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Cited by 661Oral microbiology and periodontitis researchGut microbiota and healthMicrobial Community Ecology and Physiology

The oral microbiome: diversity, biogeography and human health

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Baker, Jonathon L., Mark Welch, Jessica L., Kauffman, Kathryn M., McLean, Jeffrey S., He, Xuesong·2024·Nature Reviews Microbiology
DOI 10.1038/s41579-023-00963-6PMC PMC11084736
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Abstract

The human oral microbiota is highly diverse and has a complex ecology, comprising bacteria, microeukaryotes, archaea and viruses. These communities have elaborate and highly structured biogeography that shapes metabolic exchange on a local scale and results from the diverse microenvironments present in the oral cavity. The oral microbiota also interfaces with the immune system of the human host and has an important role in not only the health of the oral cavity but also systemic health. In this Review, we highlight recent advances including novel insights into the biogeography of several oral niches at the species level, as well as the ecological role of candidate phyla radiation bacteria and non-bacterial members of the oral microbiome. In addition, we summarize the relationship between the oral microbiota and the pathology of oral diseases and systemic diseases. Together, these advances move the field towards a more holistic understanding of the oral microbiota and its role in health, which in turn opens the door to the study of novel preventive and therapeutic strategies.

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Cited by

Sorted by citations

Authors
Baker, J. L., Mark Welch, J. L., Kauffman, K. M., McLean, J. S., & He, X.
Affiliations
  • J. Craig Venter Institute (US)
  • University at Buffalo, State University of New York (US)
  • University of Washington (US)
  • Harvard University (US)
Corresponding author
He, Xuesong
ORCID
Venue
Nature Reviews Microbiology
Publisher
Springer Science and Business Media LLC
Published
2023-09-12
Volume
22
Issue
2
Pages
89-104
ISSN
  • 1740-1526 (ISSN-L)
  • 1740-1534
DOI
10.1038/s41579-023-00963-6
PMC
PMC11084736
OpenAlex
W4386625274
Cited by
661
References
13
Citations by year
2026: 284 · 2025: 262 · 2024: 106 · 2023: 9
FWCI
31.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Dental and Craniofacial Research (R03DE030987, K99DE029228, R01DE022586, R01DE029479, R01DE031470, R00DE029228, R01DE030943, R01DE023810, R01DE016937)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords
oral microbiota, microbial biogeography, Candidate Phyla Radiation, archaea, viruses, microeukaryotes, host-microbe interactions, oral diseases, systemic disease, oral health, microbial diversity
MeSH terms
Archaea, Bacteria, Humans, Mouth, Viruses, Microbiota

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