Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

Role for a bidentate ribonuclease in the initiation step of RNA interference

Bernstein, E., Caudy, A. A., Hammond, S. M., & Hannon, G. J. (2001) · Nature · doi:10.1038/35053110 · Cited by 4,896 · see citing works

HOW CELLS RESPOND TO INTERFERONS

Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932 · see citing works

RNA interference is mediated by 21- and 22-nucleotide RNAsPreprint

Elbashir, S. M., Lendeckel, W., & Tuschl, T. (2001) · Genes & Development · doi:10.1101/gad.862301 · Cited by 3,310 · see citing works

A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants

Hamilton, A. J., & Baulcombe, D. C. (1999) · Science · doi:10.1126/science.286.5441.950 · Cited by 3,048 · see citing works

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

Hammond, S. M., Bernstein, E., Beach, D., & Hannon, G. J. (2000) · Nature · doi:10.1038/35005107 · Cited by 3,006 · see citing works

RNAi

Zamore, P. D., Tuschl, T., Sharp, P. A., & Bartel, D. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80620-0 · Cited by 2,667 · see citing works

Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy

Sullivan, T. L., Escalante‐Alcalde, D., Bhatt, H., Anver, M. R., BHAT, N. K., Nagashima, K., Stewart, C. L., & Burke, B. E. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.913 · Cited by 1,197 · see citing works

Transcriptional silencing and promoter methylation triggered by double‐stranded RNA

Mette, M. F., Aufsatz, W., van der Winden, J., Matzke, M. A., & Matzke, A. J. M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.19.5194 · Cited by 869 · see citing works

Post-transcriptional gene silencing by double-stranded RNA

Hammond, S. M., Caudy, A. A., & Hannon, G. J. (2001) · Nature Reviews Genetics · doi:10.1038/35052556 · Cited by 858 · see citing works

Use of double-stranded RNA interference in <i>Drosophila</i> cell lines to dissect signal transduction pathways

Clemens, J. C., Worby, C. A., Simonson-Leff, N., Muda, M., Maehama, T., Hemmings, B. A., & Dixon, J. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110149597 · Cited by 843 · see citing works

CpG methylation, chromatin structure and gene silencing—a three‐way connection

Razin, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.4905 · Cited by 791 · see citing works

Specific interference with gene function by double-stranded RNA in early mouse development

Wianny, F., & Zernicka‐Goetz, M. (1999) · Nature Cell Biology · doi:10.1038/35000016 · Cited by 722 · see citing works

RNA interference—2001Preprint

Sharp, P. A. (2001) · Genes & Development · doi:10.1101/gad.880001 · Cited by 703 · see citing works

RNA-triggered gene silencing

Fire, A. Z., & Fire, A. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01818-1 · Cited by 626 · see citing works

Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI

Manche, L., Green, S. R., Schmedt, C., & Mathews, M. B. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5238 · Cited by 484 · see citing works

Inhibition of cell-free protein synthesis by pppA2′ p5′ A2′ p5′ A: a novel oligonucleotide synthesized by interferon-treated L cell extracts

Clemens, M. J., & Williams, B. (1978) · Cell · doi:10.1016/0092-8674(78)90329-x · Cited by 440 · see citing works

Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference

Svoboda, P., Stein, P., Hayashi, H., & Schultz, R. M. (2000) · Development · doi:10.1242/dev.127.19.4147 · Cited by 407 · see citing works

Functional Anatomy of a dsRNA Trigger

Parrish, S., Fleenor, J., Xu, S., Mello, C. C., & Fire, A. Z. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00106-4 · Cited by 401 · see citing works

Guidebook to the cytoskeletal and motor proteins

(1994) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)90276-3 · Cited by 379 · see citing works

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells.

