Metabolism during ECM Detachment: Achilles Heel of Cancer Cells?

The emerging hallmarks of cancer metabolism

Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · see citing works

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

Disruption of epithelial cell-matrix interactions induces apoptosis

Frisch, S., & Francis, H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.4.619 · Cited by 3,272 · see citing works

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820 · see citing works

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works

Understanding the Intersections between Metabolism and Cancer Biology

Heiden, M. G. V., & DeBerardinis, R. J. (2017) · Cell · doi:10.1016/j.cell.2016.12.039 · Cited by 2,316 · see citing works

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277 · see citing works

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · see citing works

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990 · see citing works

Deconvoluting the context-dependent role for autophagy in cancer

White, E. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3262 · Cited by 1,698 · see citing works

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683 · see citing works

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

DeBerardinis, R. J., & Cheng, T. (2010) · Oncogene · doi:10.1038/onc.2009.358 · Cited by 1,365 · see citing works

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Mullen, A. R., Wheaton, W. W., Jin, E. S., Chen, P.-H., Sullivan, L. B., Cheng, T., Yang, Y., Linehan, W. M., Chandel, N. S., & DeBerardinis, R. J. (2012) · Nature · doi:10.1038/nature10642 · Cited by 1,328 · see citing works

Oxidative stress inhibits distant metastasis by human melanoma cells

Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269 · see citing works

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Anastasiou, D., Poulogiannis, G., Asara, J. M., Boxer, M. B., Jiang, J., Shen, M., Bellinger, G., Sasaki, A. T., Locasale, J. W., Auld, D. S., et al. (2011) · Science · doi:10.1126/science.1211485 · Cited by 1,196 · see citing works

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Jeon, S.-M., Chandel, N. S., & Hay, N. (2012) · Nature · doi:10.1038/nature11066 · Cited by 1,132 · see citing works

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120 · see citing works

Quantitative flux analysis reveals folate-dependent NADPH production

Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature · doi:10.1038/nature13236 · Cited by 1,114 · see citing works

Serine and glycine metabolism in cancer

Amelio, I., Cutruzzolà, F., Antonov, A., Agostini, M., & Melino, G. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.004 · Cited by 1,056 · see citing works

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature · doi:10.1038/nature08268 · Cited by 1,031 · see citing works

Pyruvate kinase M2 is a phosphotyrosine-binding protein

Christofk, H. R., Vander Heiden, M. G., Wu, N., Asara, J. M., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06667 · Cited by 995 · see citing works

Vitamin C selectively kills <i>KRAS</i> and <i>BRAF</i> mutant colorectal cancer cells by targeting GAPDH

Yun, J., Mullarky, E., Lu, C., Bosch, K. N., Kavalier, A., Rivera, K., Roper, J., Chio, I. I. C., Giannopoulou, E. G., Rago, C., et al. (2015) · Science · doi:10.1126/science.aaa5004 · Cited by 913 · see citing works

Antioxidants Accelerate Lung Cancer Progression in Mice

Sayin, V. I., Ibrahim, M. X., Larsson, E., Nilsson, J. A., Lindahl, P., & Bergo, M. O. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007653 · Cited by 867 · see citing works

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

Debnath, J., Mills, K. R., Collins, N. L., Reginato, M. J., Muthuswamy, S. K., & Brugge, J. S. (2002) · Cell · doi:10.1016/s0092-8674(02)01001-2 · Cited by 763 · see citing works

A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

Overholtzer, M., Mailleux, A. A., Mouneimne, G., Normand, G., Schnitt, S. J., King, R. W., Cibas, E. S., & Brugge, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.10.040 · Cited by 748 · see citing works

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport

Yang, C., Ko, B., Hensley, C. T., Jiang, L., Wasti, A. T., Kim, J., Sudderth, J., Calvaruso, M. A., Lumata, L., Mitsche, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.025 · Cited by 679 · see citing works

