moncusí‐Moix, A., García‐Hidalgo, M. C., Perez‐Pons, M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.942443 · Cited by 15
Perrone, S., Cannavò, L., Manti, S., Rulli, I., Buonocore, G., Esposito, S., & Gitto, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112836 · Cited by 15
Multisystem inflammatory syndrome in 1.2 million children: longitudinal cohort study of risk factors
Auger, N., Côté‐Corriveau, G., Kang, H., Quach, C., Lo, E., Lee, G. E., Healy‐Profitós, J., Brousseau, É., & Luu, T. M. (2023) · Pediatric Research · doi:10.1038/s41390-023-02633-y · Cited by 15
Immune responses to SARS-CoV-2 infection and vaccination in children
Brodin, P. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101794 · Cited by 17
Self-citationCell-free DNA reveals distinct pathology of multisystem inflammatory syndrome in children
Andargie, T. E., Roznik, K., Redekar, N. R., Hill, T., Zhou, W., Apalara, Z., Kong, H., Gordon, O. M., Meda, R., Park, W., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171729 · Cited by 15
The virus that shook the world: questions and answers about SARS-CoV-2 and COVID-19
Alexandrova, R., Beykov, P., Vassilev, D. I., Jukič, M., & Podlipnik, Č. (2020) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2020.1847683 · Cited by 16
Remestemcel-L Therapy for COVID-19–Associated Multisystem Inflammatory Syndrome in Children
Eckard, A. R., Borow, K. M., Mack, E. H., Burke, E., & Atz, A. M. (2021) · PEDIATRICS · doi:10.1542/peds.2020-046573 · Cited by 15
Family Transmission of COVID-19 Including a Child with MIS-C and Acute Pancreatitis
Abbas, M., & Törnhage, C. (2021) · International Medical Case Reports Journal · doi:10.2147/imcrj.s284480 · Cited by 15
Bottari, G., Confalone, V., Cotugno, N., Guzzo, I., Perdichizzi, S., Manno, E. C., Stoppa, F., & Cecchetti, C. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.676298 · Cited by 15
Self-citationPredicted B Cell Epitopes Highlight the Potential for COVID-19 to Drive Self-Reactive Immunity
Moody, R., Wilson, K., Boer, J. C., Holien, J. K., Flanagan, K. L., Jaworowski, A., & Plebanski, M. (2021) · Frontiers in Bioinformatics · doi:10.3389/fbinf.2021.709533 · Cited by 14
Qiu, D., Zhang, D., Yu, Z., Jiang, Y., & Zhu, D. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-022-02518-0 · Cited by 14
Severe Thrombocytopenic Purpura Associated with COVID-19 in a Pediatric Patient
Marinescu, A. R., Lăzureanu, V. E., Musta, V., Nicolescu, N., Herlo, A., Cut, T. G., Mureşan, C. O., Tudoran, C., Licker, M., & Laza, R. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s363716 · Cited by 15
Biomarkers of Endothelial Damage in Distinct Phases of Multisystem Inflammatory Syndrome in Children
Gelzo, M., Giannattasio, A., Maglione, M., Muzzica, S., D’Anna, C., Scialò, F., Gagliardo, T., Grieco, M., Tipo, V., & Castaldo, G. (2022) · Metabolites · doi:10.3390/metabo12080680 · Cited by 15
Current advances in antibody‐based serum biomarker studies: From protein microarray to phage display
Qi, H., Xue, J., Lai, D., Li, A., & Tao, S. (2022) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.202100098 · Cited by 15
Wei, Z. D., Liang, K., & Shetty, A. K. (2023) · Aging and Disease · doi:10.14336/ad.2023.0312 · Cited by 17
Takasago, S., Sakai, A., Sugiyama, M., Mizokami, M., Hamada, H., Ishizaka, Y., Miyoshi‐Akiyama, T., Matsunaga, A., Ueno, M., Shichino, H., et al. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.702318 · Cited by 14
Musolino, A. M., Boccuzzi, E., Buonsenso, D., Supino, M. C., Mesturino, M. A., Pitaro, E., Ferro, V., Nacca, R., Sinibaldi, S., Palma, P., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11010234 · Cited by 14
Self-citationAfrisham, R., Jadidi, Y., Davoudi, M., Moayedi, K., Karami, S., Sadegh‐Nejadi, S., Ashtary‐Larky, D., Seyyedebrahimi, S., & Alizadeh, S. (2022) · Epidemiology and Infection · doi:10.1017/s0950268822001480 · Cited by 14
Innate immune dysregulation in multisystem inflammatory syndrome in children (MIS-C)
Isaza-Correa, J. M., Ryan, L., Kelly, L. A., Allen, J., Melo, A. M., Jones, J. M., Huggard, D., Ryan, E., Maoldomhnaigh, C. Ó., Geoghehan, S., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-43390-6 · Cited by 14