Minks, M. A., West, D. K., Benvin, S., & Baglioni, C. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)86690-5 · Cited by 258 · see citing works

RNA-directed DNA methylation

Wassenegger, M. (2000) · Plant Molecular Biology · doi:10.1023/a:1006479327881 · Cited by 244 · see citing works

dsRNA-mediated gene silencing in cultured Drosophila cells: a tissue culture model for the analysis of RNA interference

Caplen, N. J., Fleenor, J., Fire, A. Z., & Morgan, R. A. (2000) · Gene · doi:10.1016/s0378-1119(00)00224-9 · Cited by 232 · see citing works

Guidebook to the Cytoskeletal and Motor Proteins

(1999) · doi:10.1093/oso/9780198599579.001.0001 · Cited by 211 · see citing works

Nucleocytoplasmic Shuttling Factors Including Ran and CRM1 Mediate Nuclear Export of NFAT In Vitro

Kehlenbach, R. H., Dickmanns, A., & Gerace, L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.863 · Cited by 180 · see citing works

Self assembly of NuMA: multiarm oligomers as structural units of a nuclear lattice

Harborth, J., Wang, J., Gueth-Hallonet, C., Weber, K., & Osborn, M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1689 · Cited by 118 · see citing works

Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV poliovirus using synthetic stabilized ribozymes

Macejak, D. G., Jensen, K. L., Jamison, S. F., Domenico, K., Roberts, E. C., Chaudhary, N., von Carlowitz, I., Bellon, L., Tong, M. J., Conrad, A. J., et al. (2000) · Hepatology · doi:10.1002/hep.510310331 · Cited by 114 · see citing works

Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target

Ui‐Tei, K., Zenno, S., Miyata, Y., et al. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01883-4 · Cited by 104 · see citing works

Replicating satellite RNA induces sequence-specific DNA methylation and truncated transcripts in plants

Wang, M. B., Wesley, S. V., Finnegan, E. J., et al. (2001) · RNA · doi:10.1017/s1355838201001224 · Cited by 97 · see citing works

Transcriptional and Posttranscriptional Silencing of Rodent α1(I) Collagen by a Homologous Transcriptionally Self-Silenced Transgene

Bahramian, M. B., & Zarbl, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.274 · Cited by 47 · see citing works

Induction of nuclear lamins A/C in macrophages in in vitro cultures of rat bone marrow precursor cells and human blood monocytes, and in macrophages elicited in vivo by thioglycollate stimulation

Röber, R.-A., Gieseler, R. K. H., Peters, J. H., et al. (1990) · Experimental Cell Research · doi:10.1016/0014-4827(90)90184-c · Cited by 44 · see citing works

Untitled work

(2001) · doi:10.1002/1439-7633(20010401)2:4

Knocking down barriers: advances in siRNA delivery

Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115 · see citing works

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083 · see citing works

The polycomb group protein EZH2 is involved in progression of prostate cancer

Varambally, S., Dhanasekaran, S. M., Zhou, M., Barrette, T. R., Kumar-Sinha, C., Sanda, M. G., Ghosh, D., Pienta, K. J., Sewalt, R. G. A. B., Otte, A. P., et al. (2002) · Nature · doi:10.1038/nature01075 · Cited by 2,717 · see citing works

Functional siRNAs and miRNAs exhibit strand bias

Khvorova, A., Reynolds, A., & Jayasena, S. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00801-8 · Cited by 2,645 · see citing works

RNA targeting with CRISPR–Cas13

Abudayyeh, O. O., Gootenberg, J. S., Essletzbichler, P., Han, S., Joung, J., Belanto, J. J., Verdine, V., Cox, D. B. T., Kellner, M. J., Regev, A., et al. (2017) · Nature · doi:10.1038/nature24049 · Cited by 2,093 · see citing works

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

Nishimura, K., Fukagawa, T., Takisawa, H., Kakimoto, T., & Kanemaki, M. (2009) · Nature Methods · doi:10.1038/nmeth.1401 · Cited by 1,663 · see citing works