Anoikis resistance and tumor metastasis

Simpson, C. D., Anyiwe, K., & Schimmer, A. D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.029 · Cited by 640 · see citing works

Antioxidants can increase melanoma metastasis in mice

Le Gal, K., Ibrahim, M. X., Wiel, C., Sayin, V. I., Akula, M. K., Karlsson, C., Dalin, M. G., Akyürek, L. M., Lindahl, P., Nilsson, J., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3740 · Cited by 632 · see citing works

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Jiang, L., Shestov, A. A., Swain, P., Yang, C., Parker, S. J., Wang, Q. A., Terada, L. S., Adams, N. D., McCabe, M. T., Pietrak, B., et al. (2016) · Nature · doi:10.1038/nature17393 · Cited by 582 · see citing works

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

Fung, C., Lock, R., Gao, S., Salas, E., & Debnath, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1092 · Cited by 558 · see citing works

A two-way street: reciprocal regulation of metabolism and signalling

Wellen, K. E., & Thompson, C. B. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3305 · Cited by 528 · see citing works

Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation

Lock, R., Roy, S., Kenific, C. M., Su, J. S., Salas, E., Ronen, S. M., & Debnath, J. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-06-0500 · Cited by 467 · see citing works

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H., Seo, J. H., Shan, C., Dai, Q., Zhang, L., Xie, J., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.020 · Cited by 434 · see citing works

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

Yang, C., Sudderth, J., Dang, T. T., Bachoo, R. G., McDonald, J. G., & DeBerardinis, R. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2266 · Cited by 425 · see citing works

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

Buchheit, C. L., Weigel, K. J., & Schafer, Z. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3789 · Cited by 367 · see citing works

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

Mullen, A. R., Hu, Z., Shi, X., Jiang, L., Boroughs, L. K., Kovacs, Z., Boriack, R., Rakheja, D., Sullivan, L. B., Linehan, W. M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.037 · Cited by 337 · see citing works

New aspects of the Warburg effect in cancer cell biology

Bensinger, S. J., & Christofk, H. R. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.02.003 · Cited by 309 · see citing works

Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion

Lock, R., Kenific, C. M., Leidal, A. M., Salas, E., & Debnath, J. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0841 · Cited by 280 · see citing works

BIM Regulates Apoptosis during Mammary Ductal Morphogenesis, and Its Absence Reveals Alternative Cell Death Mechanisms

Mailleux, A. A., Overholtzer, M., Schmelzle, T., Bouillet, P., Strasser, A., & Brugge, J. S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.12.003 · Cited by 255 · see citing works

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

Lien, E. C., Lyssiotis, C. A., Juvekar, A., Hu, H., Asara, J. M., Cantley, L. C., & Toker, A. (2016) · Nature Cell Biology · doi:10.1038/ncb3341 · Cited by 249 · see citing works

Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

Choo, A. Y., Kim, S. G., Heiden, M. G. V., Mahoney, S. J., Vu, H., Yoon, S.-O., Cantley, L. C., & Blenis, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.007 · Cited by 248 · see citing works

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferationPreprint

Grassian, A. R., Metallo, C. M., Coloff, J. L., Stephanopoulos, G. N., & Brugge, J. S. (2011) · Genes & Development · doi:10.1101/gad.16771811 · Cited by 178 · see citing works

Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

Avivar‐Valderas, A., Bobrovnikova-Marjon, E. V., Diehl, J. A., Bardeesy, N. M., Debnath, J., & Aguirre‐Ghiso, J. A. (2012) · Oncogene · doi:10.1038/onc.2012.512 · Cited by 163 · see citing works

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinomaPreprint

Dayton, T. L., Gocheva, V., Miller, K. M., Israelsen, W. J., Bhutkar, A. J., Clish, C. B., Davidson, S. M., Luengo, A., Bronson, R. T., Jacks, T., et al. (2016) · Genes & Development · doi:10.1101/gad.278549.116 · Cited by 158 · see citing works

SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth

Park, S., Özden, Ö., Liu, G., Song, H. Y., Zhu, Y., Yan, Y., Zou, X., Kang, H.-J., Jiang, H., Principe, D. R., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2498 · Cited by 144 · see citing works

Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix

Davison, C. A., Durbin, S., Thau, M. R., Zellmer, V. R., Chapman, S. E., Diener, J. M., Wathen, C. A., Leevy, W. M., & Schafer, Z. T. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2482 · Cited by 124 · see citing works

The regulation of cancer cell death and metabolism by extracellular matrix attachment

Buchheit, C. L., Rayavarapu, R. R., & Schafer, Z. T. (2012) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2012.04.007 · Cited by 115 · see citing works

Lack of Evidence for PKM2 Protein Kinase Activity

Hosios, A. M., Fiske, B. P., Gui, D. Y., & Heiden, M. G. V. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.013 · Cited by 107 · see citing works

Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells

Mason, J. A., Davison-Versagli, C. A., Leliaert, A. K., Pape, D. J., McCallister, C. M., Zuo, J.-L., Durbin, S., Buchheit, C. L., Zhang, S., & Schafer, Z. T. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.15 · Cited by 72 · see citing works

Antioxidant Activity during Tumor Progression: A Necessity for the Survival of Cancer Cells?

Hawk, M. A., McCallister, C. M., & Schafer, Z. T. (2016) · Cancers · doi:10.3390/cancers8100092 · Cited by 72 · see citing works

Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration

Buchheit, C. L., Angarola, B. L., Steiner, A., Weigel, K. J., & Schafer, Z. T. (2015) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2014.209 · Cited by 63 · see citing works

CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis

Weigel, K. J., Jakimenko, A., Conti, B. A., Chapman, S. E., Kaliney, W. J., Leevy, W. M., Champion, M. M., & Schafer, Z. T. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0090 · Cited by 49 · see citing works

The Role of Multicellular Aggregation in the Survival of ErbB2-positive Breast Cancer Cells during Extracellular Matrix Detachment

Rayavarapu, R. R., Heiden, B., Pagani, N., Shaw, M. M., Shuff, S., Zhang, S., & Schafer, Z. T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.612754 · Cited by 42 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death &amp; Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments

Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977 · see citing works

Role of Bruton’s tyrosine kinase in B cells and malignancies

Pal Singh, S., Dammeijer, F., & Hendriks, R. W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0779-z · Cited by 726 · see citing works

Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer

Liu, W., Chakraborty, B., Safi, R., Kazmin, D. A., Chang, C., & McDonnell, D. P. (2021) · Nature Communications · doi:10.1038/s41467-021-25354-4 · Cited by 344 · see citing works

Warburg effect in colorectal cancer: the emerging roles in tumor microenvironment and therapeutic implications

Zhong, X., He, X., Wang, Y., Hu, Z., Huang, H., Zhao, S., Wei, P., & Li, D. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01358-5 · Cited by 340 · see citing works

Could 3D models of cancer enhance drug screening?

Brancato, V., Oliveira, J. M., Correlo, V. M., Reis, R. L., & Kundu, S. C. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119744 · Cited by 283 · see citing works

Mitochondrial Reactive Oxygen Species and Mitophagy: A Complex and Nuanced Relationship

Schofield, J. H., & Schafer, Z. T. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8058 · Cited by 207 · see citing works

Mechanisms of Regulated Cell Death: Current Perspectives

Santagostino, S. F., Assenmacher, C., Tarrant, J. C., Adedeji, A. O., & Radaelli, E. (2021) · Veterinary Pathology · doi:10.1177/03009858211005537 · Cited by 133 · see citing works

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

Schroeder, B., Steen, T. V., Espinoza, I. C., Venkatapoorna, C. M. K., Hu, Z., Martín, F., Regan, K. M., Cuyàs, E., Meng, X. W., Verdura, S., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04262-x · Cited by 100 · see citing works

