The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Abstract
Oxidative stress is an increase in the reduction potential or a large decrease in the reducing capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is the production of reactive oxygen species (ROS), which include free radicals and peroxides. Some of the less reactive of these species can be converted by oxidoreduction reactions with transition metals into more aggressive radical species that can cause extensive cellular damage. In animals, ROS may influence cell proliferation, cell death (either apoptosis or necrosis) and the expression of genes, and may be involved in the activation of several signalling pathways, activating cell signalling cascades, such as those involving mitogen-activated protein kinases. Most of these oxygen-derived species are produced at a low level by normal aerobic metabolism and the damage they cause to cells is constantly repaired. The cellular redox environment is preserved by enzymes and antioxidants that maintain the reduced state through a constant input of metabolic energy. This review summarizes current studies that have been regarding the production of ROS and the general redox-sensitive targets of cell signalling cascades.
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“The CYP reaction together with POR releases superoxide as a by-product of the oxidase reaction [36], Figure 14.”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [36]
In the citing paper
“Superoxide radicals, hydrogen peroxide, singlet oxygen and hypochlorous acid HOCl are generated in the cell membrane through the action of the enzymes NADPH oxidase, myeloperoxidase and xanthine oxidase [35,36].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [36]
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Metadata
- Authors
- Genestra, M.
- Affiliations
- University of Mississippi Medical Center (US)
- Corresponding author
- Genestra, Marcelo
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 19
- Issue
- 9
- Pages
- 1807-1819
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2078111650
- Cited by
- 4,930
- References
- 235
- Citations by year
- 2026: 13 · 2025: 119 · 2024: 297 · 2023: 395 · 2022: 481 · 2021: 326 · 2020: 299 · 2019: 374 · 2018: 356 · 2017: 405 · 2016: 412 · 2015: 393 · 2014: 159 · 2013: 105 · 2012: 112
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- oxidative stress, reactive oxygen species, oxyl radicals, antioxidants, redox signaling, mitogen-activated protein kinase, transition metal catalysis, apoptosis, cell proliferation, gene expression
- MeSH terms
- Animals, Antioxidants, Humans, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, MAP Kinase Signaling System
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