New approaches and procedures for cancer treatment: Current perspectives

Debela, D. T., Muzazu, S. G., Heraro, K. D., Ndalama, M. T., Mesele, B. W., Haile, D. C., Kitui, S. K., & Manyazewal, T. (2021) · SAGE Open Medicine · doi:10.1177/20503121211034366 · Cited by 1,597 · see citing works

DNA Damage Foci at Dysfunctional Telomeres

Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409 · see citing works

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348 · see citing works

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

Kole, R., Krainer, A. R., & Altman, S. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3625 · Cited by 1,152 · see citing works

Genome-scale CRISPR-Cas9 Knockout and Transcriptional Activation Screening

Joung, J., Konermann, S., Gootenberg, J. S., Abudayyeh, O. O., Platt, R. J., Brigham, M. D., Sanjana, N. E., & Zhang, F. (2017) · Nature Protocols · doi:10.1038/nprot.2017.016 · Cited by 1,243 · see citing works

Overcoming cellular barriers for RNA therapeutics

Dowdy, S. F. (2017) · Nature Biotechnology · doi:10.1038/nbt.3802 · Cited by 1,139 · see citing works

Differential Function of the Prolyl Hydroxylases PHD1, PHD2, and PHD3 in the Regulation of Hypoxia-inducible Factor

Appelhoff, R. J., Tian, Y.-M., Raval, R. R., Turley, H., Harris, A. L., Pugh, C. W., Ratcliffe, P. J., & Gleadle, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406026200 · Cited by 1,108 · see citing works

Strategies for silencing human disease using RNA interference

Kim, D. H., & Rossi, J. J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2006 · Cited by 1,078 · see citing works

RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex

Hale, C. R., Zhao, P., Olson, S., Duff, M. O., Graveley, B. R., Wells, L., Terns, R. M., & Terns, M. P. (2009) · Cell · doi:10.1016/j.cell.2009.07.040 · Cited by 1,031 · see citing works

siRNA versus miRNA as therapeutics for gene silencing

Lam, J. K. W., Chow, M. Y. T., Zhang, Y., & Leung, S. W. S. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.23 · Cited by 1,081 · see citing works

The Connectivity Map: A new tool for biomedical research

Lamb, J. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2044 · Cited by 945 · see citing works

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works

Safety and efficacy of RNAi therapy for transthyretin amyloidosis

Coelho, T., Adams, D., Silva, A., Lozeron, P., Hawkins, P. N., Mant, T., Perez, J., Chiesa, J., Warrington, S., Tranter, E., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1208760 · Cited by 971 · see citing works

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2614 · Cited by 948 · see citing works

A Rapid, Reversible, and Tunable Method to Regulate Protein Function in Living Cells Using Synthetic Small Molecules

Banaszynski, L. A., Chen, L.-C., Maynard-Smith, L. A., Ooi, A. G. L., & Wandless, T. J. (2006) · Cell · doi:10.1016/j.cell.2006.07.025 · Cited by 902 · see citing works

Wnt/Frizzled Activation of Rho Regulates Vertebrate Gastrulation and Requires a Novel Formin Homology Protein Daam1

Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works

Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis

Basu, S., Totty, N. F., Irwin, M. S., Sudol, M., & Downward, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00776-1 · Cited by 843 · see citing works

Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System

Burger, C., Gorbatyuk, O. S., Velardo, M. J., Peden, C. S., Williams, P., Zolotukhin, S., Reier, P. J., Mandel, R. J., & Muzyczka, N. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.05.024 · Cited by 741 · see citing works

GalNAc-siRNA conjugates: leading the way for delivery of RNAi therapeutics

Springer, A. D., & Dowdy, S. F. (2018) · Nucleic Acid Therapeutics · doi:10.1089/nat.2018.0736 · Cited by 711 · see citing works