Obesity promotes gastric cancer metastasis via diacylglycerol acyltransferase 2-dependent lipid droplets accumulation and redox homeostasis

Li, S., Wu, T., Lu, Y., Wang, J., Yu, F.-H., Yang, M., Huang, Y., Li, Z.-J., Wang, S.-L., Huang, L., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101596 · Cited by 93 · see citing works

Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer

DeBlasi, J. M., & DeNicola, G. M. (2020) · Cancers · doi:10.3390/cancers12103023 · Cited by 80 · see citing works

Tumor-Associated Extracellular Matrix: How to Be a Potential Aide to Anti-tumor Immunotherapy?

He, Y., Liu, T., Dai, S., Xu, Z., Wang, L., & Luo, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.739161 · Cited by 83 · see citing works

Interplay of oxidative stress and antioxidant mechanisms in cancer development and progression

Jomová, K., Alomar, S. Y., Valko, R., Fresser, L., Nepovimová, E., Kuča, K., & Valko, M. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04146-5 · Cited by 88 · see citing works

SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells

Mason, J. A., Cockfield, J. A., Pape, D. J., Meissner, H., Sokolowski, M. T., White, T. C., Valentín López, J. C., Liu, J., Liu, X., Martínez-Reyes, I., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108821 · Cited by 64 · see citing works

Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape

Rinaldi, G., Rossi, M., & Fendt, S. (2017) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1397 · Cited by 64 · see citing works

Metabolic reprogramming sustains cancer cell survival following extracellular matrix detachment

Endo, H., Owada, S., Inagaki, Y., Shida, Y., & Tatemichi, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101643 · Cited by 63 · see citing works

Genomic control of metastasis

Patel, S. A., Rodrigues, P., Wesolowski, L., & Vanharanta, S. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01127-6 · Cited by 58 · see citing works

Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells

Cockfield, J. A., & Schafer, Z. T. (2019) · Cancers · doi:10.3390/cancers11081208 · Cited by 53 · see citing works

Correlation between the Warburg effect and progression of triple-negative breast cancer

Liu, S., Li, Y., Yuan, M., Song, Q., & Liu, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1060495 · Cited by 52 · see citing works

Arginine methylation of MTHFD1 by PRMT5 enhances anoikis resistance and cancer metastasis

Meng, Q., Lu, Y., Chen, W., Wang, Z., Lin, J., Liao, K. L., Luo, X.-J., Yu, K., Han, Y., Li, J., et al. (2022) · Oncogene · doi:10.1038/s41388-022-02387-7 · Cited by 41 · see citing works

Biomaterials to regulate tumor extracellular matrix in immunotherapy

Zhang, Y., Dong, X., Zhang, Y., Chen, Z., Zhou, G., Chen, N., Shen, W., Yang, K., & Pei, P. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.010 · Cited by 40 · see citing works

Nuclear respiratory factor 1 promotes spheroid survival and mesenchymal transition in mammary epithelial cells

Zhou, Y., Xu, Z., Quan, D. L., Zhang, F., Zhang, H., Xiao, T., Hou, S., Qiao, H., Harismendy, O., Wang, J. Y. J., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0349-2 · Cited by 31 · see citing works

Iron affects the sphere-forming ability of ovarian cancer cells in non-adherent culture conditions

Battaglia, A. M., Sacco, A., Vecchio, E., Scicchitano, S., Petriaggi, L., Giorgio, E., Bulotta, S., Levi, S., Faniello, M. C., Biamonte, F., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1272667 · Cited by 31 · see citing works

Functionalized DNA Hydrogels Produced by Polymerase‐Catalyzed Incorporation of Non‐Natural Nucleotides as a Surface Coating for Cell Culture Applications

Finke, A., Schneider, A., Spreng, A., Leist, M., Niemeyer, C. M., & Marx, A. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900080 · Cited by 31 · see citing works

