The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works

TEAD mediates YAP-dependent gene induction and growth control

Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498 · see citing works

Elucidation of a universal size-control mechanism in Drosophila and mammals

Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works

The Hippo Signaling Pathway in Development and Cancer

Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,274 · see citing works

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

Huang, J., Wu, S., Barrera, J. A., Matthews, K. A., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,870 · see citing works

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF ^β-TRCP

Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418 · see citing works

YAP1 increases organ size and expands undifferentiated progenitor cells

Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252 · see citing works

hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts

Wu, S., Huang, J., Dong, J., & Pan, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00549-x · Cited by 1,101 · see citing works

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

Heallen, T. R., Zhang, M., Wang, J., Bonilla-Claudio, M., Klysik, E., Johnson, R. L., & Martin, J. F. (2011) · Science · doi:10.1126/science.1199010 · Cited by 1,092 · see citing works

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.003 · Cited by 1,083 · see citing works

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Zender, L., Spector, M. S., Xue, W., Flemming, P., Cordon-Cardo, C., Silke, J., Fan, S.-T., Luk, J. M., Wigler, M., Hannon, G. J., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.030 · Cited by 1,065 · see citing works

Hippo signaling: growth control and beyond

Halder, G. A., & Johnson, R. L. (2010) · Development · doi:10.1242/dev.045500 · Cited by 1,061 · see citing works

Yap1 acts downstream of α-catenin to control epidermal proliferation

Schlegelmilch, K., Mohseni, M., Kirak, O., Pruszak, J., Rodriguez, J. R., Zhou, D., Kreger, B. T., Vasioukhin, V., Avruch, J., Brummelkamp, T. R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.02.031 · Cited by 1,036 · see citing works

TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation

Hong, J.-H., Hwang, E. S., McManus, M. T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B. M., Sharp, P. A., et al. (2005) · Science · doi:10.1126/science.1110955 · Cited by 1,009 · see citing works

The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis

Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 983 · see citing works

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

Justice, R. W., Zilian, O., Woods, D. F., Noll, M., & Bryant, P. J. (1995) · Genes & Development · doi:10.1101/gad.9.5.534 · Cited by 977 · see citing works

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

Lei, Q., Zhang, H., Zhao, B., Zha, Z., Bai, F., Pei, X., Zhao, S., Xiong, Y., & Guan, K. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01874-07 · Cited by 925 · see citing works

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 916 · see citing works

Transforming properties of YAP , a candidate oncogene on the chromosome 11q22 amplicon

Overholtzer, M., Zhang, J., Smolen, G. A., Muir, B., Li, W., Sgroi, D. C., Deng, C., Brugge, J. S., & Haber, D. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605579103 · Cited by 885 · see citing works

salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines

Tapon, N., Harvey, K. F., Bell, D. W., Wahrer, D. C. R., Schiripo, T. A., Haber, D. A., & Hariharan, I. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00824-3 · Cited by 858 · see citing works

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

Furuyama, K., Kawaguchi, Y., Akiyama, H., Horiguchi, M., Kodama, S., Kuhara, T., Hosokawa, S., Elbahrawy, A., Soeda, T., Koizumi, M., et al. (2011) · Nature Genetics · doi:10.1038/ng.722 · Cited by 830 · see citing works

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804 · see citing works

Identifying tumor suppressors in genetic mosaics: the <i>Drosophila lats</i> gene encodes a putative protein kinase

Xu, T., Wang, W., Zhang, S., Stewart, R. A., & Yu, W. (1995) · Development · doi:10.1242/dev.121.4.1053 · Cited by 799 · see citing works

Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP

Hao, Y., Chun, A., Cheung, K. J., Rashidi, B., & Yang, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709037200 · Cited by 780 · see citing works

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

Hamaratoǧlu, F., Willecke, M., Kango‐Singh, M., Nolo, R. M., Hyun, E., Tao, C., Jafar‐Nejad, H., & Halder, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 767 · see citing works

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C., & Halder, G. (2003) · Nature Cell Biology · doi:10.1038/ncb1050 · Cited by 747 · see citing works

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiationPreprint

Lian, I., Kim, J., Okazawa, H., Zhao, J. J., Zhao, B., Yu, J., Chinnaiyan, A. M., Israel, M. A., Goldstein, L. S. B., Abujarour, R., et al. (2010) · Genes & Development · doi:10.1101/gad.1903310 · Cited by 738 · see citing works

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G. A., Finegold, M. J., Lee, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911427107 · Cited by 721 · see citing works

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

Alarcón, C., Zaromytidou, A.-I., Xi, Q., Gao, S., Yu, J., Fujisawa, S., Barlas, A., Miller, A. N., Manova-Todorova, K., Macias, M. J., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.035 · Cited by 719 · see citing works

The Crumbs Complex Couples Cell Density Sensing to Hippo-Dependent Control of the TGF-β-SMAD Pathway

Varelas, X., Samavarchi‐Tehrani, P., Narimatsu, M., Weiss, A., Cockburn, K., Larsen, B. G., Rossant, J., & Wrana, J. L. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.012 · Cited by 683 · see citing works

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

Varelas, X., Sakuma, R., Samavarchi‐Tehrani, P., Peerani, R., Rao, B. M., Dembowy, J., Yaffe, M. B., Zandstra, P. W., & Wrana, J. L. (2008) · Nature Cell Biology · doi:10.1038/ncb1748 · Cited by 666 · see citing works

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoproteinPreprint

Zhao, B., Li, L., Lu, Q. R., Wang, L. H., Liu, C., Lei, Q., & Guan, K. (2011) · Genes & Development · doi:10.1101/gad.2000111 · Cited by 665 · see citing works

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

Wu, S., Liu, Y., Zheng, Y., Dong, J., & Pan, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.007 · Cited by 640 · see citing works

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

Zhang, L., Ren, F., Zhang, Q., Chen, Y., Wang, B., & Jiang, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.006 · Cited by 630 · see citing works

The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1

Chan, E. H. Y., Nousiainen, M., Chalamalasetty, R. B., Schäfer, A., Nigg, E. A., & Silljé, H. H. W. (2005) · Oncogene · doi:10.1038/sj.onc.1208445 · Cited by 584 · see citing works

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

Song, H., Mak, K. K., Topol, L. Z., Yun, K., Hu, J., Garrett, L. J., Chen, Y., Park, O., Chang, J., Simpson, R. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911409107 · Cited by 583 · see citing works