A Slow RNA Polymerase II Affects Alternative Splicing In Vivo

de la Mata, M., Alonso, C. R., Kadener, S., Fededa, J. P., Blaustein, M., Pelisch, F., Cramer, P., Bentley, D., & Kornblihtt, A. R. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.001 · Cited by 683 · see citing works

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

Vogiatzi, T., Xilouri, M., Vekrellis, K., & Stefanis, L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801992200 · Cited by 683 · see citing works

Mitochondrial bioenergetics and structural network organization

Benard, G., Bellance, N., James, D., Parrone, P., Fernandez, H., Letellier, T., & Rossignol, R. (2007) · Journal of Cell Science · doi:10.1242/jcs.03381 · Cited by 618 · see citing works

Advanced transfection with Lipofectamine 2000 reagent: Primary neurons, siRNA, and high-throughput applications

Dalby, B. (2004) · Methods · doi:10.1016/j.ymeth.2003.11.023 · Cited by 619 · see citing works

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578 · see citing works

A Method for the Acute and Rapid Degradation of Endogenous Proteins

Clift, D., McEwan, W. A., Labzin, L. I., Konieczny, V., Mogessie, B., James, L. C., & Schuh, M. (2017) · Cell · doi:10.1016/j.cell.2017.10.033 · Cited by 531 · see citing works

OS-9 and GRP94 deliver mutant α1-antitrypsin to the Hrd1–SEL1L ubiquitin ligase complex for ERAD

Christianson, J. C., Shaler, T. A., Tyler, R. E., & Kopito, R. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1689 · Cited by 509 · see citing works

Integrating Artificial Intelligence and Nanotechnology for Precision Cancer Medicine

Adir, O., Poley, M., Chen, G., Froim, S., Krinsky, N., Shklover, J., Shainsky‐Roitman, J., Lammers, T., & Schroeder, A. (2020) · Advanced Materials · doi:10.1002/adma.201901989 · Cited by 496 · see citing works

Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase

Gandhi, R., Gillespie, P. J., & Hirano, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.061 · Cited by 441 · see citing works

Multifunctional polymeric micelles for delivery of drugs and siRNA

Jhaveri, A. M., & Torchilin, V. P. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00077 · Cited by 466 · see citing works

A Protein Interaction Network Links GIT1, an Enhancer of Huntingtin Aggregation, to Huntington's Disease

Goehler, H., Lalowski, M., Stelzl, U., Waelter, S., Stroedicke, M., Worm, U., Droege, A., Lindenberg, K. S., Knoblich, M., Haenig, C., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.016 · Cited by 453 · see citing works

Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders

Johmura, Y., Yamanaka, T., Omori, S., Wang, T.-W., Sugiura, Y., Matsumoto, M., Suzuki, N., Kumamoto, S., Yamaguchi, K., Hatakeyama, S., et al. (2021) · Science · doi:10.1126/science.abb5916 · Cited by 440 · see citing works

Model‐guided microarray implicates the retromer complex in Alzheimer's disease

Small, S. A., Kent, K., Pierce, A., Leung, C., Kang, M. S., Okada, H., Honig, L., Vonsattel, J., & Kim, T. (2005) · Annals of Neurology · doi:10.1002/ana.20667 · Cited by 440 · see citing works

Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell Engulfment

Arur, S., Uche, U. E., Rezaul, K., Fong, M., Scranton, V., Cowan, A. E., Mohler, W., & Han, D. K. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00090-x · Cited by 434 · see citing works

Cathepsin D Triggers Bax Activation, Resulting in Selective Apoptosis-inducing Factor (AIF) Relocation in T Lymphocytes Entering the Early Commitment Phase to Apoptosis

Bidère, N., Lorenzo, H. K., Carmona, S., Laforge, M., Harper, F., Dumont, C., & Senik, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301911200 · Cited by 435 · see citing works

Preventing Mitochondrial Fission Impairs Mitochondrial Function and Leads to Loss of Mitochondrial DNA