Stromal extracellular matrix is a microenvironmental cue promoting resistance to EGFR tyrosine kinase inhibitors in lung cancer cells

Wang, Y., Zhang, T., Guo, L., Ren, T., & Yang, Y. (2018) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2018.11.001 · Cited by 29 · see citing works

Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the β-catenin/ID2 pathway

Wang, W., Shen, X., Huang, D.-B., Jia, W. P., Liu, W., & He, Y. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00460-0 · Cited by 28 · see citing works

Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells

He, J., Abikoye, A. M., McLaughlin, B. P., Middleton, R. S., Sheldon, R. D., Jones, R. G., & Schafer, Z. T. (2023) · iScience · doi:10.1016/j.isci.2023.106827 · Cited by 25 · see citing works

The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes

Zeng, Y., Li, Q., Hu, Y., Hu, H., Xu, J., Guo, M., Zhang, W., Lou, X., Wang, Y., Gao, H., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216769 · Cited by 23 · see citing works

Efficient iron utilization compensates for loss of extracellular matrix of ovarian cancer spheroids

Wang, Q., Gu, T., Ma, L., Bu, S., Zhou, W., Mao, G., Wang, L., Guo, Y., & Lai, D. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.001 · Cited by 23 · see citing works

Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX

Takáčová, M., Kajanová, I., Kolarcikova, M., Lapinova, J., Zaťovičová, M., & Pastoreková, S. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10011-5 · Cited by 20 · see citing works

Fibroblasts in cancer: Defining target structures for therapeutic intervention

Boesch, M., Baty, F., Rumpold, H. F., Sopper, S., Wolf, D. G. F., & Brutsche, M. H. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.06.003 · Cited by 20 · see citing works

What Zebrafish and Nanotechnology Can Offer for Cancer Treatments in the Age of Personalized Medicine

Cascallar, M., Alijas, S., Pensado‐López, A., Vázquez-Ríos, A. J., Sanchez, L. E., Piñeiro, R., & de la Fuente, M. (2022) · Cancers · doi:10.3390/cancers14092238 · Cited by 19 · see citing works

CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR

Qiu, L., Zhou, R., Zhou, L., Yang, S., & Wu, J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.931749 · Cited by 18 · see citing works

Loss of TP53I11 Enhances the Extracellular Matrix‐independent Survival by Promoting Activation of AMPK

Xiao, T., Xu, Z., Zhou, Y., Zhang, H., Geng, J., Liang, Y., Qiao, H., & Suo, G. (2018) · IUBMB Life · doi:10.1002/iub.1949 · Cited by 19 · see citing works

Cell death classification: A new insight based on molecular mechanisms

Dehghan, S., Kheshtchin, N., Hassannezhad, S., & Soleimani, M. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113860 · Cited by 18 · see citing works

Nanophotosensitizers for cancer therapy: a promising technology?

dos Santos, A. F., Arini, G. S., de Almeida, D. R. Q., & Labriola, L. (2021) · Journal of Physics Materials · doi:10.1088/2515-7639/abf7dd · Cited by 17 · see citing works

Hypoxia-Mediated ATF4 Induction Promotes Survival in Detached Conditions in Metastatic Murine Mammary Cancer Cells

Kiesel, V. A., Sheeley, M. P., Hicks, E. M., Andolino, C. J., Donkin, S. S., Wendt, M. K., Hursting, S. D., & Teegarden, D. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.767479 · Cited by 17 · see citing works

The critical role of glutamine and fatty acids in the metabolic reprogramming of anoikis-resistant melanoma cells

Peppicelli, S., Kersikla, T., Menegazzi, G., Andreucci, E., Ruzzolini, J., Nediani, C., Bianchini, F., & Calorini, L. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1422281 · Cited by 16 · see citing works

Integrin–ECM interactions and membrane-associated Catalase cooperate to promote resilience of the Drosophila intestinal epithelium

Mlih, M., & Karpac, J. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001635 · Cited by 16 · see citing works