Nygaard, U., Nielsen, A. B., Dungu, K. H. S., Drici, L., Holm, M., Ottenheijm, M. E., Nielsen, A. B., Glenthøj, J. P., Schmidt, L. S., Cortes, D., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06370-8 · Cited by 13
Bellos, E., Santillo, D., Vantourout, P., Jackson, H., Duret, A., Hearn, H., Seeleuthner, Y., Talouarn, E., Hodeib, S., Patel, H., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20240699 · Cited by 14
Self-citationLi, C.-H., Chiou, H.-Y. C., Lin, M., Kuo, C., Lin, Y., Lin, Y.-C., Hung, C., & Kuo, C. (2021) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2021.04.006 · Cited by 16
Atypical Inflammatory Syndrome Triggered by SARS-CoV-2 in Infants with Down Syndrome
Malle, L., Bastard, P., Martín‐Nalda, A., Carpenter, T., Bush, D. S., Patel, R. S., Colobrán, R., Soler‐Palacín, P., Casanova, J., Gans, M. D., et al. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01078-4 · Cited by 14
Public Health Interventions for COVID-19 Reduce Kawasaki Disease in Taiwan
Yang, Y., & Kuo, H. (2021) · Children · doi:10.3390/children8080623 · Cited by 14
Dhaliwal, M., Tyagi, R., Malhotra, P., Barman, P., Loganathan, S. K., Sharma, J., Sharma, K., Mondal, S., Rawat, A. K., & Singh, S. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.790273 · Cited by 15
SARS-CoV-2-specific T cell responses in patients with multisystem inflammatory syndrome in children
Lam, K. P., Chiñas, M., Julé, A. M., Taylor, M. L., Ohashi, M., Benamar, M., Crestani, E., Son, M. B. F., Chou, J. S., Gebhart, C., et al. (2022) · Clinical Immunology · doi:10.1016/j.clim.2022.109106 · Cited by 14
Bizjak, M., Emeršič, N., Avramovič, M. Z., Barbone, F., Ronchese, F., Paolera, S. D., Conversano, E., Amoroso, S., Vidoni, M., Tajnšek, T. V., et al. (2022) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/i1l2xn · Cited by 14
Folga, B. A., Karpenko, C. J., & Grygiel‐Górniak, B. (2022) · Medical Microbiology and Immunology · doi:10.1007/s00430-022-00756-3 · Cited by 14
Lakshminrusimha, S., More, K., Shah, P. S., Wynn, J. L., & Sánchez, P. J. (2023) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2023.101433 · Cited by 14
Developmental endothelial locus 1: the present and future of an endogenous factor in vessels
Jiang, D., Yue, H., Liang, W., & Wu, Z. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1347888 · Cited by 13
Taruscio, D., & Mantovani, A. (2021) · Medicina · doi:10.3390/medicina57020119 · Cited by 13
Spracklen, T. F., Mendelsohn, S. C., Butters, C., Facey‐Thomas, H. E., Stander, R., Abrahams, D., Erasmus, M., Baguma, R., Day, J., Scott, C., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.992022 · Cited by 13
Hui, W. F., Chan, R. W. Y., Wong, C. K., Kwok, K. H., Cheung, W. L., Chung, F. S., Leung, K. K. Y., Hon, K. L., & Ku, S. W. (2022) · ASAIO Journal · doi:10.1097/mat.0000000000001834 · Cited by 13
Kumar, N. P., Venkataraman, A., Varadarjan, P., Nancy, A., Rajamanickam, A., Selladurai, E., Sankaralingam, T., Thiruvengadam, K., Selvam, R., Thimmaiah, A., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.1050804 · Cited by 13
Jose, J. T., Tierney, E. S. S., Harahsheh, A. S., Dahdah, N., Raghuveer, G., Friedman, K. G., Khoury, M., Hicar, M. D., Merves, S. A., Dallaire, F., et al. (2023) · Pediatric Cardiology · doi:10.1007/s00246-023-03109-w · Cited by 13
Pathophysiological and clinical point of view on Kawasaki disease and MIS-C
Vaňková, L., Bufka, J., & Křížková, V. (2023) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2023.05.002 · Cited by 13
The mechanisms of milder clinical symptoms of COVID-19 in children compared to adults
Luo, C., Chen, W., Cai, J., & He, Y. (2024) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-024-01587-z · Cited by 16
Tran, D. M., Pham, D. V., Cao, T. V., Hoang, C. N., Nguyen, H. T. T., Nguyen, G. D., Le, C. N., Thieu, Q. Q., Tuan, T. A., Dau, H. V., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-66891-4 · Cited by 13
The past 25 years in paediatric rheumatology: insights from monogenic diseases
Özen, S., & Aksentijevich, I. A. (2024) · Nature Reviews Rheumatology · doi:10.1038/s41584-024-01145-1 · Cited by 13