TEAD Transcription Factors Mediate the Function of TAZ in Cell Growth and Epithelial-Mesenchymal Transition

Zhang, H., Liu, C., Zha, Z., Zhao, B., Yao, J., Zhao, S., Xiong, Y., Lei, Q., & Guan, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900843200 · Cited by 572 · see citing works

Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats

Lai, Z.-C., Wei, X., Shimizu, T., Ramos, E., Rohrbaugh, M., Nikolaidis, N., Ho, L., & Li, Y. (2005) · Cell · doi:10.1016/j.cell.2004.12.036 · Cited by 570 · see citing works

A WW domain‐containing Yes‐associated protein (YAP) is a novel transcriptional co‐activator

Yagi, R., Chen, L. F., Shigesada, K., Murakami, Y., & Ito, Y. (1999) · The EMBO Journal · doi:10.1093/emboj/18.9.2551 · Cited by 553 · see citing works

Expression of Yes-associated protein in common solid tumors

Steinhardt, A. A., Gayyed, M. F., Klein, A. P., Dong, J., Maitra, A., Pan, D., Montgomery, E. A., & Anders, R. A. (2008) · Human Pathology · doi:10.1016/j.humpath.2008.04.012 · Cited by 552 · see citing works

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila

Pantalacci, S., Tapon, N., & Léopold, P. (2003) · Nature Cell Biology · doi:10.1038/ncb1051 · Cited by 552 · see citing works

Yes‐associated protein is an independent prognostic marker in hepatocellular carcinoma

Xu, M. Z., Yao, T., Lee, N. P. Y., Ng, I. O. L., Chan, Y., Zender, L., Lowe, S. W., Poon, R. T. P., & Luk, J. M. (2009) · Cancer · doi:10.1002/cncr.24495 · Cited by 528 · see citing works

The Hippo Tumor Pathway Promotes TAZ Degradation by Phosphorylating a Phosphodegron and Recruiting the SCFβ-TrCP E3 Ligase

Liu, C.-Y., Zha, Z.-Y., Zhou, X., Zhang, H., Huang, W., Zhao, D., Li, T., Chan, S. W., Lim, C. J., Hong, W., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.152942 · Cited by 525 · see citing works

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W.-M., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.012 · Cited by 496 · see citing works

The Hippo–Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis

Lee, K., Lee, J., Kim, T., Kim, T., Park, H.-D., Byun, J., Kim, M., Jeong, W., Calvisi, D. F., Kim, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912203107 · Cited by 494 · see citing works

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration programPreprint

Cai, J., Zhang, N., Zheng, Y., de Wilde, R. F., Maitra, A., & Pan, D. (2010) · Genes & Development · doi:10.1101/gad.1978810 · Cited by 491 · see citing works

A Role for TAZ in Migration, Invasion, and Tumorigenesis of Breast Cancer Cells

Chan, S. W., Lim, C. J., Guo, K., Ng, C. P., Lee, I. Y., Hunziker, W., Zeng, Q., & Hong, W. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2696 · Cited by 480 · see citing works

WW Domain-containing Protein YAP Associates with ErbB-4 and Acts as a Co-transcriptional Activator for the Carboxyl-terminal Fragment of ErbB-4 That Translocates to the Nucleus

Komuro, A., Nagai, M., Navin, N. E., & Sudol, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305597200 · Cited by 459 · see citing works

SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila

Goulev, Y., Fauny, J., Gonzalez-Marti, B., Flagiello, D., Silber, J., & Zider, A. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.034 · Cited by 452 · see citing works

Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma

Zhan, L., Rosenberg, A., Bergami, K. C., Yu, M., Xuan, Z., Jaffe, A. B., Allred, C., & Muthuswamy, S. K. (2008) · Cell · doi:10.1016/j.cell.2008.09.045 · Cited by 436 · see citing works

Delineation of a Fat tumor suppressor pathway

Cho, E., Feng, Y., Rauskolb, C., Maitra, S., Fehon, R. G., & Irvine, K. D. (2006) · Nature Genetics · doi:10.1038/ng1887 · Cited by 432 · see citing works

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

Zhang, J., Ji, J., Yu, M., Overholtzer, M., Smolen, G. A., Wang, R., Brugge, J. S., Dyson, N. J., & Haber, D. A. (2009) · Nature Cell Biology · doi:10.1038/ncb1993 · Cited by 427 · see citing works

MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation

Praskova, M. D., Xia, F., & Avruch, J. (2008) · Current Biology · doi:10.1016/j.cub.2008.02.006 · Cited by 423 · see citing works

Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin

Zhang, H., Pasolli, H. A., & Fuchs, E. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019603108 · Cited by 419 · see citing works

Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity

Strano, S., Munarriz, E. R., Rossi, M., Castagnoli, L., Shaul, Y., Sacchi, A., Oren, M., Sudol, M., Cesareni, G., & Blandino, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010484200 · Cited by 418 · see citing works

RASSF1A Elicits Apoptosis through an MST2 Pathway Directing Proapoptotic Transcription by the p73 Tumor Suppressor Protein

Matallanas, D., Romano, D., Yee, K. S. Y., Meissl, K., Kučerová, L., Piazzolla, D., Baccarini, M., Vass, J. K., Kölch, W., & O’Neill, E. E. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.08.008 · Cited by 416 · see citing works

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets<i>Cyr61</i>and<i>CTGF</i>

Lai, D., Ho, K. C., Hao, Y., & Yang, X. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2711 · Cited by 416 · see citing works

Structural insights into the YAP and TEAD complexPreprint

Li, Z., Zhao, B., Wang, P., Chen, F., Dong, Z., Yang, H., Guan, K., & Xu, Y. (2010) · Genes & Development · doi:10.1101/gad.1865810 · Cited by 406 · see citing works

In vivo regulation of Yorkie phosphorylation and localization

Oh, H., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.015255 · Cited by 404 · see citing works

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 402 · see citing works

The Hippo Pathway Regulates the bantam microRNA to Control Cell Proliferation and Apoptosis in Drosophila

Thompson, B. J., & Cohen, S. M. (2006) · Cell · doi:10.1016/j.cell.2006.07.013 · Cited by 398 · see citing works

YAP regulates neural progenitor cell number via the TEA domain transcription factorPreprint

