The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies
Copin, Richard, Baum, Alina, Wloga, Elzbieta, Pascal, Kristen E., Giordano, Stephanie, Fulton, Benjamin O., Zhou, Anbo, Negron, Nicole, Lanza, Kathryn, Chan, Newton, Coppola, Angel, Chiu, Joyce, Ni, Min, Wei, Yi, Atwal, Gurinder S., Hernandez, Annabel Romero, Saotome, Kei, Zhou, Yi, Franklin, Matthew C., Hooper, Andrea T., McCarthy, Shane, Hamon, Sara, Hamilton, Jennifer D., Staples, Hilary M., Alfson, Kendra, Carrion, Ricardo, Ali, Shazia, Norton, Thomas, Somersan-Karakaya, Selin, Sivapalasingam, Sumathi, Herman, Gary A., Weinreich, David M., Lipsich, Leah, Stahl, Neil, Murphy, Andrew J., Yancopoulos, George D., Kyratsous, Christos A.·2021·Cell
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- Regen-Cov ® Antibody Cocktail Bioanalytical Strategy: Comparison of Lc-Mrm-Ms and Immunoassay Methods for Drug QuantificationSusan C. Irvin, Samit Ganguly, Rachel Weiss, Chinnasamy Elango, Xuefei Zhong, Yuan Mao, Hong Yan, Ning Li, Giane Sumner, Kenneth C. Turner et al. · 2021 · Bioanalysis
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- Estimated Health Outcomes and Costs of COVID-19 Prophylaxis With Monoclonal Antibodies Among Unvaccinated Household Contacts in the USAbraham D. Flaxman, Rodal S. Issema, Ruanne V. Barnabas, Jennifer M. Ross · 2022 · JAMA Network Open
- Serosurvey in SARS‐CoV‐2 inactivated vaccine‐elicited neutralizing antibodies against authentic SARS‐CoV‐2 and its viral variantsLirong Zou, Huan Zhang, Zhonghua Zheng, Yushan Jiang, Yushi Huang, Shujian Lin, Jianxiang Yu, Xiaoling Deng, Jianfeng He, Chenguang Shen et al. · 2022 · Journal of Medical Virology
- Efficacy and Safety of SARS-CoV-2 Neutralizing Antibody JS016 in Hospitalized Chinese Patients with COVID-19: a Phase 2/3, Multicenter, Randomized, Open-Label, Controlled TrialRun Dong, Li Jiang, Ting Yang, Changsong Wang, Yi Zhang, Xu Chen, Jianfeng Xie, Yuanbin Guo, Li Weng, Yan Ming Kang et al. · 2022 · Antimicrobial Agents and Chemotherapy
- The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized PatientsMegan McAleavy, Qian Zhang, Peter J. Ehmann, Jianing Xu, Matthew F. Wipperman, Dharani K. Ajithdoss, Pan Li, Matthew Wakai, Raphael Simonson, Abhilash Gadi et al. · 2021 · Molecular and Cellular Biology
- Impact of Casirivimab-Imdevimab on Severe Acute Respiratory Syndrome Coronavirus 2 Delta Variant Nasopharyngeal Virus Load and Spike QuasispeciesCamille Vellas, Arnaud Del Bello, Géraldine Gaube, Pauline Trémeaux, Nicolas Jeanne, Noémie Ranger, Guillaume Martin‐Blondel, Pierre Delobel, Nassim Kamar, Jacques Izopet · 2022 · Open Forum Infectious Diseases
- A comprehensive review on immunogen and immune-response proteins of SARS-CoV-2 and their applications in prevention, diagnosis, and treatment of COVID-19Daohong Zhang, Deepak Kukkar, Ki‐Hyun Kim, Poornima Bhatt · 2024 · International Journal of Biological Macromolecules
- Impact of mAb-FcRn affinity on IgG transcytosis across human well-differentiated airway epitheliumKohei Togami, Whitney Wolf, Lucas C. Olson, Madison Card, Limei Shen, Alison Schaefer, Kenichi Okuda, Larry Zeitlin, Michael H. Pauly, Kevin J. Whaley et al. · 2024 · Frontiers in Immunology
- Monoclonal antibodies against the spike protein alter the endogenous humoral response to SARS-CoV-2 vaccination and infectionChristopher D. Petro, Andrea T. Hooper, Avery Peace, Kusha A Mohammadi, Will Eagan, Sayda M. Elbashir, Anthony T. DiPiazza, Daniel L. Makrinos, Kristen E. Pascal, Pooja Bandawane et al. · 2024 · Science Translational Medicine
- Passive Immunization in the Prevention and Treatment of Viral InfectionsRomila Moirangthem, Yotam Bar‐On · 2025 · European Journal of Immunology
- Spike Protein Genetic Evolution in Patients at High Risk of Severe Coronavirus Disease 2019 Treated by Monoclonal AntibodiesValentin Leducq, Karen Zafilaza, Antoine Fauchois, Emna Ghidaoui, Sophie Sayon, Céline Dorival, Marie-Laure Meledje, Clovis Lusivika‐Nzinga, Youri Yordanov, Guillaume Martin‐Blondel et al. · 2023 · The Journal of Infectious Diseases