Parone, P. A., Da Cruz, S., Tondera, D., Mattenberger, Y., James, D. I., Maechler, P., Barja, F., & Martinou, J.-C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003257 · Cited by 415 · see citing works

Progress in antisense technology

Crooke, S. T. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.55.091902.104408 · Cited by 417 · see citing works

Bicaudal-D regulates COPI- independent Golgi-ER transport by recruiting the dynein-dynactin motor complex

Matanis, T., Akhmanova, A., Wulf, P., Del Nery, E., Weide, T., Stepanova, T., Galjart, N., Grosveld, F., Goud, B., De Zeeuw, C. I., et al. (2002) · Nature Cell Biology · doi:10.1038/ncb891 · Cited by 413 · see citing works

Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials

Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works

Lipid nanoparticle technology for therapeutic gene regulation in the liver

Witzigmann, D., Kulkarni, J. A., Leung, J., Chen, S., Cullis, P. R., & van der Meel, R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.026 · Cited by 376 · see citing works

High-throughput RNAi screening in cultured cells: a user's guide

Echeverri, C. J., & Perrimon, N. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1836 · Cited by 380 · see citing works

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

Jiang, Z. Y., Zhou, Q. L., Coleman, K. A., Chouinard, M., Boese, Q., & Czech, M. P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332633100 · Cited by 378 · see citing works

Dynamin-like protein 1 is involved in peroxisomal fission

Koch, A., Thiemann, M., Grabenbauer, M., Yoon, Y., McNiven, M. A., & Schrader, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211761200 · Cited by 374 · see citing works

Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines

Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373 · see citing works

HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

Linares, L. K., Hengstermann, A., Ciechanover, A., Müller, S., & Scheffner, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2030930100 · Cited by 361 · see citing works

<i>Helicobacter pylori</i> CagA protein targets the c-Met receptor and enhances the motogenic response

Churin, Y., Al-Ghoul, L., Kepp, O., Meyer, T. F., Birchmeier, W., & Naumann, M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208039 · Cited by 354 · see citing works

Local gene knockdown in the brain using viral-mediated RNA interference

Hommel, J. D., Sears, R. M., Georgescu, D., Simmons, D. L., & DiLeone, R. J. (2003) · Nature Medicine · doi:10.1038/nm964 · Cited by 334 · see citing works

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

Foster, D. J., Brown, C. R., Shaikh, S., Trapp, C., Schlegel, M. K., Qian, K., Sehgal, A., Rajeev, K. G., Jadhav, V., Manoharan, M., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2017.12.021 · Cited by 325 · see citing works

Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study

Suhr, O. B., Coelho, T., Buades, J., Pouget, J., Conceicao, I., Berk, J., Schmidt, H., Waddington-Cruz, M., Campistol, J. M., Bettencourt, B. R., et al. (2015) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-015-0326-6 · Cited by 321 · see citing works

The Mad2 spindle checkpoint protein has two distinct natively folded states

Luo, X., Tang, Z., Xia, G., Wassmann, K., Matsumoto, T., Rizo, J., & Yu, H. (2004) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb748 · Cited by 297 · see citing works

The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α

Dayan, F., Roux, D., Brahimi-Horn, M. C., Pouyssegur, J., & Mazure, N. M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4564 · Cited by 294 · see citing works

RNAi and small interfering RNAs in human disease therapeutic applications

Lares, M. R., Rossi, J. J., & Ouellet, D. L. (2010) · Trends in biotechnology · doi:10.1016/j.tibtech.2010.07.009 · Cited by 277 · see citing works

The superoxide‐producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells

Kuroda, J., Nakagawa, K., Yamasaki, T., Nakamura, K., Takeya, R., Kuribayashi, F., Imajoh‐Ohmi, S., Igarashi, K., Shibata, Y., Sueishi, K., et al. (2005) · Genes to Cells · doi:10.1111/j.1365-2443.2005.00907.x · Cited by 275 · see citing works

