HOIP Deficiency Causes Embryonic Lethality by Aberrant TNFR1-Mediated Endothelial Cell Death

Peltzer, Nieves, Rieser, Eva, Taraborrelli, Lucia, Draber, Peter, Darding, Maurice, Pernaute, Barbara, Shimizu, Yutaka, Sarr, Aida +6 more·2014·Cell Reports

DOI 10.1016/j.celrep.2014.08.066

Cited by (250)

Items 101–200 of 250

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Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders
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OTULIN maintains skin homeostasis by controlling keratinocyte death and stem cell identity
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Formation and removal of poly‐ubiquitin chains in the regulation of tumor necrosis factor‐induced gene activation and cell death
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Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
Hirotsugu Oda, Kalpana Manthiram, Pallavi Pimpale Chavan, Eva Rieser, Önay Veli, Öykü Kaya, Charles T. Rauch, Shuichiro Nakabo, Hye Sun Kuehn, M. Swart et al. · 2024 · Nature Immunology
LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling
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The Linear ubiquitin chain assembly complex acts as a liver tumor suppressor and inhibits hepatocyte apoptosis and hepatitis
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MLKL post-translational modifications: road signs to infection, inflammation and unknown destinations
Gianmaria Liccardi, Alessandro Annibaldi · 2022 · Cell Death and Differentiation
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Zhijun Liu, Francis Ka-Ming Chan · 2020 · Seminars in Cell and Developmental Biology
RIP1 post-translational modifications
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Regulation of Met1‐linked polyubiquitin signalling by the deubiquitinase OTULIN
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Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP
Eiji Gotō, Fuminori Tokunaga · 2017 · Biochemical and Biophysical Research Communications
Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development
Kai Song, Xiaofeng Cai, Yunzhou Dong, Hao Wu, Yong Wei, Uma T. Shankavaram, Kui Cui, Yang Lee, Bo Zhu, Sudarshan Bhattacharjee et al. · 2020 · Journal of Clinical Investigation
Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression
Jian Zhu, Ting Zhuang, Huijie Yang, Xin Li, Huandi Liu, Hui Wang · 2016 · BMC Cancer
Sharpin promotes hepatocellular carcinoma progression via transactivation of Versican expression
Yasuo Tanaka, Keisuke Tateishi, Takuma Nakatsuka, Yotaro Kudo, Ryo Takahashi, Koji Miyabayashi, Keisuke Yamamoto, Yoshinari Asaoka, Hideaki Ijichi, Ryosuke Tateishi et al. · 2016 · Oncogenesis
IAP gene deletion and conditional knockout models
John Silke, David Lawrence Vaux · 2014 · Seminars in Cell and Developmental Biology
The regulation of necroptosis by ubiquitylation
Yiliang Chen, Wenqing Ren, Qingsong Wang, Yuan He, Dan Ma, Zhenyu Cai · 2022 · APOPTOSIS
OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
Yesheng Fu, Hongtian Wang, Hongmiao Dai, Qiong Zhu, Chun‐Ping Cui, Xiaoxuan Sun, Yanchang Li, Zhikang Deng, Xuemei Zhou, Yingwei Ge et al. · 2021 · Molecular Cell
HOIP limits anti-tumor immunity by protecting against combined TNF and IFN-gamma-induced apoptosis
Andrew J. Freeman, Stephin J. Vervoort, Jessica Michie, Kelly M. Ramsbottom, John Silke, Conor J. Kearney, Jane Oliaro · 2021 · EMBO Reports
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death
Katsuhiro Sasaki, Ai Himeno, Tomoko Nakagawa, Yoshiteru Sasaki, Hiroshi Kiyonari, Kazuhiro Iwaï · 2019 · Nature Communications
Targeting RIP Kinases in Chronic Inflammatory Disease
Mary Speir, Tirta Mario Djajawi, Stephanie A. Conos, Hazel Tye, Kate E. Lawlor · 2021 · Biomolecules
RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer
Huijie Yang, Min Xue, Peng Su, Yan Zhou, Xin Li, Zhongbo Li, Yan Xia, Chenmiao Zhang, Mingxi Fu, Xiuxia Zheng et al. · 2022 · Journal of Experimental & Clinical Cancer Research
Mendelian diseases of dysregulated canonical NF-κB signaling: From immunodeficiency to inflammation