Acod1 expression in cancer cells promotes immune evasion through the generation of inhibitory peptides

Schofield, J. H., Longo, J., Sheldon, R. D., Albano, E., Ellis, A. E., Hawk, M. A., Murphy, S. P., Duong, L., Rahmy, S., Lü, X., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113984 · Cited by 14 · see citing works

A Shifty Target: Tumor-Initiating Cells and Their Metabolism

Bezuidenhout, N., & Shoshan, M. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215370 · Cited by 14 · see citing works

Loss of Fer Jeopardizes Metabolic Plasticity and Mitochondrial Homeostasis in Lung and Breast Carcinoma Cells

Mehazri, L., Shpungin, S., Bel, S., & Nir, U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073387 · Cited by 10 · see citing works

Immunotherapeutic Strategies Targeting Breast Cancer Stem Cells

Vasileiou, M., Diamantoudis, S. C., Tsianava, C., & Nguyen, N. P. (2024) · Current Oncology · doi:10.3390/curroncol31060232 · Cited by 10 · see citing works

Fer and FerT Govern Mitochondrial Susceptibility to Metformin and Hypoxic Stress in Colon and Lung Carcinoma Cells

Marciano, O., Mehazri, L., Shpungin, S., Varvak, A., Zacksenhaus, E., & Nir, U. (2021) · Cells · doi:10.3390/cells10010097 · Cited by 10 · see citing works

Synthetic Materials that Affect the Extracellular Matrix via Cellular Metabolism and Responses to a Metabolic State

Sthijns, M. M. J. P. E., van Blitterswijk, C., & LaPointe, V. L. S. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.742132 · Cited by 9 · see citing works

Use of patient‐derived tumor organoid platform to predict the benefit of postoperative adjuvant chemotherapy for poor responders to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Xue, W., Wang, T., Yao, J., Wu, W., Chen, D., Yan, B., Dong, X., Tang, Y., Zeng, Y., He, Y., et al. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10586 · Cited by 9 · see citing works

A lesson from earthquake engineering for selectively damaging cancer cell structures

Fraldi, M., Cutolo, A., Carotenuto, A. R., Palumbo, S., & Pugno, N. M. (2021) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2021.104533 · Cited by 9 · see citing works

Oncogenic signaling inhibits c-FLIPL expression and its non-apoptotic function during ECM-detachment

Tsegaye, M. A., He, J., McGeehan, K., Murphy, I. M., Nemera, M. T., & Schafer, Z. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-97715-4 · Cited by 9 · see citing works

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies

Jacintho, J. D., Baccei, C. S., Bravo, Y., Broadhead, A. R., Chen, A. C., Correa, L. D., Fischer, K., Laffitte, B. A., Lee, C. A. A., Lorrain, D. S., et al. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.12.045 · Cited by 8 · see citing works

Untargeted Metabolomics Showed Accumulation of One-Carbon Metabolites to Facilitate DNA Methylation during Extracellular Matrix Detachment of Cancer Cells

Nur, S. M., Mohammed, M. R. S., Zamzami, M. A., Choudhry, H., Ahmad, A., Ateeq, B., Rather, I. A., & Khan, M. I. (2022) · Metabolites · doi:10.3390/metabo12030267 · Cited by 7 · see citing works

Collapsing the Metabolic PON2zi Scheme in Pancreatic Ductal Adenocarcinoma

Tsegaye, M. A., & Schafer, Z. T. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.09.003 · Cited by 7 · see citing works

The genetic architecture of bone metastases: unveiling the role of epigenetic and genetic modifications in drug resistance

Dawalibi, A., Bakir, M. A., & Mohammad, K. S. (2025) · Cancer Drug Resistance · doi:10.20517/cdr.2025.28 · Cited by 7 · see citing works

RIPK1-dependent mitophagy: A novel mechanism to eliminate cells detached from the extracellular matrix