Homologues of the <i>Caenorhabditis elegans</i> Fox-1 Protein Are Neuronal Splicing Regulators in Mammals

Underwood, J. G., Boutz, P. L., Dougherty, J. D., Stoilov, P., & Black, D. L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10005-10016.2005 · Cited by 272 · see citing works

From the RNA world to the clinic

Sullenger, B. A., & Nair, S. (2016) · Science · doi:10.1126/science.aad8709 · Cited by 274 · see citing works

Patisiran, an RNAi Therapeutic for the Treatment of Hereditary Transthyretin-Mediated Amyloidosis

Kristen, A. V., Ajroud-Driss, S., Conceição, I., Gorevic, P., Kyriakides, T., & Obici, L. (2019) · Neurodegenerative Disease Management · doi:10.2217/nmt-2018-0033 · Cited by 268 · see citing works

HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

Silljé, H. H. W., Nagel, S., Körner, R., & Nigg, E. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.070 · Cited by 267 · see citing works

Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into Leydig cell mitochondria

Hauet, T., Yao, Z.-X., Bose, H. S., Wall, C. T., Han, Z., Li, W., Hales, D. B., Miller, W. L., Culty, M., & Papadopoulos, V. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0307 · Cited by 252 · see citing works

Biodegradable, polymeric nanoparticle delivery systems for cancer therapy

Pridgen, E. M., Langer, R., & Farokhzad, O. C. (2007) · Nanomedicine · doi:10.2217/17435889.2.5.669 · Cited by 249 · see citing works

Human Claspin Is Required for Replication Checkpoint Control

Chini, C. C. S., & Chen, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301136200 · Cited by 244 · see citing works

Cellular siRNA delivery using cell-penetrating peptides modified for endosomal escape

Endoh, T., & Ohtsuki, T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.04.005 · Cited by 242 · see citing works

A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic

Short, B., Preisinger, C., Körner, R., Kopajtich, R., Byron, O., & Barr, F. A. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108079 · Cited by 226 · see citing works

Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2

Leung, K. C., Doyle, N., Ballesteros, M., Sjogren, K., Watts, C. K. W., Low, T. H., Leong, G. M., Ross, R. J. M., & Ho, K. K. Y. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337600100 · Cited by 218 · see citing works

Small Interfering RNA-Mediated Gene Silencing in T Lymphocytes

McManus, M. T., Haines, B. B., Dillon, C. P., Whitehurst, C. E., van Parijs, L., Chen, J., & Sharp, P. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5754 · Cited by 215 · see citing works

Lentiviral Vpx Accessory Factor Targets VprBP/DCAF1 Substrate Adaptor for Cullin 4 E3 Ubiquitin Ligase to Enable Macrophage Infection

Srivastava, S., Swanson, S. K., Manel, N., Florens, L., Washburn, M. P., & Skowronski, J. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000059 · Cited by 209 · see citing works

Use of RNA Interference-mediated Gene Silencing and Adenoviral Overexpression to Elucidate the Roles of AKT/Protein Kinase B Isoforms in Insulin Actions

Katome, T., Obata, T., Matsushima, R., Masuyama, N., Cantley, L. C., Gotoh, Y., Kishi, K., Shiota, H., & Ebina, Y. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302094200 · Cited by 212 · see citing works

Synthetic small inhibiting RNAs: Efficient tools to inactivate oncogenic mutations and restore p53 pathways

Martinez, L. A., Naguibneva, I., Lehrmann, H., Vervisch, A., Tchénio, T., Lozano, G., & Harel-Bellan, A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222406899 · Cited by 210 · see citing works

Agonist-modulated Regulation of AMP-activated Protein Kinase (AMPK) in Endothelial Cells

Levine, Y. C., Li, G. K., & Michel, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702182200 · Cited by 207 · see citing works

Reexamining assumptions about miRNA-guided gene silencing

Kilikevicius, A., Meister, G., & Corey, D. R. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1256 · Cited by 194 · see citing works

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

Wang, Y., & Qin, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536810100 · Cited by 181 · see citing works

Oligonucleotide therapies for disorders of the nervous system

Khorkova, O., & Wahlestedt, C. (2017) · Nature Biotechnology · doi:10.1038/nbt.3784 · Cited by 179 · see citing works

How can we realize the promise of personalized antidepressant medicines?