- Antiviral therapy for COVID-19 virus: A narrative review and bibliometric analysisSaeid Mezail Mawazi, Nousheen Fathima, Syed Mahmood, Sinan Mohammed Abdullah Al-Mahmood · 2024 · The American Journal of Emergency Medicine
- Phase 2 dose-ranging study of the virologic efficacy and safety of the combination COVID-19 antibodies casirivimab and imdevimab in the outpatient settingCynthia Portal‐Celhay, Eduardo Forleo‐Neto, Will Eagan, Bret J. Musser, John D. Davis, Kenneth C. Turner, Thomas D. Norton, Andrea T. Hooper, Jennifer D. Hamilton, Cynthia Pan et al. · 2021 · medRxiv
- A Potent Recombinant Polyclonal Antibody Therapeutic for Protection Against New Severe Acute Respiratory Syndrome Coronavirus 2 Variants of ConcernNicholas P. Wayham, Ariel R. Niedecken, Jan Fredrik Simons, Yao Chiang, Angélica V. Medina‐Cucurella, Rena A. Mizrahi, Ellen K. Wagner, Ashley Gras, Ilana Segal, Peyton Witte et al. · 2023 · The Journal of Infectious Diseases
- Resistance Analysis Following Sotrovimab Treatment in Participants with COVID-19 During the Phase III COMET-ICE StudySambhavi Subramanian, Gretja Schnell, Julia di Iulio, Anil Kumar Gupta, Adrienne E. Shapiro, Elias H. Sarkis, Amanda Lopuski, Amanda Peppercorn, Melissa Aldinger, Christy M. Hebner et al. · 2023 · Future Virology
- Structural insights into immune escape at killer T cell epitope by SARS-CoV-2 Spike Y453F variantsShasha Deng, Zhihao Xu, Meihua Wang, Jing Hu, Zhuan Liu, Fang Zhu, Peiyi Zheng, Arnaud John Kombe Kombe, Hongliang Zhang, Songquan Wu et al. · 2024 · Journal of Biological Chemistry
- Isolation of human monoclonal antibodies with neutralizing activity to a broad spectrum of SARS-CoV-2 viruses including the Omicron variantsMikako Ueno, Naoko Iwata‐Yoshikawa, Akihiro Matsunaga, Tadashi Okamura, Sho Saito, Shinobu Ashida, Isao Yoshida, Mami Nagashima, Hiroyuki Asakura, Yu Yaoita et al. · 2022 · Antiviral Research
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- Structural insight into broadening SARS-CoV-2 neutralization by an antibody cocktail harbouring both NTD and RBD potent antibodiesWenling Jiang, Yanan Jiang, Hui Sun, Tingting Deng, Kunyu Yu, Qianjiao Fang, Huimin Ge, Miaoling Lan, Yanling Lin, Zhongyue Fang et al. · 2024 · Emerging Microbes & Infections
- Preparation and characterization of mouse-derived monoclonal antibodies against the hemagglutinin of the H1N1 influenza virusXiantian Lin, Fan Yang, Sijing Yan, Han‐Chung Wu, Ping Wang, Yuxi Zhao, Danrong Shi, Hangping Yao, Haibo Wu, Lanjuan Li · 2024 · Virus Research
- Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge modelNicholas J. Tursi, Sophia M. Reeder, Yevel Flores-García, Mamadou A. Bah, Shamika Mathis-Torres, Berenice Salgado-Jimenez, Rianne N. Esquivel, Ziyang Xu, Jacqueline D. Chu, Laurent M. P. F. Humeau et al. · 2022 · Scientific Reports
- SARS-CoV-2 Mutations, Diagnosis and Their ConcernYakup Artik, Nevra Pelin Cesur, Nelisa Türkoğlu Laçin · 2022 · Archives of Molecular Biology and Genetics
- Convergent evolution in SARS-CoV-2 Spike creates a variant soup that causes new COVID-19 wavesDaniele Focosi, Rodrigo Quiroga, Scott A. McConnell, Marc C. Johnson, Arturo Casadevall · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Native SEC and Reversed-Phase LC–MS Reveal Impact of Fab Glycosylation of Anti-SARS-COV-2 Antibodies on Binding to the Receptor Binding DomainDaniel W. Woodall, Christy A. Thomson, Thomas M. Dillon, Arnold McAuley, Lydia B. Green, Ian N. Foltz, Pavel V. Bondarenko · 2023 · Analytical Chemistry
- Preclinical discovery and development of the casirivimab + imdevimab cocktail for the treatment of novel coronavirus infection: the rise and fallMarco Tuccori, Irma Convertino, Sara Ferraro, Emiliano Cappello, Giulia Valdiserra, Giulia de Luca, Massimo Franchini, Daniele Focosi · 2022 · Expert Opinion on Drug Discovery
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