Oskar Schnappauf, Ivona A Aksentijevich · 2020 · Journal of Leukocyte Biology
Contribution of cell death signaling to blood vessel formation
Nathalie Tisch, Carmen Ruiz de Almodóvar · 2021 · Cellular and Molecular Life Sciences
Differential Involvement of the Npl4 Zinc Finger Domains of SHARPIN and HOIL-1L in Linear Ubiquitin Chain Assembly Complex-Mediated Cell Death Protection
Satoshi Shimizu, Hiroaki Fujita, Yoshiteru Sasaki, Tatsuaki Tsuruyama, Kazuhiko Fukuda, Kazuhiro Iwaï · 2016 · Molecular and Cellular Biology
LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores
Min Wu, Yan Zuo Chang, Huaibin Hu, Rui Mu, Yucheng Zhang, Xuan-He Qin, Xiaotao Duan, Weihua Li, Hai-Qing Tu, Weina Zhang et al. · 2019 · Nature Communications
Developmental checkpoints guarded by regulated necrosis
Christopher P. Dillon, Bart Tummers, Katherine Baran, Douglas R. Green · 2016 · Cellular and Molecular Life Sciences
A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5
Yingying Zhang, Kai Huang, Yuxia Zhang, Han Tao, Lang Li, Chenchen Ruan, Ye-hsuan Sun, Wenke Shi, Wei Han, Suqin Wu et al. · 2021 · PLoS Biology
Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development
Fang Hua, Wenzhuo Hao, Lingyan Wang, Shitao Li · 2021 · International Journal of Molecular Sciences
Biochemistry, Pathophysiology, and Regulation of Linear Ubiquitination: Intricate Regulation by Coordinated Functions of the Associated Ligase and Deubiquitinase
Yasuhiro Fuseya, Kazuhiro Iwaï · 2021 · Cells
The parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC
Jens Meschede, Maria Šadič, Nikolas Furthmann, Tim Miedema, Dominik A. Sehr, Anne Kathrin Müller-Rischart, Verian Bader, Lena A. Berlemann, Anna Pilsl, Anita Schlierf et al. · 2020 · Science Signaling
T cell–derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death
Nicholas H. Chun, Rosalind L. Ang, Mark Chan, Robert L. Fairchild, William M. Baldwin, Julian K. Horwitz, Jesse D. Gelles, Jerry E. Chipuk, Michelle A. Kelliher, Vasile I. Pavlov et al. · 2021 · JCI Insight
Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair
Kristel Martinez Lagunas, Deniz Pinar Savcigil, Matea Zrilić, Carlos Carvajal Fraile, Andrew Craxton, Emily L. Self, Iratxe Uranga-Murillo, Diego de Miguel, Maykel A. Arias, Sebastian Willenborg et al. · 2023 · Science Advances
RNF31 Regulates Skin Homeostasis by Protecting Epidermal Keratinocytes from Cell Death
Yong Tang, Hailin Tu, Guangna Liu, Guoxing Zheng, Mingchao Wang, Lin Li, Xueqiang Zhao, Xin Lin · 2018 · The Journal of Immunology
LUBAC-mediated linear ubiquitination in tissue homeostasis and disease
Katsuhiro Sasaki, Kazuhiro Iwaï · 2023 · The Journal of Biochemistry
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole
Xiao-Lin Shen, Jinfeng Yuan, Xuan-He Qin, Guang-Ping Song, Huai-Bin Hu, Hai-Qing Tu, Zeng-Qing Song, Peiyao Li, Yu-Ling Xu, Sen Li et al. · 2021 · The Journal of Cell Biology
Role of Linear Ubiquitination in Health and Disease
Patricia L. Brazee, Laura A. Dada, Jacob Iasha Sznajder · 2016 · American Journal of Respiratory Cell and Molecular Biology
Cross-regulation between LUBAC and caspase-1 modulates cell death and inflammation
Todd Douglas, Maya Saleh · 2020 · Journal of Biological Chemistry
Molecular basis for specificity of the Met1-linked polyubiquitin signal
P.R. Elliott · 2016 · Biochemical Society Transactions
LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL
Nadine Weinelt, Kaja Nicole Wächtershäuser, Gulustan Celik, Birte Jeiler, Isabelle Gollin, Laura Zein, Sonja M. Smith, Geoffroy Andrieux, Tonmoy Das, Jens Roedig et al. · 2024 · Cell Death and Disease
HOIL‐1‐catalysed, ester‐linked ubiquitylation restricts IL‐18 signaling in cytotoxic T cells but promotes TLR signalling in macrophages
Tsvetana Petrova, Jiazhen Zhang, Sambit K. Nanda, Clara Figueras‐Vadillo, Philip Cohen · 2021 · FEBS Journal
LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB
Yu-Guang Chen, E. Rieser, Amandeep Bhamra, Silvia Surinova, Peter Kreuzaler, Meng-Hsing Ho, Wen-Chiuan Tsai, N. Peltzer, D. de Miguel, H. Walczak · 2024 · Cell Death and Differentiation