Hawk, M. A., & Schafer, Z. T. (2018) · Molecular & Cellular Oncology · doi:10.1080/23723556.2018.1465015 · Cited by 5 · see citing works

Decellularized matrices for tumor cell modeling

Brancato, V., Ventre, M., Reis, R. L., & Netti, P. A. (2020) · Methods in cell biology · doi:10.1016/bs.mcb.2019.11.015 · Cited by 6 · see citing works

Transforming growth factor-β (TGF-β) signaling pathway-related genes in predicting the prognosis of colon cancer and guiding immunotherapy

Chen, J., Ji, C., Liu, S., Wang, J., Wang, C., Pan, J., Qiao, J., Yu, L., Cai, M., & Ma, J. (2023) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2023.12.002 · Cited by 5 · see citing works

Anoikis and the Human Gut Epithelium in Health and Disease

Beauséjour, M., Boutin, A., & Vachon, P. H. (2021) · Springer eBooks · doi:10.1007/978-3-030-73856-3_5 · Cited by 5 · see citing works

G‐protein‐coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1‐mediated redox modulation

Wu, T., Ding, K., Wang, C., Lin, G., Xie, C., Chen, X., Li, Q., Yu, F.-H., Mao, Y., Hong, W., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202301172rrrr · Cited by 4 · see citing works

Downregulation of MicroRNA-1 and Its Potential Molecular Mechanism in Nasopharyngeal Cancer: An Investigation Combined with In Silico and In-House Immunohistochemistry Validation

Wen, J., Qin, L.-T., Chen, G., Huang, H., Shen, M.-J., Pang, J., Tang, Y.-X., Lu, W., Wang, R., & Luo, J. (2022) · Disease Markers · doi:10.1155/2022/7962220 · Cited by 4 · see citing works

Detachment stress mediated bioenergetic switch of malignant melanoma cells into anti-Warburg phenotype

Uen, W.-C., Tseng, T., Wu, C.-P., & Lee, S.-C. (2022) · Aging · doi:10.18632/aging.204164 · Cited by 4 · see citing works

Fer and FerT: A New Regulatory Link between Sperm and Cancer Cells

Nir, U., Grinshtain, E., & Breitbart, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065256 · Cited by 4 · see citing works

SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix

Cockfield, J. A., & Schafer, Z. T. (2021) · Molecular & Cellular Oncology · doi:10.1080/23723556.2021.1976583 · Cited by 4 · see citing works

Cellular mechanometabolism: stimuli and implications

Ortiz, I., Lopez, S., Kondapaneni, R. V., Hernández, J. A., Boone, K., & Reinhart‐King, C. A. (2026) · EMBO Reports · doi:10.1038/s44319-026-00795-4 · Cited by 3 · see citing works

Anoikis in prostate cancer bone metastasis gene signatures and therapeutic implications

Xia, W., Ye, M., Jiang, B., Xu, G. G., Xiao, G., Zeng, Q.-M., & Huang, R. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1446894 · Cited by 2 · see citing works

Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer

Sundararaman, A., Saha, M., Kumar, S., & Rangarajan, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-73856-3_2 · Cited by 2 · see citing works

Assessment of Metabolic Pathways and Parameters in Extracellular Matrix-Detached Cells

Hom, L. M., & Schafer, Z. T. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3247-5_23 · Cited by 2 · see citing works

Identification of crucial anoikis-related genes as novel biomarkers and potential therapeutic targets for lung adenocarcinoma via bioinformatic analysis and experimental verification

Wu, J., Zhang, Y., You, G., Guo, W., Wang, Y., Li, J., Tan, R., Fu, X., Tang, Y., Zan, J., et al. (2024) · Aging · doi:10.18632/aging.205521 · Cited by 1 · see citing works

TP53I11 Suppresses Extracellular Matrix-independent Survival and Mesenchymal Transition in Mammary Epithelial CellsPreprint

Xiao, T., Zhang, H., Zhou, Y., Geng, J., Xu, Z., Liang, Y., Qiao, H., & Suo, G. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/301499

