The DOI matches its Crossref record; 228 of the 228 references it cites were found in a registry or an index.
Therapeutic in vivo delivery of gene editing agents
Open accessAbstract
In vivo gene editing therapies offer the potential to treat the root causes of many genetic diseases. Realizing the promise of therapeutic in vivo gene editing requires the ability to safely and efficiently deliver gene editing agents to relevant organs and tissues in vivo. Here, we review current delivery technologies that have been used to enable therapeutic in vivo gene editing, including viral vectors, lipid nanoparticles, and virus-like particles. Since no single delivery modality is likely to be appropriate for every possible application, we compare the benefits and drawbacks of each method and highlight opportunities for future improvements.
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Cites
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Cited by
Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice
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Metadata
- Authors
- Raguram, A., Banskota, S., & Liu, D. R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 185
- Issue
- 15
- Pages
- 2806-2827
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4283836459
- Cited by
- 522
- References
- 228
- FWCI
- 27.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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