The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The interferon landscape along the respiratory tract impacts the severity of COVID-19
Open accessAbstract
Severe coronavirus disease 2019 (COVID-19) is characterized by overproduction of immune mediators, but the role of interferons (IFNs) of the type I (IFN-I) or type III (IFN-III) families remains debated. We scrutinized the production of IFNs along the respiratory tract of COVID-19 patients and found that high levels of IFN-III, and to a lesser extent IFN-I, characterize the upper airways of patients with high viral burden but reduced disease risk or severity. Production of specific IFN-III, but not IFN-I, members denotes patients with a mild pathology and efficiently drives the transcription of genes that protect against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In contrast, compared to subjects with other infectious or noninfectious lung pathologies, IFNs are overrepresented in the lower airways of patients with severe COVID-19 that exhibit gene pathways associated with increased apoptosis and decreased proliferation. Our data demonstrate a dynamic production of IFNs in SARS-CoV-2-infected patients and show IFNs play opposing roles at distinct anatomical sites.
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Clinical characteristics of coronavirus disease 2019 in China
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Factors associated with COVID-19-related death using OpenSAFELY
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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
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Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
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SARS-CoV-2-Specific Immune Response and the Pathogenesis of COVID-19
Gusev, E., Sarapultsev, A., Solomatina, L., & Chereshnev, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031716 · Cited by 281
SEACells infers transcriptional and epigenomic cellular states from single-cell genomics data
Persad, S., Choo, Z.-N., Dien, C., Sohail, N., Masilionis, I., Chaligné, R., Nawy, T., Brown, C. C., Sharma, R., Pe’er, I., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01716-9 · Cited by 222
Metadata
- Authors
- Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Clementi, N., Ferrarese, R., Sisti, S., Criscuolo, E., Spreafico, R., Long, J. M., Ambrosi, A., Liu, E., Frangipane, V., Saracino, L., Bozzini, S., Marongiu, L., Facchini, F. A., Bottazzi, A., Fossali, T., Colombo, R., Clementi, M., Tagliabue, E., Chou, J., Pontiroli, A. E., Meloni, F., Wack, A., Mancini, N., & Zanoni, I.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 184
- Issue
- 19
- Pages
- 4953-4968.e16
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W3194625583
- Cited by
- 269
- References
- 46
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sposito, B., Broggi, A., Pandolfi, L., Crotta, S., Clementi, N., Ferrarese, R., Sisti, S., Criscuolo, E., Spreafico, R., Long, J. M., Ambrosi, A., Liu, E., Frangipane, V., Saracino, L., Bozzini, S., Marongiu, L., Facchini, F. A., Bottazzi, A., Fossali, T., . . . Zanoni, I. (2021). The interferon landscape along the respiratory tract impacts the severity of COVID-19. Cell. https://doi.org/10.1016/j.cell.2021.08.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
