The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity
Open accessAbstract
Summary The oral mucosa remains an understudied barrier tissue. This is a site of rich exposure to antigens and commensals, and a tissue susceptible to one of the most prevalent human inflammatory diseases, periodontitis. Towards understanding tissue-specific pathophysiology, we compile a single cell transcriptome atlas of human oral mucosa in health individuals and patients with periodontitis. We uncover the complex cellular landscape of oral mucosal tissues and identify epithelial and stromal cell populations with inflammatory signatures that promote antimicrobial defenses and neutrophil recruitment. Our findings link exaggerated stromal cell responsiveness with enhanced neutrophil and leukocyte infiltration in periodontitis. Our work provides a resource characterizing the role of tissue stroma in regulating mucosal tissue homeostasis and disease pathogenesis.
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Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Structure, function and diversity of the healthy human microbiome
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Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
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Oral diseases: a global public health challenge
Peres, M. A., Macpherson, L. M. D., Weyant, R. J., Daly, B., Venturelli, R., Mathur, M. R., Listl, S., Celeste, R. K., Guarnizo-Herreño, C. C., Kearns, C., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31146-8 · Cited by 4,054
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Self-citationThe Oral Microbiota: Dynamic Communities and Host Interactions
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NicheNet: Modeling intercellular communication by linking ligands to target genes
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Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012
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Cited by
The oral microbiome: diversity, biogeography and human health
Baker, J. L., Mark Welch, J. L., Kauffman, K. M., McLean, J. S., & He, X. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00963-6 · Cited by 661
The role of the host—Neutrophil biology
Chapple, I. L. C., Hirschfeld, J., Kantarci, A., Wilensky, A., & Shapira, L. (2023) · Periodontology 2000 · doi:10.1111/prd.12490 · Cited by 83
Single-cell and spatial detection of senescent cells using DeepScence
Qu, Y., Ji, B., Dong, R., Gu, L., Chan, C., Xie, J., Glass, C., Wang, X.-F., Nixon, A. B., & Ji, Z. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.101035 · Cited by 30
Metadata
- Authors
- Williams, D. W., Greenwell-Wild, T., Brenchley, L., Dutzan, N., Overmiller, A., Sawaya, A. P., Webb, S., Martin, D., Hajishengallis, G., Divaris, K., Morasso, M., Haniffa, M., & Moutsopoulos, N. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 184
- Issue
- 15
- Pages
- 4090-4104.e15
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3166110253
- Cited by
- 512
- References
- 54
- FWCI
- 58.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Williams, D. W., Greenwell-Wild, T., Brenchley, L., Dutzan, N., Overmiller, A., Sawaya, A. P., Webb, S., Martin, D., Hajishengallis, G., Divaris, K., Morasso, M., Haniffa, M., & Moutsopoulos, N. M. (2021). Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity. Cell. https://doi.org/10.1016/j.cell.2021.05.013
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