Non-apoptotic Fas signaling regulates invasiveness of glioma cells and modulates MMP-2 activity via NFκB-TIMP-2 pathway

Wisniewski, Pawel; Ellert-Miklaszewska, Aleksandra; Kwiatkowska, Aneta; Kaminska, Bozena

doi:10.1016/j.cellsig.2009.09.016

Cited by 46Protease and Inhibitor MechanismsCell death mechanisms and regulationGlioma Diagnosis and Treatment

Non-apoptotic Fas signaling regulates invasiveness of glioma cells and modulates MMP-2 activity via NFκB-TIMP-2 pathway

Wisniewski, Pawel, Ellert-Miklaszewska, Aleksandra, Kwiatkowska, Aneta, Kaminska, Bozena·2010·Cellular Signalling

DOI 10.1016/j.cellsig.2009.09.016

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Abstract

Fas (CD95/APO-1) is a cell surface "death receptor" that mediates apoptosis upon engagement by its ligand, FasL. Paradoxically, Fas/FasL can also promote cell invasion among non-apoptotic cells; here, we show that Fas/FasL signaling can promote tumor invasion when apoptosis is compromised. We have developed a recombinant FasL Interfering Protein (FIP) to interfere with Fas signaling in C6 glioma cells expressing both Fas receptor and its ligand. FIP administration did not affect cell viability but impaired cell motility and invasiveness of glioma cells. Blockade of Fas signaling reduced MMP-2 activity in glioma cells, that was associated with down-regulation of MAPK signaling, and AP-1 and NFkappaB-driven transcription. FIP treatment did not affect mmp-2 and mt1-mmp expression but significantly attenuated timp-2 expression and TIMP-2 amount in the culture medium. Studies with pharmacological inhibitors of JNK/c-Jun (SP600125) and NFkappaB (BAY11-7082) signaling pathways demonstrated that timp-2 expression is regulated by NFkappaB transcription factor. Our findings show that non-apoptotic Fas signaling activated in the autocrine manner or through microenvironment derived factors can regulate invasiveness of glioma cells via modulation of MMP-2 activation, likely by controlling TIMP-2 expression.

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GOF mut-p53 has been shown to abnormally regulate a multitude of genes that play critical roles in glioblastoma pathogenesis, including CD95/Fas/Apo1, PARP, PTEN, and more.
“Furthermore, GOF mut-p53 has been shown to abnormally regulate a multitude of genes that play critical roles in GBM pathogenesis, but have not been analyzed in the context of GBM. This includes CD95/Fas/Apo1, PARP, PTEN, and more [63,94,95,96,97,98].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [96]

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Authors: Wisniewski, P., Ellert-Miklaszewska, A., Kwiatkowska, A., & Kaminska, B.
Affiliations: Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
Corresponding author: Kaminska, Bozena
ORCID: Kwiatkowska, Aneta
Venue: Cellular Signalling
Publisher: Elsevier BV
Published: 2010-02
Volume: 22
Issue: 2
Pages: 212-220
ISSN: 0898-6568 (ISSN-L)
DOI: 10.1016/j.cellsig.2009.09.016
OpenAlex: W1968797465
Cited by: 46
References: 52
Citations by year: 2026: 3 · 2024: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 7 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 4
FWCI: 1.34
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cellular Signalling (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Science and Higher Education (P-N/024/2006, NN301 3945)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Keywords: Fas/FasL signaling, glioma invasion, MMP-2 activity, TIMP-2, NF-κB, MAPK signaling, AP-1, tumor cell motility, autocrine signaling, tumor microenvironment
MeSH terms: Animals, Brain Neoplasms, Glioma, Humans, Neoplasm Invasiveness, Signal Transduction, Down-Regulation, NF-kappa B, Apoptosis, fas Receptor, Tissue Inhibitor of Metalloproteinase-2, Matrix Metalloproteinase 2, Cell Line, Tumor, JNK Mitogen-Activated Protein Kinases, Rats, Upstream Stimulatory Factors, Fas Ligand Protein

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Non-apoptotic Fas signaling regulates invasiveness of glioma cells and modulates MMP-2 activity via NFκB-TIMP-2 pathway

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