The DOI matches its Crossref record; 447 of the 447 references it cites were found in a registry or an index.
Small and long non-coding RNAs: Past, present, and future
Open accessAbstract
Since the introduction of the central dogma of molecular biology in 1958, various RNA species have been discovered. Messenger RNAs transmit genetic instructions from DNA to make proteins, a process facilitated by housekeeping non-coding RNAs (ncRNAs) such as small nuclear RNAs (snRNAs), ribosomal RNAs (rRNAs), and transfer RNAs (tRNAs). Over the past four decades, a wide array of regulatory ncRNAs have emerged as crucial players in gene regulation. In celebration of Cell's 50th anniversary, this Review explores our current understanding of the most extensively studied regulatory ncRNAs-small RNAs and long non-coding RNAs (lncRNAs)-which have profoundly shaped the field of RNA biology and beyond. While small RNA pathways have been well documented with clearly defined mechanisms, lncRNAs exhibit a greater diversity of mechanisms, many of which remain unknown. This Review covers pivotal events in their discovery, biogenesis pathways, evolutionary traits, action mechanisms, functions, and crosstalks among ncRNAs. We also highlight their roles in pathophysiological contexts and propose future research directions to decipher the unknowns of lncRNAs by leveraging lessons from small RNAs.
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Cites
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Metadata
- Authors
- Chen, L.-L., & Kim, V. N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2024-11
- Volume
- 187
- Issue
- 23
- Pages
- 6451-6485
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W4404369323
- Cited by
- 425
- References
- 447
- FWCI
- 64.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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