Cao, X., Pfaff, S. L., & Gage, F. H. (2008) · Genes & Development · doi:10.1101/gad.1726608 · Cited by 398 · see citing works

The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosisPreprint

Jia, J., Zhang, W., Wang, B., Trinko, R., & Jiang, J. (2003) · Genes & Development · doi:10.1101/gad.1134003 · Cited by 392 · see citing works

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

Chan, S. W., Lim, C. J., Chong, Y. F., Pobbati, A. V., Huang, C., & Hong, W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.212621 · Cited by 386 · see citing works

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferationPreprint

Fernández-L, A., Northcott, P. A., Dalton, J., Fraga, C. H., Ellison, D. W., Angers, S., Taylor, M. D., & Kenney, A. M. (2009) · Genes & Development · doi:10.1101/gad.1824509 · Cited by 378 · see citing works

Caspase‐mediated activation and induction of apoptosis by the mammalian Ste20‐like kinase Mst1

Graves, J. D., Gotoh, Y., Draves, K. E., Ambrose, D., Han, D. K. M., Wright, M., Chernoff, J., Clark, E. A., & Krebs, E. G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.8.2224 · Cited by 375 · see citing works

Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)

Oka, T., Mazack, V., & Sudol, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804380200 · Cited by 368 · see citing works

Identification of a Novel Ras-Regulated Proapoptotic Pathway

Khokhlatchev, A. V., Rabizadeh, S., Xavier, R. J., Nedwidek, M., Chen, T., Zhang, X., Seed, B., & Avruch, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00683-8 · Cited by 357 · see citing works

Shar-pei mediates cell proliferation arrest during imaginal disc growth inDrosophila

Kango‐Singh, M., Nolo, R. M., Tao, C., Verstreken, P., Hiesinger, P. R., Bellen, H. J., & Halder, G. A. (2002) · Development · doi:10.1242/dev.00168 · Cited by 349 · see citing works

α-Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

Silvis, M. R., Kreger, B. T., Lien, W., Klezovitch, O., Rudakova, G. M., Camargo, F. D., Lantz, D. M., Seykora, J. T., & Vasioukhin, V. I. (2011) · Science Signaling · doi:10.1126/scisignal.2001823 · Cited by 342 · see citing works

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F., & Richardson, H. E. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.055 · Cited by 341 · see citing works

The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size

Willecke, M., Hamaratoǧlu, F., Kango‐Singh, M., Udan, R. S., Chen, C., Tao, C., Zhang, X., & Halder, G. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.005 · Cited by 329 · see citing works

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

Chen, L., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S., & Pan, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004279107 · Cited by 320 · see citing works

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

Baumgartner, R., Poernbacher, I., Buser, N., Hafen, E., & Stocker, H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.013 · Cited by 320 · see citing works

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

Karpowicz, P. A., Perez, J. N., & Perrimon, N. (2010) · Development · doi:10.1242/dev.060483 · Cited by 318 · see citing works

Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways

Ren, F., Wang, B., Yue, T., Yun, E.-Y., Ip, Y. T., & Jiang, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012759107 · Cited by 316 · see citing works

Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway

Bennett, F. C., & Harvey, K. F. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.045 · Cited by 314 · see citing works

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

Robinson, B. S., Huang, J., Hong, Y., & Moberg, K. H. (2010) · Current Biology · doi:10.1016/j.cub.2010.03.019 · Cited by 312 · see citing works

The Hippo pathway regulates intestinal stem cell proliferation duringDrosophilaadult midgut regeneration

Shaw, R. L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B. A., & Tapon, N. (2010) · Development · doi:10.1242/dev.052506 · Cited by 307 · see citing works

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

Chen, C., Gajewski, K. M., Hamaratoǧlu, F., Bossuyt, W., Sansores-García, L., Tao, C., & Halder, G. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004060107 · Cited by 303 · see citing works

The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway

Silva, E., Tsatskis, Y., Gardano, L., Tapon, N., & McNeill, H. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.004 · Cited by 290 · see citing works

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

Neto-Silva, R. M., de Beco, S., & Johnston, L. A. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.009 · Cited by 289 · see citing works

Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C‐terminal coiled‐coil domains, leads to its stabilization and phosphorylation

Callus, B. A., Verhagen, A. M., & Vaux, D. L. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05427.x · Cited by 276 · see citing works

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

Wang, W., Huang, J., & Chen, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.205401 · Cited by 269 · see citing works

Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liverPreprint

Benhamouche, S., Curto, M., Saotome, I., Gladden, A. B., Liu, C.-H., Giovannini, M., & McClatchey, A. I. (2010) · Genes & Development · doi:10.1101/gad.1938710 · Cited by 269 · see citing works

The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway

Nolo, R. M., Morrison, C. M., Tao, C., Zhang, X., & Halder, G. A. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.057 · Cited by 266 · see citing works

Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation

Kucuk, B., & Irvine, K. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.041 · Cited by 266 · see citing works

Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity

Tao, W., Zhang, S., Turenchalk, G. S., Stewart, R. A., John, M. A. R. S., Chen, W., & Xu, T. (1999) · Nature Genetics · doi:10.1038/5960 · Cited by 263 · see citing works

A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt–Oram syndrome

Murakami, M., Nakagawa, M., Olson, E. N., & Nakagawa, O. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509109102 · Cited by 261 · see citing works

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

Thakur, M. D., Feng, Y., Jagannathan, R., Seppa, M. J., Skeath, J. B., & Longmore, G. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.035 · Cited by 258 · see citing works

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

Lapi, E., Agostino, S. D., Donzelli, S., Gal, H., Domany, E., Rechavi, G., Pandolfi, P. P., Givol, D., Strano, S., Lü, X., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.019 · Cited by 257 · see citing works

Morphogen Control of Wing Growth through the Fat Signaling Pathway

Rogulja, D., Rauskolb, C., & Irvine, K. D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.06.003 · Cited by 251 · see citing works

Structural basis of YAP recognition by TEAD4 in the Hippo pathwayPreprint

Chen, L., Chan, S. W., Zhang, X., Walsh, M. A., Lim, C. J., Hong, W., & Song, H. (2010) · Genes & Development · doi:10.1101/gad.1865310 · Cited by 251 · see citing works

Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts

Hong, Y., Stronach, B. E., Perrimon, N., Jan, L. Y., & Jan, Y. N. (2001) · Nature · doi:10.1038/414634a · Cited by 239 · see citing works

Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling

Ribeiro, P. S., Josué, F., Wepf, A., Wehr, M. C., Rinner, O., Kelly, G. P., Tapon, N., & Gstaiger, M. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.002 · Cited by 235 · see citing works

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors

Sun, G., & Irvine, K. D. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.036 · Cited by 219 · see citing works

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

Oka, T., Remue, E., Meerschaert, K., Vanloo, B., Boucherie, C., Gfeller, D., Bader, G. D., Sidhu, S. S., Vandekerckhove, J. S., Gettemans, J., et al. (2010) · Biochemical Journal · doi:10.1042/bj20100870 · Cited by 216 · see citing works

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

Badouel, C., Gardano, L., Amin, N., Garg, A., Rosenfeld, R., Bihan, T. L., & McNeill, H. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.010 · Cited by 211 · see citing works

TAZ Interacts with TTF-1 and Regulates Expression of Surfactant Protein-C

Park, K.-S., Whitsett, J. A., Palma, T. D., Hong, J., Yaffe, M. B., & Zannini, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312569200 · Cited by 211 · see citing works

Role of the Tumor Suppressor RASSF1A in Mst1-Mediated Apoptosis

Oh, H. J., Lee, K.-K., Song, S. J., Jin, M. S., Song, M. S., Lee, J. H., Im, C. R., Lee, J., Yonehara, S., & Lim, D. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2951 · Cited by 197 · see citing works

A crucial role of WW45 in developing epithelial tissues in the mouse

Lee, J., Kim, T., Yang, T.-H., Koo, B., Oh, S.-P., Lee, K., Oh, H.-J., Lee, S., Kong, Y., Kim, J., et al. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.63 · Cited by 195 · see citing works

Transcriptional Coactivation of Bone-Specific Transcription Factor Cbfa1 by TAZ

Cui, C. B., Cooper, L. F., Yang, X., Karsenty, G., & Aukhil, I. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1004-1013.2003 · Cited by 195 · see citing works

Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins

Matakatsu, H., & Blair, S. S. (2006) · Development · doi:10.1242/dev.02401 · Cited by 189 · see citing works

Transcription factor choice in the Hippo signaling pathway: homothorax and yorkie regulation of the microRNA bantam in the progenitor domain of the Drosophila eye imaginal discPreprint

Peng, H., Slattery, M. G., & Mann, R. S. (2009) · Genes & Development · doi:10.1101/gad.1820009 · Cited by 188 · see citing works

dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells

Ziosi, M., Baena-López, L. A., Grifoni, D., Froldi, F., Pession, A., Garoia, F., Trotta, V., Bellosta, P., Cavicchi, S., & Pession, A. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001140 · Cited by 184 · see citing works

Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms

Ren, F., Zhang, L., & Jiang, J. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.046 · Cited by 181 · see citing works

Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation

Willecke, M., Hamaratoǧlu, F., Sansores-García, L., Tao, C., & Halder, G. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805201105 · Cited by 166 · see citing works

TAZ is a novel oncogene in non-small cell lung cancer

Zhou, Z., Hao, Y., Liu, N., Raptis, L. H., Tsao, M., & Yang, X. (2011) · Oncogene · doi:10.1038/onc.2010.606 · Cited by 164 · see citing works

Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development

Skouloudaki, K., Puetz, M., Simons, M., Courbard, J.-R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M. J., Englert, C., Bollig, F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811691106 · Cited by 163 · see citing works

The Drosophila RASSF Homolog Antagonizes the Hippo Pathway

Polesello, C., Huelsmann, S., Brown, N. H., & Tapon, N. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.060 · Cited by 151 · see citing works

Cooperative Regulation of Growth by Yorkie and Mad through bantam

Oh, H., & Irvine, K. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2010.12.002 · Cited by 149 · see citing works

A Feed-Forward Circuit Linking Wingless, Fat-Dachsous Signaling, and the Warts-Hippo Pathway to Drosophila Wing Growth

Zecca, M., & Struhl, G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000386 · Cited by 148 · see citing works

Modulation of Fat:Dachsous Binding by the Cadherin Domain Kinase Four-Jointed

Simon, M. A., Xu, A., Ishikawa, H., & Irvine, K. D. (2010) · Current Biology · doi:10.1016/j.cub.2010.04.016 · Cited by 146 · see citing works

A novel TEAD1 mutation is the causative allele in Sveinsson's chorioretinal atrophy (helicoid peripapillary chorioretinal degeneration)

Fossdal, R. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh106 · Cited by 132 · see citing works

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

Grusche, F., Degoutin, J. L., Richardson, H. E., & Harvey, K. F. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.11.020 · Cited by 127 · see citing works

Fat and Expanded act in parallel to regulate growth through Warts

Feng, Y., & Irvine, K. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706722105 · Cited by 125 · see citing works

Transcriptional activity of Pax3 is co-activated by TAZ

Murakami, M., Tominaga, J., Makita, R., Uchijima, Y., Kurihara, Y., Nakagawa, O., Asano, T., & Kurihara, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.214 · Cited by 121 · see citing works

Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown

Sopko, R., Silva, E., Clayton, L., Gardano, L., Barrios‐Rodiles, M., Wrana, J. L., Varelas, X., Arbouzova, N. I., Shaw, S., Saburi, S., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.05.049 · Cited by 114 · see citing works

The Hippo pathway regulates apical-domain size independently of its growth-control function

Genevet, A., Polesello, C., Blight, K., Robertson, F., Collinson, L., Franck Pichaud, N., & Tapon, N. (2009) · Journal of Cell Science · doi:10.1242/jcs.041806 · Cited by 109 · see citing works

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling

Oh, H., Reddy, B. V. V. G., & Irvine, K. D. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.08.026 · Cited by 108 · see citing works

Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways

Tyler, D. M., & Baker, N. E. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.02.004 · Cited by 105 · see citing works

Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level

Omerović, J., Puggioni, E. M. R., Napoletano, S., Visco, V., Fraioli, R., Frati, L., Gulino, A., & Alimandi, M. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.12.002 · Cited by 97 · see citing works

Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye

Grzeschik, N. A., Amin, N., Secombe, J., Brumby, A. M., & Richardson, H. E. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.025 · Cited by 97 · see citing works

TAZ interacts with zonula occludens‐1 and ‐2 proteins in a PDZ‐1 dependent manner

