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Cited by 17Hippo pathway signaling and YAP/TAZCancer-related molecular mechanisms researchMicrotubule and mitosis dynamics

Bufalin inhibits the proliferation of lung cancer cells by suppressing Hippo-YAP pathway

Qian, Zijun, Tian, Xiaoting, Miao, Yayou, Xu, Xin, Cheng, Xuehua, Wu, Mengyi, Yu, Yongchun·2023·Cellular Signalling
DOI 10.1016/j.cellsig.2023.110746
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Abstract

Lung cancer has high morbidity and mortality. This study demonstrated that Bufalin inhibits the proliferation of lung cancer cells in vivo / in vitro by suppressing Hippo-YAP pathway. Here, we found that Bufalin promoted the binding of LATS and YAP to elevate the level of YAP phosphorylation. Phosphorylated YAP could not successfully enter the nucleus to activate the expression of downstream proliferation-related target genes Cyr61 and CTGF, whereas the YAP retained in the cytoplasm further bound to β-TrCP and underwent ubiquitination and degradation. This study verified the key role of YAP in stimulating the proliferation of lung cancer and revealed the anticancer target of Bufalin. Therefore, this study provides a theoretical basis for the anticancer effect of Bufalin, and suggests that Bufalin can be a potential anticancer drug.

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Crossref · 10.1016/j.cellsig.2023.110746

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  • Bufalin could suppress multiple signaling pathways, including Hippo-YAP, Wnt/β-Catenin, JNK, SRC3/MIF, mTOR, and MAPK, leading to apoptosis, necrosis, and autophagy in different cancer cells.

    “Current pharmacological research suggests that Bufalin could suppress multiple signaling pathways, including Hippo-YAP, Wnt/β-Catenin, JNK, SRC3/MIF, mTOR, and MAPK, leading to apoptosis, necrosis, and autophagy in different cancer cells3,5–8.”

    From Harnessing artificial intelligence to identify Bufalin as a molecular glue degrader of estrogen receptor alpha (2025) · cites this paper as [6]

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Authors
Qian, Z., Tian, X., Miao, Y., Xu, X., Cheng, X., Wu, M., & Yu, Y.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Fudan University (CN)
  • Shanghai University of Traditional Chinese Medicine (CN)
Corresponding author
Yu, Yongchun
ORCID
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2023-09
Volume
109
Pages
110746
ISSN
0898-6568 (ISSN-L)
DOI
10.1016/j.cellsig.2023.110746
OpenAlex
W4379390743
Cited by
17
References
3
Citations by year
2026: 4 · 2025: 10 · 2024: 2 · 2023: 1
FWCI
2.45
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Cellular Signalling (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Shanghai Jiao Tong University School of Medicine (SHSMU-ZLCX20212302)
  • Innovative Research Team of High-level Local University in Shanghai
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Keywords
bufalin, lung cancer, Hippo signaling pathway, YAP, LATS kinase, YAP phosphorylation, YAP nuclear translocation, β-TrCP, ubiquitination, protein degradation, CYR61, connective tissue growth factor, cell proliferation, anticancer agents
MeSH terms
Bufanolides, Humans, Lung Neoplasms, Transcription Factors, Protein Serine-Threonine Kinases, Adaptor Proteins, Signal Transducing, Cell Proliferation

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