Mercier, J., Ouldali, N., Melki, I., Basmaci, R., Levy, M., Titomanlio, L., Beyler, C., & Meinzer, U. (2021) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2021.04.005 · Cited by 13
Bakhle, A., Sreekumar, K., Baracho, B., Sardessai, S., & Silveira, M. P. (2021) · Pediatric Pulmonology · doi:10.1002/ppul.25732 · Cited by 13
Sante, G. D., Buonsenso, D., Rose, C. D., Tredicine, M., Palucci, I., Maio, F. D., Camponeschi, C., Bonadia, N., Biasucci, D. G., Pata, D., et al. (2022) · Children · doi:10.3390/children9050681 · Cited by 14
Partners in crime: Autoantibodies complicit in COVID‐19 pathogenesis
Taghadosi, M., Safarzadeh, E., Asgarzadeh, A., Roghani, S. A., Shamsi, A., Jalili, C., Assar, S., Soufivand, P., Pournazari, M., Feizollahi, P., et al. (2022) · Reviews in Medical Virology · doi:10.1002/rmv.2412 · Cited by 15
Fridman, M. D., Tsoukas, P., Jeewa, A., Yeung, R. S. M., Gamulka, B. D., & McCrindle, B. W. (2022) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2022.11.012 · Cited by 13
Shingleton, J., Burton, L., Williams, H. E., Finnie, T., Bennett, E., Birrell, P., Kenny, S. E., Watson-Koszel, T., Viner, R., Arditi, M., et al. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.1034280 · Cited by 14
Abdulla, Z. A., Al-Bashir, S. M., Alzoubi, H., Al-Salih, N. S., Aldamen, A. A., & Abdulazeez, A. Z. (2023) · Pathogens · doi:10.3390/pathogens12020329 · Cited by 13
Chang, J. C. H., Young, C. C., Muscal, E., Tejtel, S. K. S., Newhams, M. M., Kücükak, S., Crandall, H., Maddux, A. B., Rowan, C. M., Halasa, N., et al. (2023) · Arthritis & Rheumatology · doi:10.1002/art.42495 · Cited by 13
Edinoff, A. N., Alpaugh, E. S., Newgaard, O., Wajid, I., Klapper, R. J., Cornett, E. M., Kaye, A. M., Iyer, P. S., & Kaye, A. D. (2023) · Life · doi:10.3390/life13040889 · Cited by 13
Lampidi, S., Maritsi, D., Charakida, M., Eleftheriou, I., Farmaki, E., Spyridis, Ν., Charisi, K., Vantsi, P., Filippatos, F., Skourti, K., et al. (2024) · European Journal of Pediatrics · doi:10.1007/s00431-023-05383-5 · Cited by 13
Zaim, S. R., Savage, A. K., Gillespie, M. A. K., Castillo, J. D., Bennett, C., Torgerson, T. R., Becker, L. A., Mähler, M., Moss, L., Feser, M. L., et al. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43175 · Cited by 13
dos Reis, B. C. S., Faccion, R. S., Amendola, F. A., Moore, D. C. B. C., Zuma, M. C. C., Plaça, D. R., Filgueiras, I. S., Fonseca, D. L. M., Cabral-Marques, O., Bonomo, A. C., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1182257 · Cited by 12
Albanji, M. H., Baghafar, A. A., Alghanmi, Y. Y., Shaaban, M. M., Alkashlan, E. A., Sende, H. H., AlZahrani, M., & Filfilan, N. N. (2023) · Cureus · doi:10.7759/cureus.46918 · Cited by 13
Emerging evidence of microbial infection in causing systematic immune vasculitis in Kawasaki disease
Wang, W., Zhu, L., Li, X., Liu, Z., Lv, H., & Qian, G. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1313838 · Cited by 12
Yeoh, S., Estrada‐Rivadeneyra, D., Jackson, H., Keren, I., Galassini, R., Cooray, S., Shah, P., Agyeman, P., Basmaci, R., Carrol, E. D., et al. (2024) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000004267 · Cited by 12
SARS-CoV-2 envelope protein regulates innate immune tolerance
Geanes, E. S., McLennan, R., Pierce, S. H., Menden, H. L., Paul, O., Sampath, V., & Bradley, T. (2024) · iScience · doi:10.1016/j.isci.2024.109975 · Cited by 12
Wurm, J., Ritz, N., & Zimmermann, P. (2024) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2024.11.012 · Cited by 12
Progress on diagnosis and treatment of multisystem inflammatory syndrome in children
Peng, Z., & Zhou, G. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1551122 · Cited by 14
Rakha, S., Sobh, A., Hager, A. H., Hafez, M. M., Alsawah, G. A., Abuelkheir, M., Zeid, M. S., Nahas, M. M., & Elmarsafawy, H. M. (2021) · Cardiology in the Young · doi:10.1017/s1047951121003140 · Cited by 12
Immunopathogenesis of Different Emerging Viral Infections: Evasion, Fatal Mechanism, and Prevention
Yang, B., & Yang, K. D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.690976 · Cited by 14
Severe Rhabdomyolysis in a Child With Multisystem Inflammatory Syndrome: An Autoimmune Mechanism?