Remue, E., Meerschaert, K., Oka, T., Boucherie, C., Vandekerckhove, J. S., Sudol, M., & Gettemans, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.09.020 · Cited by 96 · see citing works

Processing and phosphorylation of the Fat receptor

Feng, Y., & Irvine, K. D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811540106 · Cited by 94 · see citing works

Controlling the size of organs and organisms

Leevers, S. J., & McNeill, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.008 · Cited by 82 · see citing works

A Sveinsson’s chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ

Kitagawa, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.129 · Cited by 81 · see citing works

Drosophila lowfat, a novel modulator of Fat signaling

Mao, Y., Kucuk, B., & Irvine, K. D. (2009) · Development · doi:10.1242/dev.036152 · Cited by 73 · see citing works

Organ size determination and the limits of regulation

Stanger, B. Z. (2008) · Cell Cycle · doi:10.4161/cc.7.3.5348 · Cited by 58 · see citing works

A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie

Gilbert‐Ross, M., Tipping, M., Veraksa, A. N., & Moberg, K. H. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.04.012 · Cited by 52 · see citing works

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

Swift, J., Ivanovska, I. L., Buxboim, A., Harada, T., Dingal, P. C. D. P., Pinter, J., Pajerowski, J. D., Spinler, K. R., Shin, J., Tewari, M., et al. (2013) · Science · doi:10.1126/science.1240104 · Cited by 1,998 · see citing works

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053 · see citing works

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985 · see citing works

Hippo pathway effector Yap promotes cardiac regeneration

Xin, M., Kim, Y., Sutherland, L. B., Murakami, M., Qi, X., McAnally, J., Porrello, E. R., Mahmoud, A. I., Tan, W., Shelton, J. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313192110 · Cited by 895 · see citing works

Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment

Kawamura, K., Cheng, Y., Suzuki, N., Deguchi, M., Sato, Y., Takae, S., Ho, C.-H., Kawamura, N., Tamura, M., Hashimoto, S., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312830110 · Cited by 868 · see citing works

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

Rosenbluh, J., Nijhawan, D., Cox, A. G., Li, X., Neal, J. T., Schafer, E. J., Zack, T. I., Wang, X., Tsherniak, A., Schinzel, A. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.11.026 · Cited by 757 · see citing works

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

Kapoor, A., Yao, W., Ying, H., Hua, S., Liewen, A., Wang, Q., Zhong, Y., Wu, C.-J., Sadanandam, A., Hu, B., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.003 · Cited by 716 · see citing works

Alternative Wnt Signaling Activates YAP/TAZ

Park, H. W., Kim, Y. C., Yu, B., Moroishi, T., Mo, J., Plouffe, S. W., Meng, Z., Lin, K. C., Yu, F., Alexander, C. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.013 · Cited by 708 · see citing works

Intraovarian Control of Early Folliculogenesis

Hsueh, A. J. W., Kawamura, K., Cheng, Y., & Fauser, B. C. J. M. (2014) · Endocrine Reviews · doi:10.1210/er.2014-1020 · Cited by 708 · see citing works

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

Mo, J.-S., Meng, Z., Kim, Y. C., Park, H. W., Hansen, C. G., Kim, S., Lim, D.-S., & Guan, K.-L. (2015) · Nature Cell Biology · doi:10.1038/ncb3111 · Cited by 557 · see citing works

Epithelial cell polarity, stem cells and cancer

Martín‐Belmonte, F., & Pérez‐Moreno, M. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3169 · Cited by 553 · see citing works

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

Zeke, A., Misheva, M., Reményi, A., & Bogoyevitch, M. A. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00043-14 · Cited by 524 · see citing works

Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514 · see citing works

Non-histone protein methylation as a regulator of cellular signalling and function

Biggar, K. K., & Li, S. S.-C. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3915 · Cited by 479 · see citing works

Role of Merlin/NF2 inactivation in tumor biology

Petrilli, A. M., & Fernández‐Valle, C. (2015) · Oncogene · doi:10.1038/onc.2015.125 · Cited by 459 · see citing works

Mechanobiology and Developmental Control

Mammoto, T., Mammoto, A., & Ingber, D. E. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122340 · Cited by 436 · see citing works

Hepatostat: Liver regeneration and normal liver tissue maintenance

Michalopoulos, G. K. (2017) · Hepatology · doi:10.1002/hep.28988 · Cited by 444 · see citing works

The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation

Wang, Y., Lu, Y. C., Zhang, Y., Ning, Z., Li, Y., Zhao, Q., Lu, H., Huang, R., Xia, X.-Q., Feng, Q., et al. (2015) · Nature Genetics · doi:10.1038/ng.3280 · Cited by 432 · see citing works

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005465 · Cited by 414 · see citing works

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

Lu, Y., Wu, T., Gutman, O., Lu, H., Zhou, Q., Henis, Y. I., & Luo, K. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0485-0 · Cited by 373 · see citing works

Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

Deng, Y.-J., Lu, J., Li, W., Wu, A.-L., Zhang, X., Tong, W.-X., Ho, K., Qin, L., Song, H., & Mak, K. K. (2018) · Nature Communications · doi:10.1038/s41467-018-07022-2 · Cited by 305 · see citing works

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

Tschaharganeh, D. F., Chen, X., Latzko, P., Malz, M., Gaida, M. M., Felix, K., Ladu, S., Singer, S., Pinna, F., Gretz, N., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.009 · Cited by 326 · see citing works

A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis

Li, C., Wang, S., Xing, Z., Lin, A., Liang, K., Song, J. H., Hu, Q., Yao, J., Chen, Z., Park, P. K., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3464 · Cited by 318 · see citing works

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

Wang, Z., Wu, Y., Wang, H., Zhang, Y., Mei, L., Fang, X., Zhang, X., Zhang, F., Chen, H., Liu, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319190110 · Cited by 317 · see citing works

The role of mammalian target of rapamycin (mTOR) in insulin signaling

Yoon, M.-S. (2017) · Nutrients · doi:10.3390/nu9111176 · Cited by 300 · see citing works

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

Zhang, W., Gao, Y., Li, P., Shi, Z., Guo, T., Li, F., Han, X., Feng, Y., Zheng, C., Wang, Z., et al. (2014) · Cell Research · doi:10.1038/cr.2014.10 · Cited by 300 · see citing works

Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

Reginensi, A., Scott, R. P., Gregorieff, A., Bagherie-Lachidan, M., Chung, C., Lim, D., Pawson, T. J., Wrana, J. L., & McNeill, H. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003380 · Cited by 295 · see citing works

The Hippo signaling pathway and stem cell biology

Ramos, A., & Camargo, F. D. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.04.006 · Cited by 288 · see citing works

Mechanisms of Cardiac Regeneration

Uygur, A., & Lee, R. T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.018 · Cited by 293 · see citing works

The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate

(2018) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.02.002 · Cited by 286 · see citing works

MicroRNA-135b promotes lung cancer metastasis by regulating multiple targets in the Hippo pathway and LZTS1

Lin, C.-W., Chang, Y., Chang, Y.-C., Lin, J.-C., Chen, C. C., Pan, S., Wu, C., Chen, H.-Y., Yang, S. C., Hong, T.-M., et al. (2013) · Nature Communications · doi:10.1038/ncomms2876 · Cited by 282 · see citing works

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

Knippschild, U., Krüger, M., Richter, J., Xu, P., García-Reyes, B., Peifer, C., Halekotte, J., Bakulev, V. A., & Bischof, J. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00096 · Cited by 276 · see citing works

The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy

Chen, S. N., Gurha, P., Lombardi, R., Ruggiero, A., Willerson, J. T., & Marian, A. J. (2014) · Circulation Research · doi:10.1161/circresaha.114.302810 · Cited by 275 · see citing works

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Noland, C. L., Gierke, S., Schnier, P. D., Murray, J. M., Sandoval, W. N., Sagolla, M. S., Dey, A., Hannoush, R. N., Fairbrother, W. J., & Cunningham, C. N. (2015) · Structure · doi:10.1016/j.str.2015.11.005 · Cited by 268 · see citing works

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

Ma, B., Chen, Y., Chen, L., Cheng, H., Mu, C., Li, J., Gao, R., Zhou, C., Cao, L., Liu, J., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3073 · Cited by 266 · see citing works

Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation

Kim, M. H., Kim, J., Hong, H., Lee, J. J.-K., Lee, J., Jung, E., & Kim, J. (2015) · The EMBO Journal · doi:10.15252/embj.201592081 · Cited by 259 · see citing works

Biophysical Regulation of Cell Behavior—Cross Talk between Substrate Stiffness and Nanotopography

Yang, Y. S., Wang, K., Gu, X., & Leong, K. W. (2017) · Engineering · doi:10.1016/j.eng.2017.01.014 · Cited by 264 · see citing works

YAP is essential for tissue tension to ensure vertebrate 3D body shape

Porazinski, S. R., Wang, H., Asaoka, Y., Behrndt, M., Miyamoto, T., Morita, H., Hata, S., Sasaki, T., Krens, G., Osada, Y., et al. (2015) · Nature · doi:10.1038/nature14215 · Cited by 260 · see citing works

Programmed Cell Death Controlled by ANAC033/SOMBRERO Determines Root Cap Organ Size in Arabidopsis

Fendrych, M., Hautegem, T. V., Durme, M. V., Olvera-Carrillo, Y., Huysmans, M., Karimi, M., Lippens, S., Guérin, C. J., Krebs, M., Schumacher, K., et al. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.025 · Cited by 258 · see citing works

Yes-associated Protein Isoform 1 (Yap1) Promotes Cardiomyocyte Survival and Growth to Protect against Myocardial Ischemic Injury

Del Re, D. P., Yang, Y., Nakano, N., Cho, J., Zhai, P., Yamamoto, T., Zhang, N., Yabuta, N., Nojima, H., Pan, D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.436311 · Cited by 249 · see citing works

Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells

Basu-Roy, U., Bayin, N. S., Rattanakorn, K., Han, E. J., Placantonakis, D. G., Mansukhani, A., & Basilico, C. (2015) · Nature Communications · doi:10.1038/ncomms7411 · Cited by 248 · see citing works

Cellular Homeostasis and Repair in the Mammalian Liver

Stanger, B. Z. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170255 · Cited by 248 · see citing works

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

Miller, E., Yang, J., DeRan, M., Wu, C., Su, A. I., Bonamy, G. M. C., Liu, J., Peters, E. C., & Wu, X. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.07.005 · Cited by 247 · see citing works

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

Choi, H.-J., Zhang, H., Park, H., Choi, K.-S., Lee, H., Agrawal, V., Kim, Y., & Kwon, Y. (2015) · Nature Communications · doi:10.1038/ncomms7943 · Cited by 247 · see citing works

YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6

Lv, Y., Kim, K., Sheng, Y., Cho, J., Qian, Z., Zhao, Y., Hu, G., Pan, D., Malik, A. B., & Hu, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.313143 · Cited by 240 · see citing works

Engineered hydrogels for mechanobiology

Blache, U., Ford, E. M., Ha, B. H., Rijns, L., Chaudhuri, O., Dankers, P. Y. W., Kloxin, A. M., Snedeker, J. G., & Gentleman, E. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00179-7 · Cited by 236 · see citing works

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

Marti, P., Stein, C., Blumer, T., Abraham, Y., Dill, M. T., Pikiolek, M., Orsini, V., Jurisic, G., Megel, P., Makowska, Z., et al. (2015) · Hepatology · doi:10.1002/hep.27992 · Cited by 232 · see citing works

The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment

Laurenti, E., Doulatov, S. R., Zandi, S., Plumb, I., Chen, J., April, C., Fan, J., & Dick, J. E. (2013) · Nature Immunology · doi:10.1038/ni.2615 · Cited by 224 · see citing works

MicroRNA-34a Plays a Key Role in Cardiac Repair and Regeneration Following Myocardial Infarction

Yang, Y., Cheng, H.-W., Qiu, Y., Dupee, D., Noonan, M., Lin, Y., Fisch, S., Unno, K., Sereti, K., & Liao, R. (2015) · Circulation Research · doi:10.1161/circresaha.117.305962 · Cited by 229 · see citing works

Contact inhibition (of proliferation) redux

McClatchey, A. I., & Yap, A. S. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.06.009 · Cited by 228 · see citing works

The Hippo Pathway in Heart Development, Regeneration, and Diseases

Zhou, Q., Li, L., Zhao, B., & Guan, K. (2015) · Circulation Research · doi:10.1161/circresaha.116.303311 · Cited by 219 · see citing works

Epithelial-to-mesenchymal(-like) transition as a relevant molecular event in malignant gliomas