Holsboer, F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2453 · Cited by 177 · see citing works

Iron–sulfur protein maturation in human cells: evidence for a function of frataxin

Stehling, O., Elsässer, H.-P., Brückel, B., Mühlenhoff, U., & Lill, R. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh324 · Cited by 176 · see citing works

Androgen receptor represses the neuroendocrine transdifferentiation process in prostate cancer cells.

Wright, M. E., Tsai, M.-J., & Aebersold, R. (2003) · Molecular Endocrinology · doi:10.1210/me.2003-0031 · Cited by 166 · see citing works

Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors

Kim, C. S., Chang, P. Y., & Johnston, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.027 · Cited by 158 · see citing works

Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo

Saville, M. K., Sparks, A., Xirodimas, D. P., Wardrop, J., Stevenson, L. F., Bourdon, J.-C., Woods, Y. L., & Lane, D. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403362200 · Cited by 158 · see citing works

High-Throughput Analysis Reveals Rules for Target RNA Binding and Cleavage by AGO2

Becker, W. R., Ober-Reynolds, B., Jouravleva, K., Jolly, S. M., Zamore, P. D., & Greenleaf, W. J. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.06.012 · Cited by 161 · see citing works

Hypoxia and hypoxia-inducible factor-1α promote growth factor-induced proliferation of human vascular smooth muscle cells

Schultz, K., Fanburg, B. L., & Beasley, D. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01077.2005 · Cited by 159 · see citing works

Silencing of Monocarboxylate Transporters via Small Interfering Ribonucleic Acid Inhibits Glycolysis and Induces Cell Death in Malignant Glioma: An in Vitro Study

Mathupala, S. P., Parajuli, P., & Sloan, A. E. (2004) · Neurosurgery · doi:10.1227/01.neu.0000143034.62913.59 · Cited by 147 · see citing works

Gene Therapy for Retinal Degenerative Diseases: Progress, Challenges, and Future Directions

Drag, S., Dotiwala, F., & Upadhyay, A. K. (2023) · Investigative Opthalmology &amp; Visual Science · doi:10.1167/iovs.64.7.39 · Cited by 145 · see citing works

KnockTF: a comprehensive human gene expression profile database with knockdown/knockout of transcription factors

Feng, C., Song, C., Liu, Y., Qian, F., Gao, Y., Ning, Z., Wang, Q., Jiang, Y., Li, Y., Li, M., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz881 · Cited by 147 · see citing works

Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17

Pandey, A. V., Mellon, S. H., & Miller, W. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209527200 · Cited by 137 · see citing works

Stable RNA interference: Comparison of U6 and H1 promoters in endothelial cells and in mouse brain

Mäkinen, P. I., Koponen, J. K., Kärkkäinen, A., Malm, T. M., Pulkkinen, K. H., Koistinaho, J., Turunen, M. P., & Ylä‐Herttuala, S. (2006) · The Journal of Gene Medicine · doi:10.1002/jgm.860 · Cited by 134 · see citing works

L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes

Banks, D., Wu, M., Higa, L. A., Gavrilova, N., Quan, J., Ye, T., Kobayashi, R., Sun, H., & Zhang, H. (2006) · Cell Cycle · doi:10.4161/cc.5.15.3150 · Cited by 127 · see citing works

Preclinical development of a subcutaneous ALAS1 RNAi therapeutic for treatment of hepatic porphyrias using circulating RNA quantification