Induced pluripotent stem cell-derived cardiomyocytes

Regev, D., Baskin, P., Dolgopyat, I., Davidor, M., Kermani, F., Ullrich, N. D., & Binah, O. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822230-0.00010-7

Anoikis, 2022

Frisch, S. M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00188-7

Construction and validation of an anoikis-related gene prognostic signature in ovarian cancerPreprint

Tang, Z., Huang, S., Liu, D. J., Liu, Y., Chen, J., Zhou, C., & He, S. (2023) · Research Square · doi:10.21203/rs.3.rs-2745365/v1

Modelos de matriz extracelular de carcinoma mamário canino

Campanelli, T. V. D. B. (2023) · doi:10.11606/d.10.2023.tde-05052023-112923

Acod1 Expression in Cancer Cells Promotes Immune Evasion Through the Generation of Inhibitory PeptidesPreprint

Schofield, J. H., Longo, J., Sheldon, R. D., Albano, E., Hawk, M. A., Murphy, S. P., Duong, L., Rahmy, S., Lü, X., Jones, R. G., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4594899

Identification and validation an anoikis-related gene signature for clinical diagnosis, prognosis and treatment of patients with hepatocellular carcinomaPreprint

Jiang, H., Wang, T., Li, S., Pan, X., Tan, W., & Sun, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4580896/v1

Cellular metabolomics study in colorectal cancer cells and media following treatment with 5-fluorouracil by gas chromatography-tandem mass spectrometry

Oh, S., Sim, H. B., Kim, H., Mun, S., Ji, M., Choi, B., Kim, D.-Y., Kim, J.-J., & Paik, M. (2025) · Metabolomics · doi:10.1007/s11306-025-02263-x

Balance between autophagy and apoptosis determines anoikis resistance: a mathematical model on cell fatePreprint

Maiti, S., Chedere, A., Jolly, M. K., Chandra, N. R., & Rangarajan, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.09.658583

Identification of anoikis-related tumor microenvironment characteristics and prognostic signature in ovarian cancer at bulk and single-cell levels

Tang, Z., Zhou, C., Xu, Y., Chen, Z., Huang, S., Chen, J., Jin, P., Hu, J., & He, S. (2025) · Discover Oncology · doi:10.1007/s12672-025-03602-z

Brusatol inhibits metastasis of triple-negative breast cancer through metabolic reprogramming

Yu, X., Diao, X., Fan, X., Wu, C., Wang, S., Liu, M., Cheung, E. C. W., & Chen, L. (2026) · Frontiers in Oncology · doi:10.3389/fonc.2026.1708878

Transcriptomic profiling reveals autophagy-associated programs and prognostic biomarkers in anoikis-resistant pancreatic cancer cells

Lin, L., Bauden, M., Andersson, R., & Ansari, D. (2026) · BMC Cancer · doi:10.1186/s12885-026-17107-7

BindingDB Entry 50007285: Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.

BindingDB (2021) · UC San Diego · doi:10.7270/q2xk8jvq

The regulation of cancer cell death and metabolism by extracellular matrix attachment

Buchheit, C. L., Rayavarapu, R. R., & Schafer, Z. T. (2012) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2012.04.007 · Cited by 115 · see citing works

Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination

Boese, A. C., & Kang, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-73856-3_1

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

Buchheit, C. L., Weigel, K. J., & Schafer, Z. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3789 · Cited by 367 · see citing works

Extracellular Matrix Regulation of Metabolism and Implications for TumorigenesisPreprint

Grassian, A. R., Coloff, J. L., & Brugge, J. S. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010967 · Cited by 75 · see citing works

Metabolic Reprogramming and the Control of Anoikis Resistance in Cancer

Sundararaman, A., Saha, M., Kumar, S., & Rangarajan, A. (2021) · Springer eBooks · doi:10.1007/978-3-030-73856-3_2 · Cited by 2 · see citing works