Kahlert, U. D., Nikkhah, G., & Maciaczyk, J. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.12.010 · Cited by 220 · see citing works

Agrin as a Mechanotransduction Signal Regulating YAP through the Hippo Pathway

Chakraborty, S., Njah, K., Pobbati, A. V., Lim, Y. B., Raju, A., Lakshmanan, M., Tergaonkar, V., Lim, C. T., & Hong, W. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.041 · Cited by 220 · see citing works

The balancing act of the liver: tissue regeneration versus fibrosis

Cordero-Espinoza, L., & Huch, M. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93562 · Cited by 220 · see citing works

Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP ‐ TEAD complex

Wei, H., Wang, F., Wang, Y., Li, T., Xiu, P., Zhong, J., Sun, X., & Li, J. (2016) · Cancer Science · doi:10.1111/cas.13138 · Cited by 218 · see citing works

Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells

Zhao, R., Fallon, T. R., Saladi, S. V., Pardo–Saganta, A., Villoria, J., Mou, H., Vinarský, V., Gonzalez-Celeiro, M., Nunna, N., Hariri, L. P., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.06.004 · Cited by 219 · see citing works

SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage

Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216 · see citing works

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury

Planas-Paz, L., Sun, T., Pikiolek, M., Cochran, N. R., Bergling, S., Orsini, V., Yang, Z., Sigoillot, F., Jetzer, J., Syed, M., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.04.005 · Cited by 216 · see citing works

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

Cebola, I., Rodríguez-Seguí, S., Cho, C. H., Bessa, J., Rovira, M., Luengo, M., Chhatriwala, M., Berry, A. A., Ponsa-Cobas, J., Maestro, M., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3160 · Cited by 212 · see citing works

The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

Barry, E. R., & Camargo, F. D. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.12.006 · Cited by 214 · see citing works

The tension biology of wound healing

Harn, H. I., Ogawa, R., Hsu, C., Hughes, M. W., Tang, M., & Chuong, C. (2017) · Experimental Dermatology · doi:10.1111/exd.13460 · Cited by 208 · see citing works

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung

Lange, A. W., Sridharan, A., Xu, Y. J., Stripp, B. R., Perl, A. T., & Whitsett, J. A. (2014) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mju046 · Cited by 208 · see citing works

Polyploidization and Cell Fusion Contribute to Wound Healing in the Adult Drosophila Epithelium

Losick, V. P., Fox, D. T., & Spradling, A. C. (2013) · Current Biology · doi:10.1016/j.cub.2013.09.029 · Cited by 204 · see citing works

Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade

Zhang, Q., Meng, F., Chen, S., Plouffe, S. W., Wu, S., Liu, S., Li, X., Zhou, R., Wang, J., Zhao, B., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3496 · Cited by 206 · see citing works

Sarcomatoid renal cell carcinoma: biology, natural history and management

Blum, K. A., Gupta, S., Tickoo, S. K., Chan, T. A.-T., Russo, P., Motzer, R. J., Karam, J. A., & Hakimi, A. A. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-00382-9 · Cited by 210 · see citing works

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking

Kim, J., Jo, H., Hong, H., Kim, J. M., Kim, J. M., Lee, J.-K., Heo, W. D., & Kim, J. (2015) · Nature Communications · doi:10.1038/ncomms7781 · Cited by 204 · see citing works

Mechanotransduction and fibrosis

Duscher, D., Maan, Z. N., Wong, V., Rennert, R. C., Januszyk, M., Rodrigues, M., Hu, M. S.-M., Whitmore, A. J., Whittam, A. J., Longaker, M. T., et al. (2014) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2014.03.031 · Cited by 202 · see citing works

PTPN14 interacts with and negatively regulates the oncogenic function of YAP

Liu, X., Yang, N., Figel, S. A., Wilson, K. E., Morrison, C. D., Gelman, I. H., & Zhang, J. (2013) · Oncogene · doi:10.1038/onc.2012.147 · Cited by 196 · see citing works

Dual role of YAP and TAZ in renewal of the intestinal epithelium

Imajo, M., Ebisuya, M., & Nishida, E. (2014) · Nature Cell Biology · doi:10.1038/ncb3084 · Cited by 194 · see citing works

Molecular insights into NF2/Merlin tumor suppressor function

Cooper, J. M., & Giancotti, F. G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.001 · Cited by 186 · see citing works

SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

Fang, L., Teng, H., Wang, Y., Liao, G., Weng, L., Li, Y., Wang, X., Jin, J., Jiao, C., Chen, L., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.06.002 · Cited by 185 · see citing works

Claudin-18–mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis

Zhou, B., Flodby, P., Luo, J., Castillo, D. R., Liu, Y., Yu, F., McConnell, A. M., Varghese, B. A., Li, G., Chimge, N., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci90429 · Cited by 182 · see citing works

Tight junction‐related human diseases

Sawada, N. (2013) · Pathology International · doi:10.1111/pin.12021 · Cited by 177 · see citing works

Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair

Deng, Y., Wu, A., Li, P.-S., Li, G., Qin, L., Song, H. X., & Mak, K. K. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.021 · Cited by 181 · see citing works

Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components

Meran, L., Baulies, A., & Li, V. S. W. (2017) · Stem Cells International · doi:10.1155/2017/7970385 · Cited by 178 · see citing works

14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2

Xu, J., Acharya, S., Şahin, Ö., Zhang, Q., Saito, Y., Yao, J., Wang, H., Li, P., Zhang, L., Lowery, F. J., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.025 · Cited by 180 · see citing works

gp130 Controls Cardiomyocyte Proliferation and Heart Regeneration

Li, Y., Feng, J., Song, S., Li, H., Yang, H., Zhou, B., Li, Y., Zhang, Y., Lian, H., Liu, L., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.044484 · Cited by 177 · see citing works

Rewiring cell polarity signaling in cancer

Halaoui, R., & McCaffrey, L. M. (2014) · Oncogene · doi:10.1038/onc.2014.59 · Cited by 176 · see citing works

Structural and Functional Similarity between the Vgll1-TEAD and the YAP-TEAD Complexes

Pobbati, A. V., Chan, S. W., Lee, I., Song, H., & Hong, W. (2012) · Structure · doi:10.1016/j.str.2012.04.004 · Cited by 171 · see citing works