Chan, A., Liebow, A., Yasuda, M., Gan, L., Racie, T., Maier, M., Kuchimanchi, S., Foster, D., Milstein, S., Charisse, K., et al. (2015) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.36 · Cited by 128 · see citing works

Enhancement of Hypoxia-Induced Tumor Cell Death <b> <i>In vitro</i> </b> and Radiation Therapy <b> <i>In vivo</i> </b> by Use of Small Interfering RNA Targeted to Hypoxia-Inducible Factor-1α

Zhang, X., Kon, T., Wang, H., Li, F., Huang, Q., Rabbani, Z. N., Kirkpatrick, J. P., Vujaskovic, Z., Dewhirst, M. W., & Li, C.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2301 · Cited by 120 · see citing works

A chemical approach for global protein knockdown from mice to non-human primates

Sun, X., Wang, J., Yao, X., Zheng, W., Mao, Y., Lan, T., Wang, L., Sun, Y., Zhang, X., Zhao, Q., et al. (2019) · Cell Discovery · doi:10.1038/s41421-018-0079-1 · Cited by 118 · see citing works

Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts

Ryu, S. J., Oh, Y. S., & Park, S. C. (2007) · Cell Death &amp; Differentiation · doi:10.1038/sj.cdd.4402091 · Cited by 114 · see citing works

New tools for functional mammalian cancer genetics

Brummelkamp, T. R., & Bernards, R. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1191 · Cited by 114 · see citing works

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

Butler, J. S., Chan, A., Costelha, S., Fishman, S., Willoughby, J. L. S., Borland, T. D., Milstein, S., Foster, D. J., Gonçalves, P., Chen, Q., et al. (2016) · Amyloid · doi:10.3109/13506129.2016.1160882 · Cited by 113 · see citing works

RNA Mediated toll-like receptor stimulation in health and disease

Dalpke, A. H., & Helm, M. (2012) · RNA Biology · doi:10.4161/rna.20206 · Cited by 113 · see citing works

Recovery of function in osteoarthritic chondrocytes induced by p16INK4a-specific siRNA in vitro

Zhou, H. W. (2004) · Rheumatology · doi:10.1093/rheumatology/keh127 · Cited by 108 · see citing works

Gene Therapy in Retinal Dystrophies

Ziccardi, L., Cordeddu, V., Gaddini, L., Matteucci, A., Parravano, M., Malchiodi-Albedi, F., & Varano, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225722 · Cited by 107 · see citing works

Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs

Choi, K. Y., Silvestre, O. F., Huang, X., Min, K. H., Howard, G. P., Hida, N., Jin, A. J., Carvajal, N., Lee, S. W., Hong, J.-I., et al. (2014) · ACS Nano · doi:10.1021/nn500085k · Cited by 104 · see citing works

RNA Interference-Mediated Simultaneous Silencing of Four Genes Using Cross-Shaped RNA

Lee, T. Y., Chang, C. I., Lee, D., et al. (2013) · Molecules and Cells · doi:10.1007/s10059-013-2316-7 · Cited by 9 · see citing works

RNA Interference Technology

Nagesha, S. N. (2021) · Springer eBooks · doi:10.1007/978-981-16-3591-5_6 · Cited by 2 · see citing works

RNAi: An emerging field of molecular research

Kabir, M. H., Qadir, S. A., Hassan, S. H. A., et al. (2008) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.5897/ajb08.1008 · Cited by 3 · see citing works

RNA interference--significance and applications.

Stanisławska, J., & Olszewski, W. L. (2005) · PubMed · Cited by 14 · see citing works

SiRNA Mediated Gene Silencing: A Mini Review

Joseph, B., Ajisha, S. U., & Jeevitha, M. V. (2012) · Aceh International Journal of Science and Technology · doi:10.13170/aijst.1.3.140 · Cited by 4 · see citing works