Fabi, M., Guida, F., Pierantoni, L., Greco, L., Luca, D. D., & Lanari, M. (2021) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2021.07.015 · Cited by 12
Deakin, C. T., Cornish, G. H., Ng, K. W., Faulkner, N., Bolland, W., Hope, J., Rosa, A., Harvey, R., Hussain, S., Earl, C. P., et al. (2021) · Med · doi:10.1016/j.medj.2021.08.001 · Cited by 12
Arteaga, A. A., Tran, J., Frey, H., & Lewis, A. F. (2021) · Annals of Otology Rhinology & Laryngology · doi:10.1177/00034894211055337 · Cited by 12
Evaluation of Clinical and Immune Responses in Recovered Children with Mild COVID-19
Tian, X., Bai, Z., Cao, Y., Liu, H., Liu, D., Liu, W., & Li, J. (2022) · Viruses · doi:10.3390/v14010085 · Cited by 13
Phung, N. T. N., Tran, T. T., Nguyen, T. H., Nguyen, T. H., & Nguyen, T. M. (2022) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2022.05.009 · Cited by 12
Clinical and Laboratory Characteristics of Pediatric COVID-19 Population—A Bibliometric Analysis
Maniu, I., Maniu, G., & Totan, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11205987 · Cited by 12
Manno, E. C., Amodio, D., Cotugno, N., Rossetti, C., Giancotta, C., Santilli, V., Zangari, P., Rotulo, G. A., Villani, A., Giglioni, E., et al. (2022) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000003762 · Cited by 15
Self-citationButters, C., Benede, N., Moyo-Gwete, T., Richardson, S. I., Rohlwink, U. K., Shey, M. S., Ayres, F., Manamela, N. P., Makhado, Z., Balla, S. R., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109877 · Cited by 13
Henrina, J., Putra, I. C. S., Lawrensia, S., Marta, D. S., Wijaya, E., Saboe, A., Cool, C. J., & Suciadi, L. P. (2021) · Progress in Pediatric Cardiology · doi:10.1016/j.ppedcard.2021.101365 · Cited by 12
DEL-1: a potential therapeutic target in inflammatory and autoimmune disease?
