Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh +4 more·2014·Cell Reports

DOI 10.1016/j.celrep.2014.04.037

Cited by (337)

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Qian Jiang, Liuqin He, Yongqing Hou, Jiashun Chen, Yehui Duan, Dun Deng, Guoyao Wu, Yulong Yin, Yao Kang · 2016 · Amino Acids
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Kinetic simulation of malate-aspartate and citrate-pyruvate shuttles in association with Krebs cycle
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