Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 632

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Glioblastoma hijacks neuronal mechanisms for brain invasion

Open access
Venkataramani, Varun, Yang, Yvonne, Schubert, Marc Cicero, Reyhan, Ekin, Tetzlaff, Svenja Kristin, Wißmann, Niklas, Botz, Michael, Soyka, Stella Judith, Beretta, Carlo Antonio, Pramatarov, Rangel Lyubomirov, Fankhauser, Laura, Garofano, Luciano, Freudenberg, Alexander, Wagner, Julia, Tanev, Dimitar Ivanov, Ratliff, Miriam, Xie, Ruifan, Kessler, Tobias, Hoffmann, Dirk C., Hai, Ling, Dörflinger, Yvette, Hoppe, Simone, Yabo, Yahaya A., Golebiewska, Anna, Niclou, Simone P., Sahm, Felix, Lasorella, Anna, Slowik, Martin, Döring, Leif, Iavarone, Antonio, Wick, Wolfgang, Kuner, Thomas, Winkler, Frank·2022·Cell
DOI 10.1016/j.cell.2022.06.054
Open this paper in CoChat — free account

Abstract

Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma cells forms a functional and therapy-resistant tumor cell network interconnected by tumor microtubes (TMs). Other subpopulations appear unconnected, and their biological role remains unclear. Here, we demonstrate that whole-brain colonization is fueled by glioblastoma cells that lack connections with other tumor cells and astrocytes yet receive synaptic input from neurons. This subpopulation corresponds to neuronal and neural-progenitor-like tumor cell states, as defined by single-cell transcriptomics, both in mouse models and in the human disease. Tumor cell invasion resembled neuronal migration mechanisms and adopted a Lévy-like movement pattern of probing the environment. Neuronal activity induced complex calcium signals in glioblastoma cells followed by the de novo formation of TMs and increased invasion speed. Collectively, superimposing molecular and functional single-cell data revealed that neuronal mechanisms govern glioblastoma cell invasion on multiple levels. This explains how glioblastoma's dissemination and cellular heterogeneity are closely interlinked.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.cell.2022.06.054

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 102 references

Cited by

See all 632

Metadata

Authors
Venkataramani, V., Yang, Y., Schubert, M. C., Reyhan, E., Tetzlaff, S. K., Wißmann, N., Botz, M., Soyka, S. J., Beretta, C. A., Pramatarov, R. L., Fankhauser, L., Garofano, L., Freudenberg, A., Wagner, J., Tanev, D. I., Ratliff, M., Xie, R., Kessler, T., Hoffmann, D. C., Hai, L., Dörflinger, Y., Hoppe, S., Yabo, Y. A., Golebiewska, A., Niclou, S. P., Sahm, F., Lasorella, A., Slowik, M., Döring, L., Iavarone, A., Wick, W., Kuner, T., & Winkler, F.
Venue
Cell
Publisher
Elsevier BV
Published
2022-08
Volume
185
Issue
16
Pages
2899-2917.e31
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2022.06.054
OpenAlex
W4288950914
Cited by
632
References
102
FWCI
61.66
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Glioblastoma hijacks neuronal mechanisms for brain invasion. https://app.cochat.ai/papers/10.1016/j.cell.2022.06.054
The paper
Venkataramani, V., Yang, Y., Schubert, M. C., Reyhan, E., Tetzlaff, S. K., Wißmann, N., Botz, M., Soyka, S. J., Beretta, C. A., Pramatarov, R. L., Fankhauser, L., Garofano, L., Freudenberg, A., Wagner, J., Tanev, D. I., Ratliff, M., Xie, R., Kessler, T., Hoffmann, D. C., . . . Winkler, F. (2022). Glioblastoma hijacks neuronal mechanisms for brain invasion. Cell. https://doi.org/10.1016/j.cell.2022.06.054

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.