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Deletion of Human tarbp2 Reveals Cellular MicroRNA Targets and Cell-Cycle Function of TRBP

Kim, Yoosik, Yeo, Jinah, Lee, Jung Hyun, Cho, Jun, Seo, Daekwan, Kim, Jong-Seo, Kim, V. Narry·2014·Cell Reports
DOI 10.1016/j.celrep.2014.09.039
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  • Changes in Dicer processing sites produce isomiRs with altered thermodynamic end stabilities that reverse strand selection of mammalian miRNAs in vitro.

    “Indeed, changes in Dicer processing sites produce isomiRs with altered thermodynamic end stabilities that reverse strand selection of mammalian miRNAs in vitro (Kim et al., 2014; Lee & Doudna, 2012; Wilson & Doudna, 2014; Figure 4d).”

    From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Kim et al., 2014

    The Results report that altered Dicer cleavage generates iso-miRs with changed thermodynamic stability and demonstrate altered strand selection in human cells. They describe the earlier miR-200a work as a demonstration of this possibility, but do not establish that the strand-selection reversal in this paper occurred in vitro; its own demonstration was in cells. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Kim, Y., Yeo, J., Lee, J. H., Cho, J., Seo, D., Kim, J.-S., & Kim, V. N.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2014-11
Volume
9
Issue
3
Pages
1061-1074
ISSN
2211-1247
DOI
10.1016/j.celrep.2014.09.039
Cited by
116
References
1
Language
en
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