Ubiquitination Enzymes in Cancer, Cancer Immune Evasion, and Potential Therapeutic Opportunities
Aiman B. Awan, Maryiam Jama Ali Osman, Omar M. Khan · 2025 · Cells
Linear ubiquitination of PTEN impairs its function to promote prostate cancer progression
Yanmin Guo, Jianfeng He, Hailong Zhang, Ran Chen, Lian Li, Xiaojia Liu, Caihu Huang, Zhe Qiang, Zihan Zhou, Yanli Wang et al. · 2022 · Oncogene
Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti
Élodie Bal, Emmanuel Laplantine, Yamina Hamel, Virginie Dubosclard, Bertrand Boisson, Alessandra Pescatore, Capucine Pïcard, Smail Hadj-Rabia, Ghislaine Royer, Julie Steffann et al. · 2017 · Journal of Allergy and Clinical Immunology
Keeping Cell Death in Check: Ubiquitylation-Dependent Control of TNFR1 and TLR Signaling
Laura Griewahn, Aaron Köser, Ulrich Maurer · 2019 · Frontiers in Cell and Developmental Biology
M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation
Anna L. Aalto, Gabriela Martínez‐Chacón, Christa Kietz, Nadezhda Tsyganova, Joose Kreutzer, Pasi J. Kallio, Meike Broemer, Annika Meinander · 2022 · FEBS Journal
LUBAC is required for RIG-I sensing of RNA viruses
Helena Teague, Charlotte Lefèvre, Eva Rieser, L. Wolfram, Diego de Miguel, Daniel de Oliveira Patricio, Marisa Oliveira, Daniel Santos Mansur, Nerea Irigoyen, Henning Walczak et al. · 2023 · Cell Death and Differentiation
Linear ubiquitination in immune and neurodegenerative diseases, and beyond
Fuminori Tokunaga, Fumiyo Ikeda · 2022 · Biochemical Society Transactions
New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways
Tomoko Asaoka, Fumiyo Ikeda · 2015 · International review of cytology
Site‐specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling
Lilian M. Fennell, Carlos Gomez Diaz, Luiza Deszcz, Anoop Murthy Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkrüys, Josef Martin Penninger et al. · 2020 · The EMBO Journal
Linear Ubiquitination of RIPK1 on Lys612 Regulates Systemic Inflammation via Preventing Cell Death
Hailin Tu, Yong Tang, Jie Zhang, Liqing Cheng, Donghyun Joo, Xueqiang Zhao, Xin Lin · 2021 · The Journal of Immunology
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Kidong Kang, Sora Lee, Xuezhe Piao, Gang Min Hur · 2019 · Archives of Pharmacal Research
Ripoptocide – A Spark for Inflammation
Rosalind L. Ang, Mark Chan, Adrian T. Ting · 2019 · Frontiers in Cell and Developmental Biology
Reduced SHARPIN and LUBAC Formation May Contribute to CCl4- or Acetaminophen-Induced Liver Cirrhosis in Mice
Takeshi Yamamotoya, Yusuke Nakatsu, Yasuka Matsunaga, Toshiaki Fukushima, Hiroki Yamazaki, Sunao Kaneko, Midori Fujishiro, Takako Kikuchi, Akifumi Kushiyama, Fuminori Tokunaga et al. · 2017 · International Journal of Molecular Sciences
Dysregulation of Cell Death in Human Chronic Inflammation
Yue Li, Christoph Klein, Daniel Kotlarz · 2019 · Cold Spring Harbor Perspectives in Biology
Role of linear ubiquitination in inflammatory responses and tissue homeostasis
Katsuhiro Sasaki, Kazuhiro Iwaï · 2022 · International Immunology
MLKL activity requires a splicing-regulated, druggable intramolecular interaction
Uris Ros, Veronica Martinez-Osorio, Pedro Alberto Valiente, Yasmin Abdelwahab, Miloš Gojković, Raed Shalaby, Silvia Zanna, Julia Saggau, Laurens Wachsmuth, Harshal Nemade et al. · 2025 · Molecular Cell
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N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling
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The LUBAC participates in Lysophosphatidic Acid-induced NF-κB Activation
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Repressive Control of Keratinocyte Cytoplasmic Inflammatory Signaling
Liam E. Carman, Michael L. Samulevich, Brian J. Aneskievich · 2023 · International Journal of Molecular Sciences
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Ximena Hildebrandt, Önay Veli, Armel Hyoubi, Julia Zinngrebe, Ali Taleb Abdallah, Julian Rodefeld, Anne Hoffmann, Liane Gardeweg, Öykü Kaya, Elena Wagner et al. · 2025 · Science Advances
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