Hajishengallis, G., & Chavakis, T. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1915771 · Cited by 12
Rodriguez, L., Tan, Z., Lakshmikanth, T., Wang, J., Barcenilla, H., Swank, Z., Zuo, F., Abolhassani, H., Pavlovitch-Bedzyk, A. J., Wang, C., et al. (2024) · medRxiv · doi:10.1101/2024.02.11.24302636 · Cited by 15
Self-citationImmunological Mechanisms Underlying Allergy Predisposition After SARS-CoV-2 Infection in Children
Filippatos, F., Matara, D.-I., Michos, A. G., & Kakleas, K. (2025) · Cells · doi:10.3390/cells14191511 · Cited by 11
Outcomes of MIS-C patients treated with anakinra: a retrospective multicenter national study
Licciardi, F., Covizzi, C., Dellepiane, M., Olivini, N., Mastrolia, M. V., Vecchio, A. L., Monno, V. A., Tardi, M., Mauro, A., Alessio, M., et al. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1137051 · Cited by 11
Self-citationReiter, A., Verweyen, E. L., Queste, E., Fuehner, S., Jakob, A., Masjosthusmann, K., Hinze, C. H., Wittkowski, H., Foell, D., Meinzer, U., et al. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110237 · Cited by 11
Multisystem inflammatory syndrome in children: A review
Benvenuto, S., Avčin, T., & Taddio, A. (2024) · Acta Paediatrica · doi:10.1111/apa.17267 · Cited by 11
Taffarel, P., Barón, F. J., Rodríguez, A. P., Widmer, J., & Meregalli, C. (2021) · Archivos Argentinos de Pediatria · doi:10.5546/aap.2021.eng.e26 · Cited by 11
Lauro, R., Irrera, N., Eid, A. H., & Bitto, A. (2021) · Pathogens · doi:10.3390/pathogens10040476 · Cited by 12
Sica, R., Pennoni, S., Penta, L., Cara, G. D., & Verrotti, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136961 · Cited by 11
The Gut Microbiome of Children during the COVID-19 Pandemic
Bacorn, M., Romero-Soto, H. N., Levy, S., Chen, Q., & Hourigan, S. K. (2022) · Microorganisms · doi:10.3390/microorganisms10122460 · Cited by 14
Pillai, A., Nayak, A., Tiwari, D., Pillai, P. K., Pandita, A., Sakharkar, S., Balasubramanian, H., & Kabra, N. S. (2023) · Vaccines · doi:10.3390/vaccines11030693 · Cited by 11
Amodio, D., Pascucci, G. R., Cotugno, N., Rossetti, C., Manno, E. C., Pighi, C., Rocchi, F., D’Alessandro, A., Perrone, M. A., Valentini, A., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109751 · Cited by 10
Self-citationComing Out to Play: Privacy, Data Protection, Children’s Health, and COVID-19 Research
Beauvais, M. J. S., & Knoppers, B. M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.659027 · Cited by 11
Hensley‐McBain, T., & Manuzak, J. A. (2021) · Journal of Clinical Investigation · doi:10.1172/jci151467 · Cited by 11
Generalić, A., Davidović, M., Kos, I., Vrljičak, K., & Lamot, L. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.760070 · Cited by 11
Metadata
- Authors
- Consiglio, C. R., Cotugno, N., Sardh, F., Pou, C., Amodio, D., Rodriguez, L., Tan, Z., Zicari, S., Ruggiero, A., Pascucci, G. R., Santilli, V., Campbell, T., Bryceson, Y., Eriksson, D., Wang, J., Marchesi, A., Lakshmikanth, T., Campana, A., Villani, A., Rossi, P., Landegren, N., Palma, P., & Brodin, P.
- Affiliations
- Science for Life Laboratory (SE)
- University of Rome Tor Vergata (IT)
- Karolinska University Hospital (SE)
- Bambino Gesù Children's Hospital (IT)
- Karolinska Institutet (SE)
- Uppsala University (SE)
- Corresponding author
- Rossi, Paolo
- Landegren, Nils
- Brodin, Petter
- ORCID
- Consiglio, Camila Rosat
- Cotugno, Nicola
- Pou, Christian
- Amodio, Donato
- Rodriguez, Lucie
- Tan, Ziyang
- Zicari, Sonia
- Ruggiero, Alessandra
- Pascucci, Giuseppe Rubens
- Santilli, Veronica
- Campbell, Tessa
- Bryceson, Yenan
- Eriksson, Daniel
- Wang, Jun
- Marchesi, Alessandra
- Lakshmikanth, Tadepally
- Campana, Andrea
- Villani, Alberto
- Rossi, Paolo
- Landegren, Nils
- Palma, Paolo
- Brodin, Petter
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 183
- Issue
- 4
- Pages
- 968-981.e7
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC7474869
- OpenAlex
- W3083424448
- Cited by
- 919
- References
- 58
- Citations by year
- 2026: 30 · 2025: 46 · 2024: 89 · 2023: 185 · 2022: 218 · 2021: 311 · 2020: 36
- FWCI
- 171.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, cc-by)
- Uppsala University Publications (Uppsala University) (submittedVersion, other-oa)
- Funders
- Knut och Alice Wallenbergs Stiftelse
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Kawasaki Disease and Coronary Complications
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Keywords
- multisystem inflammatory syndrome in children, COVID-19 pandemic, SARS-CoV-2, Kawasaki disease, vasculitis, autoimmunity, cytokine storm, T cell subsets, IL-17A, autoantibodies, pediatric immunology, blood immune cells
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Autoantibodies, Child, Child, Preschool, Female, Humans, Infant, Male, Mucocutaneous Lymph Node Syndrome, Pneumonia, Viral, Severity of Illness Index, T-Lymphocyte Subsets, Cytokines, Coronavirus Infections, Systemic Inflammatory Response Syndrome, Proteome, Principal Component Analysis, Immunity, Humoral, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