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification

Musah, S., Wrighton, P. J., Zaltsman, Y., Zhong, X., Zorn, S., Parlato, M. B., Hsiao, C., Palecek, S. P., Chang, Q., Murphy, W. L., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1415330111 · Cited by 169 · see citing works

The Hippo transducer TAZ promotes epithelial to mesenchymal transition and cancer stem cell maintenance in oral cancer

Li, Z., Wang, Y., Zhu, Y., Yuan, C., Wang, D., Zhang, W., Qi, B., Qiu, J. F., Song, X., Ye, J., et al. (2015) · Molecular Oncology · doi:10.1016/j.molonc.2015.01.007 · Cited by 169 · see citing works

Signal integration in TGF-β, WNT, and Hippo pathways

Attisano, L., & Wrana, J. L. (2013) · F1000Prime Reports · doi:10.12703/p5-17 · Cited by 168 · see citing works

The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis

Yi, C., Shen, Z., Stemmer-Rachamimov, A. O., Dawany, N. B., Troutman, S. A., Showe, L. C., Liu, Q., Shimono, A., Sudol, M., Holmgren, L., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004060 · Cited by 168 · see citing works

The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

Santucci, M., Vignudelli, T., Ferrari, S., Mor, M., Scalvini, L., Bolognesi, M. L., Uliassi, E., & Costi, M. P. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501615v · Cited by 167 · see citing works

Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

Huang, Z., Zhang, Z., Zhou, C., Liu, L., & Huang, C. (2022) · MedComm · doi:10.1002/mco2.144 · Cited by 167 · see citing works

Lipid Mediators Regulate Pulmonary Fibrosis: Potential Mechanisms and Signaling Pathways

Suryadevara, V., Ramchandran, R., Kamp, D. W., & Natarajan, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124257 · Cited by 164 · see citing works

Glycosaminoglycan-Binding Hydrogels Enable Mechanical Control of Human Pluripotent Stem Cell Self-Renewal

Musah, S., Morin, S. A., Wrighton, P. J., Zwick, D. B., Jin, S., & Kiessling, L. L. (2012) · ACS Nano · doi:10.1021/nn3039148 · Cited by 165 · see citing works

The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size

Watt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F., & Gregorevic, P. (2015) · Nature Communications · doi:10.1038/ncomms7048 · Cited by 164 · see citing works

Palmitic acid dysregulates the Hippo–YAP pathway and inhibits angiogenesis by inducing mitochondrial damage and activating the cytosolic DNA sensor cGAS–STING–IRF3 signaling mechanism

Yuan, L., Mao, Y. J., Luo, W., Wu, W., Xu, H. Y., Wang, X. L., & Shen, Y. H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.804005 · Cited by 161 · see citing works

Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap

Lee, Y. A., Noon, L. A., Akat, K. M., Ybanez, M. D., Lee, T.-F., Berres, M.-L., Fujiwara, N., Goossens, N., Chou, H.-I., Parvin-Nejad, F. P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07338-z · Cited by 161 · see citing works

TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function

Wang, J., Park, J., Wei, Y., Rajurkar, M., Cotton, J. L., Fan, Q., Lewis, B. C., Ji, H., & Mao, J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.05.013 · Cited by 160 · see citing works

The Mevalonate Pathway, a Metabolic Target in Cancer Therapy

Guerra, B., Recio, C., Aranda-Tavío, H., Guerra-Rodríguez, M., García-Castellano, J. M., & Fernández‐Pérez, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626971 · Cited by 160 · see citing works

The Hippo Transducer TAZ Interacts with the SWI/SNF Complex to Regulate Breast Epithelial Lineage Commitment

Skibinski, A., Breindel, J. L., Prat, A., Galván, P., Smith, E., Rolfs, A., Gupta, P. B., LaBaer, J., & Kuperwasser, C. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.038 · Cited by 159 · see citing works

Genomic Analyses Reveal Demographic History and Temperate Adaptation of the Newly Discovered Honey Bee Subspecies Apis mellifera sinisxinyuan n. ssp

Chen, C., Liu, Z., Pan, Q., Chen, X., Wang, H., Guo, H., Liu, S., Lü, H., Tian, S., Li, R., et al. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw017 · Cited by 157 · see citing works

VGLL4 targets a TCF4–TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer

Jiao, S., Li, C., Qian, H., Miao, H., Zhang, L., Li, L., & Zhou, Z. (2017) · Nature Communications · doi:10.1038/ncomms14058 · Cited by 157 · see citing works

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta

Meinhardt, G., Haider, S., Kunihs, V., Saleh, L., Pollheimer, J., Fiala, C., Hetey, S., Feher, Z., Szilágyi, A., Than, N. G., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002630117 · Cited by 153 · see citing works

YAP promotes the activation of NLRP3 inflammasome via blocking K27-linked polyubiquitination of NLRP3

Wang, D., Zhang, Y., Xu, X., Wu, J., Peng, Y., Li, J., Luo, R., Huang, L., Liu, L., Yu, S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22987-3 · Cited by 156 · see citing works

Targeting YAP1/LINC00152/FSCN1 Signaling Axis Prevents the Progression of Colorectal Cancer

Ou, C., Sun, Z., He, X., Li, X., Fan, S., Zheng, X., Qiu, P., Li, G., Li, X., & Ma, J. (2019) · Advanced Science · doi:10.1002/advs.201901380 · Cited by 155 · see citing works

Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas

Gao, T., Zhou, D., Yang, C., Singh, T., Penzo‐Méndez, A., Maddipati, R., Tzatsos, A., Bardeesy, N. M., Avruch, J., & Stanger, B. Z. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.037 · Cited by 151 · see citing works

The history and regulatory mechanism of the Hippo pathway

Kim, W., & Jho, E. (2018) · BMB Reports · doi:10.5483/bmbrep.2018.51.3.022 · Cited by 77 · see citing works

Hippo signaling in organ size controlPreprint

Pan, D. (2007) · Genes & Development · doi:10.1101/gad.1536007 · Cited by 648 · see citing works

The Hippo pathway in organ development, homeostasis, and regeneration

Fu, V. X., Plouffe, S. W., & Guan, K. (2017) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2017.12.012 · Cited by 229 · see citing works

Hippo Growth Control Pathway and Organ Size

Waghmare, I., Verghese, S., & Kango-Singh, M. (2015) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0026054

The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

Barry, E. R., & Camargo, F. D. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.12.006 · Cited by 214 · see citing works