CoChat
Sign Up
Cited by 4,930Redox biology and oxidative stressAntioxidant Activity and Oxidative StressNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, Marcelo·2007·Cellular Signalling
DOI 10.1016/j.cellsig.2007.04.009
Open this paper in CoChat — free account

Abstract

Oxidative stress is an increase in the reduction potential or a large decrease in the reducing capacity of the cellular redox couples. A particularly destructive aspect of oxidative stress is the production of reactive oxygen species (ROS), which include free radicals and peroxides. Some of the less reactive of these species can be converted by oxidoreduction reactions with transition metals into more aggressive radical species that can cause extensive cellular damage. In animals, ROS may influence cell proliferation, cell death (either apoptosis or necrosis) and the expression of genes, and may be involved in the activation of several signalling pathways, activating cell signalling cascades, such as those involving mitogen-activated protein kinases. Most of these oxygen-derived species are produced at a low level by normal aerobic metabolism and the damage they cause to cells is constantly repaired. The cellular redox environment is preserved by enzymes and antioxidants that maintain the reduced state through a constant input of metabolic energy. This review summarizes current studies that have been regarding the production of ROS and the general redox-sensitive targets of cell signalling cascades.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.cellsig.2007.04.009

Cites

235 of 235 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 235 references

Research works printed but not linked: 19

  1. Sahnoun, 1997, Therapies, 52, 251
  2. Klebanoff, 1978, Ciba Found. Symp., 68, 263
  3. Gaut, 2002, J. Clin. Invest., 109, 1311, 10.1172/JCI0215021 · DOI
  4. Rpshchupkin, 1998, Biofizika, 43, 323
  5. Babior, 1999, Blood, 93, 1464, 10.1182/blood.V93.5.1464 · DOI
  6. Griendling, 2000, Arterioscler. Thromb. Vasc. Biol., 20, 2175, 10.1161/01.ATV.20.10.2175 · DOI
  7. Acker, 1995, Nips, 10, 211
  8. Denu, 1998, Biochemistry, 37, 5633, 10.1021/bi973035t · DOI
  9. Meng, 2002, Mol. Cell., 9, 387, 10.1016/S1097-2765(02)00445-8 · DOI · Paper page
  10. Nakamura, 1993, Oncogene, 8, 3133
  11. Hehner, 2000, J. Immunol., 165, 4319, 10.4049/jimmunol.165.8.4319 · DOI
  12. Kim, 2007, J. Proteome Res., 6, 93
  13. A.J. Whitmarsh AJ. Biochim Biophys Acta. 2006 (in press).
  14. Pu, 1996, Oncogene, 13, 2615
  15. Yoshizumi, 2000, J. Biol. Chem., 275, 11706, 10.1074/jbc.275.16.11706 · DOI
  16. O'Hara, 2003, Toxicol. Appl. Pharmacol., 190, 214, 10.1016/S0041-008X(03)00188-1 · DOI
  17. Ichijo, 1997, Science, 275, 90, 10.1126/science.275.5296.90 · DOI
  18. Wilden, 1987, Biochem. J., 245, 325, 10.1042/bj2450325 · DOI
  19. Schmid, 1999, FASEB J., 13, 1491, 10.1096/fasebj.13.12.1491 · DOI

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Genestra, M.
Affiliations
University of Mississippi Medical Center (US)
Corresponding author
Genestra, Marcelo
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2007-09
Volume
19
Issue
9
Pages
1807-1819
ISSN
0898-6568 (ISSN-L)
DOI
10.1016/j.cellsig.2007.04.009
OpenAlex
W2078111650
Cited by
4,930
References
235
Citations by year
2026: 13 · 2025: 119 · 2024: 297 · 2023: 395 · 2022: 481 · 2021: 326 · 2020: 299 · 2019: 374 · 2018: 356 · 2017: 405 · 2016: 412 · 2015: 393 · 2014: 159 · 2013: 105 · 2012: 112
FWCI
8.82
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cellular Signalling (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
oxidative stress, reactive oxygen species, oxyl radicals, antioxidants, redox signaling, mitogen-activated protein kinase, transition metal catalysis, apoptosis, cell proliferation, gene expression
MeSH terms
Animals, Antioxidants, Humans, Oxidation-Reduction, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, MAP Kinase Signaling System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review